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1. 发明申请

WO02083711A2 MOLECULAR MIMETICS OF MENINGOCOCCAL B EPITOPES WHICH ELICIT FUNCTIONALLY ACTIVE ANTIBODIES 审中-公开
标题翻译：分子功能活性抗体的MENOCOCCAL B抗体的分子模型
公开(公告)号：WO02083711A2
公开(公告)日：2002-10-24
申请号：PCT/US0211501
申请日：2002-04-11
申请人： CHIRON CORP , CHILDRENS HOSP OAK RES INST , GRANOFF DAN , MOE GREGORY , RAPPUOLI RINO
发明人： GRANOFF DAN , MOE GREGORY , RAPPUOLI RINO
IPC分类号： G01N33/53 , A61K39/00 , A61K39/095 , A61K39/395 , A61K39/40 , A61P31/04 , A61P43/00 , C07K1/22 , C07K2/00 , C07K14/22 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/13 , C12N15/63 , C12P21/00 , C12P21/02 , C12P21/08 , C12R1/36 , G01N33/569 , C07K
CPC分类号： C07K14/22 , A61K39/00 , A61K2039/505 , Y10S530/825
摘要： Molecular mimetics of a surface-exposed epitope on loop 4 of PorA of Neisseria meningitidis serogroup B (MenB) P1.2 serosubtype and antibodies produced against the same are disclosed. Compositions containing such molecular mimetics or the antibodies thereto can be used to prevent MenB disease, as well as for diagnosis of MenB infection.
摘要翻译：公开了脑膜炎奈瑟氏球菌血清群B（MenB）P1.2血清型的PorA的环4上的表面暴露的表位的分子模拟物和针对其产生的抗体。含有这种分子模拟物的组合物或其抗体可用于预防MenB疾病以及MenB感染的诊断。

2. 发明公开

EP1379272A4 MOLECULAR MIMETICS OF MENINGOCOCCAL B EPITOPES WHICH ELICIT FUNCTIONALLY ACTIVE ANTIBODIES 有权
标题翻译：脑膜炎球菌B的分子模拟表位教育功能抗体有效作用
公开(公告)号：EP1379272A4
公开(公告)日：2005-12-14
申请号：EP02721722
申请日：2002-04-11
申请人： CHIRON CORP , CHILDRENS HOSP OAK RES INST
发明人： GRANOFF DAN , MOE GREGORY , RAPPUOLI RINO
IPC分类号： G01N33/53 , A61K39/00 , A61K39/095 , A61K39/395 , A61K39/40 , A61P31/04 , A61P43/00 , C07K1/22 , C07K2/00 , C07K14/22 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/13 , C12N15/63 , C12P21/00 , C12P21/02 , C12P21/08 , C12R1/36 , G01N33/569 , C07H21/02 , C07H21/04 , C12P19/34 , C12Q1/68
CPC分类号： C07K14/22 , A61K39/00 , A61K2039/505 , Y10S530/825

3. 发明专利

AU2002252638A1 Molecular mimetics of meningococcal b epitopes which elicit functionally active antibodies 未知
公开(公告)号：AU2002252638A1
公开(公告)日：2002-10-28
申请号：AU2002252638
申请日：2002-04-11
申请人： CHIRON CORP , CHILDRENS HOSP OAK RES INST
发明人： GRANOFF DAN , RAPPUOLI RINO , MOE GREGORY
IPC分类号： G01N33/53 , A61K39/00 , A61K39/095 , A61K39/395 , A61K39/40 , A61P31/04 , A61P43/00 , C07K1/22 , C07K2/00 , C07K14/22 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/13 , C12N15/63 , C12P21/00 , C12P21/02 , C12P21/08 , C12R1/36 , G01N33/569 , C07H21/02 , C12P19/34 , C12Q1/68 , C07H21/04
摘要： Molecular mimetics of a surface-exposed epitope on loop 4 of PorA of Neisseria meningitidis serogroup B (MenB) P1.2 serosubtype and antibodies produced against the same are disclosed. Compositions containing such molecular mimetics or the antibodies thereto can be used to prevent MenB disease, as well as for diagnosis of MenB infection.

4. 发明专利

CA2439428A1 MOLECULAR MIMETICS OF MENINGOCOCCAL B EPITOPES WHICH ELICIT FUNCTIONALLY ACTIVE ANTIBODIES 未知
公开(公告)号：CA2439428A1
公开(公告)日：2002-10-24
申请号：CA2439428
申请日：2002-04-11
申请人： CHIRON CORP , CHILDRENS HOSP OAK RES INST
发明人： RAPPUOLI RINO , GRANOFF DAN , MOE GREGORY
IPC分类号： G01N33/53 , A61K39/00 , A61K39/095 , A61K39/395 , A61K39/40 , A61P31/04 , A61P43/00 , C07K1/22 , C07K2/00 , C07K14/22 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/13 , C12N15/63 , C12P21/00 , C12P21/02 , C12P21/08 , C12R1/36 , G01N33/569 , C12N15/31 , C07K7/06 , A61K38/08 , C12N15/11
摘要： Molecular mimetics of a surface-exposed epitope on loop 4 of PorA of Neisser ia meningitidis serogroup B (MenB) P1.2 serosubtype and antibodies produced against the same are disclosed. Compositions containing such molecular mimetics or the antibodies thereto can be used to prevent MenB disease, as well as for diagnosis of MenB infection.

5. 发明专利

DE60235155D1 未知
公开(公告)号：DE60235155D1
公开(公告)日：2010-03-11
申请号：DE60235155
申请日：2002-04-11
申请人： CHILDRENS HOSP OAK RES INST , NOVARTIS VACCINES & DIAGNOSTIC
发明人： GRANOFF DAN , MOE GREGORY , RAPPUOLI RINO
IPC分类号： A61K39/095 , G01N33/53 , A61K39/00 , A61K39/395 , A61K39/40 , A61P31/04 , A61P43/00 , C07K1/22 , C07K2/00 , C07K14/22 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/13 , C12N15/63 , C12P21/00 , C12P21/02 , C12P21/08 , C12R1/36 , G01N33/569
摘要： Molecular mimetics of a surface-exposed epitope on loop 4 of PorA of Neisseria meningitidis serogroup B (MenB) P1.2 serosubtype and antibodies produced against the same are disclosed. Compositions containing such molecular mimetics or the antibodies thereto can be used to prevent MenB disease, as well as for diagnosis of MenB infection.

6. 发明专利

AT455793T 未知
公开(公告)号：AT455793T
公开(公告)日：2010-02-15
申请号：AT02721722
申请日：2002-04-11
申请人： NOVARTIS VACCINES & DIAGNOSTIC , CHILDRENS HOSP OAK RES INST
发明人： GRANOFF DAN , MOE GREGORY , RAPPUOLI RINO
IPC分类号： C07K16/12 , G01N33/53 , A61K39/00 , A61K39/095 , A61K39/395 , A61K39/40 , A61P31/04 , A61P43/00 , C07K1/22 , C07K2/00 , C07K14/22 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/13 , C12N15/63 , C12P21/00 , C12P21/02 , C12P21/08 , C12R1/36 , G01N33/569
摘要： Molecular mimetics of a surface-exposed epitope on loop 4 of PorA of Neisseria meningitidis serogroup B (MenB) P1.2 serosubtype and antibodies produced against the same are disclosed. Compositions containing such molecular mimetics or the antibodies thereto can be used to prevent MenB disease, as well as for diagnosis of MenB infection.

8. 发明专利

RU2355704C2 МОНОКЛОНАЛЬНОЕ АНТИТЕЛО, НАПРАВЛЕННОЕ ПРОТИВ GNA33 ПЕПТИДА, И ЕГО ПРИМЕНЕНИЕ 未知
公开(公告)号：RU2355704C2
公开(公告)日：2009-05-20
申请号：RU2006146886
申请日：2002-04-11
申请人： NOVARTIS VACCINES & DIAGNOSTIC , CHILDRENS HOSP OAK RES INST
发明人： GRANOFF DEHN , MOEH GREGORI , RAPPUOLI RINO
IPC分类号： C07K16/12 , C12P21/00 , G01N33/53
摘要： Изобретениераскрываетмоноклональноеантитело, направленноепротив GNA33 пептидас определеннойаминокислотнойпоследовательностью, котороепроявляеткомплемент-опосредованнуюбактерициднуюи/илиопсоническуюактивностьпротивбактерий Neisseria meningitidis серогруппыВ (MenB). Наосновемоноклональногоантителасконструированакомпозициядлялеченияилипрофилактики MenB заболевания, ииспользованиекомпозицииспособствуетвыработкеиммуннойреакциипротивуказанныхбактерийприеевведениив организмсубъекта-млекопитающего. Моноклональноеантителопоизобретениюможетбытьиспользованотакжедлявыделениямолекулярногомиметикаэпитопабактерии Neisseria meningitidis серогруппыВ (MenB) путемконтактированияантителас предполагаемыммиметикоми выделениемобразующегосякомплекаантитело-миметик. Антителапоизобретениюи композициинаихосновеможноэффективноиспользоватьдляпрофилактики MenB заболевания, атакжедлядиагностики MenB инфекции. 5 н.п. ф-лы, 5 ил., 6 табл.

9. 发明申请

WO0022430A2 NEISSERIA GENOMIC SEQUENCES AND METHODS OF THEIR USE 审中-公开
标题翻译： NEISSERIA基因组序列及其使用方法
公开(公告)号：WO0022430A2
公开(公告)日：2000-04-20
申请号：PCT/US9923573
申请日：1999-10-08
申请人： CHIRON CORP , FRAZER CLAIRE M , HICKEY ERIN , PETERSON JEREMY , TETTELIN HERVE , VENTER J CRAIG , MASIGNANI VEGA , GALEOTTI CESIRA , MORA MARIROSA , RATTI GIULIO , SCARSELLI MARIA , SCARLATO VINCENZO , RAPPUOLI RINO , PIZZA MARIAGRATIA
发明人： FRAZER CLAIRE M , HICKEY ERIN , PETERSON JEREMY , TETTELIN HERVE , VENTER J CRAIG , MASIGNANI VEGA , GALEOTTI CESIRA , MORA MARIROSA , RATTI GIULIO , SCARSELLI MARIA , SCARLATO VINCENZO , RAPPUOLI RINO , PIZZA MARIAGRATIA
IPC分类号： G01N33/53 , A61K35/76 , A61K38/00 , A61K39/00 , A61K39/095 , A61K39/395 , A61K48/00 , A61P31/04 , C07K14/22 , C07K16/12 , C12N15/09 , C12N15/11 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/48
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , C12Q1/689 , C12Q2600/156
摘要： The invention provides methods of obtaining immunogenic proteins from genomic sequences including Neisseria, including the amino acid sequences and the corresponding nucleotide sequences, as well as the genomic sequence of Neisseria meningitidis B. The proteins so obtained are useful antigens for vaccines, immunogenic compositions, and/or diagnostics.
摘要翻译：本发明提供了从包括奈瑟氏球菌在内的基因组序列获得免疫原性蛋白质的方法，包括氨基酸序列和相应的核苷酸序列以及脑膜炎奈瑟氏球菌B的基因组序列。如此获得的蛋白质是疫苗，免疫原性组合物和 /或诊断。

10. 发明申请

WO2006110413A2 HAEMOPHILUS INFLUENZAE TYPE B 审中-公开
标题翻译： HAEMOPHILUS INFLUENZAE型B
公开(公告)号：WO2006110413A2
公开(公告)日：2006-10-19
申请号：PCT/US2006012606
申请日：2006-03-30
申请人： CHIRON CORP , INST GENOMIC RESEARCH , MASIGNANI VEGA , RAPPUOLI RINO , TETTELIN HERVE
发明人： MASIGNANI VEGA , RAPPUOLI RINO , TETTELIN HERVE
IPC分类号： C12N15/74
CPC分类号： C07K14/285 , A61K39/00 , A61K39/102 , A61K39/12 , C07K14/005 , C07K16/1242
摘要： Polypeptides comprising various amino acid sequences derived from Haemophilus influenzae type b, including a number of lipoproteins. These can be used in the development of vaccines for preventing and/or treating bacterial meningitis. They may also be useful for diagnostic purposes, and as targets for antibiotics. Antibodies against the polypeptides are also disclosed, as are the coding nucleic acids.
摘要翻译：包含衍生自b型流感嗜血杆菌的各种氨基酸序列的多肽，包括许多脂蛋白。这些可用于开发用于预防和/或治疗细菌性脑膜炎的疫苗。它们也可用于诊断目的，也可用作抗生素的靶标。编码核酸也公开了抗多肽的抗体。

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