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81. 发明授权

US08951959B2 Glucagon-like peptide-1 analogues and uses thereof 有权
标题翻译：胰高血糖素样肽-1类似物及其用途
公开(公告)号：US08951959B2
公开(公告)日：2015-02-10
申请号：US13643840
申请日：2011-04-29
申请人： Yinxiang Wang , Fenlai Tan , Shaojing Hu , Xiangdong Zhao , Cunbo Ma , Yanping Wang , Xiaoyan Shen , Lieming Ding , Yunyan Hu , Hong Cao , Wei Long
发明人： Yinxiang Wang , Fenlai Tan , Shaojing Hu , Xiangdong Zhao , Cunbo Ma , Yanping Wang , Xiaoyan Shen , Lieming Ding , Yunyan Hu , Hong Cao , Wei Long
IPC分类号： A61K38/00 , A61P9/10 , C07K14/47 , A61P3/04 , A61K38/22 , A61P3/08 , A61P3/10 , A61K38/26 , A61P7/12 , C07K14/605 , A61K38/28 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00
CPC分类号： C07K14/605 , A61K38/00
摘要： Provided is a glucagon-like peptide-1 (GLP-1) analog shown as the following formula, wherein X is selected from glycine and glycinamide. The GLP-1 analog has a non-proteogenic amino acid residue in position 8 relative to the sequence GLP-1, and is acylated with a moiety comprising two acidic groups to the lysine residue in position 26. The GLP-1 analog is resistant to dipeptidyl peptidase IV so as to have an extended half-life in vivo. Also provided is a use of the GLP-1 analog in conquering blood sugar.
摘要翻译：本发明提供如下式所示的胰高血糖素样肽-1（GLP-1）类似物，其中X选自甘氨酸和甘氨酰胺。 GLP-1类似物相对于序列GLP-1具有位置8的非蛋白原性氨基酸残基，并且用包含两个酸性基团的部分酰化至位置26的赖氨酸残基。GLP-1类似物对二肽基肽酶IV，以使体内延长半衰期。还提供了GLP-1类似物在征服血糖中的用途。

82. 发明申请

US20140343137A1 Stable Polymorphic Forms of Compound as Hypoxia Mimetics, and Uses Thereof 有权
标题翻译：作为缺氧模拟物的化合物的稳定多晶型及其用途
公开(公告)号：US20140343137A1
公开(公告)日：2014-11-20
申请号：US14166203
申请日：2012-07-30
申请人： Xinshan Kang , Wei Long , Fei Wang , Cunbo Ma , Liufeng Zhou , Yunyan Hu , Yanping Wang , Hong Cao , Yinxiang Wang , Fenlai Tan
发明人： Xinshan Kang , Wei Long , Fei Wang , Cunbo Ma , Liufeng Zhou , Yunyan Hu , Yanping Wang , Hong Cao , Yinxiang Wang , Fenlai Tan
IPC分类号： C07D311/56
CPC分类号： C07D311/56
摘要： The polymorphic forms of the compound of Formula I, the preparation thereof including the preparation of the intermediates, the pharmaceutical compositions thereof and the uses of a polymorph above in the manufacture of medicaments for treating a disease, a disorder or a condition are disclosed.
摘要翻译：公开了式I化合物的多晶型物，其制备方法，包括制备中间体，其药物组合物，以及上述多晶型物在制备用于治疗疾病，病症或病症的药物中的用途。

83. 发明申请

US20080161797A1 Ablation catheter electrode having multiple thermal sensors and method of use 有权
标题翻译：消融导管电极具有多个热传感器和使用方法
公开(公告)号：US20080161797A1
公开(公告)日：2008-07-03
申请号：US11647282
申请日：2006-12-29
申请人： Huisun Wang , Hong Cao , Jeremy D. Dando
发明人： Huisun Wang , Hong Cao , Jeremy D. Dando
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B18/14 , A61B2018/00011 , A61B2018/00023 , A61B2018/00577 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , Y10T29/49117
摘要： The invention relates to electrodes used in ablation catheter devices, where the electrodes contain two or more thermal sensors at different positions within the electrode that are capable of detecting temperature differences along the external surface of the electrode. In preferred embodiments, the thermal sensors are separated by one or more thermal insulating members and the thermal sensors are positioned near the external surface of the electrode at about the same distance from the end of the electrode, so that temperature measurements can indicate the position of the electrode with respect to the tissue desired to be ablated.
摘要翻译：本发明涉及消融导管装置中使用的电极，其中电极在电极内的不同位置包含能够检测沿着电极外表面的温度差的两个或多个热传感器。在优选实施例中，热传感器被一个或多个绝热构件隔开，并且热传感器位于与电极端部大约相同距离处的电极的外表面附近，使得温度测量可以指示位置电极相对于希望烧蚀的组织。

84. 发明授权

US08460285B2 Ablation catheter electrode having multiple thermal sensors and method of use 有权
公开(公告)号：US08460285B2
公开(公告)日：2013-06-11
申请号：US11647282
申请日：2006-12-29
申请人： Huisun Wang , Hong Cao , Jeremy D. Dando
发明人： Huisun Wang , Hong Cao , Jeremy D. Dando
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B18/14 , A61B2018/00011 , A61B2018/00023 , A61B2018/00577 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , Y10T29/49117
摘要： The invention relates to electrodes used in ablation catheter devices, where the electrodes contain two or more thermal sensors at different positions within the electrode that are capable of detecting temperature differences along the external surface of the electrode. In preferred embodiments, the thermal sensors are separated by one or more thermal insulating members and the thermal sensors are positioned near the external surface of the electrode at about the same distance from the end of the electrode, so that temperature measurements can indicate the position of the electrode with respect to the tissue desired to be ablated.

85. 发明申请

US20110178092A1 HIV-1 Protease Inhibitors 审中-公开
标题翻译： HIV-1蛋白酶抑制剂
公开(公告)号：US20110178092A1
公开(公告)日：2011-07-21
申请号：US11960120
申请日：2007-12-19
申请人： Akbar Ali , Michael D. Altman , Saima G. Anjum , Hong Cao , Sripriya Chellappan , Miguel X. Fernandes , Michael K. Gilson , Visvaldas Kairys , Nancy King , Ellen Nalivaika , Moses Prabu , Tariq M. Rana , Kiran Kumar Sai , Celia A. Schiffer , Bruce Tidor
发明人： Akbar Ali , Michael D. Altman , Saima G. Anjum , Hong Cao , Sripriya Chellappan , Miguel X. Fernandes , Michael K. Gilson , Visvaldas Kairys , Nancy King , Ellen Nalivaika , Moses Prabu , Tariq M. Rana , Kiran Kumar Sai , Celia A. Schiffer , Bruce Tidor
IPC分类号： A61K31/501 , C07D403/12 , A61K31/4178 , C07D401/14 , A61K31/4439 , C07D413/12 , A61K31/422 , C07C311/29 , A61K31/18 , C07D277/36 , A61K31/426 , C07D277/64 , A61K31/428 , C07C233/81 , A61K31/166 , C07D215/48 , A61K31/47 , A61P31/18
CPC分类号： C07C311/05 , C07C233/36 , C07C235/20 , C07C235/50 , C07C235/60 , C07C235/74 , C07C237/22 , C07C311/29 , C07C2601/02 , C07C2601/10 , C07C2601/14 , C07D215/48 , C07D263/24 , C07D277/36 , C07D277/64 , C07D307/20 , C07D307/79 , C07D401/14 , C07D403/12 , C07D413/12 , C07D417/12 , C07D493/04
摘要： Described are novel protease inhibitors and methods for using said protease inhibitors in the treatment of human immunodeficiency virus (HIV) infection.
摘要翻译：描述了新型蛋白酶抑制剂和使用所述蛋白酶抑制剂治疗人类免疫缺陷病毒（HIV）感染的方法。

86. 发明申请

US20080161794A1 Irrigated ablation catheter having a pressure sensor to detect tissue contact 有权
标题翻译：灌注消融导管具有检测组织接触的压力传感器
公开(公告)号：US20080161794A1
公开(公告)日：2008-07-03
申请号：US11646270
申请日：2006-12-28
申请人： Huisun Wang , Hong Cao
发明人： Huisun Wang , Hong Cao
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00029 , A61B2090/065 , A61B2218/002
摘要： The invention relates to an irrigated ablation catheter that has a pressure sensor to determine tissue contact as well as methods of using the same. The irrigated ablation catheter contains fluid tubing, an electrode with passages and a lumen and a pressure sensor located inside the lumen of the electrode. In some embodiments, a cooling fluid, such as saline, is passed through the catheter.
摘要翻译：本发明涉及一种具有确定组织接触的压力传感器的灌洗消融导管及其使用方法。灌注消融导管包含流体管，具有通道的电极和内腔，位于电极内腔内的压力传感器。在一些实施例中，诸如盐水的冷却流体通过导管。

87. 发明授权

US09238637B2 Stable polymorphic forms of compound as hypoxia mimetics, and uses thereof 有权
标题翻译：作为缺氧模拟物的化合物的稳定多晶形式及其用途
公开(公告)号：US09238637B2
公开(公告)日：2016-01-19
申请号：US14166203
申请日：2012-07-30
申请人： Xinshan Kang , Wei Long , Fei Wang , Cunbo Ma , Liufeng Zhou , Yunyan Hu , Yanping Wang , Hong Cao , Yinxiang Wang , Fenlai Tan
发明人： Xinshan Kang , Wei Long , Fei Wang , Cunbo Ma , Liufeng Zhou , Yunyan Hu , Yanping Wang , Hong Cao , Yinxiang Wang , Fenlai Tan
IPC分类号： A01N43/16 , C07D311/56
CPC分类号： C07D311/56
摘要： The polymorphic forms of the compound of Formula I, the preparation thereof including the preparation of the intermediates, the pharmaceutical compositions thereof and the uses of a polymorph above in the manufacture of medicaments for treating a disease, a disorder or a condition are disclosed.
摘要翻译：公开了式I化合物的多晶型物，其制备方法，包括制备中间体，其药物组合物，以及上述多晶型物在制备用于治疗疾病，病症或病症的药物中的用途。

88. 发明授权

US09069526B2 Audio data processing method and audio data processing system 有权
标题翻译：音频数据处理方法和音频数据处理系统
公开(公告)号：US09069526B2
公开(公告)日：2015-06-30
申请号：US13337055
申请日：2011-12-24
申请人： Hong Cao
发明人： Hong Cao
IPC分类号： G06F5/00 , G06F3/16 , H04L12/18 , H04L12/58 , G06F3/00
CPC分类号： G06F3/162 , H04L12/1827 , H04L51/04 , H04L51/063 , H04L51/10
摘要： Audio data processing method and an audio data processing system are described. The audio data processing system includes an audio collect module, a processing module, a virtual play module, a virtual collect module, and a buffer memory. The virtual play module and the virtual collect module are registered in an application interface layer of a third-part software. The third-part software chooses the virtual play module and the virtual collect module. The virtual play module is configured for receiving audio data processed by the processing module and storing the processed audio data in the buffer memory. The virtual collect module is configured for collecting the processed audio data from the buffer memory and transmitting the processed audio data to the third-part software. The invention provides a universal solution suitable for any chatting tool by installing the virtual speaker and the virtual microphone.
摘要翻译：描述音频数据处理方法和音频数据处理系统。音频数据处理系统包括音频收集模块，处理模块，虚拟播放模块，虚拟收集模块和缓冲存储器。虚拟播放模块和虚拟收集模块被注册在第三部分软件的应用接口层中。第三部分软件选择虚拟播放模块和虚拟收集模块。虚拟播放模块被配置用于接收由处理模块处理的音频数据，并将经处理的音频数据存储在缓冲存储器中。虚拟收集模块被配置为从缓冲存储器收集经处理的音频数据，并将经处理的音频数据发送到第三部分软件。本发明通过安装虚拟扬声器和虚拟麦克风提供了适用于任何聊天工具的通用解决方案。

89. 发明申请

US20130203672A1 Novel Glucagon Like Peptide Analogs, Composition, and Method of Use 有权
标题翻译：新型胰高血糖素类似物，组合物和使用方法
公开(公告)号：US20130203672A1
公开(公告)日：2013-08-08
申请号：US13698819
申请日：2010-05-17
申请人： Shaojing Hu , Fenlai Tan , Yanping Wang , Cunbo Ma , Yunyan Hu , Hong Cao , Xiangdong Zhao , Wei Long , Yinxiang Wang , Lieming Ding
发明人： Shaojing Hu , Fenlai Tan , Yanping Wang , Cunbo Ma , Yunyan Hu , Hong Cao , Xiangdong Zhao , Wei Long , Yinxiang Wang , Lieming Ding
IPC分类号： C07K14/605
CPC分类号： C07K14/605 , A61K9/0019 , A61K38/00
摘要： The present invention relates to novel analogs of glucagon like peptide and compositions that are useful for up-regulating insulin expression in mammals and for treating diabetes. In particular, these peptide derivatives have a peptide mimic linker and provides long duration of action for the treatment of diabetes and other insulinotropic peptide related diseases, gastrointestinal function and activities associated with glucagon levels.
摘要翻译：本发明涉及胰高血糖素样肽的新型类似物和可用于上调哺乳动物胰岛素表达和治疗糖尿病的组合物。特别地，这些肽衍生物具有肽模拟接头并且提供用于治疗糖尿病和其它促胰岛素肽相关疾病，胃肠功能和与胰高血糖素水平相关的活性的长期作用。

90. 发明授权

US08221409B2 Thermally insulated irrigation catheter assembly 有权
标题翻译：绝热冲洗导管组件
公开(公告)号：US08221409B2
公开(公告)日：2012-07-17
申请号：US11962600
申请日：2007-12-21
申请人： Hong Cao , Huisun Wang
发明人： Hong Cao , Huisun Wang
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00083 , A61B2018/00101 , A61B2218/002
摘要： The present invention relates to ablation electrode assemblies. The present invention further relates to an insulated irrigated ablation electrode assembly. The insulated irrigated ablation electrode assembly of the present invention includes a proximal member, a distal member and an intermediate thermally insulating member. The proximal member includes a body portion defined by an outer surface, an inner cavity defined within the outer body portion, and at least one passageway that extends from the inner cavity to the outer surface of the body portion. The distal member of the electrode assembly includes a distal end. Moreover, the intermediate member of the electrode assembly is disposed between the proximal member and the distal member thereby thermally insulating the proximal member from the distal member.
摘要翻译：本发明涉及消融电极组件。本发明还涉及绝缘灌溉消融电极组件。本发明的绝缘灌溉消融电极组件包括近端构件，远侧构件和中间隔热构件。近端构件包括由外表面限定的主体部分，限定在外主体部分内的内腔以及从内腔延伸到主体部分的外表面的至少一个通道。电极组件的远端构件包括远端。此外，电极组件的中间构件设置在近端构件和远端构件之间，从而使近端构件与远端构件热绝缘。

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