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81. 发明授权

US08088817B2 Pyrrole derivative having, as substituents, ureido group, aminocarbonly group and bicyclic group which may have substituent 失效
标题翻译：作为取代基的吡咯衍生物，可以具有取代基的脲基，氨基碳基和双环
公开(公告)号：US08088817B2
公开(公告)日：2012-01-03
申请号：US12737807
申请日：2009-08-25
申请人： Kenji Kawashima , Noriko Kawashima , Hiroshi Enomoto , Minoru Yamamoto , Masaaki Murai
发明人： Kenji Kawashima , Noriko Kawashima , Hiroshi Enomoto , Minoru Yamamoto , Masaaki Murai
IPC分类号： A61K31/4025 , A61K31/401 , C07D207/34 , C07D405/04 , C07D409/04
CPC分类号： C07D207/34 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04
摘要： A compound represented by the following formula (1) or a salt thereof: The compound has an inhibitory activity on the production of interleukin-6, and is therefore useful as a therapeutic agent for a disease associated with interleukin-6, ocular inflammatory diseases and the like. In the formula, R1 represents a halogen atom, a hydrogen atom, a lower alkyl group which may have a substituent, a formyl group, or a lower alkylcarbonyl group which may have a substituent, R2 represents a bicyclic hydrocarbon group which may have a substituent or a bicyclic heterocyclic group which may have a substituent, R3 represents a hydrogen atom, a lower alkyl group which may have a substituent, an aryl group which may have a substituent, or an acyl group.
摘要翻译：由下式（1）表示的化合物或其盐：该化合物对白细胞介素-6的产生具有抑制活性，因此可用作与白介素-6，眼炎性疾病相关疾病的治疗剂，类似。式中，R 1表示卤素原子，氢原子，可具有取代基的低级烷基，甲酰基或可具有取代基的低级烷基羰基，R 2表示可具有取代基的二环烃基，或可以具有取代基的二环杂环基，R 3表示氢原子，可以具有取代基的低级烷基，可以具有取代基的芳基或酰基。

82. 发明授权

US07957890B2 Valve control device and method for internal combustion engine 有权
标题翻译：内燃机用阀控制装置及方法
公开(公告)号：US07957890B2
公开(公告)日：2011-06-07
申请号：US11989317
申请日：2006-07-21
申请人： Hiroshi Enomoto
发明人： Hiroshi Enomoto
IPC分类号： G06F19/00
CPC分类号： F02D41/0055 , F02D41/042 , F02D2011/108 , F02D2250/16 , F02M26/48 , F02M26/49 , F02M26/50 , F02M26/54 , F02M26/70 , F02M26/73 , Y02T10/47
摘要： A valve control device performs control for eliminating or preventing fixation of an EGR valve (30) by opening/closing the valve near its fully closed position. After an engine stops, the valve control device performs “a fixation avoiding operation” for opening/closing EGR valve (30) near the fully closed position, and further, performs “a fixation determining operation”. When it is determined that the fixation of EGR valve (30) is eliminated, EGR valve (30) is positioned at the fully closed position, and a reference position is corrected such that the fully closed position is regarded as a reference position at which a valve opening/closing control is performed during the operation of the engine.
摘要翻译：阀控制装置通过在其完全关闭位置附近打开/关闭阀来执行用于消除或防止EGR阀（30）的固定的控制。发动机停止后，阀控制装置在完全关闭位置附近进行用于打开/关闭EGR阀（30）的“固定避免操作”，并且进行“固定确定操作”。当确定EGR阀（30）的固定被消除时，EGR阀（30）位于完全关闭位置，并且校正基准位置使得完全关闭位置被认为是基准位置在发动机运转期间进行阀门开/关控制。

83. 发明授权

US07923461B2 TNF-α production inhibitors 失效
标题翻译： TNF-α产生抑制剂
公开(公告)号：US07923461B2
公开(公告)日：2011-04-12
申请号：US12586515
申请日：2009-09-23
申请人： Masakazu Ban , Hiroshi Suhara , Masato Horiuchi , Noriyoshi Yamamoto , Hiroshi Enomoto , Hiroyuki Inoue
发明人： Masakazu Ban , Hiroshi Suhara , Masato Horiuchi , Noriyoshi Yamamoto , Hiroshi Enomoto , Hiroyuki Inoue
IPC分类号： C07D213/46 , A61K31/4409
CPC分类号： C07D213/56 , C07D213/30 , C07D213/32 , C07D213/38 , C07D213/40 , C07D213/68 , C07D213/75 , C07D401/06
摘要： A compound having the following formula wherein A is —O—; B is alkylene or alkenylene optionally containing —O—, —S—, —(NR7)—, —CO— or —N═; R1 and R2 are alkyl, alkenyl, alkynyl, cycloalkyl or cycloalkenyl, wherein the alkyl, alkenyl, alkynyl, cycloalkyl or cycloalkenyl is unsubstituted or substituted by halogen, cycloalkyl, aryl, adamantyl or amino; R3 is a substituted or unsubstituted pyridine ring; R5 and R6 are hydrogen or alkyl; R7 is hydrogen or alkyl; X is O or S; and each hydrogen of the said amino is unsubstituted or substituted by alkyl, alkoxycarbonyl, cycloalkyloxycarbonyl, arylalkoxycarbonyl or halogenoalkyloxycarbonyl. The compound is a TNF-α production inhibitor that is useful for treating autoimmune diseases such as rheumatoid arthritis.
摘要翻译：具有下式的化合物其中A是-O-; B是任选含有-O - ， - S - ， - （NR 7） - ， - CO-或-N =的亚烷基或亚烯基; R1和R2是烷基，烯基，炔基，环烷基或环烯基，其中烷基，烯基，炔基，环烷基或环烯基是未取代的或被卤素，环烷基，芳基，金刚烷基或氨基取代; R3是取代或未取代的吡啶环; R5和R6是氢或烷基; R7是氢或烷基; X是O或S; 并且所述氨基的每个氢未被取代或被烷基，烷氧基羰基，环烷氧基羰基，芳基烷氧基羰基或卤代烷氧基羰基取代。该化合物是可用于治疗自身免疫疾病如类风湿性关节炎的TNF-α产生抑制剂。

84. 发明授权

US07832373B2 Valve control apparatus of internal combustion engine 有权
标题翻译：内燃机气门控制装置
公开(公告)号：US07832373B2
公开(公告)日：2010-11-16
申请号：US12065552
申请日：2006-08-30
申请人： Hiroshi Enomoto
发明人： Hiroshi Enomoto
IPC分类号： F02D1/00 , F02D9/08
CPC分类号： F02D41/042 , F02D41/0055 , F02D2011/108 , F02M26/11 , F02M26/48 , F02M26/50 , F02M26/54 , F02M26/70 , F02M26/73 , Y02T10/47
摘要： A valve control apparatus of a diesel engine (1) is provided with an EGR valve (30), which is provided in an EGR passage (26) of the engine (1) and varies the flow rate of exhaust gas flowing through a passage (26) by carrying out an opening and closing motion, and an actuator (28), which executes a sticking avoiding operation for dissolving or preventing a sticking of a valve (30) by causing the valve (30) to move to and fro so as to open and close the valve (30) by a predetermined moving amount respectively in one direction and the other direction near a full-close position of the valve (30). The apparatus inhibits the sticking avoiding operation by the actuator (28) when an ignition OFF operation is carried out without starting an operation of the engine (1) after an ignition ON operation is carried out. As a result, it is possible to prevent a useless valve opening and closing motion and achieve power saving.
摘要翻译：柴油发动机（1）的阀控制装置设置有EGR阀（30），其设置在发动机（1）的EGR通路（26）中，并且改变流过通道的排气的流量（ 26），以及致动器（28），其执行用于通过使阀（30）来回移动来溶解或防止阀（30）的粘附的粘附避免操作，以便分别在阀（30）的完全关闭位置附近的一个方向和另一个方向上打开和关闭阀（30）预定的移动量。在执行点火ON操作之后，当进行点火OFF操作而不启动发动机（1）的操作时，该装置禁止致动器（28）的防止操作。结果，可以防止无用的阀开闭动作，实现省电。

85. 发明申请

US20100016380A1 TNF-alpha production inhibitors 失效
标题翻译： TNF-α产生抑制剂
公开(公告)号：US20100016380A1
公开(公告)日：2010-01-21
申请号：US12586515
申请日：2009-09-23
申请人： Masakazu Ban , Hiroshi Suhara , Masato Horiuchi , Noriyoshi Yamamoto , Hiroshi Enomoto , Hiroyuki Inoue
发明人： Masakazu Ban , Hiroshi Suhara , Masato Horiuchi , Noriyoshi Yamamoto , Hiroshi Enomoto , Hiroyuki Inoue
IPC分类号： A61K31/4409 , C07D213/46
CPC分类号： C07D213/56 , C07D213/30 , C07D213/32 , C07D213/38 , C07D213/40 , C07D213/68 , C07D213/75 , C07D401/06
摘要： A compound having the following formula wherein A is —O—; B is alkylene or alkenylene optionally containing —O—, —S—, —(NR7)—, —CO— or —N═; R1 and R2 are alkyl, alkenyl, alkynyl, cycloalkyl or cycloalkenyl, wherein the alkyl, alkenyl, alkynyl, cycloalkyl or cycloalkenyl is unsubstituted or substituted by halogen, cycloalkyl, aryl, adamantyl or amino; R3 is a substituted or unsubstituted pyridine ring; R5 and R6 are hydrogen or alkyl; R7 is hydrogen or alkyl; X is O or S; and each hydrogen of the said amino is unsubstituted or substituted by alkyl, alkoxycarbonyl, cycloalkyloxycarbonyl, arylalkoxycarbonyl or halogenoalkyloxycarbonyl. The compound is a TNF-α production inhibitor that is useful for treating autoimmune diseases such as rheumatoid arthritis.
摘要翻译：具有下式的化合物其中A是-O-; B是任选含有-O - ， - S-， - （NR 7） - ， - CO-或-N-的亚烯基或亚烯基; R1和R2是烷基，烯基，炔基，环烷基或环烯基，其中烷基，烯基，炔基，环烷基或环烯基是未取代的或被卤素，环烷基，芳基，金刚烷基或氨基取代; R3是取代或未取代的吡啶环; R5和R6是氢或烷基; R7为氢或烷基; X是O或S; 并且所述氨基的每个氢未被取代或被烷基，烷氧基羰基，环烷氧基羰基，芳基烷氧基羰基或卤代烷氧基羰基取代。该化合物是可用于治疗自身免疫疾病如类风湿性关节炎的TNF-α产生抑制剂。

86. 发明授权

US07345064B2 TNF-α production inhibitors 失效
标题翻译： TNF-α产生抑制剂
公开(公告)号：US07345064B2
公开(公告)日：2008-03-18
申请号：US11472603
申请日：2006-06-22
申请人： Masakazu Ban , Hiroshi Suhara , Masato Horiuchi , Noriyoshi Yamamoto , Hiroshi Enomoto , Hiroyuki Inoue
发明人： Masakazu Ban , Hiroshi Suhara , Masato Horiuchi , Noriyoshi Yamamoto , Hiroshi Enomoto , Hiroyuki Inoue
IPC分类号： C07D211/80 , A61K31/44
CPC分类号： C07D213/56 , C07D213/30 , C07D213/32 , C07D213/38 , C07D213/40 , C07D213/68 , C07D213/75 , C07D401/06
摘要： A purpose of the present invention is to provide TNF-α production inhibitors being useful as therapeutic agents for autoimmune diseases such as rheumatoid arthritis. Novel compounds having the structure represented by the general formula [1] or salts thereof according to the present invention have excellent TNF-α production inhibitory activities, wherein A is —(NR4)—, —(CR5R6)— or —O—, B is alkylene or alkenylene, R1, R2, R4, R5 and R6 are hydrogen, alkyl, alkenyl, adamantyl or the like, R3 is aryl or an unsaturated heterocycle, and X is oxygen or sulfer respectively.
摘要翻译：本发明的目的是提供TNF-α产生抑制剂，其可用作自身免疫疾病如类风湿性关节炎的治疗剂。具有本发明通式[1]所示结构或其盐的新化合物具有优异的TNF-α产生抑制活性，其中A是 - （NR 4） - ， - （CR 或-O - ，B是亚烷基或亚烯基，R 1，R 2，R 2， R 4，R 5和R 6是氢，烷基，链烯基，金刚烷基等，R 3，是芳基或不饱和杂环，X分别是氧或硫。

87. 发明申请

US20060241155A1 TNF-alpha production inhibitors 失效
标题翻译： TNF-α产生抑制剂
公开(公告)号：US20060241155A1
公开(公告)日：2006-10-26
申请号：US11472603
申请日：2006-06-22
申请人： Masakazu Ban , Hiroshi Suhara , Masato Horiuchi , Noriyoshi Yamamoto , Hiroshi Enomoto , Hiroyuki Inoue
发明人： Masakazu Ban , Hiroshi Suhara , Masato Horiuchi , Noriyoshi Yamamoto , Hiroshi Enomoto , Hiroyuki Inoue
IPC分类号： A61K31/44 , C07D211/80
CPC分类号： C07D213/56 , C07D213/30 , C07D213/32 , C07D213/38 , C07D213/40 , C07D213/68 , C07D213/75 , C07D401/06
摘要： A purpose of the present invention is to provide TNF-α production inhibitors being useful as therapeutic agents for autoimmune diseases such as rheumatoid arthritis. Novel compounds having the structure represented by the general formula [1] or salts thereof according to the present invention have excellent TNF-α production inhibitory activities, wherein A is —(NR4)—, —(CR5R6)— or —O—, B is alkylene or alkenylene, R1, R2, R4, R5 and R6 are hydrogen, alkyl, alkenyl, adamantyl or the like, R3 is aryl or an unsaturated heterocycle, and X is oxygen or sulfer respectively.
摘要翻译：本发明的目的是提供TNF-α产生抑制剂，其可用作自身免疫疾病如类风湿性关节炎的治疗剂。具有本发明通式[1]所示结构或其盐的新化合物具有优异的TNF-α产生抑制活性，其中A是 - （NR 4） - ， - （CR 或-O - ，B是亚烷基或亚烯基，R 1，R 2，R 2， R 4，R 5和R 6是氢，烷基，链烯基，金刚烷基等，R 3，是芳基或不饱和杂环，X分别是氧或硫。

88. 发明申请

US20060229342A1 TNF-a production inhibitors 有权
标题翻译： TNF-α产生抑制剂
公开(公告)号：US20060229342A1
公开(公告)日：2006-10-12
申请号：US11448634
申请日：2006-06-07
申请人： Masakazu Ban , Hiroshi Suhara , Masato Horiuchi , Noriyoshi Yamamoto , Hiroshi Enomoto , Hiroyuki Inoue
发明人： Masakazu Ban , Hiroshi Suhara , Masato Horiuchi , Noriyoshi Yamamoto , Hiroshi Enomoto , Hiroyuki Inoue
IPC分类号： C07D213/06 , A61K31/44
CPC分类号： C07D213/56 , C07D213/30 , C07D213/32 , C07D213/38 , C07D213/40 , C07D213/68 , C07D213/75 , C07D401/06
摘要： A purpose of the present invention is to provide TNF-α production inhibitors being useful as therapeutic agents for autoimmune diseases such as rheumatoid arthritis. Novel compounds having the structure represented by the general formula [1] or salts thereof according to the present invention have excellent TNF-α production inhibitory activities, wherein “A” is —(NR4)—, —(CR5R6)— or —O—, “B” is alkylene or alkenylene, R1, R2, R4, R5 and R6 are hydrogen, alkyl, alkenyl, adamantyl or the like, R3 is aryl or an unsaturated heterocycle, and “X” is oxygen or sulfer respectively.
摘要翻译：本发明的目的是提供TNF-α产生抑制剂，其可用作自身免疫疾病如类风湿性关节炎的治疗剂。具有本发明的通式[1]所示结构或其盐的新化合物具有优异的TNF-α产生抑制活性，其中“A”为 - （NR 4 - ） - ， - （CR 5）6 - 或-O-，“B”是亚烷基或亚烯基，R 1，R 2， R 4，R 5，R 6和R 6是氢，烷基，烯基，金刚烷基等，R 3 芳基或不饱和杂环，“X”分别是氧或硫。

89. 发明申请

US20060012937A1 Piezoelectric actuator driver 审中-公开
标题翻译：压电执行器驱动
公开(公告)号：US20060012937A1
公开(公告)日：2006-01-19
申请号：US10536825
申请日：2003-12-11
申请人： Kazuhisa Watanabe , Satoshi Enomoto , Hiroshi Enomoto , Shigeru Kanai , Toshiaki Takane
发明人： Kazuhisa Watanabe , Satoshi Enomoto , Hiroshi Enomoto , Shigeru Kanai , Toshiaki Takane
IPC分类号： H01H47/00
CPC分类号： H02N2/067 , H01L41/094
摘要： To provide a driver for driving piezoelectric actuators with drastically reduced drive currents during on/off switch control, thereby reducing the power consumption of an overall device. Each of the plural piezoelectric actuators 1a to 1h is composed of a plate and piezoelectric sheets attached to the opposed surfaces of the plate. A positive feeder line 19 or a negative feeder line 21 is connected to the opposite side of each piezoelectric sheet to the side attached to the plate. The controller 27 on-controls the piezoelectric sheets of each of the piezoelectric actuators 1a to 1h by selectively applying a positive or negative drive voltage thereto. Thereafter, the controller 27 turns off the drive voltage applied to the piezoelectric sheets subjected to on-control and simultaneously with this, turns on a drive voltage to the piezoelectric sheets of any other one the piezoelectric electric actuators 1a to 1h to be driven next.
摘要翻译：为了提供用于驱动压电致动器的驱动器，其在开/关开关控制期间具有显着降低的驱动电流，从而降低了整个装置的功耗。多个压电致动器1a至1h中的每一个由板和连接到板的相对表面的压电片组成。正的馈线19或负馈线21连接到每个压电片的与安装在该板上的一侧相反的一侧。控制器27通过选择性地施加正或负的驱动电压来控制每个压电致动器1a至1h的压电片。此后，控制器27关闭施加在受控制的压电片材上的驱动电压，同时，驱动电压驱动压电电致动器1a至1h的压电片材驱动下一个。

90. 发明授权

US06334335B1 Method of manufacturing a glass optical element 失效
标题翻译：制造玻璃光学元件的方法
公开(公告)号：US06334335B1
公开(公告)日：2002-01-01
申请号：US08841689
申请日：1997-04-30
申请人： Shin-Ichiro Hirota , Jun Ichnose , Hiroshi Enomoto
发明人： Shin-Ichiro Hirota , Jun Ichnose , Hiroshi Enomoto
IPC分类号： C03B1112
CPC分类号： C03B11/122 , B29C43/021 , B29C43/3642 , B29C2043/3618 , C03B11/08 , C03B11/12 , C03B11/125 , C03B29/02 , C03B35/005 , C03B40/04 , C03B2215/72 , Y02P40/57
摘要： A method for forming a glass optical element by press forming a thermally softened glass material with a preheated forming mold composed of an upper and a lower die. The glass material, the upper die and the lower die are heated within respectively prescribed temperature ranges, the preheating temperature of the upper die being below the preheating temperature of the lower die. The thermally softened glass material is pressed in the preheated forming mold, and the forming surfaces of the upper and the lower dies are cooled simultaneously with the start of the initial pressing, during the process of the initial pressing, or after the completion of the initial pressing.
摘要翻译：一种通过用上模和下模组成的预热成形模来压制成形为软化玻璃材料的玻璃光学元件的形成方法。玻璃材料，上模和下模在分别规定的温度范围内被加热，上模的预热温度低于下模的预热温度。将热软化的玻璃材料压在预热的成型模具中，并且在初始压制的过程中，或者在初始压制完成之后，上模和下模的成形表面同时被冷却，紧迫。

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