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1. 发明专利

SK263992A3 SUBSTITUTED DERIVATIVES OF MANDELIC ACID, A METHOD OF PRODUCING THE SAME, THEIR USE IN DRUGS AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME 未知
公开(公告)号：SK263992A3
公开(公告)日：1998-06-03
申请号：SK263992
申请日：1992-08-26
申请人： BAYER AG
发明人： MOHRS KLAUS-HELMUT , RADDATZ SIEGFRIED , MATZKE MICHAEL , FRUCHTMANN ROMANIS , HATZELMANN ARMIN , KOHLSDORFER CHRISTIAN , MULLER-PEDDINGHAUS REINER , THEISEN-POPP PIA
IPC分类号： A61P7/02 , A61P9/10 , A61K31/47 , A61P11/00 , A61P11/06 , A61P29/00 , A61P37/08 , C07D215/14 , C07D215/20
摘要： Substituted mandelic acid derivatives can be prepared by reaction of glyoxylic esters with Grignard compounds. The substituted mandelic acid derivatives are suitable as active compounds in medicaments, in particular for medicaments which inhibit leukotriene synthesis.

2. 发明专利

PL171026B1 METHOD OF OBTAINING NOVEL 2-SUBSTITUTED QUINOLINE 未知
公开(公告)号：PL171026B1
公开(公告)日：1997-02-28
申请号：PL31469892
申请日：1992-02-19
申请人： BAYER AG
发明人： RADDATZ SIEGFRIED , MOHRS KLAUS-HELMUT , MATZKE MICHAEL , FRUCHTMANN ROMANIS , HATZELMANN ARMIN , KOHLSDORFER CHRISTIAN , MUELLER-PEDDINGHAUS REINER , THEISEN-POPP PIA
IPC分类号： A61K31/4709 , A61P7/02 , A61P9/10 , A61K31/47 , A61P11/00 , A61P11/06 , A61P37/08 , C07D215/12 , C07D215/14 , C07D215/16 , C07D401/12 , C07D405/12
摘要： 2-substituted quinolines of the general formula The title compounds are prepared by reacting either the corresponding halomethylquinolines with substituted phenols, then optionally alkylating these and hydrolysing esters to acids, or by reacting phenyl-substituted quinolinecarboxylic acid derivatives with sulphonamides. The novel phenyl-substituted quinolines can be used as active compounds in medicaments, in particular as lipoxygenase inhibitors.

3. 发明专利

PL170726B1 METHOD OF OBTAINING 2-SUBSTITUTED QUINOLINES 未知
公开(公告)号：PL170726B1
公开(公告)日：1997-01-31
申请号：PL29353492
申请日：1992-02-19
申请人： BAYER AG
发明人： RADDATZ SIEGFRIED , MOHRS KLAUS-HELMUT , MATZKE MICHAEL , FRUCHTMANN ROMANIS , HATZELMANN ARMIN , KOHLSDORFER CHRISTIAN , MUELLER-PEDDINGHAUS REINER , THEISEN-POPP PIA
IPC分类号： A61K31/4709 , A61P7/02 , A61P9/10 , A61K31/47 , A61P11/00 , A61P11/06 , A61P37/08 , C07D215/12 , C07D215/14 , C07D215/16 , C07D401/12 , C07D405/12
摘要： 2-substituted quinolines of the general formula The title compounds are prepared by reacting either the corresponding halomethylquinolines with substituted phenols, then optionally alkylating these and hydrolysing esters to acids, or by reacting phenyl-substituted quinolinecarboxylic acid derivatives with sulphonamides. The novel phenyl-substituted quinolines can be used as active compounds in medicaments, in particular as lipoxygenase inhibitors.

4. 发明专利

NO179948B 未知
公开(公告)号：NO179948B
公开(公告)日：1996-10-07
申请号：NO932731
申请日：1993-07-29
申请人： BAYER AG
发明人： RADDATZ SIEGFRIED , MOHRS KLAUS-HELMUT , MATZKE MICHAEL , FRUCHTMANN ROMANIS , MULLER-PEDDINGHAUS REINER , HATZELMANN ARMIN
IPC分类号： A61K31/47 , A61P1/16 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P11/00 , A61P11/06 , A61P29/00 , A61P37/08 , A61P43/00 , C07D215/14
摘要： Isobutyl-substituted methanesulphonylquinolylmethoxyphenylcycloalkylacetamides of the formula in which R stands for cyclohexyl in the form of the racemate and of the enantiomers and also the enantiomers when R stands for cyclopentyl or cycloheptyl and their salts. The isobutyl-substituted methanesulphonylquinolylmethoxyphenylcycloalkylacetamides can be prepared by reaction of the corresponding racemic or enantiomeric acids with methanesulphonamide, it being possible to separate the racemic final products into the enantiomers by customary methods. The N-methanesulphonyl-2-[3-isobutyl-3-(quinolin-2-yl-methoxy)phenyl]-2-ay eloalkylacetamides can be employed as active compounds in pharmaceuticals. The substances can act as inhibitors of enzymatic reactions in arachidonic acid metabolism, in particular of lipoxygenase.

5. 发明专利

HUT70171A NOVEL ISOBUTYL SUBSTITUTED AMIDES OF METHANESULFONYL-QUINOLYMETHOXYPNENYL-CYCLOALKYLACETIC ACID, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND PROCESS FOR PRODUCING THEREOF 未知
公开(公告)号：HUT70171A
公开(公告)日：1995-09-28
申请号：HU9302320
申请日：1993-08-11
申请人： BAYER AG
发明人： RADDATZ SIEGFRIED , FRUCHTMANN ROMANIS , MUELLER-PEDDINGHAUS REINER , MOHRS KLAUS-HELMUT , HATZELMANN ARMIN , MATZKE MICHAEL
IPC分类号： A61K31/47 , A61P1/16 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P11/00 , A61P11/06 , A61P29/00 , A61P37/08 , A61P43/00 , C07D215/14
摘要： Isobutyl-substituted methanesulphonylquinolylmethoxyphenylcycloalkylacetamides of the formula in which R stands for cyclohexyl in the form of the racemate and of the enantiomers and also the enantiomers when R stands for cyclopentyl or cycloheptyl and their salts. The isobutyl-substituted methanesulphonylquinolylmethoxyphenylcycloalkylacetamides can be prepared by reaction of the corresponding racemic or enantiomeric acids with methanesulphonamide, it being possible to separate the racemic final products into the enantiomers by customary methods. The N-methanesulphonyl-2-[3-isobutyl-3-(quinolin-2-yl-methoxy)phenyl]-2-ay eloalkylacetamides can be employed as active compounds in pharmaceuticals. The substances can act as inhibitors of enzymatic reactions in arachidonic acid metabolism, in particular of lipoxygenase.

6. 发明专利

NZ245326A QUINOLYLMETHOXYPHENYLACETIC ACID ACYLAMIDES AND UREAS; PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF 未知
公开(公告)号：NZ245326A
公开(公告)日：1995-07-26
申请号：NZ24532692
申请日：1992-12-01
申请人： BAYER AG
发明人： RADDATZ SIEGFRIED , MOHRS KLAUS-HELMUT , MATZKE MICHAEL , FRUCHTMANN ROMANIS , HATZELMANN ARMIN , MULLER-PEDDINGHAUS REINER
IPC分类号： A61K31/47 , A61P9/00 , A61P11/00 , A61P37/08 , A61P43/00 , C07D215/14 , C07D215/16 , C07D215/48
摘要： Quinolylmethoxyphenylacetic acid acylamides and ureas can be prepared either by reacting corresponding carboxylic acids with amides or reacting corresponding amides with isocyanates or ureas. The quinolylmethoxyphenylacetic acid acylamides or ureas can be used as active compounds in medicaments.

7. 发明专利

AU654067B2 Quinolylmethoxyphenylacetic acid acylamides and ureas 未知
公开(公告)号：AU654067B2
公开(公告)日：1994-10-20
申请号：AU2980092
申请日：1992-12-01
申请人： BAYER AG
发明人： RADDATZ SIEGFRIED , MOHRS KLAUSE-HELMUT , MATZKE MICHAEL , FRUCHTMANN ROMANIS , HATZELMANN ARMIN , MULLER-PEDDINGHAUS REINER
IPC分类号： A61K31/47 , A61P9/00 , A61P11/00 , A61P37/08 , A61P43/00 , C07D215/14 , C07D215/16 , C07D215/48
摘要： Quinolylmethoxyphenylacetic acid acylamides and ureas can be prepared either by reacting corresponding carboxylic acids with amides or reacting corresponding amides with isocyanates or ureas. The quinolylmethoxyphenylacetic acid acylamides or ureas can be used as active compounds in medicaments.

8. 发明专利

HUT65252A PROCESS FOR PRODUCING OF QUINOLIN-2-YL-METHOXYBENZYLHYDROXYUREAS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM 未知
公开(公告)号：HUT65252A
公开(公告)日：1994-05-02
申请号：HU9202501
申请日：1992-07-31
申请人： BAYER AG
发明人： RADDATZ SIEGFRIED , FRUCHTMANN ROMANIS , KOHLSDORFER CHRISTIAN , MUELLER-PEDDINGHAUS REINER , MOHRS KLAUS-HELMUT , MATZKE MICHAEL , HATZELMANN ARMIN , THEISEN-POPP PIA
IPC分类号： A61K31/47 , A61P7/02 , A61P9/08 , A61P9/10 , A61P11/00 , A61P17/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07D215/14 , C07D215/16 , C07D215/20 , C07D215/48
摘要： The novel quinolin-2-yl-methoxybenzylhydroxyureas can be prepared by reaction of appropriate ketones with hydroxylamine and reduction of the ketoximes and subsequent reaction with isocyanates. The new substances can be employed as active substances in medicaments.

9. 发明专利

FI933512A 未知
公开(公告)号：FI933512A
公开(公告)日：1994-02-12
申请号：FI933512
申请日：1993-08-09
申请人： BAYER AG
发明人： MATZKE MICHAEL , MOHRS KLAUS-HELMUT , RADDATZ SIEGFRIED , FRUCHTMANN ROMANIS , MUELLER-PEDDINHAUS REINER , HATZELMANN ARMIN
IPC分类号： A61P7/02 , A61K31/47 , A61P29/00 , A61P37/08 , A61P43/00 , C07D215/14 , C07D215/16 , C07D215/12
摘要： 2-Substituted quinolylmethoxyphenylacetic acid derivatives of the general formula (I) in which A, B, D, E, G and L are identical or different and stand for hydrogen, hydroxyl, halogen, cyano, carboxyl, nitro, trifluoromethyl, trifluoromethoxy or for straight-chain or branched alkyl or alkoxy in each case having up to 8 carbon atoms, or for aryl having 6 to 10 carbon atoms, which is optionally substituted by halogen, hydroxyl, nitro or cyano, R stands for halogen, cyano, nitro, azido, hydroxyl, carboxyl, trifluoromethyl, trifluoromethoxy or trifluoromethylthio, or for straight-chain or branched alkenyl or alkynyl in each case having up to 8 carbon atoms, each of which is optionally substituted by phenyl or cycloalkyl having 3 to 8 carbon atoms, or for cycloalkyl having 3 to 8 carbon atoms or phenyl, or for straight-chain or branched alkoxy or alkoxycarbonyl in each case having up to 6 carbon atoms, R stands for hydrogen or for straight-chain or branched alkyl having up to 6 carbon atoms, or for cycloalkyl having 3 to 12 carbon atoms, R stands for hydroxyl, for straight-chain or branched alkoxy having up to 8 carbon atoms or phenyl, or for a group of the formula -NR SO2R or -NR R , in which R , R and R are identical or different and denote hydrogen, straight-chain or branched alkyl having up to 6 carbon atoms, phenyl or benzyl, R denotes trifluoromethyl or phenyl which is optionally substituted by halogen, cyano, hydroxyl, nitro, trifluoromethyl, trifluoromethoxy, trifluoromethylthio or by straight-chain or branched alkyl or alkoxy in each case having up to 6 carbon atoms, or denotes straight-chain or branched alkyl having up to 8 carbon atoms, which is optionally substituted by phenyl which, for its part, can be substitued by halogen, cyano, nitro, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, hydroxyl or by straight-chain or branched alkyl or alkoxy in each case having up to 6 carbon atoms and their salts. 2-Substituted quinolylmethoxyphenylacetic acid derivatives are prepared by reaction of appropriately substituted phenols with quinolylmethyl halides or by reaction of unsubstituted phenols with quinolylmethyl halides and subsequent alkylation. The 2-substituted quinolylmethoxyphenylacetic acid derivatives can be employed as active compounds in medicaments. The substances can act as inhibitors of enzymatic reactions in arachidonic acid metabolism, in particular of lipoxygenase.

10. 发明专利

CA2103521A1 SUBSTITUTED QUINOL-2-YL-METHOXY-PHENYLACETIC ACID DERIVATIVES 未知
公开(公告)号：CA2103521A1
公开(公告)日：1994-02-12
申请号：CA2103521
申请日：1993-08-06
申请人： BAYER AG
发明人： MATZKE MICHAEL , MOHRS KLAUS-HELMUT , RADDATZ SIEGFRIED , FRUCHTMANN ROMANIS , MUELLER-PEDDINGHAUS REINER , HATZELMANN ARMIN
IPC分类号： A61K31/47 , A61P7/02 , A61P29/00 , A61P37/08 , A61P43/00 , C07D215/14 , C07D215/16
摘要： Substituted quinol-2-yl-methoxy-phenylacetic acid derivatives A b s t r a c t Substituted quinol-2-yl-methoxy-phenylacetic acid derivatives are prepared by reacting correspondingly substituted phenols with quinolylmethyl halides or by reacting unsubstituted phenols with quinolylmethyl halides and subsequent alkylation. The substituted quinol-2-yl-methoxy-phenylacetic acid derivatives may be employed as active substances in medicaments.

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