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81. 发明专利

HUT65445A PROCESS FOR PREPARATION OF THIAZOLYL-SUBSTITUTED QUINOLINYL-METHOXY-PHENYL ACETIC ACID DERIVATIVES AND PHARMACEUTICALS CONTAINING THEM 未知
公开(公告)号：HUT65445A
公开(公告)日：1994-06-28
申请号：HU9203812
申请日：1992-12-02
申请人： BAYER AG
发明人： RADDATZ SIEGFRIED , FRUCHTMANN ROMANIS , MUELLER-PEDDINGHAUS REINER , MOHRS KLAUS-HELMUT , HATZELMANN ARMIN , MATZKE MICHAEL
IPC分类号： A61K31/47 , A61P43/00 , C07D215/14 , C07D417/12 , C07D521/00
摘要： Thiazolyl-substituted quinolylmethoxyphenylacetic acid derivatives are prepared by reaction of halogenoacetoacetic acid esters with quinolylmethoxyphenylacetic acid thioamides, which are obtainable from corresponding amides with Lawesson's reagent. The substances can be employed in medicaments as inhibitors of enzymatic reactions in the context of arachidonic acid metabolism.

82. 发明专利

HU209293B PROCESS FOR PRODUCING CYCLIC SUBSTITUTED (QUINOLIN-2-YL-METHOXY)-PHENYL ACETIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 未知
公开(公告)号：HU209293B
公开(公告)日：1994-04-28
申请号：HU530590
申请日：1990-08-23
申请人： BAYER AG
发明人： MOHRS KLAUS , RADDATZ SIEGFRIED , FRUCHTMANN ROMANIS , KOHLSDORFER CHRISTIAN , MUELLER-PEDDINGHAUS REINER , THEISEN-POPP PIA
IPC分类号： A61K31/47 , A61P29/00 , A61P37/08 , C07D215/14 , C07D409/12 , A61K31/38
摘要： Cyclically substituted (quinolin-2-ylmethoxy)phenylacetic acid derivatives can be prepared by reaction of corresponding CH acidic compounds with open-chain dihalogen compounds. The cyclically substituted (quinolin-2-ylmethoxy)phenylacetic acid derivatives can be employed as active substances in medicaments.

83. 发明专利

PL300026A1 2-SUBSTITUTED DERIVATIVES OF QUINOLINOMETHOXY-PHENYLOACETIC ACID 未知
公开(公告)号：PL300026A1
公开(公告)日：1994-03-21
申请号：PL30002693
申请日：1993-08-10
申请人： BAYER AG
发明人： MATZKE MICHAEL , MOHRS KLAUS-HELMUT , RADDATZ SIEGFRIED , FRUCHTMANN ROMANIS , MULLER-PEDDINGHAUS REINER , HATZELMANN ARMIN
IPC分类号： A61P7/02 , A61K31/47 , A61P29/00 , A61P37/08 , A61P43/00 , C07D215/14 , C07D215/16 , C07D215/04
摘要： 2-Substituted quinolylmethoxyphenylacetic acid derivatives of the general formula (I) in which A, B, D, E, G and L are identical or different and stand for hydrogen, hydroxyl, halogen, cyano, carboxyl, nitro, trifluoromethyl, trifluoromethoxy or for straight-chain or branched alkyl or alkoxy in each case having up to 8 carbon atoms, or for aryl having 6 to 10 carbon atoms, which is optionally substituted by halogen, hydroxyl, nitro or cyano, R stands for halogen, cyano, nitro, azido, hydroxyl, carboxyl, trifluoromethyl, trifluoromethoxy or trifluoromethylthio, or for straight-chain or branched alkenyl or alkynyl in each case having up to 8 carbon atoms, each of which is optionally substituted by phenyl or cycloalkyl having 3 to 8 carbon atoms, or for cycloalkyl having 3 to 8 carbon atoms or phenyl, or for straight-chain or branched alkoxy or alkoxycarbonyl in each case having up to 6 carbon atoms, R stands for hydrogen or for straight-chain or branched alkyl having up to 6 carbon atoms, or for cycloalkyl having 3 to 12 carbon atoms, R stands for hydroxyl, for straight-chain or branched alkoxy having up to 8 carbon atoms or phenyl, or for a group of the formula -NR SO2R or -NR R , in which R , R and R are identical or different and denote hydrogen, straight-chain or branched alkyl having up to 6 carbon atoms, phenyl or benzyl, R denotes trifluoromethyl or phenyl which is optionally substituted by halogen, cyano, hydroxyl, nitro, trifluoromethyl, trifluoromethoxy, trifluoromethylthio or by straight-chain or branched alkyl or alkoxy in each case having up to 6 carbon atoms, or denotes straight-chain or branched alkyl having up to 8 carbon atoms, which is optionally substituted by phenyl which, for its part, can be substitued by halogen, cyano, nitro, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, hydroxyl or by straight-chain or branched alkyl or alkoxy in each case having up to 6 carbon atoms and their salts. 2-Substituted quinolylmethoxyphenylacetic acid derivatives are prepared by reaction of appropriately substituted phenols with quinolylmethyl halides or by reaction of unsubstituted phenols with quinolylmethyl halides and subsequent alkylation. The 2-substituted quinolylmethoxyphenylacetic acid derivatives can be employed as active compounds in medicaments. The substances can act as inhibitors of enzymatic reactions in arachidonic acid metabolism, in particular of lipoxygenase.

84. 发明专利

PL300025A1 NOVEL ISOBUTYL SUBSTITUTED QUINOLINOMETHOXYPHENYL-CYCLOALKYOACETIC METHANOSULFONYL AMIDES 未知
公开(公告)号：PL300025A1
公开(公告)日：1994-03-21
申请号：PL30002593
申请日：1993-08-10
申请人： BAYER AG
发明人： RADDATZ SIEGFRIED , MOHRS KLAUS-HELMUT , MATZKE MICHAEL , FRUCHTMANN ROMANIS , MULLER-PEDDINGHAUS REINER , HATZELMANN ARMIN
IPC分类号： A61K31/47 , A61P1/16 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P11/00 , A61P11/06 , A61P29/00 , A61P37/08 , A61P43/00 , C07D215/14 , C07D215/04
摘要： Isobutyl-substituted methanesulphonylquinolylmethoxyphenylcycloalkylacetamides of the formula in which R stands for cyclohexyl in the form of the racemate and of the enantiomers and also the enantiomers when R stands for cyclopentyl or cycloheptyl and their salts. The isobutyl-substituted methanesulphonylquinolylmethoxyphenylcycloalkylacetamides can be prepared by reaction of the corresponding racemic or enantiomeric acids with methanesulphonamide, it being possible to separate the racemic final products into the enantiomers by customary methods. The N-methanesulphonyl-2-[3-isobutyl-3-(quinolin-2-yl-methoxy)phenyl]-2-ay eloalkylacetamides can be employed as active compounds in pharmaceuticals. The substances can act as inhibitors of enzymatic reactions in arachidonic acid metabolism, in particular of lipoxygenase.

85. 发明专利

HU208960B PROCESS FOR PRODUCING DISUBSTITUTED (QUINOLIN-2-YL-METHOXY)-PHENYLACETIC ACID DERIVATIVES 未知
公开(公告)号：HU208960B
公开(公告)日：1994-02-28
申请号：HU530490
申请日：1990-08-23
申请人： BAYER AG
发明人： MOHRS KLAUS , RADDATZ SIEGFRIED , FRUCHTMANN ROMANIS , KOHLSDORFER CHRISTIAN , MUELLER-PEDDINGHAUS REINER , THEISEN-POPP PIA
IPC分类号： A61K31/47 , A61P29/00 , A61P37/08 , A61P43/00 , C07D215/14
摘要： Disubstituted (quinolin-2-ylmethoxy)phenylacetic acid derivatives can be prepared by reduction of correspondingly disubstituted ketoesters by means of Grignard reagents and, for the preparation of the thio compounds, by subsequent reaction with thiols. The compounds can be used as active substances in medicaments.

86. 发明专利

HU208813B PROCESS FOR PRODUCING SUBSTITUTED N-(QUINOLIN-2-YL-METHOXY)-BENZYLSULFONYLUREAS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SUCH COMPOUNDS 未知
公开(公告)号：HU208813B
公开(公告)日：1994-01-28
申请号：HU505590
申请日：1990-08-17
申请人： BAYER AG
发明人： MOHRS KLAUS , RADDATZ SIEGFRIED , FRUCHTMANN ROMANIS , KOHLSDORFER CHRISTIAN , MUELLER-PEDDINGHAUS REINER , THEISEN-POPP PIA
IPC分类号： A61K31/47 , A61K31/64 , A61P3/02 , A61P29/00 , C07D215/14
摘要： Substituted N-(quinolin-2-ylmethoxy)benzylsulphonylureas are prepared by reaction of (quinolin-2-ylmethoxy)benzylamines with sulphonyl isocyanates. The substituted N-(quinolin-2-ylmethoxy)benzylsulphonylureas can be employed as active substances in medicaments, in particular as lipoxygenase inhibitors.

87. 发明专利

CZ109593A3 SUBSTITUTED DERIVATIVES OF (BENZOTHIAZOLYL- AND QUINOXALYL-METHOXY) PHENYLACETIC ACID 未知
公开(公告)号：CZ109593A3
公开(公告)日：1994-01-19
申请号：CZ109593
申请日：1993-06-07
申请人： BAYER AG
发明人： MOHRS KLAUS-HELMUT DR , RADDATZ SIEGFRIED DR , MATZKE MICHAEL DR , FUGMANN BURKHARD DR , FRUCHTMANN ROMANIS , HATZELMANN ARMIN DR , MULLER-PEDDINGHAUS REINER PROF
IPC分类号： A61K31/425 , A61K31/428 , A61K31/495 , A61P7/02 , A61P9/08 , A61P9/10 , A61P11/00 , A61P17/00 , A61P29/00 , A61P37/08 , C07D241/42 , C07D241/44 , C07D277/42 , C07D277/64
摘要： Substituted benzothiazolyl- and quinoxalyl-methoxyphenylacetic acid derivatives are prepared either by reaction of heterocyclylmethyl-halogen compounds with corresponding phenoxy compounds, either directly or with subsequent alkylation, or by reaction of the heterocyclylmethyl-halogen compound with phenoxy compounds and subsequent reaction with suitable Grignard compounds. The substituted benzothiazolyl- and quinoxalyl-methoxyphenylacetic acid derivatives can be employed as active compounds in medicaments.

88. 发明专利

NO932031A 未知
公开(公告)号：NO932031A
公开(公告)日：1993-12-20
申请号：NO932031
申请日：1993-06-03
申请人： BAYER AG
发明人： MOHRS KLAS HELMUT , RADDATZ SIEGFRIED , MATZKE MICHAEL , FUGMANN BUCKHARD , FRUCHTMANN ROMANIS , HATZELMANN ARMIN , MUELLER PEDDINGHAUS REINER
IPC分类号： A61K31/425 , A61K31/428 , A61K31/495 , A61P7/02 , A61P9/08 , A61P9/10 , A61P11/00 , A61P17/00 , A61P29/00 , A61P37/08 , C07D241/42 , C07D241/44 , C07D277/42 , C07D277/64
CPC分类号： C07D241/42 , C07D277/64

89. 发明专利

FI932743A 未知
公开(公告)号：FI932743A
公开(公告)日：1993-12-18
申请号：FI932743
申请日：1993-06-15
申请人： BAYER AG
发明人： MOHRS KLAUS-HELMUT , RADDATZ SIEGFRIED , MATZKE MICHAEL , FUGMANN BURKHARD , FRUCHTMANN ROMANIS , HATZELMANN ARMIN , MUELLER-PEDDINGHAUS REINER
IPC分类号： A61K31/425 , A61K31/428 , A61K31/495 , A61P7/02 , A61P9/08 , A61P9/10 , A61P11/00 , A61P17/00 , A61P29/00 , A61P37/08 , C07D241/42 , C07D241/44 , C07D277/42 , C07D277/64
摘要： Substituted benzothiazolyl- and quinoxalyl-methoxyphenylacetic acid derivatives are prepared either by reaction of heterocyclylmethyl-halogen compounds with corresponding phenoxy compounds, either directly or with subsequent alkylation, or by reaction of the heterocyclylmethyl-halogen compound with phenoxy compounds and subsequent reaction with suitable Grignard compounds. The substituted benzothiazolyl- and quinoxalyl-methoxyphenylacetic acid derivatives can be employed as active compounds in medicaments.

90. 发明专利

CZ356092A3 AMIDES OF QUINOLYLMETHOXYPHENYLACETIC ACID 未知
公开(公告)号：CZ356092A3
公开(公告)日：1993-09-15
申请号：CS356092
申请日：1992-12-03
申请人： BAYER AG
发明人： RADDATZ SIEGFRIED DR , MOHRS KLAUS-HELMUT DR , MATZKE MICHAEL DR , FRUCHTMANN ROMANIS , HATZELMANN ARMIN DR , MULLER-PEDDINGHAUS REINER PROF
IPC分类号： A61K31/47 , A61K31/495 , A61K31/535 , A61P9/00 , A61P11/00 , A61P37/08 , C07D215/14 , C07D215/16 , C07D215/48
摘要： Quinolylmethoxyphenyl-acetamides of the formula: rogen, hydroxyl, halogen, cyano, carboxyl, nitro, trifluoromethyl, trifluoromethoxy, alkyl, alkoxy or optionally substituted aryl; R1 represents optionally substituted cycloalkyl; and R2 and R3 independently represent hydrogen, alkyl, benzyl, or optionally substituted cycloalkyl; or together represent piperidinyl, morpholino, or piperazinyl; show a high in vitro activity as leukotriene synthesis inhibitors and, therefore, are suitable for the treatment and prevention of inflammations.

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