发明专利
PL300025A1 NOVEL ISOBUTYL SUBSTITUTED QUINOLINOMETHOXYPHENYL-CYCLOALKYOACETIC METHANOSULFONYL AMIDES
未知
基本信息:
- 专利标题： NOVEL ISOBUTYL SUBSTITUTED QUINOLINOMETHOXYPHENYL-CYCLOALKYOACETIC METHANOSULFONYL AMIDES
- 申请号：PL30002593 申请日：1993-08-10
- 公开(公告)号：PL300025A1 公开(公告)日：1994-03-21
- 发明人： RADDATZ SIEGFRIED , MOHRS KLAUS-HELMUT , MATZKE MICHAEL , FRUCHTMANN ROMANIS , MULLER-PEDDINGHAUS REINER , HATZELMANN ARMIN
- 申请人： BAYER AG
- 专利权人： BAYER AG
- 当前专利权人： BAYER AG
- 优先权： DE4226649 1992-08-12
- 主分类号： A61K31/47
- IPC分类号： A61K31/47 ; A61P1/16 ; A61P7/02 ; A61P9/00 ; A61P9/08 ; A61P9/10 ; A61P11/00 ; A61P11/06 ; A61P29/00 ; A61P37/08 ; A61P43/00 ; C07D215/14 ; C07D215/04
摘要：
Isobutyl-substituted methanesulphonylquinolylmethoxyphenylcycloalkylacetamides of the formula in which R stands for cyclohexyl in the form of the racemate and of the enantiomers and also the enantiomers when R stands for cyclopentyl or cycloheptyl and their salts. The isobutyl-substituted methanesulphonylquinolylmethoxyphenylcycloalkylacetamides can be prepared by reaction of the corresponding racemic or enantiomeric acids with methanesulphonamide, it being possible to separate the racemic final products into the enantiomers by customary methods. The N-methanesulphonyl-2-[3-isobutyl-3-(quinolin-2-yl-methoxy)phenyl]-2-ay eloalkylacetamides can be employed as active compounds in pharmaceuticals. The substances can act as inhibitors of enzymatic reactions in arachidonic acid metabolism, in particular of lipoxygenase.
公开/授权文献:
信息查询:
EspacenetIPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/33 | .杂环化合物 |
| ----------A61K31/335 | ..仅有氧作为环杂原子的，例如制霉色基素 |
| ------------A61K31/40 | ...有仅以1个氮作为环杂原子的五元环的，例如舒必利、琥珀酰亚胺、托尔米丁、甲氧吡丁苯 |
| --------------A61K31/47 | ....喹啉；异喹啉 |