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1. 发明授权

US09745567B2 Compositions and methods for treating multiple sclerosis 有权
公开(公告)号：US09745567B2
公开(公告)日：2017-08-29
申请号：US12430728
申请日：2009-04-27
申请人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
发明人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
IPC分类号： A61K9/14 , C12N13/00
CPC分类号： C12N13/00
摘要： Provided are electrokinetically-altered fluids (gas-enriched electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for use in treating inflammatory neurodegenerative condition or disease or at least one symptom thereof. The electrokinetically-altered fluids or therapeutic compositions and methods include electrokinetically-altered ioinic aqueous fluids optionally in combination with other therapeutic agents. Particular aspects provide for regulating or modulating intracellular signal transduction associated with said inflammatory responses by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular routes of administration or formulations for the electrokinetically-altered fluids (e.g., electrokinetically-altered gas-enriched fluids and solutions) and therapeutic compositions.

2. 发明授权

US08980325B2 Compositions and methods for treating digestive disorders 有权
标题翻译：用于治疗消化系统疾病的组合物和方法
公开(公告)号：US08980325B2
公开(公告)日：2015-03-17
申请号：US12432571
申请日：2009-04-29
申请人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
发明人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
IPC分类号： A61F13/00 , A61K33/00 , A61K45/06
CPC分类号： A61K9/0087 , A61K33/00 , A61K45/06 , Y02A50/473 , Y02A50/475 , Y02A50/481 , Y02A50/491 , A61K2300/00
摘要： Provided are electrokinetically-altered fluids (e.g., gas-enriched (e.g., oxygen-enriched) electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide, upon contact with a cell, modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for using same in treating digestive disorders or at least one symptom thereof. The electrokinetically-altered fluid compositions and methods include electrokinetically-altered ioinic aqueous fluids optionally in combination with other therapeutic agents. Particular aspects provide for regulating or modulating intracellular signal transduction associated with said digestive disorders by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular routes of administration or formulations for the electrokinetically-altered fluids and therapeutic compositions.
摘要翻译：提供了电动改变的流体（例如，富含气体（例如富氧）电动流体），其包含电荷稳定的含氧纳米结构的离子水溶液，其量足以在与电池接触时提供调制细胞膜电位和细胞膜电导率中的至少一种，以及用于治疗消化系统疾病或其至少一种症状的治疗组合物和方法。电动改变的流体组合物和方法包括任选与其它治疗剂组合的电动改变的碘代水性流体。特定方面提供通过调节细胞膜，膜电位，膜蛋白例如膜受体（包括但不限于G-蛋白偶联受体（GPCR））中的至少一种来调节或调节与所述消化系统疾病相关的细胞内信号转导和细胞间连接（例如，紧密连接，间隙连接，zona adherins和desmasomes）。其它实施方案包括用于电动改变的流体和治疗组合物的特定给药途径或制剂。

3. 发明申请

US20120039958A1 COMPOSITIONS AND METHODS FOR TREATMENT OF TAUPATHY 有权
标题翻译：用于治疗TAUPATHY的组合物和方法
公开(公告)号：US20120039958A1
公开(公告)日：2012-02-16
申请号：US13209201
申请日：2011-08-12
申请人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
发明人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
IPC分类号： A61K9/00 , A61K31/58 , A61K38/21 , A61K31/136 , A61K39/395 , A61K31/137 , A61K31/44 , A61K31/167 , A61K31/46 , A61K31/47 , A61K31/436 , A61P25/28 , A61P25/00 , A61P29/00 , A61K31/56
CPC分类号： A61K31/136 , A61K31/137 , A61K31/167 , A61K31/436 , A61K31/44 , A61K31/46 , A61K31/47 , A61K31/56 , A61K31/58 , A61K38/13 , A61K38/21 , A61K41/0004 , A61K2300/00
摘要： Provided are electrokinetically-altered fluids (e.g., electrokinetically-altered gas-enriched fluids and solutions) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient for treating an inflammatory neurodegenerative condition or disease (e.g., a taupathy) or at least one symptom thereof. The electrokinetically-altered fluids or therapeutic compositions and methods include electrokinetically-altered ionic aqueous fluids optionally in combination with other therapeutic agents. Particular aspects provide for modulating phosphorylation of tau protein. Particular aspects provide for regulating or modulating intracellular signal transduction associated with said inflammatory responses by modulation of at least one of cellular membrane potential and/or conductance, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular routes of administration or formulations for the electrokinetically-altered fluids and therapeutic compositions.
摘要翻译：提供了包含电荷稳定的含氧纳米结构的离子水溶液的电动改变的流体（例如，电动改变的富含气体的流体和溶液），其量足以治疗炎症性神经变性病症或疾病（例如，甲状腺炎）或其至少一种症状。电动改变的流体或治疗组合物和方法包括任选与其它治疗剂组合的电动改变的离子水性流体。特定方面提供了调节tau蛋白的磷酸化。特定方面提供通过调节细胞膜电位和/或电导中的至少一种来调节或调节与所述炎症反应相关的细胞内信号转导，膜蛋白例如膜受体，包括但不限于G-蛋白偶联受体（GPCR），和细胞间结（例如，紧密连接处，间隙连接处，zona adherins和desmasomes）。其它实施方案包括用于电动改变的流体和治疗组合物的特定给药途径或制剂。

4. 发明申请

US20100303917A1 COMPOSITIONS AND METHODS FOR TREATING CYSTIC FIBROSIS 审中-公开
标题翻译：用于治疗CYSTIC FIBROSIS的组合物和方法
公开(公告)号：US20100303917A1
公开(公告)日：2010-12-02
申请号：US12772506
申请日：2010-05-03
申请人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
发明人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
IPC分类号： A61K9/14 , A61K39/395 , A61K33/00
CPC分类号： C12N13/00 , A61K33/00 , G01N33/6872
摘要： Provided are electrokinetically-altered fluids (gas-enriched (e.g., oxygen-enriched) electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide, upon contact with a cell, modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for using same in treating cystic fibrosis or a symptom thereof. The electrokinetically-altered fluid compositions and methods include electrokinetically-altered fluids optionally in combination with other therapeutic agents (e.g., antibiotics, albuterol, budesonide, etc.). Particular embodiments comprise use and/or synergy with tobramycin for treating bacterial infection, and use and/or synergy with a bronchiodilator. In certain aspects, the methods comprise regulating intracellular signal transduction by modulation of at least one of cellular membranes, membrane potential, membrane proteins (like, membrane receptors, including but not limited to G protein coupled receptors, and intercellular junctions).
摘要翻译：提供了电动改变的流体（气体富集（例如富氧）电动流体），其包含电荷稳定的含氧纳米结构的离子水溶液，其量足以在与电池接触时提供至少调节细胞膜电位和细胞膜电导率之一，以及用于治疗囊性纤维化或其症状的治疗组合物和方法。电动改变的流体组合物和方法包括任选与其它治疗剂（例如抗生素，沙丁胺醇，布地奈德等）组合的电动改变的流体。具体实施方案包括用于治疗细菌感染的妥布霉素的使用和/或协同作用，以及与支气管扩张剂的使用和/或协同作用。在某些方面，所述方法包括通过调节细胞膜，膜电位，膜蛋白（例如膜受体，包括但不限于G蛋白偶联受体和细胞间连接）中的至少一种调节细胞内信号转导。

5. 发明申请

US20100029764A1 COMPOSITIONS AND METHODS FOR MODULATING CELLULAR MEMBRANE-MEDIATED INTRACELLULAR SIGNAL TRANSDUCTION 审中-公开
标题翻译：用于调节细胞膜介导的细胞内信号转导的组合物和方法
公开(公告)号：US20100029764A1
公开(公告)日：2010-02-04
申请号：US12435262
申请日：2009-05-04
申请人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
发明人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
IPC分类号： C12N5/00 , A61K31/22 , A61P11/00
CPC分类号： C12N13/00 , G01N33/6872
摘要： Provided are electrokinetically-altered fluids (e.g., gas-enriched (e.g., oxygen-enriched) electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide, upon contact with a cell, modulation of at least one of cellular membrane potential and cellular membrane conductivity. Particular aspects of the present invention provide compositions and methods suitable for modulation of at least one of cellular membrane potential and cellular membrane conductivity. Additional aspects provide compositions and methods suitable for modulating intracellular signal transduction, including modulation of at least one of membrane structure, membrane potential or membrane conductivity, membrane proteins or receptors, ion channels, and calcium dependant cellular messaging systems, comprising use of the inventive electrokinetically altered solutions to impart electrochemical and/or conformational changes in membranous structures (e.g., membrane proteins, receptors and/or other components) including G-protein coupled receptors (GPCRs), G-proteins, and/or intracellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes).
摘要翻译：提供了电动改变的流体（例如，富含气体（例如富氧）电动流体），其包含电荷稳定的含氧纳米结构的离子水溶液，其量足以在与电池接触时提供调制细胞膜电位和细胞膜电导率中的至少一种。本发明的特定方面提供了适于调节细胞膜电位和细胞膜电导率中的至少一种的组合物和方法。另外的方面提供适用于调节细胞内信号转导的组合物和方法，包括调节膜结构，膜电位或膜电导率，膜蛋白或受体，离子通道和钙依赖性细胞消化系统中的至少一种，包括使用本发明的电动改变的溶液以赋予包括G蛋白偶联受体（GPCR），G蛋白和/或细胞内结（例如紧密连接）的膜结构（例如膜蛋白，受体和/或其它组分）的电化学和/或构象变化，间隙连接，zona adherins和desmasomes）。

6. 发明申请

US20100028443A1 COMPOSITIONS AND METHODS FOR TREATING INFLAMMATION 有权
标题翻译：用于治疗炎症的组合物和方法
公开(公告)号：US20100028443A1
公开(公告)日：2010-02-04
申请号：US12433825
申请日：2009-04-30
申请人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
发明人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
IPC分类号： A61K9/14 , A61K33/00
CPC分类号： C12N13/00
摘要： Provided are electrokinetically-altered fluids (gas-enriched (e.g., oxygen-enriched) electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide, upon contact with a cell, modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for using same in treating inflammation or at least one symptom thereof. The electrokinetically-altered fluid compositions and methods include electrokinetically-altered ionic aqueous fluids optionally in combination with other therapeutic agents. Particular aspects provide for regulating or modulating intracellular signal transduction associated with inflammatory responses by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular routes of administration or formulations for the electrokinetically-generated fluids (electrokinetically-generated gas-enriched fluids and solutions) and therapeutic compositions.
摘要翻译：提供了电动改变的流体（气体富集（例如富氧）电动流体），其包含电荷稳定的含氧纳米结构的离子水溶液，其量足以在与电池接触时提供至少调节细胞膜电位和细胞膜电导率之一，以及用于治疗炎症或其至少一种症状的治疗组合物和方法。电动改变的流体组合物和方法包括任选与其它治疗剂组合的电动改变的离子水性流体。特定方面提供通过调节细胞膜，膜电位，膜蛋白如膜受体，包括但不限于G-蛋白偶联受体（GPCR）和细胞间的细胞膜中的至少一种来调节或调节与炎性反应相关的细胞内信号转导交汇处（紧密连接处，间隙连接处，电子邮件地址和地址）。其他实施方案包括用于电动产生的流体（电动产生的富含气体的流体和溶液）和治疗组合物的特定给药途径或制剂。

7. 发明申请

US20090274730A1 COMPOSITIONS AND METHODS FOR TREATING INFLAMMATION 审中-公开
标题翻译：用于治疗炎症的组合物和方法
公开(公告)号：US20090274730A1
公开(公告)日：2009-11-05
申请号：US12258210
申请日：2008-10-24
申请人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
发明人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
IPC分类号： A61K9/00 , A61K31/56 , A61K38/12 , A61K39/395 , A61K38/16 , A61P29/00
CPC分类号： C12N13/00 , G01N33/6872
摘要： Provided are electrokinetically-generated fluids (e.g., gas-enriched electrokinetic fluids or solutions), and therapeutic compositions and methods for use in treating inflammation or at least one symptom of inflammation. The electrokinetically-generated fluids or therapeutic compositions and methods include electrokinetically-generated aqueous fluids optionally in combination with other therapeutic agents. Particular aspects provide for regulating or modulating intracellular signal transduction associated with inflammatory responses by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular routes of administration or formulations for the electrokinetically-generated fluids (e.g., electrokinetically-generated gas-enriched fluids and solutions) and therapeutic compositions.
摘要翻译：提供了电动产生的流体（例如，富气电动液或溶液），以及用于治疗炎症或至少一种炎症症状的治疗组合物和方法。电动产生的流体或治疗组合物和方法包括任选与其它治疗剂组合的电动产生的水性流体。特定方面提供通过调节细胞膜，膜电位，膜蛋白如膜受体，包括但不限于G-蛋白偶联受体（GPCR）和细胞间的细胞膜中的至少一种来调节或调节与炎性反应相关的细胞内信号转导交界处（例如，紧密连接处，间隙连接处，粘合层和脱水垫）。其它实施方案包括用于电动产生的流体（例如，电动产生的富含气体的流体和溶液）和治疗组合物的特定给药途径或制剂。

8. 发明申请

US20090247458A1 COMPOSITIONS AND METHODS FOR TREATING CYSTIC FIBROSIS 审中-公开
标题翻译：用于治疗CYSTIC FIBROSIS的组合物和方法
公开(公告)号：US20090247458A1
公开(公告)日：2009-10-01
申请号：US12257607
申请日：2008-10-24
申请人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
发明人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
IPC分类号： A61K38/16 , A61K31/137 , A61K31/58 , A61P31/04 , A61K31/70 , A61P11/00 , A61P11/08
CPC分类号： C12N13/00 , G01N33/6872
摘要： Particular aspects provide electrokinetically-generated fluids (e.g., electrokinetically-generated gas-enriched fluids and solutions), and therapeutic compositions and methods comprising use thereof in treating at least one symptom of cystic fibrosis. In particular embodiments, at least one symptom of cystic fibrosis treated by the present invention include inhibition of Pseudomonas infection, synergy with tobramycin (including TOBI) for use against bacterial infection, and synergy with a bronchiodilator. In particular embodiments, the electrokinetically-generated fluids or therapeutic compositions and methods comprise combination with other therapeutic agents (e.g., antibiotics, albuterol, budesonide, etc.). In certain aspects, the methods comprise regulating or modulating intracellular signal transduction by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G protein coupled receptors, and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes).
摘要翻译：具体方面提供电动产生的流体（例如，电动产生的富含气体的流体和溶液）以及包含其用于治疗囊性纤维化至少一种症状的治疗组合物和方法。在具体实施方案中，通过本发明治疗的囊性纤维化的至少一种症状包括抑制假单胞菌感染，与用于抗细菌感染的妥布霉素（包括TOBI）的协同作用以及与支气管扩张剂的协同作用。在具体实施方案中，电动产生的流体或治疗组合物和方法包括与其它治疗剂（例如抗生素，沙丁胺醇，布地奈德等）的组合。在某些方面，所述方法包括通过调节细胞膜，膜电位，膜蛋白例如膜受体（包括但不限于G蛋白偶联受体）和细胞间结（例如，紧密的）至少一种来调节或调节细胞内信号转导交界处，间隙连接处，zona adherins和desmasomes）。

9. 发明授权

US09492404B2 Compositions and methods for treatment of taupathy 有权
标题翻译：用于治疗甲状腺炎的组合物和方法
公开(公告)号：US09492404B2
公开(公告)日：2016-11-15
申请号：US13209201
申请日：2011-08-12
申请人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
发明人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
IPC分类号： A61K38/21 , A61P25/28 , A61K9/00 , A61K31/46 , A61K31/47 , A61K31/137 , A61P29/00 , A61K31/58 , A61K31/56 , A61K31/167 , A61K31/44 , A61K31/436 , A61K31/136 , A61P25/00 , A61K39/395 , A61K38/13 , A61K41/00
CPC分类号： A61K31/136 , A61K31/137 , A61K31/167 , A61K31/436 , A61K31/44 , A61K31/46 , A61K31/47 , A61K31/56 , A61K31/58 , A61K38/13 , A61K38/21 , A61K41/0004 , A61K2300/00
摘要： Provided are electrokinetically-altered fluids (e.g., electrokinetically-altered gas-enriched fluids and solutions) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient for treating an inflammatory neurodegenerative condition or disease (e.g., a taupathy) or at least one symptom thereof. The electrokinetically-altered fluids or therapeutic compositions and methods include electrokinetically-altered ionic aqueous fluids optionally in combination with other therapeutic agents. Particular aspects provide for modulating phosphorylation of tau protein. Particular aspects provide for regulating or modulating intracellular signal transduction associated with said inflammatory responses by modulation of at least one of cellular membrane potential and/or conductance, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular routes of administration or formulations for the electrokinetically-altered fluids and therapeutic compositions.
摘要翻译：提供了包含电荷稳定的含氧纳米结构的离子水溶液的电动改变的流体（例如，电动改变的富含气体的流体和溶液），其量足以治疗炎症性神经变性病症或疾病（例如，甲状腺炎）或其至少一种症状。电动改变的流体或治疗组合物和方法包括任选与其它治疗剂组合的电动改变的离子水性流体。特定方面提供了调节tau蛋白的磷酸化。特定方面提供通过调节细胞膜电位和/或电导中的至少一种来调节或调节与所述炎症反应相关的细胞内信号转导，膜蛋白例如膜受体，包括但不限于G-蛋白偶联受体（GPCR），和细胞间结（例如，紧密连接处，间隙连接处，zona adherins和desmasomes）。其它实施方案包括用于电动改变的流体和治疗组合物的特定给药途径或制剂。

10. 发明授权

US09198929B2 Compositions and methods for enhancing physiological performance and recovery time 有权
标题翻译：用于增强生理性能和恢复时间的组合物和方法
公开(公告)号：US09198929B2
公开(公告)日：2015-12-01
申请号：US13102930
申请日：2011-05-06
申请人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
发明人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
IPC分类号： A61K9/14 , A61K33/00 , A23L1/30 , A23L2/54 , A61K41/00
CPC分类号： A61K33/00 , A23L2/54 , A23L33/10 , A23V2002/00 , A61K9/0053 , A61K9/08 , A61K33/14 , A61K41/0004 , A23V2200/25 , A23V2200/33 , A23V2250/126
摘要： Provided are methods for enhancing exercise (e.g., intense, eccentric, elevated temperature, repetitive, aerobic, and high altitude) performance, comprising administering electrokinetically-altered aqueous fluids comprising an ionic aqueous solution of stably configured charge-stabilized oxygen-containing nanostructures predominantly having an average diameter of less than 100 nanometers. In certain aspects, enhancing exercise performance comprises at least one of: reducing plasma inflammatory cytokines (e.g., IFN-alpha, ENA-78 and BDNF); ameliorating muscle/tendon damage or enhancing muscle/tendon recovery; reducing biomarkers of exercise-induced muscle injury (e.g., CK-, plasma myoglobin); ameliorating exercise induced tendinosis, tendonitis, tenosynovitis, avulsion, and tendon strain associated with chronic repetitive movement or enhancing recovering therefrom; increasing VO2 max; decreasing RPE; reducing blood lactate; preserving muscle contractile function (e.g., maximal force, joint ROM); reducing muscle soreness; ameliorating onset of fatigue in an exercising subject. Improved methods for producing electrokinetically altered aqueous fluids (including sports beverages) are also provided.
摘要翻译：提供了用于增强运动（例如，强烈，偏心，升高的温度，重复，有氧和高海拔）性能的方法，包括施用电动改变的含水流体，其包含稳定配置的电荷稳定的含氧纳米结构的离子水溶液，其主要具有平均直径小于100纳米。在某些方面，增强运动性能包括降低血浆炎性细胞因子（例如IFN-α，ENA-78和BDNF）中的至少一种; 改善肌肉/肌腱损伤或增强肌肉/肌腱恢复; 减少运动性肌肉损伤的生物标志物（例如，CK-，血浆肌红蛋白）; 改善运动诱导的腱鞘炎，腱炎，腱鞘炎，撕脱和与慢性重复运动相关的肌腱菌株或增强其从其中的恢复; 增加VO2 max; 减少RPE; 减少血液乳酸盐保持肌肉收缩功能（例如，最大力，关节ROM）; 减轻肌肉酸痛; 改善运动受试者的疲劳发作。还提供了用于生产电动改变的含水流体（包括运动饮料）的改进的方法。

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