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81. 发明专利

AU2002252638A1 Molecular mimetics of meningococcal b epitopes which elicit functionally active antibodies 未知
公开(公告)号：AU2002252638A1
公开(公告)日：2002-10-28
申请号：AU2002252638
申请日：2002-04-11
申请人： CHIRON CORP , CHILDRENS HOSP OAK RES INST
发明人： GRANOFF DAN , RAPPUOLI RINO , MOE GREGORY
IPC分类号： G01N33/53 , A61K39/00 , A61K39/095 , A61K39/395 , A61K39/40 , A61P31/04 , A61P43/00 , C07K1/22 , C07K2/00 , C07K14/22 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/13 , C12N15/63 , C12P21/00 , C12P21/02 , C12P21/08 , C12R1/36 , G01N33/569 , C07H21/02 , C12P19/34 , C12Q1/68 , C07H21/04
摘要： Molecular mimetics of a surface-exposed epitope on loop 4 of PorA of Neisseria meningitidis serogroup B (MenB) P1.2 serosubtype and antibodies produced against the same are disclosed. Compositions containing such molecular mimetics or the antibodies thereto can be used to prevent MenB disease, as well as for diagnosis of MenB infection.

82. 发明专利

CA2439428A1 MOLECULAR MIMETICS OF MENINGOCOCCAL B EPITOPES WHICH ELICIT FUNCTIONALLY ACTIVE ANTIBODIES 未知
公开(公告)号：CA2439428A1
公开(公告)日：2002-10-24
申请号：CA2439428
申请日：2002-04-11
申请人： CHIRON CORP , CHILDRENS HOSP OAK RES INST
发明人： RAPPUOLI RINO , GRANOFF DAN , MOE GREGORY
IPC分类号： G01N33/53 , A61K39/00 , A61K39/095 , A61K39/395 , A61K39/40 , A61P31/04 , A61P43/00 , C07K1/22 , C07K2/00 , C07K14/22 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/13 , C12N15/63 , C12P21/00 , C12P21/02 , C12P21/08 , C12R1/36 , G01N33/569 , C12N15/31 , C07K7/06 , A61K38/08 , C12N15/11
摘要： Molecular mimetics of a surface-exposed epitope on loop 4 of PorA of Neisser ia meningitidis serogroup B (MenB) P1.2 serosubtype and antibodies produced against the same are disclosed. Compositions containing such molecular mimetics or the antibodies thereto can be used to prevent MenB disease, as well as for diagnosis of MenB infection.

83. 发明专利

AU1202200A Neisseria genomic sequences and methods of their use 未知
公开(公告)号：AU1202200A
公开(公告)日：2000-05-01
申请号：AU1202200
申请日：1999-10-08
申请人： CHIRON CORP , INSTITUTE FOR GENOMIC RESEARCH THE
发明人： FRAZER CLAIRE M , HICKEY ERIN , PETERSON JEREMY , TETTELIN HERVE , VENTER J CRAIG , MASIGNANI VEGA , GALEOTTI CESIRA , MORA MARIROSA , RATTI GIULIO , SCARSELLI MARIA , SCARLATO VINCENZO , RAPPUOLI RINO , PIZZA MARIAGRATIA
IPC分类号： G01N33/53 , A61K35/76 , A61K38/00 , A61K39/00 , A61K39/095 , A61K39/395 , A61K48/00 , A61P31/04 , C07K14/22 , C07K16/12 , C12N15/09 , C12N15/11 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/48
摘要： The invention provides methods of obtaining immunogenic proteins from genomic sequences including Neisseria, including the amino acid sequences and the corresponding nucleotide sequences, as well as the genomic sequence of Neisseria meningitidis B. The proteins so obtained are useful antigens for vaccines, immunogenic compositions, and/or diagnostics.

84. 发明专利

DE69827779T2 未知
公开(公告)号：DE69827779T2
公开(公告)日：2005-12-15
申请号：DE69827779
申请日：1998-03-19
申请人： CHIRON CORP
发明人： BARCHFELD GAIL , DEL GIUDICE GIUSEPPE , RAPPUOLI RINO
IPC分类号： A61K39/00 , A61K39/10 , A61K39/106 , A61K39/108 , A61K39/145 , A61K39/21 , A61K39/245 , A61K39/39 , A61P31/04 , A61P31/12 , A61P31/16 , A61P31/18 , A61P31/22 , C07K14/235 , C07K14/245 , C07K14/28
摘要： The present invention provides parenteral adjuvants comprising detoxified mutants of bacterial ADP-ribosylating toxins, particularly those from pertussis (PT), cholera (CT), and heat-labile E. coli (LT).

85. 发明专利

CA2522379A1 THE SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 未知
公开(公告)号：CA2522379A1
公开(公告)日：2004-10-28
申请号：CA2522379
申请日：2004-04-09
申请人： CHIRON CORP
发明人： RAPPUOLI RINO , MASIGNANI VEGA , STADLER KONRAD , POLO JOHN , VALIANTE NICHOLAS , SONG HYUN CHUL , HOUGHTON MICHAEL , WEINER AMY , SEO MI YOUNG , KLENK HANS DIETER , GREGERSEN JENS-PETER , DONNELLY JOHN J , CHIEN DAVID , HAN JANG
IPC分类号： A61K35/76 , A61K38/16 , A61K39/00 , A61K39/215 , C07K14/165 , C07K16/10 , C12N7/06 , C12Q1/70
摘要： An outbreak of a virulent respiratory virus, now known as Severe Acute Respiratory Syndrome (SARS), was identified in Hong Kong, China and a growin g number of countries around the world in 2003. The invention relates to nucle ic acids and proteins from the SARS coronavirus. These nucleic acids and protei ns can be used in the preparation and manufacture of vaccine formulations, diagnostic reagents, kits, etc. The invention also provides methods for treating SARS by administering small molecule antiviral compounds, as well a s methods of identifying potent small molecules for the treatment of SARS.

86. 发明专利

AU2003299535A8 Group b streptococcus vaccine 未知
公开(公告)号：AU2003299535A8
公开(公告)日：2004-06-07
申请号：AU2003299535
申请日：2003-09-15
申请人： CHIRON CORP
发明人： RAPPUOLI RINO
IPC分类号： A61K31/00 , A61K39/09 , A61K39/385 , A61K39/02 , A61K39/00
摘要： This application relates to improved Group B Streptococcus ("GBS") saccharide-based vaccines comprising combinations of GBS polysaccharides with polypeptide antigens, and vice versa, such that the polypeptide and the saccharide each contribute to the immunological response in a recipient. The combination is particularly advantageous where the saccharide and polypeptide are from different GBS serotypes. The combined antigens may be present as a simple combination where separate saccharide and polypeptide antigens are administered together, or they may be present as a conjugated combination, where the saccharide and polypeptide antigens are covalently linked to each other. Preferably, the immunogenic compositions of the invention comprise a GBS saccharide antigen and at least two GBS polypeptide antigens, wherein said GBS saccharide antigen comprises a saccharide selected form GBS serotype Ia, Ib, and III, and wherein said GBS polypeptide antigens comprise a combination of at least two polypeptide or fragments thereof selected from the antigen group consisting of GBS 80, GBS 91, GBS 104, GBS 147, GBS 173, GBS 276, GBS 305, GBS 313, GBS 322, GBS 328, GBS 330, GBS 338, GBS 358, GBS 361, GBS 404, GBS 656, GBS 690, and GBS 691.

87. 发明专利

BR9914374A 未知
公开(公告)号：BR9914374A
公开(公告)日：2002-09-17
申请号：BR9914374
申请日：1999-10-08
申请人： CHIRON CORP
发明人： FRAZER CLAIRE M , GALEOTTI CESIRA , MASIGNANI VEGA , MORA MARIROSA , PIZZA MARIAGRATIA , RAPPUOLI RINO , RATTI GIULIO , SCARSELLI MARIA , HICKEY ERIN , PETERSON JEREMY , TETTELIN HERVE , VENTER J CRAIG , SCARLATO VICENZO
IPC分类号： G01N33/53 , A61K35/76 , A61K38/00 , A61K39/00 , A61K39/095 , A61K39/395 , A61K48/00 , A61P31/04 , C07K14/22 , C07K16/12 , C12N15/09 , C12N15/11 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/48
摘要： The invention provides methods of obtaining immunogenic proteins from genomic sequences including Neisseria, including the amino acid sequences and the corresponding nucleotide sequences, as well as the genomic sequence of Neisseria meningitidis B. The proteins so obtained are useful antigens for vaccines, immunogenic compositions, and/or diagnostics.

88. 发明专利

AU741902B2 Detoxified mutants of bacterial adp-ribosylating toxins as parenteral adjuvants 未知
公开(公告)号：AU741902B2
公开(公告)日：2001-12-13
申请号：AU6571398
申请日：1998-03-19
申请人： CHIRON CORP
发明人： BARCHFELD GAIL , GIUDICE GIUSEPPE DEL , RAPPUOLI RINO
IPC分类号： A61K39/00 , A61K39/10 , A61K39/106 , A61K39/108 , A61K39/145 , A61K39/21 , A61K39/245 , A61K39/39 , A61P31/04 , A61P31/12 , A61P31/16 , A61P31/18 , A61P31/22 , C07K14/235 , C07K14/245 , C07K14/28
摘要： The present invention provides parenteral adjuvants comprising detoxified mutants of bacterial ADP-ribosylating toxins, particularly those from pertussis (PT), cholera (CT), and heat-labile E. coli (LT).

89. 发明专利

CA2284541A1 DETOXIFIED MUTANTS OF BACTERIAL ADP-RIBOSYLATING TOXINS AS PARENTERAL ADJUVANTS 未知
公开(公告)号：CA2284541A1
公开(公告)日：1998-10-01
申请号：CA2284541
申请日：1998-03-19
申请人： CHIRON CORP
发明人： RAPPUOLI RINO , DEL GIUDICE GIUSEPPE , BARCHFELD GAIL
IPC分类号： A61K39/00 , A61K39/10 , A61K39/106 , A61K39/108 , A61K39/145 , A61K39/21 , A61K39/245 , A61K39/39 , A61P31/04 , A61P31/12 , A61P31/16 , A61P31/18 , A61P31/22 , C07K14/235 , C07K14/245 , C07K14/28
摘要： The present invention provides parenteral adjuvants comprising detoxified mutants of bacterial ADP-ribosylating toxins, particularly those form pertussis (PT), cholera (CT), and heat-labile E. coli (LT).

90. 发明专利

CA2284541C DETOXIFIED MUTANTS OF BACTERIAL ADP-RIBOSYLATING TOXINS AS PARENTERAL ADJUVANTS 未知
公开(公告)号：CA2284541C
公开(公告)日：2009-05-26
申请号：CA2284541
申请日：1998-03-19
申请人： CHIRON CORP
发明人： BARCHFELD GAIL , RAPPUOLI RINO , DEL GIUDICE GIUSEPPE
IPC分类号： A61K39/39 , A61K39/00 , A61K39/002 , A61K39/02 , A61K39/095 , A61K39/10 , A61K39/106 , A61K39/108 , A61K39/12 , A61K39/13 , A61K39/145 , A61K39/21 , A61K39/245 , A61P31/04 , A61P31/12 , A61P31/16 , A61P31/18 , A61P31/22 , C07K14/005 , C07K14/195 , C07K14/235 , C07K14/245 , C07K14/28 , C07K14/44
摘要： The present invention provides parenteral adjuvants comprising detoxified mutants of bacterial ADP-ribosylating toxins, particularly those from pertussis (PT), cholera (CT ), and heat-labile E.coli (LT).

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