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81. 发明申请

US20090110049A1 Radio Receiver in a Wireless Communications System 有权
标题翻译：无线电接收机在无线通信系统中
公开(公告)号：US20090110049A1
公开(公告)日：2009-04-30
申请号：US12016640
申请日：2008-01-18
申请人： Carlo Luschi , Simon Huckett , Simon Walker , Steve Allpress , Philip Jones
发明人： Carlo Luschi , Simon Huckett , Simon Walker , Steve Allpress , Philip Jones
IPC分类号： H04L27/01
CPC分类号： H04L25/03114 , H04B2201/7071 , H04L25/0212 , H04L2025/03566 , H04L2025/03726
摘要： Techniques are described for optimizing processing facilities of a receiver in a wireless communication environment, taking into consideration processing performance set against the computing resources and/or power consumption required to obtain the processing performance. An embodiment of a radio receiver is described that includes a channel equalization means arranged to receive digital samples of an incoming signal and to generate an equalized output, said channel equalization means including means for processing said digital samples in accordance with an equalizer algorithm utilizing a set of equalizer parameters. The receiver can include means for estimating at least one parameter of a channel over which the signal has been received, and means for selecting at least one of said equalizer parameters based on at least one of said estimated channel parameters. Related methods, algorithms, and computer program products are also described.
摘要翻译：描述了在无线通信环境中优化接收机的处理设施的技术，考虑到针对获得处理性能所需的计算资源和/或功耗设置的处理性能。描述了一种无线电接收机的实施例，其包括信道均衡装置，其被配置为接收输入信号的数字样本并产生均衡的输出，所述信道均衡装置包括用于根据利用集合的均衡器算法处理所述数字样本的装置均衡器参数。接收机可以包括用于估计已经在其上接收信号的信道的至少一个参数的装置，以及用于基于所述估计的信道参数中的至少一个来选择所述均衡器参数中的至少一个的装置。还描述了相关方法，算法和计算机程序产品。

82. 发明申请

US20090082550A1 ANTIBODY COMPOSITIONS AND METHODS 审中-公开
标题翻译：抗体组合物和方法
公开(公告)号：US20090082550A1
公开(公告)日：2009-03-26
申请号：US12186245
申请日：2008-08-05
申请人： Ian Tomlinson , Amrik Basran , Philip Jones
发明人： Ian Tomlinson , Amrik Basran , Philip Jones
IPC分类号： C07K16/18
CPC分类号： C07K16/005 , A61K47/60 , A61K2039/505 , C07K16/18 , C07K16/241 , C07K16/2875 , C07K16/2878 , C07K16/40 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/56 , C07K2317/567 , C07K2317/569 , C07K2317/70 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： Provided are concentrated preparations comprising single immunoglobulin variable domain polypeptides that bind target antigen with high affinity and are soluble at high concentration, without aggregation or precipitation, providing, for example, for increased storage stability and the ability to administer higher therapeutic doses.
摘要翻译：提供了包含单一免疫球蛋白可变结构域多肽的浓缩制剂，其以高亲和力结合靶抗原并且可以高浓度溶解，无聚集或沉淀，提供例如提高储存稳定性和施用较高治疗剂量的能力。

83. 发明授权

US07279580B2 Imidazo-pyridine derivatives as ligands for GABA receptors 失效
标题翻译：咪唑并吡啶衍生物作为GABA受体的配体
公开(公告)号：US07279580B2
公开(公告)日：2007-10-09
申请号：US10512984
申请日：2003-05-23
申请人： Simon Charles Goodacre , David James Hallett , Alexander Charles Humphries , Philip Jones , Sarah Margaret Kelly , Kevin John Merchant , Kevin William Moore , Michael Reader
发明人： Simon Charles Goodacre , David James Hallett , Alexander Charles Humphries , Philip Jones , Sarah Margaret Kelly , Kevin John Merchant , Kevin William Moore , Michael Reader
IPC分类号： C07D471/02 , C07D491/02 , C07D498/02 , A01N43/42 , A61K31/44
CPC分类号： C07D471/04
摘要： A class of 8-fluoro-3-phenylimidazo[1,2-α]pyridine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group, or by a pyrrolidinonyl group, which is directly attached or bridged by an oxygen atom or by a —NH— or —OCH2— linkage, being selective ligands for GABAA receptors, in particular having high affinity for the α2 and/or α3 and/or α5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.
摘要翻译：一类在苯环的间位被任意取代的芳基或杂芳基取代的8-氟-3-苯基咪唑并[1,2-α]吡啶衍生物，或直接连接或桥连的吡咯烷基由氧原子或-NH-或-OCH 2 - 键组成，是GABA A A受体的选择性配体，特别是对α2和/或 α3和/或α5亚基因此有益于治疗和/或预防中枢神经系统的不利条件，包括焦虑，抽搐和认知障碍。

84. 发明授权

US07271191B2 Pyrazole derivatives as gamma-secretase inhibitors useful in the treatment of Alzheimer's disease 失效
标题翻译：吡唑衍生物作为可用于治疗阿尔茨海默病的γ-分泌酶抑制剂
公开(公告)号：US07271191B2
公开(公告)日：2007-09-18
申请号：US10549226
申请日：2004-04-01
申请人： Michela Bettati , Mark Stuart Chambers , Peter Alan Hunt , Philip Jones , Angus Murray MacLeod , Helen Jane Szekeres , Martin Richard Teall
发明人： Michela Bettati , Mark Stuart Chambers , Peter Alan Hunt , Philip Jones , Angus Murray MacLeod , Helen Jane Szekeres , Martin Richard Teall
IPC分类号： A61K31/415 , C07D231/24 , C07D231/12
CPC分类号： C07D231/12 , C07D401/04 , C07D401/06 , C07D409/12
摘要： The compounds of formula I: inhibit gamma secretase and hence are of utility in the treatment or prevention of Alzheimer's Disease.
摘要翻译：式I化合物：抑制γ-分泌酶，因此可用于治疗或预防阿尔茨海默氏病。

85. 发明申请

US20070195486A1 Charge storage device 有权
标题翻译：充电存储设备
公开(公告)号：US20070195486A1
公开(公告)日：2007-08-23
申请号：US11228294
申请日：2005-09-19
申请人： George Paul , Rory Pynenburg , Peter Mahon , Anthony Vassallo , Philip Jones , Sarkis Keshishian , Anthony Pandolfo
发明人： George Paul , Rory Pynenburg , Peter Mahon , Anthony Vassallo , Philip Jones , Sarkis Keshishian , Anthony Pandolfo
IPC分类号： H01G9/00
CPC分类号： H01G9/016 , H01G9/008 , H01G9/045 , H01G9/048 , H01G9/058 , H01G9/08 , H01G9/155 , H01G11/12 , H01G11/24 , H01G11/26 , H01G11/32 , H01G11/42 , H01G11/52 , H01G11/72 , H01G11/76 , Y02E60/13 , Y02T10/7022
摘要： A charge storage device comprising: a first electrode; a second electrode being opposed to and spaced apart from the first electrode; a porous separator disposed between the electrodes; a sealed package for containing the electrodes, the separator and an electrolyte in which the electrodes are immersed; and a first terminal and a second terminal being electrically connected to the first electrode and the second electrode respectively and both extending from the package to allow external electrical connect to the respective electrodes, wherein the gravimetric FOM of the device is greater than about 2.1 Watts/gram. Also described is a method of manufacturing a charge storage device, the method comprising the steps of: providing a first electrode; disposing a second electrode in opposition to and spaced apart from the first electrode; disposing a porous separator between the electrodes; containing within a sealed package the electrodes, the separator and an electrolyte, wherein the electrodes are immersed in the electrolyte; and electrically connecting a first terminal and a second terminal to the first electrode and the second electrode respectively such that the terminals extending from the package to allow external electrical connection to the respective electrodes, wherein the gravimetric FOM of the device is greater than about 2.1 Watts/gram.
摘要翻译：一种电荷存储装置，包括：第一电极; 与所述第一电极相对并间隔开的第二电极; 设置在电极之间的多孔隔膜; 用于容纳电极的密封包装，分离器和电极浸入其中的电解质; 以及第一端子和第二端子，其分别电连接到第一电极和第二电极，并且两者从封装延伸以允许外部电连接到相应的电极，其中该器件的重量FOM大于约2.1瓦特/ 公克。还描述了一种制造电荷存储装置的方法，该方法包括以下步骤：提供第一电极; 将第二电极设置成与第一电极相对并间隔开; 在电极之间设置多孔隔板; 在密封包装中包含电极，隔板和电解质，其中电极浸入电解质中; 以及分别将第一端子和第二端子电连接到第一电极和第二电极，使得从封装件延伸的端子允许与各个电极的外部电连接，其中该装置的重量FOM大于约2.1瓦 /公克。

86. 发明申请

US20070179138A1 6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives 失效
标题翻译： 6-苯基-1H-咪唑并[4,5-c]吡啶-4-甲腈衍生物
公开(公告)号：US20070179138A1
公开(公告)日：2007-08-02
申请号：US11653600
申请日：2007-01-16
申请人： Jiaqiang Cai , Zoran Rankovic , Philip Jones , David Bennett , Iain Cumming , Jonathan Gillespie
发明人： Jiaqiang Cai , Zoran Rankovic , Philip Jones , David Bennett , Iain Cumming , Jonathan Gillespie
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/4745 , C07D471/02
CPC分类号： C07D471/04
摘要： The present invention relates to 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives having the general Formula I wherein each of the substituents is given the definition as set forth in the specification and claims, pharmaceutical compositions comprising the same as well as to the use of these derivatives for the preparation of a medicament for the treatment of cathepsin S and/or cathepsin K related diseases such as osteoporosis, atherosclerosis, inflammation and immune disorders, such as rheumatoid arthritis, and chronic pain, such as neuropathic pain.
摘要翻译：本发明涉及具有通式I的6-苯基-1H-咪唑并[4,5-c]吡啶-4-腈衍生物，其中每个取代基被给出如说明书和权利要求书中所阐述的定义，药物组合物包括这些以及这些衍生物用于制备用于治疗组织蛋白酶S和/或组织蛋白酶K相关疾病如骨质疏松症，动脉粥样硬化，炎症和免疫疾病如类风湿性关节炎和慢性疼痛的药物的用途，如神经性疼痛。

87. 发明申请

US20070154990A1 Assays for identifying inhibitors of fatty acid amide hydrolase 审中-公开
标题翻译：鉴定脂肪酸酰胺水解酶抑制剂的方法
公开(公告)号：US20070154990A1
公开(公告)日：2007-07-05
申请号：US11635806
申请日：2006-12-07
申请人： Yuren Wang , Philip Jones , Jun Xu , Albert Uveges
发明人： Yuren Wang , Philip Jones , Jun Xu , Albert Uveges
IPC分类号： C12P21/06
CPC分类号： C12Q1/34 , G01N33/542 , G01N33/543 , G01N33/573 , G01N33/60 , G01N2333/98
摘要： Assays for screening compounds suspected of binding fatty acid amide hydrolase (FAAH) using scintillation proximity assay (SPA) technology are described. The assays utilize the interactions of reversible inhibitors such as [3H]—R(+)-methanandamide (MAEA) and membrane-associated FAAH, such as FAAH-containing microsomes, to evaluate the displacement activity of candidate FAAH inhibitors. The assays are specific for FAAH where FAAH binding compounds can be detected. Various embodiments of the assay have been validated and demonstrated to be simple, sensitive and amenable to high-throughput screening. Kits for performing the assays are also disclosed.
摘要翻译：描述了使用闪烁亲近测定（SPA）技术筛选疑似结合脂肪酸酰胺水解酶（FAAH）的化合物的测定。该测定法利用可逆抑制剂如[3 H] -R（+） - 甲烷酰胺（MAEA）和膜相关FAAH（如含FAAH的微粒体）的相互作用来评估候选FAAH抑制剂。该测定法对FAAH是特异性的，其中可以检测到FAAH结合化合物。测定的各种实施方案已被验证并被证明是简单，敏感和适于高通量筛选。还公开了用于进行测定的试剂盒。

88. 发明申请

US20070132442A1 Filter tuning 审中-公开
标题翻译：滤波器调谐
公开(公告)号：US20070132442A1
公开(公告)日：2007-06-14
申请号：US11301096
申请日：2005-12-12
申请人： Philip Jones
发明人： Philip Jones
IPC分类号： G01R23/165
CPC分类号： H03H11/1291 , H03H2011/0494
摘要： Calibrating a filter includes configuring a connection network coupled to input and output ports of first and second processing components into a first state in which the first and second processing components are connected to form at least part of an oscillator, and reconfiguring the connection network into a second state in which the first and second processing components are connected to form at least part of a polyphase filter.
摘要翻译：校准过滤器包括将耦合到第一和第二处理组件的输入和输出端口的连接网络配置到第一状态，其中第一和第二处理组件被连接以形成振荡器的至少一部分，以及将连接网络重新配置为第二状态，其中第一和第二处理部件被连接以形成多相滤波器的至少一部分。

89. 发明申请

US20070065440A1 Antibody compositions and methods 审中-公开
标题翻译：抗体组合物和方法
公开(公告)号：US20070065440A1
公开(公告)日：2007-03-22
申请号：US11401745
申请日：2006-04-10
申请人： Ian Tomlinson , Amrik Basran , Philip Jones
发明人： Ian Tomlinson , Amrik Basran , Philip Jones
IPC分类号： C07K16/24 , A61K39/395
CPC分类号： C07K16/005 , A61K47/60 , A61K2039/505 , C07K16/18 , C07K16/241 , C07K16/2875 , C07K16/2878 , C07K16/40 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/56 , C07K2317/567 , C07K2317/569 , C07K2317/70 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： Provided are concentrated preparations comprising single immunoglobulin variable domain polypeptides that bind target antigen with high affinity and are soluble at high concentration, without aggregation or precipitation, providing, for example, for increased storage stability and the ability to administer higher therapeutic doses.
摘要翻译：提供了包含单一免疫球蛋白可变结构域多肽的浓缩制剂，其以高亲和力结合靶抗原并且可以高浓度溶解，无聚集或沉淀，提供例如提高储存稳定性和施用较高治疗剂量的能力。

90. 发明申请

US20060292018A1 Hydraulic powered pneumatic super charger for on-board inert gas generating system 审中-公开
标题翻译：用于车载惰性气体发生系统的液压动力气动超级充电器
公开(公告)号：US20060292018A1
公开(公告)日：2006-12-28
申请号：US11178049
申请日：2005-07-08
申请人： Philip Jones
发明人： Philip Jones
IPC分类号： F04B35/00
CPC分类号： F04B45/022 , B64D37/32
摘要： The inert gas generating system includes an air separation module (ASM) and a super charger. The ASM includes an ASM inlet configured for receiving an air flow, and an ASM outlet configured for expelling nitrogen enriched air (NEA). The super charger has a hydraulic system including a cylinder, a hydraulic piston housed within the cylinder, and a switching valve. The switching valve has a hydraulic fluid inlet, a hydraulic fluid outlet, and hydraulic passages fluidly coupling the switching valve to the cylinder near opposing ends of the cylinder. The switching valve is configured to alternate hydraulic fluid received at the fluid inlet between the hydraulic passages. The super charger also has a pneumatic system having identical pneumatic pistons coupled to opposing sides of the hydraulic piston, where each pneumatic piston is coupled to a pneumatic chamber having an air inlet and an air outlet coupled to the ASM inlet.
摘要翻译：惰性气体发生系统包括空气分离模块（ASM）和超级充电器。 ASM包括配置为接收空气流的ASM入口和被配置为排出富氮空气（NEA）的ASM出口。超级充电器具有包括气缸，容纳在气缸内的液压活塞和切换阀的液压系统。切换阀具有液压流体入口，液压流体出口和液压通道，其将切换阀流体地连接到气缸附近的气缸两端。切换阀构造成交替在液压通道之间的流体入口处接收的液压流体。超级充电器还具有气动系统，其具有联接到液压活塞的相对侧的相同的气动活塞，其中每个气动活塞联接到具有连接到ASM入口的空气入口和空气出口的气动室。

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