专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

81. 发明授权

US07172860B2 Apparatus and method for measuring activity signals of biological samples 有权
标题翻译：用于测量生物样品活动信号的装置和方法
公开(公告)号：US07172860B2
公开(公告)日：2007-02-06
申请号：US10678138
申请日：2003-10-06
申请人： Hiroaki Oka , Nobuhiko Ozaki , Hirokazu Sugihara
发明人： Hiroaki Oka , Nobuhiko Ozaki , Hirokazu Sugihara
IPC分类号： C12Q1/00
CPC分类号： G01N33/48728 , G01N33/54373 , G01N33/5438
摘要： The present invention provides an apparatus for measuring activity signals of a biological sample comprising: a measurement chamber (A) storing a target liquid containing a biological sample; a porous insulating substrate (5) provided with a measurement electrode (1) on at least one side; and a conveying device (8) which conveys the target liquid stored in the measurement chamber (A) and passes the target liquid through the porous insulating substrate (5) from the measurement electrode (1) side, wherein the conveying device (8) is operated to trap the biological sample contained in the target liquid onto the measurement electrode (1), so that the activity signals of the biological sample are measured through the measurement electrode (1). According to the apparatus, activity signals emitted from the biological sample can be detected easily, rapidly and accurately.
摘要翻译：本发明提供了一种用于测量生物样品的活动信号的装置，包括：存储含有生物样品的目标液体的测量室（A）在至少一侧设置有测量电极（1）的多孔绝缘基板（5）以及输送装置（8），其输送存储在测量室（A）中的目标液体，并将目标液体通过多孔绝缘基板（5）从测量电极（1）侧移动，其中输送装置（8）为操作以将包含在目标液体中的生物样品捕获到测量电极（1）上，从而通过测量电极（1）测量生物样品的活性信号。根据该装置，可以容易，快速且准确地检测从生物样品发射的活动信号。

82. 发明申请

US20070017320A1 Method and device for removing slag 有权
标题翻译：除渣方法和装置
公开(公告)号：US20070017320A1
公开(公告)日：2007-01-25
申请号：US11490253
申请日：2006-07-21
申请人： Hiroaki Oka , Nariaki Oka
发明人： Hiroaki Oka , Nariaki Oka
IPC分类号： C22B9/02
CPC分类号： B22C9/086 , B22D43/005 , F27D3/1563
摘要： A method for removing slag comprises: preparing a filter 21 of heat-resistant porous ceramics, which passes a molten metal and catches slag, liquidizing metal material to form a molten metal A on which slag is floating; and traveling filter 21 along a surface of the molten metal A and removing slag. And a device for removing slag comprises: a filter 21 of heat-resistant porous ceramics, which passes a molten metal and catches slag; and a driving device for traveling filter 21 along a surface of the molten metal on which slag is floating and removing slag.
摘要翻译：一种除渣方法包括：制备耐熔多孔陶瓷过滤器21，使过滤金属熔渣，使金属材料液化，形成熔渣，浮渣; 和沿着熔融金属A的表面的移动过滤器21，并去除渣。另外，除渣装置包括：通过熔融金属并捕获渣的耐热多孔陶瓷过滤器21; 以及沿熔融金属浮渣并去除渣的熔融金属表面的行进过滤器21的驱动装置。

83. 发明授权

US06999905B2 Method for extracting significant signal, recording medium and program 有权
标题翻译：提取重要信号，记录介质和程序的方法
公开(公告)号：US06999905B2
公开(公告)日：2006-02-14
申请号：US10296007
申请日：2002-04-26
申请人： Ryuta Ogawa , Hiroaki Oka , Nobuhiko Ozaki , Hirokazu Sugihara
发明人： Ryuta Ogawa , Hiroaki Oka , Nobuhiko Ozaki , Hirokazu Sugihara
IPC分类号： G06F15/00
CPC分类号： G01D1/14
摘要： A method for extracting a signal of interest from a signal generated from at least one subject, comprises the steps of (A) obtaining a time-series signal generated from the subject as a data group consisting of a plurality of pieces of data, (B) obtaining a plurality of extracted data groups from the data group, wherein each extracted data group comprises a predetermined number of pieces of data selected from the data group, (C) calculating standard deviations of the plurality of extracted data groups to obtain a standard deviation group, and (D) referencing each standard deviation included in the standard deviation group and selecting the signal of interest.
摘要翻译：一种用于从至少一个对象产生的信号中提取感兴趣的信号的方法，包括以下步骤：（A）获得从被摄体产生的时间序列信号作为由多条数据组成的数据组（B ）从所述数据组中获取多个提取的数据组，其中每个提取的数据组包括从所述数据组中选择的预定数量的数据，（C）计算所述多个提取的数据组的标准偏差以获得标准偏差组和（D）参考包括在标准偏差组中的每个标准偏差并选择感兴趣的信号。

84. 发明申请

US20050279634A1 Instrument and system for pharmacologic measurement and well vessel used therein 有权
标题翻译：用于药物测量的仪器和系统及其中使用的井筒
公开(公告)号：US20050279634A1
公开(公告)日：2005-12-22
申请号：US11213961
申请日：2005-08-30
申请人： Nobuhiko Ozaki , Hiroaki Oka
发明人： Nobuhiko Ozaki , Hiroaki Oka
IPC分类号： C12M1/34 , G01N33/483 , G01N7/00
CPC分类号： G01N33/48728
摘要： It is an object of the invention to provide an instrument for pharmacologic measurement capable of detecting a very small and short time change in electric signal caused by a pharmacologic action of a biologic specimen with quickness and a high sensitivity by steeply decreasing an external disturbance component mixed into the system while dropping/exchange of medicinal solutions is conducted in a batch mode. The pharmacologic measurement instrument 20 detects a change in electric signal caused by a pharmacologic action or electrophysiologic action of a biologic specimen, and includes: an electrically conductive box 2 having an opening section 8 at the top surface thereof; and a well vessel 19 disposed in the opening section 8 thereof, wherein the well vessel 19 includes: a base 1 having recesses 4 in which the biologic specimens 6 are put; measurement electrodes 10 formed on the bottom surfaces of the respective recesses 4; and reference electrodes 13 electrically insulated from the respective measurement electrodes 10, and the reference electrodes 13 together with the electrically conductive box 2 electrostatically shields the well vessel 19.
摘要翻译：本发明的目的是提供一种用于药物测量的仪器，其能够通过快速和高灵敏度来检测由生物样本的药理作用引起的电信号的非常小的和短的时间变化，通过急剧地降低混合的外部干扰成分在分批模式下进行药物溶液的滴加/交换时进入系统。药理学测量仪器20检测由生物样本的药理作用或电生理作用引起的电信号变化，并且包括：导电盒2，其顶表面具有开口部分8; 以及设置在其开口部分8中的井管19，其中井筒19包括：具有凹部4的基部1，生物标本6放置在其中; 形成在各个凹部4的底面上的测量电极10; 并且与各测量电极10电绝缘的参考电极13以及参考电极13与导电盒2一起静电屏蔽井管19。

85. 发明申请

US20050221469A1 Extracellular potential measuring device and its manufacturing method 有权
标题翻译：细胞外电位测定装置及其制造方法
公开(公告)号：US20050221469A1
公开(公告)日：2005-10-06
申请号：US10513392
申请日：2004-03-08
申请人： Masaya Nakatani , Hiroaki Oka , Fumiaki Emoto
发明人： Masaya Nakatani , Hiroaki Oka , Fumiaki Emoto
IPC分类号： G01N33/487 , C12M1/34
CPC分类号： G01N33/48728
摘要： An extracellular potential measuring device includes a plate portion having a first surface and a second surface opposite to the first surface, and an electrode provided on the second surface of the plate portion. In the plate portion, a pocket having an opening which opens to the first surface is formed, and a through-hole communicating to the second surface from the pocket. The through-hole communicates from a position which is closer to the opening than a deepest point of the first pocket. The electrode is provided around of the opening of the through-hole. In this device, even if a cell to be examined does not reach the deepest point of the pocket, a cell membrane of the cell can tightly attaches onto the through-hole securely without a clearance. Hence, culture solution inside the through-hole is isolated from culture solution over an upper surface of the plate portion, thereby allowing electrochemical changes caused by activities of the cell to be detected efficiently with a detector electrode.
摘要翻译：细胞外电位测量装置包括具有第一表面和与第一表面相对的第二表面的板部分，以及设置在板部分的第二表面上的电极。在该板部分中，形成具有向第一表面开口的开口的口袋，以及从口袋连通到第二表面的通孔。通孔从比第一口袋的最深点更靠近开口的位置连通。电极设置在通孔的开口周围。在该装置中，即使要检查的细胞未达到口袋的最深点，细胞的细胞膜可以牢固地紧贴在通孔上而没有间隙。因此，通孔内部的培养液在培养液的上表面上与培养液分离，从而能够通过检测器电极有效地检测细胞活性引起的电化学变化。

86. 发明申请

US20050004442A1 Measurement device for measuring electric signal emitted by biological sample 有权
标题翻译：用于测量生物样品发出的电信号的测量装置
公开(公告)号：US20050004442A1
公开(公告)日：2005-01-06
申请号：US10495621
申请日：2002-11-19
申请人： Nobuhiko Ozaki , Hiroaki Oka , Hirokazu Sugihara
发明人： Nobuhiko Ozaki , Hiroaki Oka , Hirokazu Sugihara
IPC分类号： B01L3/00 , G01N33/487 , A61B5/05
CPC分类号： G01N33/48707 , B01L3/5027
摘要： A measurement device 10 includes a measurement cell 11. The measurement cell 11 includes a substrates 17 and a substrate 16 formed on the substrate 17. The substrates 16 and 17 are bonded to each other. Thus, a flow pass 9 is formed in the measurement cell 11. As shown in FIG. 3, on the substrate 17 of the measurement cell 11, provided are a concave well 19, a protruding microelectrode 1 connected to a terminal 4a and formed on a side wall surface of the well 19, communicating tubes 15a and 15b connected to both of side surfaces of the well 19 (i.e., the flow pass 9) to face to each other, resistance baths 6a and 6b connected to the communicating tubes 15a and 15b, thin film resistors 3a and 3b arranged in the resistance baths 6a and 6b, and a reference electrode 2 connected to a terminal 4b.
摘要翻译：测量装置10包括测量单元11.测量单元11包括基板17和形成在基板17上的基板16.基板16和17彼此接合。因此，在测量单元11中形成流路9。如图3所示，在测量单元11的基板17上设置凹槽19，连接到端子4a并形成在井19的侧壁表面上的突出微电极1，连接到两侧的连通管15a和15b 孔19的表面（即，流路9）彼此相对，连接到连通管15a和15b的电阻槽6a和6b，布置在电阻槽6a和6b中的薄膜电阻器3a和3b，以及参考电极2连接到端子4b。

87. 发明授权

US5429819A Antiviral composition 失效
标题翻译：抗病毒组成
公开(公告)号：US5429819A
公开(公告)日：1995-07-04
申请号：US134124
申请日：1993-10-08
申请人： Hiroaki Oka , Toshikazu Tomioka , Katsumi Tomita , Kenji Hoshino , Atsushi Nishino , Shigeharu Ueda
发明人： Hiroaki Oka , Toshikazu Tomioka , Katsumi Tomita , Kenji Hoshino , Atsushi Nishino , Shigeharu Ueda
IPC分类号： A01N59/16 , A01N59/20 , A61K9/16
CPC分类号： A01N59/16 , A01N59/20
摘要： An antiviral composition comprising: a thiosulfate salt and at least one of thiosulfate complex salt of a metal and a porous particulate carrier; said metal being at least one selected from the group consisting of silver, copper and zinc; said salts being carried on said porous particulate carrier. It is applicable to a wide range of living environment such as medical instruments and appliances, hygienic implements as well as kitchen utensils, and also demonstrates an antibacterial activity in addition to the antiviral activity. The composition releases its salts slowly to the environment and the antiviral and antibacterial activities of said composition lasts for a long period of time. A method for preparing said composition as well as an antiviral disinfection method and a virucidal disinfection fluid using said composition are also disclosed.
摘要翻译：一种抗病毒组合物，其包含：硫代硫酸盐和金属的硫代硫酸盐配合盐和多孔颗粒载体中的至少一种; 所述金属为选自银，铜和锌的至少一种; 所述盐被携带在所述多孔颗粒载体上。它适用于各种生活环境，如医疗仪器和电器，卫生用具以及厨房用具，除抗病毒活性外，还具有抗菌活性。该组合物缓慢地将其盐释放到环境中，并且所述组合物的抗病毒和抗菌活性持续很长时间。还公开了使用所述组合物制备所述组合物的方法以及抗病毒消毒方法和杀病毒消毒液。

88. 发明申请

US20130010300A1 PLASMON SENSOR, AND USAGE METHOD AND MANUFACTURING METHOD THEREOF 审中-公开
标题翻译： PLASMON传感器及其使用方法及其制造方法
公开(公告)号：US20130010300A1
公开(公告)日：2013-01-10
申请号：US13613325
申请日：2012-09-13
申请人： Masaya Tamura , Hiroshi Kagata , Hiroaki Oka
发明人： Masaya Tamura , Hiroshi Kagata , Hiroaki Oka
IPC分类号： G01N21/55 , B05D5/06
CPC分类号： G01N21/553
摘要： A plasmon sensor includes a first metal layer and a second metal layer having an upper surface facing a lower surface of the first metal layer. The upper surface of the first metal layer is configured to receive an electromagnetic wave. A hollow space is provided between the first and second metal layers, and is configured to be filled with a test sample containing a medium. This plasmon sensor has a small size and a simple structure.
摘要翻译：等离子体激元传感器包括第一金属层和具有面向第一金属层的下表面的上表面的第二金属层。第一金属层的上表面被配置为接收电磁波。在第一和第二金属层之间设置中空空间，并且被配置为填充含有介质的测试样品。该等离子体传感器具有体积小且结构简单的特点。

89. 发明授权

US08257962B2 Extracellular potential measuring device and its manufacturing method 有权
标题翻译：细胞外电位测定装置及其制造方法
公开(公告)号：US08257962B2
公开(公告)日：2012-09-04
申请号：US10513392
申请日：2004-03-08
申请人： Masaya Nakatani , Hiroaki Oka , Fumiaki Emoto
发明人： Masaya Nakatani , Hiroaki Oka , Fumiaki Emoto
IPC分类号： C12M1/42 , C12M3/00 , C12N13/00
CPC分类号： G01N33/48728
摘要： An extracellular potential measuring device includes a plate portion having a first surface and a second surface opposite to the first surface, and an electrode provided on the second surface of the plate portion. In the plate portion, a pocket having an opening which opens to the first surface is formed, and a through-hole communicating to the second surface from the pocket. The through-hole communicates from a position which is closer to the opening than a deepest point of the first pocket. The electrode is provided around of the opening of the through-hole. In this device, even if a cell to be examined does not reach the deepest point of the pocket, a cell membrane of the cell can tightly attaches onto the through-hole securely without a clearance. Hence, culture solution inside the through-hole is isolated from culture solution over an upper surface of the plate portion, thereby allowing electrochemical changes caused by activities of the cell to be detected efficiently with a detector electrode.
摘要翻译：细胞外电位测量装置包括具有第一表面和与第一表面相对的第二表面的板部分，以及设置在板部分的第二表面上的电极。在该板部分中，形成具有向第一表面开口的开口的口袋，以及从口袋连通到第二表面的通孔。通孔从比第一口袋的最深点更靠近开口的位置连通。电极设置在通孔的开口周围。在该装置中，即使要检查的细胞未达到口袋的最深点，细胞的细胞膜可以牢固地紧贴在通孔上而没有间隙。因此，通孔内部的培养液在培养液的上表面上与培养液分离，从而能够通过检测器电极有效地检测细胞活性引起的电化学变化。

90. 发明授权

US08202687B2 Method for transporting potassium ions from front side to back side of lipid bilayer membrane 有权
标题翻译：从脂质双层膜的正面到背面输送钾离子的方法
公开(公告)号：US08202687B2
公开(公告)日：2012-06-19
申请号：US13248880
申请日：2011-09-29
申请人： Masato Suzuki , Hiroaki Oka , Shigeki Kiyonaka , Yasuo Mori
发明人： Masato Suzuki , Hiroaki Oka , Shigeki Kiyonaka , Yasuo Mori
IPC分类号： C12Q1/00 , G01N33/53
CPC分类号： G01N33/566 , G01N33/6872
摘要： An object of the present invention is to detect a specific chemical substance with high sensitivity and high precision. By using a specific lipid bilayer membrane, a chemical substance is detected with high sensitivity and high precision. Here, the specific lipid bilayer membrane comprises a chemical substance receptor, a chimeric G protein, and a potassium ion channel. The chimeric G protein comprises a chimeric Gα subunit and a Gβγ subunit complex. The chimeric Gα subunit is selected from the group consisting of Gi/olf13 (SEQ ID NO: 04), Gi/olf28 (SEQ ID NO: 05), Gi/olf94 (SEQ ID NO: 07), Gi/olf113 (SEQ ID NO: 08), Gi/olf α3-β5,C (SEQ ID NO: 12), and Gi/olfα4-β6,C (SEQ ID NO: 15).
摘要翻译：本发明的目的是检测具有高灵敏度和高精度的特定化学物质。通过使用特定的脂质双层膜，以高灵敏度和高精度检测化学物质。这里，特定脂质双层膜包含化学物质受体，嵌合G蛋白和钾离子通道。嵌合G蛋白包含嵌合Gα亚基和G＆bgrγγ亚基复合物。嵌合Gα亚基选自Gi / olf13（SEQ ID NO：04），Gi / olf28（SEQ ID NO：05），Gi / olf94（SEQ ID NO：07），Gi / olf113（SEQ ID NO： NO：08），Gi /olfα3-和bgr; 5，C（SEQ ID NO：12）和Gi /olfα4-＆bgr; 6，C（SEQ ID NO：15）。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式