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    • 84. 发明申请
    • SPECTRUM-DRIVEN ARRHYTHMIA TREATMENT METHOD
    • 光谱驱动的ARRHYTHMIA治疗方法
    • US20080200961A1
    • 2008-08-21
    • US12111036
    • 2008-04-28
    • Mark W. KrollPeter Boileau
    • Mark W. KrollPeter Boileau
    • A61N1/00
    • A61N1/3622
    • A method and apparatus for treating an arrhythmia is provided. The method includes the steps of: (a) sensing at least one electrical signal from the patient's heart; (b) calculating a frequency spectrum of each electrical signal; (c) calculating a center frequency for each frequency spectrum; and (d) selecting an electro-therapy for delivery to the patient's heart based on the center frequency. The electro-therapy can be a pre-programmed anti-tachycardia pacing (ATP) therapy, a shock therapy, or no therapy at all. The method is performed through the use of an implantable cardioverter defibrillator (ICD). Also provided is a method of determining the optimal location to deliver the electro-therapy.
    • 提供了一种治疗心律失常的方法和装置。 该方法包括以下步骤:(a)感测来自患者心脏的至少一个电信号; (b)计算每个电信号的频谱; (c)计算每个频谱的中心频率; 以及(d)根据中心频率选择电疗以传送到患者的心脏。 电疗可以是预先编程的抗心动过速起搏(ATP)治疗,休克疗法,或根本没有治疗。 该方法通过使用植入式心律转复除颤器(ICD)进行。 还提供了确定递送电疗的最佳位置的方法。
    • 85. 发明授权
    • Super plastic design for CHF pacemaker lead
    • 超级塑料设计为CHF起搏器主导
    • US07403823B1
    • 2008-07-22
    • US11205865
    • 2005-08-16
    • Mark W. KrollJohn R. HellandYougandh ChitreMichael Yang
    • Mark W. KrollJohn R. HellandYougandh ChitreMichael Yang
    • A61N1/05
    • A61N1/056A61N1/0563A61N2001/0585
    • An implantable lead assembly for a body implantable medical system adapted to transmit electrical signals between a proximal end portion of the lead assembly and a distal end portion of the lead assembly to thereby stimulate selected body tissue includes an elongated insulative sheath of flexible resilient material having at least one longitudinally extending lumen, an electrical conductor received within the lumen of the insulative sheath and extending between a proximal end and a distal end, and at least one elongated super plastic element slidably received within the lumen of the insulative sheath, the super plastic element being bendable to configure the lead assembly to negotiate tortuous turns in the vasculature of the body. An electrical connector is coupled to the proximal end of the conductor for releasable attachment to a stimulating pulse generator and an electrode is coupled to the distal end of the conductor.
    • 一种用于身体可植入医疗系统的可植入引线组件,其适于在引线组件的近端部分和引线组件的远端部分之间传输电信号,从而刺激所选择的身体组织,包括柔性弹性材料的细长绝缘护套, 至少一个纵向延伸的内腔,电导体,其容纳在绝缘护套的内腔内并在近端和远端之间延伸;以及至少一个细长超塑料元件,其可滑动地容纳在绝缘护套的内腔内,超塑料元件 可以弯曲以配置导线组件来协商身体脉管系统中的曲折转弯。 电连接器耦合到导体的近端,用于可释放地附接到刺激脉冲发生器,并且电极耦合到导体的远端。
    • 86. 发明授权
    • Self adjusting optimal waveforms
    • 自适应最佳波形
    • US07398122B1
    • 2008-07-08
    • US11102331
    • 2005-04-07
    • Steve HofstadterMark W. Kroll
    • Steve HofstadterMark W. Kroll
    • A61N1/39
    • A61N1/3937A61B5/053A61N1/3906A61N1/3912
    • An exemplary method includes detecting fibrillation, measuring impedance of a defibrillation circuit that includes myocardial tissue, determining one or more defibrillation shock parameters based at least in part on the impedance, delivering a defibrillation shock using the one or more defibrillation shock parameters and, if the shock was unsuccessful, adjusting a membrane time constant and determining one or more new defibrillation shock parameters based at least in part on the adjusted membrane time constant. Various other exemplary methods are disclosed as well as various exemplary devices, systems, etc.
    • 示例性方法包括检测原纤维化,测量包括心肌组织的除颤电路的阻抗,至少部分地基于阻抗确定一个或多个除颤冲击参数,使用一个或多个去纤维颤动参数递送除颤休克,以及如果 冲击不成功,调整膜时间常数并且至少部分地基于调整的膜时间常数来确定一种或多种新的除颤冲击参数。 公开了各种其它示例性方法以及各种示例性装置,系统等
    • 87. 发明授权
    • System and method for responding to pulsed gradient magnetic fields using an implantable medical device
    • 使用可植入医疗装置对脉冲梯度磁场进行响应的系统和方法
    • US07369898B1
    • 2008-05-06
    • US11020438
    • 2004-12-22
    • Mark W. KrollGene A. BornzinSergio ShkurovichNirav Dalal
    • Mark W. KrollGene A. BornzinSergio ShkurovichNirav Dalal
    • A61N1/08A61B5/05
    • A61B5/055A61N1/36514A61N1/3688A61N1/37A61N1/3718
    • Implantable medical devices, such as pacemakers or implantable cardioverter defibrillators (ICDs), are vulnerable to the powerful magnetic fields associated with magnetic resonance imaging (MRI). In particular, pulsed gradient components, if strong enough, can induce parasitic currents that may damage the device or cause parasitic pacing that may trigger an arrhythmia in the patient. The static magnetic field components of the MRI typically do not induce parasitic currents, even though they may be as strong as the pulsed gradient components. Accordingly, techniques are described herein for specifically addressing the pulsed gradient components of the MRI fields so as to reduce the risk of parasitic currents. In one example, a pacemaker switches to tri-state pacing outputs in the presence of strong pulsed gradient magnetic fields. The device continues with normal bi-state pacing outputs so long as the pulsed gradient fields are not strong, even in the presence of a strong static magnetic field. As an added safety feature, the pacemaker switches to fixed-rate ventricular pacing whenever strong static MRI fields are detected.
    • 可植入的医疗设备,如起搏器或植入式心律转复除颤器(ICD)易受到与磁共振成像(MRI)相关的强大磁场的影响。 特别地,如果足够强的脉冲梯度分量可以引起寄生电流,这些寄生电流可能会损坏器件或引起可引发患者心律失常的寄生起搏。 MRI的静态磁场分量通常不会引起寄生电流,即使它们可能与脉冲梯度分量一样强。 因此,本文描述了用于专门寻址MRI场的脉冲梯度分量的技术,以便降低寄生电流的风险。 在一个示例中,起搏器在存在强脉冲梯度磁场的情况下切换到三态起搏输出。 只要脉冲梯度场不强,即使在存在强静态磁场的情况下,器件将继续进行正常的双态起搏输出。 作为增加的安全功能,每当检测到强静态MRI场时,起搏器就切换到固定速率心室起搏。
    • 90. 发明授权
    • Cardiac pacing/sensing lead providing far-field signal rejection
    • 心脏起搏/感应引线提供远场信号抑制
    • US07305270B1
    • 2007-12-04
    • US11112508
    • 2005-04-21
    • Mark W. KrollJohn R. Helland
    • Mark W. KrollJohn R. Helland
    • A61N1/05
    • A61N1/056A61N1/0573A61N1/3702A61N1/3704
    • A proximal end of a lead body carries a connector assembly. A first electrical conductor within the lead body electrically connects a tip electrode to a first electrical contact on the connector assembly. A collar electrode is carried by a distal end portion of the lead body. A second electrical conductor within the lead body electrically connects the collar electrode to a second electrical contact on the connector assembly. A ring electrode, carried by the distal end portion of the lead body, is disposed proximally of the collar electrode in spaced-apart relationship thereto and is connected through a switching device to a node point along the first conductor. The switching device has a first state permitting an electrical current to be conducted between the ring electrode and the node point and a second state in which the ring electrode is electrically isolated from the node point. Preferably, the switching device comprises a diode.
    • 引线体的近端承载连接器组件。 引线体内的第一电导体将尖端电极与连接器组件上的第一电触点电连接。 凸缘电极由引线体的远端部分承载。 引线体内的第二电导体将接头电极电连接到连接器组件上的第二电触头。 由引线体的远端部分承载的环形电极以与其成间隔开的关系设置在套环电极的近侧,并且通过开关装置连接到沿着第一导体的节点。 开关器件具有允许电流在环形电极和节点之间传导的第一状态和环形电极与节点电气隔离的第二状态。 优选地,开关装置包括二极管。