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81. 发明申请

US20100267796A1 THERAPEUTIC AGENT FOR IRRITABLE BOWEL SYNDROME 审中-公开
标题翻译：可治疗性皮肤病综合征的治疗药物
公开(公告)号：US20100267796A1
公开(公告)日：2010-10-21
申请号：US12065120
申请日：2007-10-26
申请人： Tsuyoshi Yamagata , Kenji Shibata , Yoichi Nishiya , Takashi Seishi , Takashi Sakuma
发明人： Tsuyoshi Yamagata , Kenji Shibata , Yoichi Nishiya , Takashi Seishi , Takashi Sakuma
IPC分类号： A61K31/38 , C07D495/04 , A61K31/4155 , A61K31/381 , A61P1/00 , A61P1/12 , A61P1/14
CPC分类号： A61K31/38 , A61K31/381 , A61K31/4155 , C07D495/04
摘要： The present invention provides a therapeutic agent for irritable bowel syndrome which comprises, as an active ingredient, a compound having an adenosine uptake inhibitory activity, a therapeutic agent for irritable bowel syndrome which comprises, as an active ingredient, a tricyclic compound represented by formula (I) [wherein L represents —NHC(═O)— or the like, R1 represents a hydrogen atom, halogen, or the like, X1—X2—X3 represents S—CR7═CR8 (wherein R7 and R8 may be the same or different and each represents a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, or the like), or the like, Y represents —CH2SO2—, —SO2CH2— or the like, R2 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, substituted or unsubstituted aryl, or the like] or a pharmaceutically acceptable salt thereof, and the like.
摘要翻译：本发明提供一种肠易激综合征治疗剂，其包含作为活性成分的具有腺苷摄取抑制活性的化合物，用于肠易激综合征的治疗剂，其包含作为活性成分的由式（3）表示的三环化合物 I）[其中L表示-NHC（= O） - 等，R 1表示氢原子，卤素等，X 1 -X 2 -X 3表示S-CR 7 = CR 8（其中R 7和R 8可以相同或不同，各自表示氢原子，卤素，取代或未取代的低级烷基等）等，Y表示-CH 2 SO 2 - ， - SO 2 CH 2 - 等，R 2表示取代或未取代的低级烷基，取代或未取代的低级烷氧基，取代或未取代的芳基等）或其药学上可接受的盐等。

82. 发明申请

US20100221178A1 Method for Treating the TH2-Mediated Disease 有权
标题翻译：治疗TH2介导性疾病的方法
公开(公告)号：US20100221178A1
公开(公告)日：2010-09-02
申请号：US12684651
申请日：2010-01-08
申请人： Kenya SHITARA , Nobuo Hanai , Emi Shoji , Mikiko Sakurada , Akiko Furuya , Kazuyasu Nakamura , Rinpei Niwa , Kenji Shibata , Motoo Yamasaki
发明人： Kenya SHITARA , Nobuo Hanai , Emi Shoji , Mikiko Sakurada , Akiko Furuya , Kazuyasu Nakamura , Rinpei Niwa , Kenji Shibata , Motoo Yamasaki
IPC分类号： A61K39/395 , A61K51/10 , A61P37/00
CPC分类号： G01N33/543 , A61K2039/505 , C07K16/2866 , C07K2317/24 , C07K2317/565 , C07K2317/732 , C07K2319/00 , G01N2333/78
摘要： A recombinant antibody or the antibody fragment thereof which specifically reacts with an extracellular domain of human CCR4; a DNA which encodes the recombinant antibody or the antibody fragment thereof; a method for producing the recombinant antibody or the antibody fragment thereof; a method for immunologically detecting CCR4, a method for immunologically detecting a cell which expressed CCR4 on the cell surface, a method for depleting a cell which expresses CCR4 on the cell surface, and a method for inhibiting production of Th2 cytokine, which comprise using the recombinant antibody according or antibody fragment thereof; a therapeutic or diagnostic agent for Th2-mediated immune diseases; and a therapeutic or diagnostic agent for a blood cancer.
摘要翻译：与人CCR4的细胞外结构域特异性反应的重组抗体或其抗体片段; 编码重组抗体或其抗体片段的DNA; 制备重组抗体或其抗体片段的方法; 用于免疫学检测CCR4的方法，用于免疫检测在细胞表面上表达CCR4的细胞的方法，用于在细胞表面上表达CCR4的细胞消耗的方法，以及抑制Th2细胞因子产生的方法，其包括使用重组抗体或其抗体片段; Th2介导的免疫疾病的治疗或诊断剂; 和用于血液癌的治疗或诊断剂。

83. 发明授权

US07666418B2 Method for treating Th2-mediated disease 有权
标题翻译：治疗Th2介导的疾病的方法
公开(公告)号：US07666418B2
公开(公告)日：2010-02-23
申请号：US11094718
申请日：2005-03-31
申请人： Kenya Shitara , Nobuo Hanai , Emi Shoji , Mikiko Sakurada , Akiko Furuya , Kazuyasu Nakamura , Rinpei Niwa , Kenji Shibata , Motoo Yamasaki
发明人： Kenya Shitara , Nobuo Hanai , Emi Shoji , Mikiko Sakurada , Akiko Furuya , Kazuyasu Nakamura , Rinpei Niwa , Kenji Shibata , Motoo Yamasaki
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： G01N33/543 , A61K2039/505 , C07K16/2866 , C07K2317/24 , C07K2317/565 , C07K2317/732 , C07K2319/00 , G01N2333/78
摘要： A recombinant antibody or the antibody fragment thereof which specifically reacts with an extracellular domain of human CCR4; a DNA which encodes the recombinant antibody or the antibody fragment thereof; a method for producing the recombinant antibody or the antibody fragment thereof; a method for immunologically detecting CCR4, a method for immunologically detecting a cell which expressed CCR4 on the cell surface, a method for depleting a cell which expresses CCR4 on the cell surface, and a method for inhibiting production of Th2 cytokine, which comprise using the recombinant antibody according or antibody fragment thereof; a therapeutic or diagnostic agent for Th2-mediated immune diseases; and a therapeutic or diagnostic agent for a blood cancer.
摘要翻译：与人CCR4的细胞外结构域特异性反应的重组抗体或其抗体片段; 编码重组抗体或其抗体片段的DNA; 制备重组抗体或其抗体片段的方法; 用于免疫学检测CCR4的方法，用于免疫检测在细胞表面上表达CCR4的细胞的方法，用于在细胞表面上表达CCR4的细胞消耗的方法，以及抑制Th2细胞因子产生的方法，其包括使用重组抗体或其抗体片段; Th2介导的免疫疾病的治疗或诊断剂; 和用于血液癌的治疗或诊断剂。

84. 发明授权

US07433219B2 Method and apparatus for address allotting and verification in a semiconductor device 有权
标题翻译：用于半导体器件中的地址分配和验证的方法和装置
公开(公告)号：US07433219B2
公开(公告)日：2008-10-07
申请号：US11341029
申请日：2006-01-27
申请人： Shozo Kawabata , Kenji Shibata , Takaaki Furuyama , Satoru Kawamoto
发明人： Shozo Kawabata , Kenji Shibata , Takaaki Furuyama , Satoru Kawamoto
IPC分类号： G11C15/00
CPC分类号： G11C15/00
摘要： A semiconductor device includes a CAM cell array that stores the operation setting information as to the semiconductor device, a controller that controls read and write of the CAM cell array, a row decoder, and a column decoder. With this structure, different row addresses are allocated to respective functions of the operation setting information. Accordingly, stress is not caused in the CAM cell array of the unselected functions at the time of programming.
摘要翻译：半导体器件包括存储关于半导体器件的操作设置信息的CAM单元阵列，控制CAM单元阵列的读和写的控制器，行解码器和列解码器。利用这种结构，将不同的行地址分配给操作设置信息的各个功能。因此，在编程时，在未选择的功能的CAM单元阵列中不会引起应力。

85. 发明申请

US20060227629A1 Memory device and control method therefor 有权
标题翻译：存储器及其控制方法
公开(公告)号：US20060227629A1
公开(公告)日：2006-10-12
申请号：US11378444
申请日：2006-03-16
申请人： Koji Shimbayashi , Takaaki Furuyama , Kenji Shibata
发明人： Koji Shimbayashi , Takaaki Furuyama , Kenji Shibata
IPC分类号： G11C7/06
CPC分类号： G11C7/08 , G11C7/1018 , G11C16/26 , G11C16/32
摘要： An access identification circuit (4) identifies a first access operation or a second access operation and outputs an identification signal S. During the first access operation, stored data is read out after detecting a column address CADD, a burst address, and updating a word line to newly select memory cells MC. In the second access operation, the memory cells MC connected to the common word line which has been selected are selected by sequentially switching column selector switches. Operating condition information Dx (DAx and/or DBx) used for setting a load condition in a dummy load circuit (5) and/or setting a pulse width for an equalize signal EQ in an amplification control circuit (6) is stored in each of first and second storage sections (1, 2) that are provided for the first and second access operations, respectively. The operating condition information Dx is selected by a selector circuit (3) in response to the identification signal S and fed to the dummy load circuit (5) and/or the amplification control circuit (6). A suitable operating condition is selected for each of the access operations.
摘要翻译：访问识别电路（4）识别第一访问操作或第二访问操作并输出识别信号S.在第一访问操作期间，在检测列地址CADD，突发地址和更新字之后读出存储的数据行新选择存储单元MC。在第二访问操作中，通过依次切换列选择器开关来选择连接到所选择的公共字线的存储单元MC。在放大控制电路（6）中用于设置虚拟负载电路（5）中的负载条件和/或设定均衡信号EQ的脉冲宽度的工作条件信息Dx（DAx和/或DBx）被存储在分别为第一和第二存取操作提供的第一和第二存储部分（1,2）。操作条件信息Dx由选择器电路（3）响应于识别信号S选择并馈送到虚拟负载电路（5）和/或放大控制电路（6）。为每个访问操作选择合适的操作条件。

86. 发明授权

US07071160B2 Insulin-like growth factor-binding protein 失效
标题翻译：胰岛素样生长因子结合蛋白
公开(公告)号：US07071160B2
公开(公告)日：2006-07-04
申请号：US10311129
申请日：2001-06-15
申请人： Kazuya Yamano , Susumu Sekine , Mitsuo Satoh , Toshio Ota , Akiko Furuya , Kenji Shibata , Yuki Kobayashi , Miho Takebayashi , Yusuke Nakamura , Sumio Sugano
发明人： Kazuya Yamano , Susumu Sekine , Mitsuo Satoh , Toshio Ota , Akiko Furuya , Kenji Shibata , Yuki Kobayashi , Miho Takebayashi , Yusuke Nakamura , Sumio Sugano
IPC分类号： C07K14/00
CPC分类号： C07K16/26 , A61K38/00 , A61K2039/505 , C07K14/4743 , C07K16/18 , C07K2317/34
摘要： Using the proteins of the present invention, DNAs encoding the proteins, and antibodies recognizing the proteins, detection methods for diseases relating to the novel insulin-like growth factor binding proteins of the present invention, as well as diagnostic agents, preventive agents, and therapeutic agents for diseases relating to the proteins of the present invention can be provided.
摘要翻译：使用本发明的蛋白质，编码蛋白质的DNA和识别蛋白质的抗体，与本发明的新型胰岛素样生长因子结合蛋白相关的疾病的检测方法以及诊断试剂，预防剂和治疗剂可以提供与本发明的蛋白质相关的疾病的药剂。

87. 发明授权

US07046043B2 Current-voltage converter circuit and its control method 有权
标题翻译：电流 - 电压转换电路及其控制方法
公开(公告)号：US07046043B2
公开(公告)日：2006-05-16
申请号：US11061119
申请日：2005-02-18
申请人： Kenji Shibata , Satoru Kawamoto
发明人： Kenji Shibata , Satoru Kawamoto
IPC分类号： G01R19/00
CPC分类号： G11C16/28
摘要： An input current flowing into a current-voltage conversion circuit (1) is converted to a voltage value at an output terminal SAIN and, then, a differential amplification circuit (5) amplifies and outputs a differential voltage between the voltage value and the reference voltage Vref. PMOS and NMOS transistors T1, T2 are connected between the output terminal SAIN and the power-supply voltage VCC. After the output terminal SAIN is precharged to the power-supply voltage VCC by making the transistors conductive, the current-voltage conversion operation is performed by making a voltage drop corresponding to the input current. The precharge operation precharges the output terminal SAIN up to the power-supply voltage VCC and supplies precharge to a common data line N3 and bit lines.
摘要翻译：流入电流 - 电压转换电路（1）的输入电流被转换为输出端子SAIN处的电压值，然后差分放大电路（5）放大并输出电压值与基准电压之间的差分电压 Vref。 PMOS和NMOS晶体管T 1，T 2连接在输出端子SAIN和电源电压VCC之间。在通过使晶体管导通来将输出端子SAIN预充电到电源电压VCC之后，通过使与输入电流相对应的电压降来执行电流 - 电压转换操作。预充电操作将输出端子SAIN预充电到电源电压VCC，并将预充电提供给公共数据线N 3和位线。

88. 发明授权

US06872803B1 Peptides 失效
标题翻译：多肽
公开(公告)号：US06872803B1
公开(公告)日：2005-03-29
申请号：US09349707
申请日：1999-07-08
申请人： Kenji Shibata , Toshiyuki Suzawa , Motoo Yamasaki , Koji Yamada , Tatsuhiro Ogawa , Takeo Tanaka , Shiro Soga
发明人： Kenji Shibata , Toshiyuki Suzawa , Motoo Yamasaki , Koji Yamada , Tatsuhiro Ogawa , Takeo Tanaka , Shiro Soga
IPC分类号： C07K14/58 , C07K14/745 , A61K38/10
CPC分类号： C07K14/745 , C07K14/58
摘要： The present invention provides peptides represented by the following formula (A): wherein Q represents a physiologically active peptide moiety; X each represents the same or different α-amino acid residue; M represents Gly or Cys; m represents an integer of from 5 to 8; and n represents an integer of from 0 to 3, or their pharmaceutically acceptable salts thereof. The peptides of the present invention have higher stability and/or higher activity than physiologically active linear peptides to which no cyclic peptide is bonded.
摘要翻译：本发明提供由下式（A）表示的肽：其中Q表示生理活性肽部分; X各自表示相同或不同的α-氨基酸残基; M表示Gly或Cys; m表示5〜8的整数，和n表示0〜3的整数，或其药学上可接受的盐。本发明的肽与没有结合肽的生理活性线性肽相比，具有更高的稳定性和/或更高的活性。

89. 发明授权

US06721326B1 Cell multiplexing system and method for an ATM network 失效
标题翻译： ATM网络的小区复用系统和方法
公开(公告)号：US06721326B1
公开(公告)日：2004-04-13
申请号：US09524321
申请日：2000-03-13
申请人： Kenji Shibata
发明人： Kenji Shibata
IPC分类号： H04L1228
CPC分类号： H04L49/3081 , H04L12/5601 , H04L2012/5615 , H04L2012/5656 , H04L2012/5672
摘要： A multiplexing system in an ATM network is disclosed. The system produces low deviation in generation timing of a standard ATM cell and low transmission delay to realize high transmission efficiency. A cell multiplexing means is provided for assembling data received from a plurality of terminal lines into a short cell to be multiplexed into a standard ATM cell. A short cell is selected from a plurality of short cells to define a reference line. The short cell generation timing of the reference line is used as the reference timing to generate short cells for other lines so as to synchronize the generation timing. The short cells thus generated are then multiplexed into a standard ATM cell.
摘要翻译：公开了ATM网络中的复用系统。该系统产生标准ATM信元的生成定时偏差小，传输延迟低，实现高传输效率。提供了一个单元复用装置，用于将从多个终端线路接收到的数据组装成一个要被复用到标准ATM信元的短信元。从多个短单元中选择短单元以限定参考线。基准线的短信元生成定时被用作生成用于其它行的短信元的基准定时，以便同步发生定时。然后将由此产生的短信元复用到标准ATM信元中。

90. 发明授权

US06642355B2 Endothelin-antagonizing peptide 失效
标题翻译：内皮素拮抗肽
公开(公告)号：US06642355B2
公开(公告)日：2003-11-04
申请号：US09750754
申请日：2001-01-02
申请人： Takeo Tanaka , Yoshikazu Morishita , Mika Makino , Shigeru Chiba , Isao Kawamoto , Eiji Tsukuda , Mayumi Yoshida , Chieko Bando , Kazuo Yamaguchi , Yuzuru Matsuda , Shigeto Kitamura , Toshihide Ikemura , Tatsuhiro Ogawa , Keiichi Yano , Toshiyuki Suzawa , Kenji Shibata , Motoo Yamasaki
发明人： Takeo Tanaka , Yoshikazu Morishita , Mika Makino , Shigeru Chiba , Isao Kawamoto , Eiji Tsukuda , Mayumi Yoshida , Chieko Bando , Kazuo Yamaguchi , Yuzuru Matsuda , Shigeto Kitamura , Toshihide Ikemura , Tatsuhiro Ogawa , Keiichi Yano , Toshiyuki Suzawa , Kenji Shibata , Motoo Yamasaki
IPC分类号： C07K700
CPC分类号： C07K7/06 , A61K38/00 , C07K5/1021 , C07K5/1024 , C07K7/08 , C07K14/36 , C07K14/57536 , C12R1/465
摘要： The invention relates to an endothelin antagonistic peptide of the formula (I): X-A-Trp-B-Gly-Thr-E-G-Y (I) SEQ ID NO: 2 wherein represents Asn or Asp; B represents His or Lys; E represents Ala or Ser; G represents Ala or Pro; X represents X1-Gly or and Y represents hydroxy, lower alkoxy, amino, wherein X1, X3, Y1, Y2 and Z are further defined, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及式（I）的内皮素拮抗肽：其中代表Asn或Asp; B代表His或Lys; E表示Ala或Ser; G表示Ala或Pro; X表示X 1 -Gly或Y表示羟基，低级烷氧基，氨基，其中X 1，X 3，Y 1，Y 2和Z进一步定义，或其药学上可接受的盐。

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