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81. 发明授权

US5732698A Systems for examining the electrical characteristics of cardiac tissue while minimizing contact with blood within the heart 失效
标题翻译：用于检查心脏组织的电学特征同时最小化与心脏内的血液接触的系统
公开(公告)号：US5732698A
公开(公告)日：1998-03-31
申请号：US571682
申请日：1995-12-13
申请人： David K. Swanson , Dorin Panescu
发明人： David K. Swanson , Dorin Panescu
IPC分类号： A61B5/042 , A61B5/053 , A61B18/00 , A61B18/14 , A61B5/0408 , A61N1/05
CPC分类号： A61B5/6855 , A61B5/0422 , A61B5/0536 , A61B5/6858 , A61B18/00 , A61B18/1492 , A61B2562/0209 , A61B2562/043
摘要： Systems for examining heart tissue morphology deploy one or more electrodes into the heart in contact with endocardial tissue. The systems transmit electrical current from the electrodes in paths through the contacted endocardial tissue. Based upon these current transmissions, the systems derive the electrical characteristics of tissue lying in the path. This electrical characteristic can be directly correlated to tissue morphology. The systems maximize surface contact with endocardial tissue, while minimizing contact with the surrounding blood pool, to obtain accurate tissue electrical characteristic measurements.
摘要翻译：用于检查心脏组织形态的系统将一个或多个电极部署到与心内膜组织接触的心脏中。系统通过穿过所接触的心内膜的路径从电极传输电流。基于这些当前传输，系统导出位于路径中的组织的电特性。这种电气特性可以直接与组织形态相关。系统最大限度地与心内膜组织的表面接触，同时最小化与周围血液池的接触，以获得精确的组织电特征测量。

82. 发明授权

US5485849A System and methods for matching electrical characteristics and propagation velocities in cardiac tissue 失效
标题翻译：用于匹配心脏组织中电特性和传播速度的系统和方法
公开(公告)号：US5485849A
公开(公告)日：1996-01-23
申请号：US189445
申请日：1994-01-31
申请人： Dorin Panescu , David K. Swanson
发明人： Dorin Panescu , David K. Swanson
IPC分类号： A61B5/05 , A61B5/053 , A61N1/05 , A61C5/04
CPC分类号： A61B5/053 , A61B5/0538 , A61N1/056
摘要： Systems and methods examine heart tissue morphology using three or more spaced apart electrodes, at least two of which are located within the heart in contact with endocardial tissue. The systems and methods transmit electrical current through a region of heart tissue lying between selected pairs of the electrodes, at least one of the electrodes in each pair being located within the heart. The systems and methods derive the electrical characteristic of tissue lying between the electrode pairs based, at least in part, upon sensing tissue impedances. The systems and methods also sense the timing of local depolarization events in the tissue in which impedance is sensed and derive therefrom the propagation velocities of the sensed depolarization events. The systems and methods match the derived tissue electrical characteristics with the derived propagation velocities in spatial relation to the electrodes to characterize the morphology of the contacted heart tissue. This matching provides precise differentiation between regions of infarcted heart tissue and healthy heart tissue.
摘要翻译：系统和方法使用三个或更多个间隔开的电极检查心脏组织形态，其中至少两个电极位于心脏内与心内膜组织接触。所述系统和方法将电流透过位于所选择的电极对之间的心脏组织的区域，每对电极中的至少一个位于心脏内。系统和方法至少部分地基于感测组织阻抗而导出位于电极对之间的组织的电特性。系统和方法还感测组织中局部去极化事件的定时，其中阻抗被感测并从其导出感测的去极化事件的传播速度。系统和方法将衍生的组织电特征与与电极空间关系的导出传播速度相匹配，以表征所接触的心脏组织的形态。这种匹配提供梗塞心脏组织和健康心脏组织的区域之间的精确分化。

83. 发明授权

US06370435B2 Systems and methods for examining the electrical characteristic of cardiac tissue 有权
公开(公告)号：US06370435B2
公开(公告)日：2002-04-09
申请号：US09783778
申请日：2001-02-14
申请人： Dorin Panescu , David K. Swanson , Mark S. Mirotznik , David S. Schwartzman , Kenneth R. Foster
发明人： Dorin Panescu , David K. Swanson , Mark S. Mirotznik , David S. Schwartzman , Kenneth R. Foster
IPC分类号： A61B504
CPC分类号： A61B5/6855 , A61B5/0422 , A61B5/05 , A61B5/053 , A61B5/0538 , A61B5/6858 , A61B18/00 , A61B2562/0209 , A61B2562/043 , A61N1/056
摘要： Systems and methods examine heart tissue morphology using three or more spaced apart electrodes, at least two of which are located within the heart in contact with endocardial tissue. The systems and methods transmit electrical current through a region of heart tissue lying between selected pairs of the electrodes, at least one of the electrodes in each pair being located within the heart. The systems and methods derive the electrical characteristic of tissue lying between the electrode pairs based, at least in part, upon sensing tissue impedances. The systems and methods make possible the use of multiple endocardial electrodes for taking multiple measurements of the electrical characteristics of heart tissue. Multiplexing can be used to facilitate data processing. The systems and methods also make possible the identification of regions of low relative electrical characteristics, indicative of infarcted tissue, without invasive surgical techniques.

84. 发明授权

US06256540B1 Systems and methods for examining the electrical characteristic of cardiac tissue 失效
标题翻译：检查心脏组织电学特征的系统和方法
公开(公告)号：US06256540B1
公开(公告)日：2001-07-03
申请号：US08888456
申请日：1997-07-07
申请人： Dorin Panescu , David K. Swanson , Mark S. Mirotznik , David S. Schwartzman , Kenneth R. Foster
发明人： Dorin Panescu , David K. Swanson , Mark S. Mirotznik , David S. Schwartzman , Kenneth R. Foster
IPC分类号： A61B504
CPC分类号： A61B5/6855 , A61B5/0422 , A61B5/05 , A61B5/053 , A61B5/0538 , A61B5/6858 , A61B18/00 , A61B2562/0209 , A61B2562/043 , A61N1/056
摘要： Systems and methods examine heart tissue morphology using three or more spaced apart electrodes, at least two of which are located within the heart in contact with endocardial tissue. The systems and methods transmit electrical current through a region of heart tissue lying between selected pairs of the electrodes, at least one of the electrodes in each pair being located within the heart. The systems and methods derive the electrical characteristic of tissue lying between the electrode pairs based, at least in part, upon sensing tissue impedances. The systems and methods make possible the use of multiple endocardial electrodes for taking multiple measurements of the electrical characteristics of heart tissue. Multiplexing can be used to facilitate data processing. The systems and methods also make possible the identification of regions of low relative electrical characteristics, indicative of infarcted tissue, without invasive surgical techniques.
摘要翻译：系统和方法使用三个或更多个间隔开的电极检查心脏组织形态，其中至少两个电极位于心脏内与心内膜组织接触。所述系统和方法将电流透过位于所选择的电极对之间的心脏组织的区域，每对电极中的至少一个位于心脏内。系统和方法至少部分地基于感测组织阻抗而导出位于电极对之间的组织的电特性。系统和方法使得可以使用多个心内膜电极进行心脏组织的电特征的多次测量。可以使用多路复用来促进数据处理。系统和方法还可以鉴定低相对电特征的区域，指示梗死组织，无侵入性手术技术。

85. 发明授权

US06245065B1 Systems and methods for controlling power in an electrosurgical probe 有权
标题翻译：用于控制电外科探头功率的系统和方法
公开(公告)号：US06245065B1
公开(公告)日：2001-06-12
申请号：US09150831
申请日：1998-09-10
申请人： Dorin Panescu , David K. Swanson , Robert Burnside
发明人： Dorin Panescu , David K. Swanson , Robert Burnside
IPC分类号： A61B1818
CPC分类号： A61B18/1492 , A61B18/1206 , A61B2018/0016 , A61B2018/00351 , A61B2018/00577 , A61B2018/00654 , A61B2018/0069 , A61B2018/00702 , A61B2018/00714 , A61B2018/00726 , A61B2018/00791 , A61B2018/00797 , A61B2018/00803 , A61B2018/00821 , A61B2018/00875 , A61B2018/124 , A61B2018/1253 , A61B2018/128 , A61B2018/1467
摘要： Systems and methods for controlling the power supplied to an electrosurgical probe. The systems and methods may be used to monitor electrode-tissue contact, adjust power in response to a loss of contact, and apply power in such a manner that charring, coagulum formation and tissue popping are less likely to occur.
摘要翻译：用于控制供给电外科探头的功率的系统和方法。系统和方法可以用于监测电极组织接触，响应于接触失去的情况调节功率，并且以不太可能发生炭化，凝结物形成和组织爆裂的方式施加功率。

86. 发明授权

US06245061B1 Tissue heating and ablation systems and methods using self-heated electrodes 失效
标题翻译：组织加热和消融系统和使用自热电极的方法
公开(公告)号：US06245061B1
公开(公告)日：2001-06-12
申请号：US09464952
申请日：1999-12-15
申请人： Dorin Panescu , Sidney D. Fleischman , David K. Swanson
发明人： Dorin Panescu , Sidney D. Fleischman , David K. Swanson
IPC分类号： A01B1739
CPC分类号： A61B18/1206 , A61B18/1402 , A61B18/1492 , A61B2018/00083 , A61B2018/00095 , A61B2018/00791 , A61B2018/00803 , A61N1/403
摘要： Systems and methods using an electrode able to transmit heating or ablation energy into tissue include first and second sensing elements associated with the electrode for measuring first and second temperatures. The electrode also includes a heating element in thermal conductive contact with the electrode for heating the electrode. The systems and methods sequentially activate the heating element and sense temperatures without transmitting tissue heating or ablation energy, and then transmit heating or ablation energy and sense temperatures without activating the heating element, to derive from the sensed temperatures a prediction of maximum tissue temperature.
摘要翻译：使用能够将加热或消融能量传递到组织中的电极的系统和方法包括与用于测量第一和第二温度的电极相关联的第一和第二感测元件。电极还包括与用于加热电极的电极导热接触的加热元件。系统和方法顺序地激活加热元件并且感测温度而不传递组织加热或消融能量，然后传递加热或消融能量并感测温度而不激活加热元件，从感测的温度导出最大组织温度的预测。

87. 发明授权

US6030382A Flexible tissue ablatin elements for making long lesions 失效
标题翻译：灵活的组织消融元件用于制造长期病变
公开(公告)号：US6030382A
公开(公告)日：2000-02-29
申请号：US55175
申请日：1998-04-03
申请人： Sidney D. Fleischman , Russell B. Thompson , Dorin Panescu , David K. Swanson
发明人： Sidney D. Fleischman , Russell B. Thompson , Dorin Panescu , David K. Swanson
IPC分类号： A61B5/042 , A61B17/00 , A61B18/00 , A61B18/14 , A61N1/05 , A61N1/06 , A61N1/40 , G01K1/02 , G01K3/14
CPC分类号： A61B5/0422 , A61B18/1492 , A61B5/6858 , A61N1/056 , A61N1/06 , A61N1/40 , G01K1/026 , G01K3/14 , A61B2017/00088 , A61B2017/00092 , A61B2017/0088 , A61B2018/00083 , A61B2018/00107 , A61B2018/00148 , A61B2018/0016 , A61B2018/00791 , A61B2018/1435
摘要： Devices and methods for ablating body tissue. The devices include a support body and at least one elongated electrode. Adjacent windings are spaced apart to impart enhanced flexibility to the elongated electrode.
摘要翻译：用于烧伤身体组织的装置和方法。这些装置包括支撑体和至少一个细长电极。相邻的绕组间隔开以赋予细长电极增强的柔性。

88. 发明授权

US5928228A Flexible high density multiple electrode circuit assemblies employing ribbon cable 失效
标题翻译：柔性高密度多电极电路组件采用带状电缆
公开(公告)号：US5928228A
公开(公告)日：1999-07-27
申请号：US801483
申请日：1997-02-18
申请人： Thomas F. Kordis , Dorin Panescu , David K. Swanson
发明人： Thomas F. Kordis , Dorin Panescu , David K. Swanson
IPC分类号： A61B5/042 , A61B18/14 , A61B17/39
CPC分类号： A61B5/6858 , A61B5/0422 , A61B18/1492 , A61B2018/00267 , A61B2018/1407 , A61B2018/1435 , A61B2562/0209 , A61B2562/043
摘要： An electrode circuit has a distal region for carrying at least one electrode, a proximal region for connection to external apparatus, and an intermediate region electrically coupling the distal region with the proximal region. At least one, and preferably all, of the regions comprises flexible ribbon cable having two or more adjacent tracks of electrical conduction material and adjoining electrical insulating material. Use of ribbon cable make possible highly dense, extremely reliable electrical connections. Its reliability and density obviate the need for complicated multiplexing schemes at the distal region. Instead, less complicated, proximal multiplexing schemes can be used.
摘要翻译：电极电路具有用于承载至少一个电极的远端区域，用于连接到外部设备的近侧区域和将远端区域与近端区域电耦合的中间区域。至少一个，优选地，所有这些区域包括柔性带状电缆，其具有两个或更多个导电材料的相邻轨道和邻接的电绝缘材料。使用带状电缆可以实现高密度，极其可靠的电气连接。其可靠性和密度避免了在远端区域的复杂复用方案的需要。相反，可以使用较不复杂的近端复用方案。

89. 发明授权

US5795303A Systems and methods for making time-sequential measurements of biopotentials sensed in myocardial tissue 失效
标题翻译：用于对心肌组织中感测到的生物电位进行时间顺序测量的系统和方法
公开(公告)号：US5795303A
公开(公告)日：1998-08-18
申请号：US921878
申请日：1997-09-02
申请人： David K. Swanson , Dorin Panescu
发明人： David K. Swanson , Dorin Panescu
IPC分类号： A61B5/0428 , A61B5/00 , A61B5/042 , A61B5/0452 , A61N1/05 , A61N1/37 , A61N1/40 , A61B5/0402
CPC分类号： A61B5/6855 , A61B5/0422 , A61B5/04525 , A61B5/6858 , A61N1/056 , A61N1/3702 , A61N1/403 , A61B2562/0209 , A61B2562/043
摘要： Analog or digital systems and methods generate a composite signal derived from a biological event in a time-sequential fashion. The systems and methods input a first set of signals derived from a biological event using a first group of sensors during a first time interval. The systems and methods input a second set of signals derived from the biological event during a second time interval sequentially after the first time interval using a second group of sensors. The second group of sensors has at least one common sensor that is part of the first group and other sensors that are not part of the first group. The systems and methods time align the first and second sets of signals using the signals sensed by the at least one common sensor, thereby generating the composite signal. The systems and methods time align by shifting the first and second sets of signals either with or without computing a time difference between them.
摘要翻译：模拟或数字系统和方法以时间顺序的方式产生从生物事件导出的复合信号。系统和方法在第一时间间隔期间使用第一组传感器输入从生物事件导出的第一组信号。系统和方法使用第二组传感器在第一时间间隔之后，在第二时间间隔期间输入从生物事件导出的第二组信号。第二组传感器具有至少一个共同的传感器，其是第一组的一部分和不是第一组的一部分的其它传感器。系统和方法使用由至少一个公共传感器感测的信号来对准第一和第二组信号，由此产生复合信号。系统和方法通过移动第一组信号和第二组信号，或者在计算或不计算它们之间的时间差的情况下对准时间。

90. 发明授权

US5755715A Tissue heating and ablation systems and methods using time-variable set point temperature curves for monitoring and control 失效
标题翻译：组织加热和消融系统和方法使用时变设定点温度曲线进行监测和控制
公开(公告)号：US5755715A
公开(公告)日：1998-05-26
申请号：US656756
申请日：1996-06-03
申请人： Roger A. Stern , Dorin Panescu , David K. Swanson
发明人： Roger A. Stern , Dorin Panescu , David K. Swanson
IPC分类号： A61B17/00 , A61B18/00 , A61B18/10 , A61B18/12 , A61B18/14 , A61B19/00 , A61B17/39
CPC分类号： A61B18/00 , A61B18/1206 , A61B18/1492 , A61B18/14 , A61B2017/00017 , A61B2017/00084 , A61B2017/00101 , A61B2017/00292 , A61B2017/003 , A61B2017/00482 , A61B2018/00083 , A61B2018/00095 , A61B2018/00101 , A61B2018/00178 , A61B2018/00351 , A61B2018/00357 , A61B2018/00577 , A61B2018/00642 , A61B2018/00666 , A61B2018/00684 , A61B2018/0069 , A61B2018/00702 , A61B2018/00779 , A61B2018/00791 , A61B2018/00797 , A61B2018/00803 , A61B2018/00815 , A61B2018/00827 , A61B2018/00869 , A61B2018/00875 , A61B2018/00892 , A61B2018/00916 , A61B2018/00988 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1425 , A61B2018/1435 , A61B2090/0803 , A61B2562/08 , A61M2205/273 , A61M2205/6018 , A61M2205/6027 , A61M2205/70 , A61M2230/50
摘要： Systems and methods employ an energy emitting electrode to heat tissue. The systems and methods follow a prescribed temperature set curve, in which a setpoint temperature changes over time, to control the application of energy to the electrode.
摘要翻译：系统和方法采用能量发射电极来加热组织。系统和方法遵循规定的温度设定曲线，其中设定点温度随时间而变化，以控制向电极施加能量。

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