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81. 发明授权

US09527865B2 Quinazoline analogs as receptor tyrosine kinase inhibitors 有权
公开(公告)号：US09527865B2
公开(公告)日：2016-12-27
申请号：US13607016
申请日：2012-09-07
申请人： Eli Wallace , George Topalov , Joseph Lyssikatos , Alexandre Buckmelter , Qian Zhao
发明人： Eli Wallace , George Topalov , Joseph Lyssikatos , Alexandre Buckmelter , Qian Zhao
IPC分类号： C07D239/94 , C07D498/10 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D498/04 , C04B35/632
摘要： This invention provides quinazoline analogs of Formula I: where A is bonded to at least one of the carbons at the 5, 6, 7 or 8 position of the bicyclic ring, and the ring is substituted by up to two independent R3 groups. The invention also includes methods of using compounds of Formula I as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

82. 发明授权

US09434719B2 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH 有权
标题翻译： 3-嘧啶-4-基 - 恶唑烷-2-酮作为突变体IDH的抑制剂
公开(公告)号：US09434719B2
公开(公告)日：2016-09-06
申请号：US14408418
申请日：2014-03-12
申请人： Thomas Raymond Caferro , Zhuoliang Chen , Young Shin Cho , Abran Q. Costales , Julian Roy Levell , Gang Liu , James R. Manning , Martin Sendzik , Cynthia Shafer , Michael David Shultz , James Sutton , Yaping Wang , Qian Zhao
发明人： Thomas Raymond Caferro , Zhuoliang Chen , Young Shin Cho , Abran Q. Costales , Julian Roy Levell , Gang Liu , James R. Manning , Martin Sendzik , Cynthia Shafer , Michael David Shultz , James Sutton , Yaping Wang , Qian Zhao
IPC分类号： C07D413/04 , A61K31/506 , C07D413/14 , C07D417/14 , A61K31/5377
CPC分类号： C07D413/14 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D413/04 , C07D417/14
摘要： The invention is directed to a formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b and R3-R7 are herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.

83. 发明授权

US09377286B2 Device for globally measuring thickness of metal film 有权
标题翻译：用于全球测量金属膜厚度的装置
公开(公告)号：US09377286B2
公开(公告)日：2016-06-28
申请号：US13985789
申请日：2011-11-17
申请人： Xinchun Lu , Dewen Zhao , Zilian Qu , Qian Zhao , Yongyong He , Yonggang Meng
发明人： Xinchun Lu , Dewen Zhao , Zilian Qu , Qian Zhao , Yongyong He , Yonggang Meng
IPC分类号： G01B7/06 , G01B1/00 , G01R1/00
CPC分类号： G01B7/10 , G01B1/00 , G01B7/105 , G01R1/00 , H01L2221/00
摘要： A device for globally measuring a thickness of a metal film (901), comprises: a base (10); a rotating unit (20) comprising a fixed member (21) fixed on the base (10) and a rotating member (22) having a rotating joint (23); a working table (50) fixed on the rotating member (22) and having a vacuum passage which is formed therein and connected with the rotating joint (23); a linear driving unit (30) including a guide rail (31) fixed on the base (10) and a sliding block (32) slidable along the guide rail (31); a cantilever beam (40) disposed horizontally and defining a first end fixed with the sliding block (32) and a second end; a measuring head (80) connected to the second end of the cantilever beam (40), facing a surface of the working table (50) and having an eddy current probe (82) disposed therein.
摘要翻译：用于全面测量金属膜（901）的厚度的装置包括：基座（10）; 旋转单元（20）包括固定在基座（10）上的固定构件（21）和具有旋转接头（23）的旋转构件（22）; 固定在旋转构件（22）上并具有形成在其中并与旋转接头（23）连接的真空通道的工作台（50）; 线性驱动单元（30），其包括固定在基座（10）上的导轨（31）和可沿导轨（31）滑动的滑块（32）; 悬臂梁（40）水平设置并且限定固定有滑块（32）的第一端和第二端; 连接到所述悬臂梁（40）的第二端的测量头（80），面向所述工作台（50）的表面并且具有布置在其中的涡流探针（82）。

84. 发明授权

US08933084B2 Macrocyclic compounds as Trk kinase inhibitors 有权
标题翻译：大环化合物作为Trk激酶抑制剂
公开(公告)号：US08933084B2
公开(公告)日：2015-01-13
申请号：US13698922
申请日：2011-05-13
申请人： Steven Wade Andrews , Kevin Ronald Condroski , Julia Haas , Yutong Jiang , Gabrielle R. Kolakowski , Jeongbeob Seo , HongWoon Yang , Qian Zhao
发明人： Steven Wade Andrews , Kevin Ronald Condroski , Julia Haas , Yutong Jiang , Gabrielle R. Kolakowski , Jeongbeob Seo , HongWoon Yang , Qian Zhao
IPC分类号： A61K31/519 , C07D487/02 , C07D519/00 , C07D498/22 , C07D487/04 , C07D471/22
CPC分类号： C07D498/22 , A61K31/519 , C07D471/22 , C07D487/04 , C07D487/22 , C07D519/00
摘要： Compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R2, R2a, R3, R3a, and Z are as defined herein, are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.
摘要翻译：式I化合物及其药学上可接受的盐，其中环A，环B，W，m，D，R2，R2a，R3，R3a和Z如本文所定义，是Trk激酶的抑制剂，可用于治疗疼痛，癌症，炎症，神经变性疾病和某些传染病。

85. 发明授权

US08765944B2 Compounds for the treatment of hepatitis C 有权
公开(公告)号：US08765944B2
公开(公告)日：2014-07-01
申请号：US13210776
申请日：2011-08-16
申请人： Li-Qiang Sun , Eric Mull , Qian Zhao , Tao Wang , Zhongxing Zhang , Paul Michael Scola
发明人： Li-Qiang Sun , Eric Mull , Qian Zhao , Tao Wang , Zhongxing Zhang , Paul Michael Scola
IPC分类号： C07D251/52 , A61K31/53 , A61P31/12
CPC分类号： C07D251/52 , A61K31/53 , A61K45/06 , C07D401/04 , C07D401/12 , C07D403/12 , A61K2300/00
摘要： The disclosure provides compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

86. 发明申请

US20130274244A1 SUBSTITUTED N-(1H-INDAZOL-4-YL)IMIDAZO[1,2-]PYRIDINE-3-CARBOXAMIDE COMPOUNDS AS TYPE III RECEPTOR TYROSINE KINASE INHIBITORS 有权
标题翻译：取代的N-（1H-咪唑-4-基）咪唑并[1,2-]吡啶-3-羧酸酰胺化合物作为III型受体酪氨酸激酶抑制剂
公开(公告)号：US20130274244A1
公开(公告)日：2013-10-17
申请号：US13994048
申请日：2011-12-13
申请人： Mark Laurence Boys , Robert Kirk Delisle , Erik James Hicken , April L. Kennedy , David A. Mareska , Fredrik P. Marmsater , Mark C. Munson , Brad Newhouse , Bryson Rast , James P. Rizzi , Martha E. Rodriguez , George T. Topalov , Qian Zhao
发明人： Mark Laurence Boys , Robert Kirk Delisle , Erik James Hicken , April L. Kennedy , David A. Mareska , Fredrik P. Marmsater , Mark C. Munson , Brad Newhouse , Bryson Rast , James P. Rizzi , Martha E. Rodriguez , George T. Topalov , Qian Zhao
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , A61K31/496 , A61K45/06
摘要： Compounds of Formula I: and pharmaceutically acceptable salts thereof in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of fibrosis, bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases, pain and burns in a mammal.
摘要翻译：式I化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5和R 6具有说明书中给出的含义，是cFMS的抑制剂，可用于治疗纤维化，骨相关疾病，癌症，自身免疫性疾病，炎性疾病，心血管疾病，哺乳动物的疼痛和灼伤。

87. 发明申请

US20130245256A1 QUINAZOLINE ANALOGS AS RECEPTOR TYROSINE KINASE INHIBITORS 有权
公开(公告)号：US20130245256A1
公开(公告)日：2013-09-19
申请号：US13607016
申请日：2012-09-07
申请人： Eli Wallace , George Topalov , Joseph Lyssikatos , Alexandre Buckmelter , Qian Zhao
发明人： Eli Wallace , George Topalov , Joseph Lyssikatos , Alexandre Buckmelter , Qian Zhao
IPC分类号： C07D498/10 , C07D498/04 , C07D413/12 , C07D239/94 , C07D401/12
CPC分类号： C07D498/10 , C04B35/632 , C07D239/94 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D498/04
摘要： This invention provides quinazoline analogs of Formula I: where A is bonded to at least one of the carbons at the 5, 6, 7 or 8 position of the bicyclic ring, and the ring is substituted by up to two independent R3 groups. The invention also includes methods of using compounds of Formula I as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

88. 发明申请

US20130115190A1 Hepatitis C Virus Inhibitors 有权
公开(公告)号：US20130115190A1
公开(公告)日：2013-05-09
申请号：US13459403
申请日：2012-04-30
申请人： Sheldon Hiebert , Ramkumar Rajamani , Li-Qiang Sun , Eric Mull , Eric P. Gillis , Michael S. Bowsher , Qian Zhao , Nicholas A. Meanwell , Kishore V. Renduchintala , Kandhasamy Sarkunam , Pulicharla Nagalakshmi , P. V. K. Suresh Babu , Paul Michael Scola
发明人： Sheldon Hiebert , Ramkumar Rajamani , Li-Qiang Sun , Eric Mull , Eric P. Gillis , Michael S. Bowsher , Qian Zhao , Nicholas A. Meanwell , Kishore V. Renduchintala , Kandhasamy Sarkunam , Pulicharla Nagalakshmi , P. V. K. Suresh Babu , Paul Michael Scola
IPC分类号： A61K38/12 , C07K5/12
CPC分类号： C07K5/0823 , A61K31/13 , A61K31/4745 , A61K31/7056 , A61K38/00 , A61K38/06 , A61K38/2013 , A61K38/204 , A61K38/2053 , A61K38/21 , A61K38/212 , A61K45/06 , C07D487/04 , C07K5/0804 , C07K5/0827 , A61K2300/00
摘要： Hepatitis C virus inhibitors having the general formula (I) are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

89. 发明申请

US20130053073A1 METHOD AND DEVICE FOR CONTROLLING WIRELESS COMMUNICATION TERMINAL SERVICE BASED ON POSITIONAL AREA 有权
标题翻译：基于位置控制无线通信终端服务的方法和设备
公开(公告)号：US20130053073A1
公开(公告)日：2013-02-28
申请号：US13581324
申请日：2010-09-21
申请人： Qian Zhao , Zhenzhuo Zeng , Chenxi Li
发明人： Qian Zhao , Zhenzhuo Zeng , Chenxi Li
IPC分类号： H04W4/02
CPC分类号： H04W48/04 , H04M1/72572 , H04M1/72577
摘要： A method for controlling wireless communication terminals based on location areas is disclosed, including: a wireless communication terminal obtaining its own current location information (101); using a service and function control table to deactivate services and functions that need to be restricted according to the obtained location information, and storing the location information and the deactivated services and functions (102); the wireless communication terminal re-obtaining the location information, activating restriction-cancelled services and functions or deactivating restricted services and functions according to the re-obtained location information, the stored location information and/or the deactivated services and functions; a device for controlling wireless communication terminals based on location areas is also disclosed, and the method and device can be used to control all the services and functions of the wireless communication terminal at the terminal side, so that controlling the wireless communication terminal is more flexibly and more targeted.
摘要翻译：公开了一种基于位置区域控制无线通信终端的方法，包括：无线通信终端获取其自己的当前位置信息（101）; 使用服务和功能控制表来根据所获得的位置信息去激活需要限制的服务和功能，并存储位置信息和停用的服务和功能（102）; 无线通信终端根据重新获得的位置信息，存储的位置信息和/或停用的服务和功能，重新获取位置信息，激活限制取消的服务和功能或停用受限服务和功能; 还公开了一种基于位置区域来控制无线通信终端的装置，并且该方法和装置可用于控制终端侧无线通信终端的所有业务和功能，从而更灵活地控制无线通信终端更具针对性。

90. 发明授权

US08369819B2 Double frequency-conversion receiving circuit and method used for radio-frequency SIM card 有权
标题翻译：双频变频接收电路和方法用于射频SIM卡
公开(公告)号：US08369819B2
公开(公告)日：2013-02-05
申请号：US13120362
申请日：2009-09-21
申请人： Jianbo Zhou , Qian Zhao
发明人： Jianbo Zhou , Qian Zhao
IPC分类号： H04B1/26
CPC分类号： G06K19/0723 , H04B1/28
摘要： A double frequency-conversion receiving circuit used for a radio-frequency SIM card, including a low-noise amplifier (01), a high-medium-frequency mixer (02), a low-medium-frequency mixer (03), a local oscillator (04), a quadrature I/Q circuit (05), and a low-medium-frequency processing circuit (07), characterized in that it also includes a frequency divider (06) that performs N frequency dividing to a high-local-oscillation signal generated by the local oscillator (04), wherein the divided low-local-oscillation signal is inputted into the quadrature I/Q circuit (05), the outputted I/Q local-oscillation signal is inputted into the low-medium-frequency mixer (03) to obtain, after mixing, a low-medium-frequency signal, and the low-medium-frequency signal is further processed by the low-medium-frequency processing circuit (07) to output the signal needed, which has gone through the double frequency-conversion. The scheme described in this invention can improve the signal image frequency to approximately 3 GHz through smart frequency distribution without using an external image rejection filter. This effectively solves the image rejection problem when the radio-frequency SIM card is used in the 2.4 GHz ISM frequency band, and reduces power consumption of the chip.
摘要翻译：一种用于射频SIM卡的双频率转换接收电路，包括低噪声放大器（01），高中频混频器（02），低中频混频器（03），本地振荡器（04），正交I / Q电路（05）和低中频处理电路（07），其特征在于还包括分频器（06），其将N频分频到高局部由本地振荡器（04）产生的振荡信号，其中分频的低本振信号被输入到正交I / Q电路（05）中，输出的I / Q本地振荡信号被输入到低介质频率混频器（03）在混频后获得低中频信号，低频中频信号由低中频处理电路（07）进一步处理，输出所需的信号，已经经历了双重频率转换。本发明描述的方案可以通过智能频率分布将信号图像频率提高到大约3GHz，而不使用外部镜像抑制滤波器。当在2.4GHz ISM频段使用射频SIM卡时，这有效地解决了图像抑制问题，降低了芯片的功耗。

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