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81. 发明授权

US09149631B2 Cardiac lead placement using multiple spatially distributed sensors 有权
标题翻译：使用多个空间分布传感器的心脏导联放置
公开(公告)号：US09149631B2
公开(公告)日：2015-10-06
申请号：US12236838
申请日：2008-09-24
申请人： Shantha Arcot-Krishnamurthy , Quan Ni , Michael Stucky , Allan C. Shuros
发明人： Shantha Arcot-Krishnamurthy , Quan Ni , Michael Stucky , Allan C. Shuros
IPC分类号： A61N1/05 , A61N1/365
CPC分类号： A61N1/056 , A61N1/36514
摘要： Systems and methods facilitate placement of a lead in or on a patient's heart. At least one reference sensor is positioned at a right heart location of a patient's heart and a cardiac lead apparatus comprising at least one lead apparatus sensor is advanced to a plurality of left heart locations. Using the reference sensor and the lead apparatus sensor, a distance parameter indicative of a distance between the reference and lead apparatus sensors is measured for each of the plurality of left heart locations. Strain or stress estimates are determined for the plurality of left heart locations derived from the distance parameter measurements. Using the strain or stress estimates, a physician perceivable output is produced indicating suitability of the left heart locations as pacing sites.
摘要翻译：系统和方法有利于将铅放置在患者心脏中或患者的心脏上。至少一个参考传感器位于患者心脏的右心脏位置，并且包括至少一个引导装置传感器的心脏引导装置前进到多个左心脏位置。使用参考传感器和引导装置传感器，针对多个左心脏位置中的每一个测量指示参考和引导装置传感器之间的距离的距离参数。对于从距离参数测量导出的多个左心脏位置确定应变或应力估计。使用应变或压力估计，产生医生可感知的输出，指示左心脏位置作为起搏部位的适合性。

82. 发明申请

US20150039045A1 METHOD AND SYSTEM FOR APPLYING STIMULATION IN TREATING SLEEP DISORDERED BREATHING 审中-公开
标题翻译：应用刺激治疗睡眠障碍性呼吸的方法和系统
公开(公告)号：US20150039045A1
公开(公告)日：2015-02-05
申请号：US14238359
申请日：2012-08-13
申请人： Quan Ni , Mark A. Christopherson , John Rondoni
发明人： Quan Ni , Mark A. Christopherson , John Rondoni
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36139 , A61B5/0402 , A61B5/053 , A61B5/08 , A61B5/0826 , A61B5/085 , A61B5/087 , A61B5/4836 , A61B5/686 , A61B2562/0247 , A61N1/0556 , A61N1/3611
摘要： A stimulation protocol determination system includes an input module and a selector module. The input module is provided to receive an indication of an upper airway flow limitation via sensed respiratory effort information. The selection module is provided to automatically select, based on the indicated upper airway flow limitation, a stimulation protocol.
摘要翻译：刺激方案确定系统包括输入模块和选择器模块。提供输入模块以通过感测的呼吸努力信息接收上呼吸道流量限制的指示。提供选择模块以根据所指示的上呼吸道流量限制自动选择刺激方案。

83. 发明申请

US20130204097A1 METHOD AND SYSTEM FOR IDENTIFYING A LOCATION FOR NERVE STIMULATION 有权
标题翻译：用于识别神经刺激位置的方法和系统
公开(公告)号：US20130204097A1
公开(公告)日：2013-08-08
申请号：US13634333
申请日：2011-03-10
申请人： John Rondoni , Mark A. Christopherson , Quan Ni
发明人： John Rondoni , Mark A. Christopherson , Quan Ni
IPC分类号： A61B5/053 , A61B5/0488 , A61B5/08 , A61B5/04
CPC分类号： A61B5/0536 , A61B5/04001 , A61B5/0488 , A61B5/08 , A61B5/1104 , A61B5/4519 , A61B5/4818 , A61B5/4893 , A61B5/6814 , A61B5/682 , A61B5/6822 , A61B5/6839 , A61B5/6843 , A61B5/6849 , A61B5/7425 , A61B5/7435 , A61B34/20 , A61B34/25 , A61B2034/2065 , A61B2505/05 , A61B2562/043 , A61N1/36 , A61N1/372 , A61N1/37241 , A61N1/37247
摘要： A system and method for identifying a stimulation location on a nerve is disclosed. The system includes an image-based navigation interface used to facilitate advancing a stimulation element within a patient body toward a target nerve stimulation site. Using the system one determines, separately for each potential target nerve stimulation site, a neuromuscular response of muscles produced upon applying a stimulation signal at the respective separate potential target stimulation sites. The image-based navigation interface is configured to display a graphic identification of which muscles were activated for each respective potential target nerve stimulation site upon applying the stimulation signal.
摘要翻译：公开了用于识别神经上的刺激位置的系统和方法。该系统包括基于图像的导航界面，用于促进将患者体内的刺激元件推向目标神经刺激部位。使用该系统，对于每个潜在的目标神经刺激部位，单独确定在相应的单独的潜在目标刺激部位应用刺激信号时产生的肌肉的神经肌肉反应。基于图像的导航界面被配置为在施加刺激信号时显示针对每个相应的潜在目标神经刺激部位激活了哪些肌肉的图形标识。

84. 发明授权

US08475388B2 Detection of disordered breathing 有权
标题翻译：检测无序呼吸
公开(公告)号：US08475388B2
公开(公告)日：2013-07-02
申请号：US12847711
申请日：2010-07-30
申请人： Quan Ni , John D. Hatlestad , Jesse W. Hartley , Jeffrey E. Stahmann , Jaeho Kim , Kent Lee
发明人： Quan Ni , John D. Hatlestad , Jesse W. Hartley , Jeffrey E. Stahmann , Jaeho Kim , Kent Lee
IPC分类号： A61B5/08
CPC分类号： A61B5/4818 , A61B5/0205 , A61B5/4806 , A61B5/4809 , A61B5/7264
摘要： Devices and methods for detecting disordered breathing involve determining that the patient is asleep and sensing one or more signals associated with disordered breathing indicative of sleep-disordered breathing while the patient is asleep. Sleep-disordered breathing is detected using the sensed signals associated with disordered breathing. The sensed signals associated with disordered breathing may also be used to acquire a respiration pattern of one or more respiration cycles. Characteristics of the respiration pattern are determined. The respiration pattern is classified as a disordered breathing episode based on the characteristics of the respiration pattern. One or more processes involved in the detection of disordered breathing are performed using an implantable device.
摘要翻译：用于检测无序呼吸的装置和方法涉及确定患者睡着并且感测与患者睡着时指示睡眠呼吸紊乱的无序呼吸相关联的一个或多个信号。使用与无序呼吸相关的感测信号来检测睡眠呼吸障碍。与无序呼吸相关联的感测信号也可用于获取一个或多个呼吸循环的呼吸模式。确定呼吸模式的特征。根据呼吸模式的特点，呼吸模式被分类为无序呼吸发作。使用可植入装置进行涉及无序呼吸检测的一个或多个过程。

85. 发明授权

US08442638B2 Adaptive baroreflex stimulation therapy for disordered breathing 有权
标题翻译：适应性压力反射刺激治疗无序呼吸
公开(公告)号：US08442638B2
公开(公告)日：2013-05-14
申请号：US12781447
申请日：2010-05-17
申请人： Imad Libbus , Quan Ni , Kent Lee
发明人： Imad Libbus , Quan Ni , Kent Lee
IPC分类号： A61N1/3601 , A61N1/3611
CPC分类号： A61N1/3611 , A61N1/3601 , A61N1/36135
摘要： An approach to providing disordered breathing therapy includes delivering electrical stimulation therapy modifying a patient's baroreflex response. Disordered breathing therapy may be delivered in response to prediction or detection of disordered breathing events. Various conditions affecting the patient may be evaluated and the baroreflex therapy modified. The therapy may be modified to improve therapy efficacy, to reduce an impact to the patient and/or to mitigate therapy interactions.
摘要翻译：提供无序呼吸治疗的方法包括进行改变患者压力反射反应的电刺激疗法。无序呼吸治疗可以响应于预测或检测到无序呼吸事件而被传送。可以评估影响患者的各种状况，并修改压力反射治疗。可以修改治疗以改善治疗功效，减少对患者的影响和/或减轻治疗相互作用。

86. 发明授权

US08380296B2 Automatic activation of medical processes 失效
标题翻译：自动激活医疗过程
公开(公告)号：US08380296B2
公开(公告)日：2013-02-19
申请号：US12649753
申请日：2009-12-30
申请人： Kent Lee , Jeffrey E. Stahmann , Jesse W. Hartley , Quan Ni
发明人： Kent Lee , Jeffrey E. Stahmann , Jesse W. Hartley , Quan Ni
IPC分类号： A61B5/04
CPC分类号： A61N1/3601 , A61B5/04012 , A61B5/1107 , A61B5/4094 , A61B5/4818 , A61B5/6869 , A61B2505/09 , A61M16/024 , A61M16/10 , A61M2016/0039 , A61M2016/0042 , A61M2205/3561 , A61M2205/3584 , A61M2230/04 , A61M2230/10 , A61M2230/63 , A61N1/3611 , A61N1/36114 , A61N1/36135 , A61N1/36514
摘要： Systems and methods involve automatic activation, de-activation or modification of therapies or other medical processes based on brain state. A medical system includes a sensor system having one or more sensors configured to sense signals related to the brain state of the patient. A brain state analyzer detects various brain states, including sleep stage and/or brain seizures. A controller uses the brain state detection information to control a medical system configured to perform at least one respiratory or cardiac process. Methods involve sensing signals related to brain state and determining the brain state of a patient based on the sensed signals. At least one respiratory or cardiac medical process is controlled based on the patient's brain state.
摘要翻译：系统和方法涉及基于脑状态的治疗或其他医疗过程的自动激活，去激活或修饰。医疗系统包括具有一个或多个传感器的传感器系统，该传感器被配置为感测与患者的脑状态相关的信号。脑状态分析仪检测各种脑状态，包括睡眠阶段和/或脑癫痫发作。控制器使用脑状态检测信息来控制被配置为执行至少一个呼吸或心脏过程的医疗系统。方法涉及感测与脑状态相关的信号，并且基于感测到的信号来确定患者的大脑状态。至少一个呼吸或心脏医疗过程是根据患者的大脑状态进行控制的。

87. 发明申请

US20120283527A1 RESPIRATION MONITORING FOR HEART FAILURE USING IMPLANTABLE DEVICE 失效
标题翻译：使用可移植设备进行心脏衰竭的呼吸监测
公开(公告)号：US20120283527A1
公开(公告)日：2012-11-08
申请号：US13553098
申请日：2012-07-19
申请人： Yachuan Pu , Kent Lee , Jonathan Kwok , Quan Ni
发明人： Yachuan Pu , Kent Lee , Jonathan Kwok , Quan Ni
IPC分类号： A61B5/0205 , A61B5/11 , A61B5/08
CPC分类号： A61B5/0816 , A61B5/0031 , A61B5/0452 , A61B5/4818 , A61N1/3627 , A61N1/36521
摘要： An implantable respiration monitor can be used to detect disordered breathing or periodic breathing events that can be categorized, such as according to one or more of sleep, exercise, and resting awake states. The categorized frequency of such events can be compared to independently specifiable thresholds, such as to trigger an alert or responsive therapy, or to display one or more trends. The information can also be combined with detection of one or more other congestive heart failure (CHF) symptoms to generate a CHF status indicator or to trigger an alarm or responsive therapy or to display one or more trends. The alert can notify the patient or a caregiver, such as via remote monitoring. The sleep state information can be further categorized according to central sleep apnea (CSA) or obstructive sleep apnea (OSA) events.
摘要翻译：可植入式呼吸监测器可用于检测可分类的无序呼吸或定期呼吸事件，例如根据睡眠，运动和休眠状态中的一种或多种。这些事件的分类频率可以与独立指定的阈值进行比较，例如触发警报或响应治疗，或显示一个或多个趋势。该信息还可以与一种或多种其他充血性心力衰竭（CHF）症状的检测相结合，以产生CHF状态指示器或触发警报或反应性治疗或显示一种或多种趋势。该警报可以通过远程监视来通知病人或看护者。睡眠状态信息可以根据中枢性睡眠呼吸暂停（CSA）或阻塞性睡眠呼吸暂停（OSA）事件进一步分类。

88. 发明授权

US08251061B2 Methods and systems for control of gas therapy 有权
标题翻译：气体治疗方法和系统
公开(公告)号：US08251061B2
公开(公告)日：2012-08-28
申请号：US10929306
申请日：2004-08-30
申请人： Kent Lee , Jesse W. Hartley , Jeffrey E. Stahmann , Quan Ni
发明人： Kent Lee , Jesse W. Hartley , Jeffrey E. Stahmann , Quan Ni
IPC分类号： A61M15/00 , A61M16/00 , A61M15/08 , A62B7/00 , A62B9/02
CPC分类号： A61M16/024 , A61M2016/0039 , A61M2230/04 , A61M2230/08 , A61M2230/205 , A61M2230/63
摘要： A gas therapy system involves sensing the blood gas concentration of the patient and adapting a gas therapy based on the sensed gas concentration. Disordered breathing may be detected bases on blood gas concentration, and gas or cardiac electrical therapy may be adapted to treat the detected disordered breathing. One or more of sensing the blood gas concentration, detecting disordered breathing, or adapting the therapy may be performed at least in part implantably. The gas therapy is delivered to the patient through an external respiratory device, such as a positive airway pressure device.
摘要翻译：气体治疗系统包括感测患者的血液气体浓度，并根据检测到的气体浓度调整气体治疗。可能会根据血气浓度检测到无效呼吸，气体或心脏电疗可适用于治疗检测到的无序呼吸。感测血气浓度，检测无序呼吸或适应治疗的一种或多种可以至少部分地可植入地进行。气体治疗通过外部呼吸装置（例如气道正压装置）输送给患者。

89. 发明授权

US08241212B2 Cardiac signal display and event detection using multiresolution Z-score transform 有权
标题翻译：使用多分辨率Z分数变换的心脏信号显示和事件检测
公开(公告)号：US08241212B2
公开(公告)日：2012-08-14
申请号：US12510927
申请日：2009-07-28
申请人： Dan Li , Quan Ni
发明人： Dan Li , Quan Ni
IPC分类号： A61B5/00 , A61B5/04
CPC分类号： A61N1/37211 , A61B5/021 , A61B5/024 , A61B5/0816 , A61B5/11 , A61N1/3702
摘要： A system comprising a medical device including a processor and a Z-score transformation (ZST) module. The system also includes a display in communication with the processor. The processor is adapted to receive sensor data obtained from at least first and second sensors adapted to produce a time-varying physiologic electrical sensor signal. At least one of the first and second sensors is implantable. The ZST module calculates a ZST for the sensor data received from the first sensor and a ZST for the sensor data received from the second sensor. The display is adapted to display the ZSTs in visual correspondence with each other over time.
摘要翻译：一种包括医疗装置的系统，包括处理器和Z分数变换（ZST）模块。该系统还包括与处理器通信的显示器。处理器适于接收从至少第一和第二传感器获得的传感器数据，该传感器适于产生时变生理电传感器信号。第一和第二传感器中的至少一个是可植入的。 ZST模块计算从第一个传感器接收的传感器数据的ZST和从第二个传感器接收的传感器数据的ZST。该显示器适于随时间显示可视对应的ZST。

90. 发明授权

US08224445B2 Far-field sensing channel for implantable cardiac device 有权
标题翻译：用于可植入心脏装置的远场感测通道
公开(公告)号：US08224445B2
公开(公告)日：2012-07-17
申请号：US13205387
申请日：2011-08-08
申请人： Geng Zhang , Douglas R. Daum , James O. Gilkerson , Quan Ni
发明人： Geng Zhang , Douglas R. Daum , James O. Gilkerson , Quan Ni
IPC分类号： A61N1/37
CPC分类号： A61N1/371 , A61N1/3621 , A61N1/3756
摘要： An implantable pacemaker is provided with a far-field sensing channel which requires a reduced refractory period during the time when pacing pulses are delivered as compared with sensing channels using intra-cardiac electrodes. The far-field sensing channel may use the conductive housing of the implantable device or can and an indifferent electrode mounted on the device header as the electrodes for its differential inputs. Such a far-field sensing channel is able to sense activity occurring in either the atria or the ventricles for the purposes of arrhythmia detection and/or capture verification.
摘要翻译：植入式心脏起搏器设置有远场感测通道，与使用心脏内电极的感测通道相比，在进行起搏脉冲的时间期间需要减少的不应期。远场感测通道可以使用可植入装置的导电外壳或者可以将安装在设备头上的无关电极用作其差分输入的电极。为了心律失常检测和/或捕获验证的目的，这种远场感测通道能够感测在心房或心室中发生的活动。

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