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1. 发明申请

WO0022430A2 NEISSERIA GENOMIC SEQUENCES AND METHODS OF THEIR USE 审中-公开
标题翻译： NEISSERIA基因组序列及其使用方法
公开(公告)号：WO0022430A2
公开(公告)日：2000-04-20
申请号：PCT/US9923573
申请日：1999-10-08
申请人： CHIRON CORP , FRAZER CLAIRE M , HICKEY ERIN , PETERSON JEREMY , TETTELIN HERVE , VENTER J CRAIG , MASIGNANI VEGA , GALEOTTI CESIRA , MORA MARIROSA , RATTI GIULIO , SCARSELLI MARIA , SCARLATO VINCENZO , RAPPUOLI RINO , PIZZA MARIAGRATIA
发明人： FRAZER CLAIRE M , HICKEY ERIN , PETERSON JEREMY , TETTELIN HERVE , VENTER J CRAIG , MASIGNANI VEGA , GALEOTTI CESIRA , MORA MARIROSA , RATTI GIULIO , SCARSELLI MARIA , SCARLATO VINCENZO , RAPPUOLI RINO , PIZZA MARIAGRATIA
IPC分类号： G01N33/53 , A61K35/76 , A61K38/00 , A61K39/00 , A61K39/095 , A61K39/395 , A61K48/00 , A61P31/04 , C07K14/22 , C07K16/12 , C12N15/09 , C12N15/11 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/48
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , C12Q1/689 , C12Q2600/156
摘要： The invention provides methods of obtaining immunogenic proteins from genomic sequences including Neisseria, including the amino acid sequences and the corresponding nucleotide sequences, as well as the genomic sequence of Neisseria meningitidis B. The proteins so obtained are useful antigens for vaccines, immunogenic compositions, and/or diagnostics.
摘要翻译：本发明提供了从包括奈瑟氏球菌在内的基因组序列获得免疫原性蛋白质的方法，包括氨基酸序列和相应的核苷酸序列以及脑膜炎奈瑟氏球菌B的基因组序列。如此获得的蛋白质是疫苗，免疫原性组合物和 /或诊断。

2. 发明公开

EP1379272A4 MOLECULAR MIMETICS OF MENINGOCOCCAL B EPITOPES WHICH ELICIT FUNCTIONALLY ACTIVE ANTIBODIES 有权
标题翻译：脑膜炎球菌B的分子模拟表位教育功能抗体有效作用
公开(公告)号：EP1379272A4
公开(公告)日：2005-12-14
申请号：EP02721722
申请日：2002-04-11
申请人： CHIRON CORP , CHILDRENS HOSP OAK RES INST
发明人： GRANOFF DAN , MOE GREGORY , RAPPUOLI RINO
IPC分类号： G01N33/53 , A61K39/00 , A61K39/095 , A61K39/395 , A61K39/40 , A61P31/04 , A61P43/00 , C07K1/22 , C07K2/00 , C07K14/22 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/13 , C12N15/63 , C12P21/00 , C12P21/02 , C12P21/08 , C12R1/36 , G01N33/569 , C07H21/02 , C07H21/04 , C12P19/34 , C12Q1/68
CPC分类号： C07K14/22 , A61K39/00 , A61K2039/505 , Y10S530/825

3. 发明申请

WO2006110413A2 HAEMOPHILUS INFLUENZAE TYPE B 审中-公开
标题翻译： HAEMOPHILUS INFLUENZAE型B
公开(公告)号：WO2006110413A2
公开(公告)日：2006-10-19
申请号：PCT/US2006012606
申请日：2006-03-30
申请人： CHIRON CORP , INST GENOMIC RESEARCH , MASIGNANI VEGA , RAPPUOLI RINO , TETTELIN HERVE
发明人： MASIGNANI VEGA , RAPPUOLI RINO , TETTELIN HERVE
IPC分类号： C12N15/74
CPC分类号： C07K14/285 , A61K39/00 , A61K39/102 , A61K39/12 , C07K14/005 , C07K16/1242
摘要： Polypeptides comprising various amino acid sequences derived from Haemophilus influenzae type b, including a number of lipoproteins. These can be used in the development of vaccines for preventing and/or treating bacterial meningitis. They may also be useful for diagnostic purposes, and as targets for antibiotics. Antibodies against the polypeptides are also disclosed, as are the coding nucleic acids.
摘要翻译：包含衍生自b型流感嗜血杆菌的各种氨基酸序列的多肽，包括许多脂蛋白。这些可用于开发用于预防和/或治疗细菌性脑膜炎的疫苗。它们也可用于诊断目的，也可用作抗生素的靶标。编码核酸也公开了抗多肽的抗体。

4. 发明申请

WO2004092360A3 THE SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 审中-公开
标题翻译：严重急性呼吸道综合症冠状病毒
公开(公告)号：WO2004092360A3
公开(公告)日：2005-08-04
申请号：PCT/US2004011710
申请日：2004-04-09
申请人： CHIRON CORP , RAPPUOLI RINO , MASIGNANI VEGA , STADLER KONRAD , GREGERSEN JENS-PETER , CHIEN DAVID , HAN JANG , POLO JOHN , WEINER AMY , HOUGHTON MICHAEL , SONG HYUN CHUL , SEO MI YOUNG , DONNELLY JOHN J , KLENK HANS DIETER , VALIANTE NICHOLAS
发明人： RAPPUOLI RINO , MASIGNANI VEGA , STADLER KONRAD , GREGERSEN JENS-PETER , CHIEN DAVID , HAN JANG , POLO JOHN , WEINER AMY , HOUGHTON MICHAEL , SONG HYUN CHUL , SEO MI YOUNG , DONNELLY JOHN J , KLENK HANS DIETER , VALIANTE NICHOLAS
IPC分类号： A61K35/76 , A61K38/16 , A61K39/00 , A61K39/215 , C07K14/165 , C07K16/10 , C12N7/06 , C12Q1/70
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/215 , A61K2039/5252 , A61K2039/545 , A61K2039/55505 , A61K2039/55511 , A61K2039/55566 , C07K16/10 , C07K2317/34 , C07K2317/76 , C07K2319/21 , C12N7/00 , C12N2770/20021 , C12N2770/20022 , C12N2770/20034 , C12N2770/20043 , C12N2770/20051 , C12N2770/20063 , C12Q1/701 , G01N2333/165 , G01N2469/20
摘要： An outbreak of a virulent respiratory virus, now known as Severe Acute Respiratory Syndrome (SARS), was identified in Hong Kong, China and a growing number of countries around the world in 2003. The invention relates to nucleic acids and proteins from the SARS coronavirus. These nucleic acids and proteins can be used in the preparation and manufacture of vaccine formulations, diagnostic reagents, kits, etc. The invention also provides methods for treating SARS by administering small molecule antiviral compounds, as well as methods of identifying potent small molecules for the treatment of SARS.
摘要翻译：在2003年，中国香港和世界各地越来越多的国家确定了现在称为严重急性呼吸综合征（SARS）的毒性呼吸道病毒的爆发。本发明涉及SARS冠状病毒的核酸和蛋白质。这些核酸和蛋白质可用于制备和制造疫苗制剂，诊断试剂，试剂盒等。本发明还提供了通过施用小分子抗病毒化合物治疗SARS的方法，以及鉴定用于治疗SARS的有效小分子的方法治疗SARS。

5. 发明申请

WO9957280A2 NEISSERIA MENINGITIDIS ANTIGENS AND COMPOSITIONS 审中-公开
标题翻译： NEISSERIA MENINGITIDIS抗生素和组合物
公开(公告)号：WO9957280A2
公开(公告)日：1999-11-11
申请号：PCT/US9909346
申请日：1999-04-30
申请人： CHIRON CORP , INST GENOMIC RESEARCH , FRASER CLAIRE , GALEOTTI CESIRA , GRANDI GUIDO , HICKEY ERIN , MASIGNANI VEGA , MORA MARIROSA , PETERSEN JEREMY , PIZZA MARIAGRATIA , RAPPUOLI RINO , RATTI GIULIO , SCALATO ENZO , SCARSELLI MARIA , TETTELIN HERVE , VENTER J CRAIG
发明人： FRASER CLAIRE , GALEOTTI CESIRA , GRANDI GUIDO , HICKEY ERIN , MASIGNANI VEGA , MORA MARIROSA , PETERSEN JEREMY , PIZZA MARIAGRATIA , RAPPUOLI RINO , RATTI GIULIO , SCALATO ENZO , SCARSELLI MARIA , TETTELIN HERVE , VENTER J CRAIG
IPC分类号： G01N33/50 , A61K38/00 , A61K39/00 , A61K39/095 , A61P31/04 , C07K14/22 , C07K16/12 , C12N15/09 , C12N15/31 , C12P21/08 , C12Q1/68 , C12R1/36
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
摘要： The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
摘要翻译：本发明提供脑膜炎奈瑟氏球菌的蛋白质，包括氨基酸序列和相应的核苷酸序列。蛋白质被预测为用于疫苗和/或诊断的有用的抗原。

6. 发明申请

WO2006084179A3 HIV TAT-CD4 HYBRIED MOLECULES AND METHODS OF USE THEREOF 审中-公开
标题翻译： HIV TAT-CD4杂交分子及其使用方法
公开(公告)号：WO2006084179A3
公开(公告)日：2006-12-14
申请号：PCT/US2006003935
申请日：2006-02-03
申请人： CHIRON CORP , BARNETT SUSAN , RAPPUOLI RINO , SHARMA VICTORIA , SRIVASTAVA INDRESH
发明人： BARNETT SUSAN , RAPPUOLI RINO , SHARMA VICTORIA , SRIVASTAVA INDRESH
IPC分类号： C07K19/00 , A61K39/00 , A61K48/00 , C12N15/09 , C12N15/12 , C12N15/62
CPC分类号： C07K14/70514 , C07K2319/01
摘要： Hybrid molecules comprising CD4 minimal modules or mimetics that bind to HIV Env polypeptides in combination with one or more HIV Tat polypeptides are described. Also described are complexes of these hybrid molecules with Env as well as methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides.
摘要翻译：描述了包含CD4最小模块或与一种或多种HIV Tat多肽组合的HIV Env多肽结合的模拟物的杂合分子。还描述了这些杂合分子与Env的复合物以及使用多核苷酸和多肽的诊断，治疗和预防方法。

7. 发明申请

WO2005028618A3 IMMUNOGENIC COMPOSITIONS FOR STREPTOCOCCUS AGALACTIAE 审中-公开
标题翻译：用于结核分枝杆菌的免疫组化
公开(公告)号：WO2005028618A3
公开(公告)日：2006-01-26
申请号：PCT/US2004030032
申请日：2004-09-15
申请人： CHIRON CORP , RAPPUOLI RINO
发明人： RAPPUOLI RINO
IPC分类号： A61K39/09 , C12N20060101 , A61K39/385 , A61K39/00 , A61K39/02 , A61K39/116 , A61K39/38
CPC分类号： A61K39/092
摘要： This application relates to Group B Streptococcus ("GBS") vaccines comprising combinations of GBS polypeptide antigens where the polypeptides contribute to the immunological response in a recipient. Preferably, the compositions of the invention comprise a combination of two or more GBS antigens, wherein said combination includes GBS 80 or a fragment thereof. In one embodiment, the combination may consist of two to thirteen GBS antigens selected from an antigen group consisting of GBS 80, GBS 91, GBS 104, GBS 184, GBS 276, GBS 305, GBS 322, GBS 330, GBS 338, GBS 361, GBS 404, GBS 690, and GBS 691.
摘要翻译：本申请涉及包含GBS多肽抗原组合的B组链球菌（“GBS”）疫苗，其中多肽有助于受体中的免疫应答。优选地，本发明的组合物包含两种或更多种GBS抗原的组合，其中所述组合包括GBS 80或其片段。在一个实施方案中，该组合可以由选自GBS 80，GBS 91，GBS 104，GBS 184，GBS 276，GBS 305，GBS 322，GBS 330，GBS 338，GBS 361的抗原组中的两至十三个GBS抗原组成，GBS 404，GBS 690和GBS 691。

8. 发明申请

WO2004041157A3 GROUP B STREPTOCOCCUS VACCINE 审中-公开
标题翻译： B组STRPTOCOCCUS VACCINE
公开(公告)号：WO2004041157A3
公开(公告)日：2004-09-16
申请号：PCT/US0329167
申请日：2003-09-15
申请人： CHIRON CORP , RAPPUOLI RINO
发明人： RAPPUOLI RINO
IPC分类号： A61K31/00 , A61K39/09 , A61K39/385 , A61K39/00 , A61K39/02
CPC分类号： A61K39/092 , A61K31/00
摘要： This application relates to improved Group B Streptococcus ("GBS") saccharide-based vaccines comprising combinations of GBS polysaccharides with polypeptide antigens, and vice versa, such that the polypeptide and the saccharide each contribute to the immunological response in a recipient. The combination is particularly advantageous where the saccharide and polypeptide are from different GBS serotypes. The combined antigens may be present as a simple combination where separate saccharide and polypeptide antigens are administered together, or they may be present as a conjugated combination, where the saccharide and polypeptide antigens are covalently linked to each other. Preferably, the immunogenic compositions of the invention comprise a GBS saccharide antigen and at least two GBS polypeptide antigens, wherein said GBS saccharide antigen comprises a saccharide selected form GBS serotype Ia, Ib, and III, and wherein said GBS polypeptide antigens comprise a combination of at least two polypeptide or fragments thereof selected from the antigen group consisting of GBS 80, GBS 91, GBS 104, GBS 147, GBS 173, GBS 276, GBS 305, GBS 313, GBS 322, GBS 328, GBS 330, GBS 338, GBS 358, GBS 361, GBS 404, GBS 656, GBS 690, and GBS 691.
摘要翻译：本申请涉及包含GBS多糖与多肽抗原的组合的改进的B组链球菌（“GBS”）糖基疫苗，反之亦然，使得多肽和糖各自对接受者的免疫应答有贡献。当糖和多肽来自不同的GBS血清型时，该组合是特别有利的。组合的抗原可以作为单独的组合存在，其中单独的糖和多肽抗原一起施用，或者它们可以作为共轭组合存在，其中糖和多肽抗原彼此共价连接。优选地，本发明的免疫原性组合物包含GBS糖抗原和至少两种GBS多肽抗原，其中所述GBS糖抗原包含选自GBS血清型Ia，Ib和III的糖，并且其中所述GBS多肽抗原包含至少两种选自GBS 80，GBS 91，GBS 104，GBS 147，GBS 173，GBS 276，GBS 305，GBS 313，GBS 322，GBS 328，GBS 330，GBS 338， GBS 358，GBS 361，GBS 404，GBS 656，GBS 690和GBS 691。

9. 发明申请

WO9957280A9 NEISSERIA MENINGITIDIS ANTIGENS AND COMPOSITIONS 审中-公开
标题翻译： NEISSERIA MENINGITIDIS抗生素和组合物
公开(公告)号：WO9957280A9
公开(公告)日：2002-08-29
申请号：PCT/US9909346
申请日：1999-04-30
申请人： CHIRON CORP , INST GENOMIC RESEARCH , FRASER CLAIRE , GALEOTTI CESIRA , GRANDI GUIDO , HICKEY ERIN , MASIGNANI VEGA , MORA MARIROSA , PETERSEN JEREMY , PIZZA MARIAGRATIA , RAPPUOLI RINO , RATTI GIULIO , SCALATO ENZO , SCARSELLI MARIA , TETTELIN HERVE , VENTER J CRAIG
发明人： FRASER CLAIRE , GALEOTTI CESIRA , GRANDI GUIDO , HICKEY ERIN , MASIGNANI VEGA , MORA MARIROSA , PETERSEN JEREMY , PIZZA MARIAGRATIA , RAPPUOLI RINO , RATTI GIULIO , SCALATO ENZO , SCARSELLI MARIA , TETTELIN HERVE , VENTER J CRAIG
IPC分类号： G01N33/50 , A61K38/00 , A61K39/00 , A61K39/095 , A61P31/04 , C07K14/22 , C07K16/12 , C12N15/09 , C12N15/31 , C12P21/08 , C12Q1/68 , C12R1/36
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
摘要： The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
摘要翻译：本发明提供脑膜炎奈瑟氏球菌的蛋白质，包括氨基酸序列和相应的核苷酸序列。蛋白质被预测为用于疫苗和/或诊断的有用的抗原。

10. 发明申请

WO02083711A2 MOLECULAR MIMETICS OF MENINGOCOCCAL B EPITOPES WHICH ELICIT FUNCTIONALLY ACTIVE ANTIBODIES 审中-公开
标题翻译：分子功能活性抗体的MENOCOCCAL B抗体的分子模型
公开(公告)号：WO02083711A2
公开(公告)日：2002-10-24
申请号：PCT/US0211501
申请日：2002-04-11
申请人： CHIRON CORP , CHILDRENS HOSP OAK RES INST , GRANOFF DAN , MOE GREGORY , RAPPUOLI RINO
发明人： GRANOFF DAN , MOE GREGORY , RAPPUOLI RINO
IPC分类号： G01N33/53 , A61K39/00 , A61K39/095 , A61K39/395 , A61K39/40 , A61P31/04 , A61P43/00 , C07K1/22 , C07K2/00 , C07K14/22 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/13 , C12N15/63 , C12P21/00 , C12P21/02 , C12P21/08 , C12R1/36 , G01N33/569 , C07K
CPC分类号： C07K14/22 , A61K39/00 , A61K2039/505 , Y10S530/825
摘要： Molecular mimetics of a surface-exposed epitope on loop 4 of PorA of Neisseria meningitidis serogroup B (MenB) P1.2 serosubtype and antibodies produced against the same are disclosed. Compositions containing such molecular mimetics or the antibodies thereto can be used to prevent MenB disease, as well as for diagnosis of MenB infection.
摘要翻译：公开了脑膜炎奈瑟氏球菌血清群B（MenB）P1.2血清型的PorA的环4上的表面暴露的表位的分子模拟物和针对其产生的抗体。含有这种分子模拟物的组合物或其抗体可用于预防MenB疾病以及MenB感染的诊断。

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