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1. 发明授权

US07923461B2 TNF-α production inhibitors 失效
标题翻译： TNF-α产生抑制剂
公开(公告)号：US07923461B2
公开(公告)日：2011-04-12
申请号：US12586515
申请日：2009-09-23
申请人： Masakazu Ban , Hiroshi Suhara , Masato Horiuchi , Noriyoshi Yamamoto , Hiroshi Enomoto , Hiroyuki Inoue
发明人： Masakazu Ban , Hiroshi Suhara , Masato Horiuchi , Noriyoshi Yamamoto , Hiroshi Enomoto , Hiroyuki Inoue
IPC分类号： C07D213/46 , A61K31/4409
CPC分类号： C07D213/56 , C07D213/30 , C07D213/32 , C07D213/38 , C07D213/40 , C07D213/68 , C07D213/75 , C07D401/06
摘要： A compound having the following formula wherein A is —O—; B is alkylene or alkenylene optionally containing —O—, —S—, —(NR7)—, —CO— or —N═; R1 and R2 are alkyl, alkenyl, alkynyl, cycloalkyl or cycloalkenyl, wherein the alkyl, alkenyl, alkynyl, cycloalkyl or cycloalkenyl is unsubstituted or substituted by halogen, cycloalkyl, aryl, adamantyl or amino; R3 is a substituted or unsubstituted pyridine ring; R5 and R6 are hydrogen or alkyl; R7 is hydrogen or alkyl; X is O or S; and each hydrogen of the said amino is unsubstituted or substituted by alkyl, alkoxycarbonyl, cycloalkyloxycarbonyl, arylalkoxycarbonyl or halogenoalkyloxycarbonyl. The compound is a TNF-α production inhibitor that is useful for treating autoimmune diseases such as rheumatoid arthritis.
摘要翻译：具有下式的化合物其中A是-O-; B是任选含有-O - ， - S - ， - （NR 7） - ， - CO-或-N =的亚烷基或亚烯基; R1和R2是烷基，烯基，炔基，环烷基或环烯基，其中烷基，烯基，炔基，环烷基或环烯基是未取代的或被卤素，环烷基，芳基，金刚烷基或氨基取代; R3是取代或未取代的吡啶环; R5和R6是氢或烷基; R7是氢或烷基; X是O或S; 并且所述氨基的每个氢未被取代或被烷基，烷氧基羰基，环烷氧基羰基，芳基烷氧基羰基或卤代烷氧基羰基取代。该化合物是可用于治疗自身免疫疾病如类风湿性关节炎的TNF-α产生抑制剂。

2. 发明申请

US20100016380A1 TNF-alpha production inhibitors 失效
标题翻译： TNF-α产生抑制剂
公开(公告)号：US20100016380A1
公开(公告)日：2010-01-21
申请号：US12586515
申请日：2009-09-23
申请人： Masakazu Ban , Hiroshi Suhara , Masato Horiuchi , Noriyoshi Yamamoto , Hiroshi Enomoto , Hiroyuki Inoue
发明人： Masakazu Ban , Hiroshi Suhara , Masato Horiuchi , Noriyoshi Yamamoto , Hiroshi Enomoto , Hiroyuki Inoue
IPC分类号： A61K31/4409 , C07D213/46
CPC分类号： C07D213/56 , C07D213/30 , C07D213/32 , C07D213/38 , C07D213/40 , C07D213/68 , C07D213/75 , C07D401/06
摘要： A compound having the following formula wherein A is —O—; B is alkylene or alkenylene optionally containing —O—, —S—, —(NR7)—, —CO— or —N═; R1 and R2 are alkyl, alkenyl, alkynyl, cycloalkyl or cycloalkenyl, wherein the alkyl, alkenyl, alkynyl, cycloalkyl or cycloalkenyl is unsubstituted or substituted by halogen, cycloalkyl, aryl, adamantyl or amino; R3 is a substituted or unsubstituted pyridine ring; R5 and R6 are hydrogen or alkyl; R7 is hydrogen or alkyl; X is O or S; and each hydrogen of the said amino is unsubstituted or substituted by alkyl, alkoxycarbonyl, cycloalkyloxycarbonyl, arylalkoxycarbonyl or halogenoalkyloxycarbonyl. The compound is a TNF-α production inhibitor that is useful for treating autoimmune diseases such as rheumatoid arthritis.
摘要翻译：具有下式的化合物其中A是-O-; B是任选含有-O - ， - S-， - （NR 7） - ， - CO-或-N-的亚烯基或亚烯基; R1和R2是烷基，烯基，炔基，环烷基或环烯基，其中烷基，烯基，炔基，环烷基或环烯基是未取代的或被卤素，环烷基，芳基，金刚烷基或氨基取代; R3是取代或未取代的吡啶环; R5和R6是氢或烷基; R7为氢或烷基; X是O或S; 并且所述氨基的每个氢未被取代或被烷基，烷氧基羰基，环烷氧基羰基，芳基烷氧基羰基或卤代烷氧基羰基取代。该化合物是可用于治疗自身免疫疾病如类风湿性关节炎的TNF-α产生抑制剂。

3. 发明授权

US07345064B2 TNF-α production inhibitors 失效
标题翻译： TNF-α产生抑制剂
公开(公告)号：US07345064B2
公开(公告)日：2008-03-18
申请号：US11472603
申请日：2006-06-22
申请人： Masakazu Ban , Hiroshi Suhara , Masato Horiuchi , Noriyoshi Yamamoto , Hiroshi Enomoto , Hiroyuki Inoue
发明人： Masakazu Ban , Hiroshi Suhara , Masato Horiuchi , Noriyoshi Yamamoto , Hiroshi Enomoto , Hiroyuki Inoue
IPC分类号： C07D211/80 , A61K31/44
CPC分类号： C07D213/56 , C07D213/30 , C07D213/32 , C07D213/38 , C07D213/40 , C07D213/68 , C07D213/75 , C07D401/06
摘要： A purpose of the present invention is to provide TNF-α production inhibitors being useful as therapeutic agents for autoimmune diseases such as rheumatoid arthritis. Novel compounds having the structure represented by the general formula [1] or salts thereof according to the present invention have excellent TNF-α production inhibitory activities, wherein A is —(NR4)—, —(CR5R6)— or —O—, B is alkylene or alkenylene, R1, R2, R4, R5 and R6 are hydrogen, alkyl, alkenyl, adamantyl or the like, R3 is aryl or an unsaturated heterocycle, and X is oxygen or sulfer respectively.
摘要翻译：本发明的目的是提供TNF-α产生抑制剂，其可用作自身免疫疾病如类风湿性关节炎的治疗剂。具有本发明通式[1]所示结构或其盐的新化合物具有优异的TNF-α产生抑制活性，其中A是 - （NR 4） - ， - （CR 或-O - ，B是亚烷基或亚烯基，R 1，R 2，R 2， R 4，R 5和R 6是氢，烷基，链烯基，金刚烷基等，R 3，是芳基或不饱和杂环，X分别是氧或硫。

4. 发明申请

US20060241155A1 TNF-alpha production inhibitors 失效
标题翻译： TNF-α产生抑制剂
公开(公告)号：US20060241155A1
公开(公告)日：2006-10-26
申请号：US11472603
申请日：2006-06-22
申请人： Masakazu Ban , Hiroshi Suhara , Masato Horiuchi , Noriyoshi Yamamoto , Hiroshi Enomoto , Hiroyuki Inoue
发明人： Masakazu Ban , Hiroshi Suhara , Masato Horiuchi , Noriyoshi Yamamoto , Hiroshi Enomoto , Hiroyuki Inoue
IPC分类号： A61K31/44 , C07D211/80
CPC分类号： C07D213/56 , C07D213/30 , C07D213/32 , C07D213/38 , C07D213/40 , C07D213/68 , C07D213/75 , C07D401/06
摘要： A purpose of the present invention is to provide TNF-α production inhibitors being useful as therapeutic agents for autoimmune diseases such as rheumatoid arthritis. Novel compounds having the structure represented by the general formula [1] or salts thereof according to the present invention have excellent TNF-α production inhibitory activities, wherein A is —(NR4)—, —(CR5R6)— or —O—, B is alkylene or alkenylene, R1, R2, R4, R5 and R6 are hydrogen, alkyl, alkenyl, adamantyl or the like, R3 is aryl or an unsaturated heterocycle, and X is oxygen or sulfer respectively.
摘要翻译：本发明的目的是提供TNF-α产生抑制剂，其可用作自身免疫疾病如类风湿性关节炎的治疗剂。具有本发明通式[1]所示结构或其盐的新化合物具有优异的TNF-α产生抑制活性，其中A是 - （NR 4） - ， - （CR 或-O - ，B是亚烷基或亚烯基，R 1，R 2，R 2， R 4，R 5和R 6是氢，烷基，链烯基，金刚烷基等，R 3，是芳基或不饱和杂环，X分别是氧或硫。

5. 发明申请

US20060229342A1 TNF-a production inhibitors 有权
标题翻译： TNF-α产生抑制剂
公开(公告)号：US20060229342A1
公开(公告)日：2006-10-12
申请号：US11448634
申请日：2006-06-07
申请人： Masakazu Ban , Hiroshi Suhara , Masato Horiuchi , Noriyoshi Yamamoto , Hiroshi Enomoto , Hiroyuki Inoue
发明人： Masakazu Ban , Hiroshi Suhara , Masato Horiuchi , Noriyoshi Yamamoto , Hiroshi Enomoto , Hiroyuki Inoue
IPC分类号： C07D213/06 , A61K31/44
CPC分类号： C07D213/56 , C07D213/30 , C07D213/32 , C07D213/38 , C07D213/40 , C07D213/68 , C07D213/75 , C07D401/06
摘要： A purpose of the present invention is to provide TNF-α production inhibitors being useful as therapeutic agents for autoimmune diseases such as rheumatoid arthritis. Novel compounds having the structure represented by the general formula [1] or salts thereof according to the present invention have excellent TNF-α production inhibitory activities, wherein “A” is —(NR4)—, —(CR5R6)— or —O—, “B” is alkylene or alkenylene, R1, R2, R4, R5 and R6 are hydrogen, alkyl, alkenyl, adamantyl or the like, R3 is aryl or an unsaturated heterocycle, and “X” is oxygen or sulfer respectively.
摘要翻译：本发明的目的是提供TNF-α产生抑制剂，其可用作自身免疫疾病如类风湿性关节炎的治疗剂。具有本发明的通式[1]所示结构或其盐的新化合物具有优异的TNF-α产生抑制活性，其中“A”为 - （NR 4 - ） - ， - （CR 5）6 - 或-O-，“B”是亚烷基或亚烯基，R 1，R 2， R 4，R 5，R 6和R 6是氢，烷基，烯基，金刚烷基等，R 3 芳基或不饱和杂环，“X”分别是氧或硫。

6. 发明申请

US20130310576A1 3-HYDROXY-6H-BENZO [C] CHROMENE-6-ONE DERIVATIVE AND MANUFACTURING METHOD THEREOF 有权
标题翻译： 3-羟基-6H-苯并[C]吡喃-6-酮衍生物及其制备方法
公开(公告)号：US20130310576A1
公开(公告)日：2013-11-21
申请号：US13982534
申请日：2012-02-08
申请人： Kazuhiro Kudou , Noriyoshi Yamamoto , Masakazu Ban , Atsushi Ohno
发明人： Kazuhiro Kudou , Noriyoshi Yamamoto , Masakazu Ban , Atsushi Ohno
IPC分类号： C07D311/80
CPC分类号： C07D311/80 , C07C231/12 , C07C233/54
摘要： A method of manufacturing a compound or a salt thereof expressed with a formula (III) below, characterized by causing a compound or a salt thereof expressed with a formula (I) below and a compound or a salt thereof expressed with a formula (II) below to react in the presence of carbonate and copper salt or in the presence of hydroxide salt, carbonate, and copper salt.
摘要翻译：一种以下式（III）表示的化合物或其盐的制造方法，其特征在于使由下式（Ⅰ）表示的化合物或其盐及式（Ⅱ）表示的化合物或其盐，在碳酸盐和铜盐的存在下或在氢氧化物盐，碳酸盐和铜盐的存在下反应。

7. 发明授权

US5706937A Flexible dual-chambered container 失效
标题翻译：灵活的双腔容器
公开(公告)号：US5706937A
公开(公告)日：1998-01-13
申请号：US617162
申请日：1996-03-18
申请人： Hitoshi Futagawa , Noriyoshi Yamamoto , Masanobu Iwasa
发明人： Hitoshi Futagawa , Noriyoshi Yamamoto , Masanobu Iwasa
IPC分类号： A61J1/00 , A61J1/05 , A61J1/10 , A61J1/20 , B32B15/20 , B65D30/22 , B65D81/26 , B65D81/32
CPC分类号： A61J1/2093 , B32B15/20 , B65D81/3266 , A61J1/10 , A61J1/2024
摘要： A flexible and dual-chambered container includes a first frontal sheet fusion bonded to a first rear sheet to define a first chamber for containing, for example, a medical liquid. The first frontal sheet is a flexible and transparent sheet for intercepting water, moisture, and oxygen gas. The first rear sheet is a flexible composite sheet composed of aluminum foil and a water-absorbing stratum. A second frontal sheet is fusion bonded to a second rear sheet to define a second chamber for containing, for example, a medical liquid. The second frontal and rear sheets are joined to the first frontal and rear sheets so that the first and second chambers are isolated by a breakable or weak seal. An opaque and flexible cover sheet composed of aluminum foil is removably disposed on the first frontal sheet. When the weak seal is broken by manually compressing the second chamber, the first and second chambers are brought into liquid communication. Any residual amount of water or vapor can be eliminated from the container during manufacturing so that the dry drug contained therein is protected from oxygen, water, and light beams.
摘要翻译：柔性和双室容器包括结合到第一后片的第一正面片材熔合物，以限定用于容纳例如医用液体的第一室。第一个正面片材是用于拦截水，湿气和氧气的柔性和透明的片材。第一后片是由铝箔和吸水层组成的柔性复合片。第二正面片材被熔合到第二后片材以限定用于容纳例如医用液体的第二腔室。第二正面片和后片连接到第一正面片和后片，使得第一和第二腔通过易碎或弱密封隔离。由铝箔构成的不透明和柔性的覆盖片可移除地设置在第一正面片上。当通过手动压缩第二室来破坏弱密封件时，第一和第二腔室进入液体连通状态。在制造过程中可以从容器中除去任何残留量的水或蒸气，使得其中所含的干燥药物免受氧气，水和光束的保护。

8. 发明授权

US5692960A Homokinetic joint having balls with axial play in cage pockets and interference fits between inner and outer rings 失效
标题翻译：具有在保持架凹穴中具有轴向游隙的球的均动接头和内圈与外圈之间的过盈配合
公开(公告)号：US5692960A
公开(公告)日：1997-12-02
申请号：US455555
申请日：1995-05-31
申请人： Tatsuro Sugiyama , Noriyoshi Yamamoto , Hisaaki Kura
发明人： Tatsuro Sugiyama , Noriyoshi Yamamoto , Hisaaki Kura
IPC分类号： F16D3/20 , F16D3/2245 , F16D3/223
CPC分类号： F16D3/2237 , F16D2003/22309 , Y10S464/906
摘要： The homokinetic joint has an inner ring and and an outer ring formed with axial track grooves so as to be opposite to each other, balls received in the track grooves, a cage mounted between the inner and outer rings and having pockets accommodating the respective balls, whereby torque is transmitted between the inner and outer rings through the balls so that the inner and outer rings will rotate at the same speed. The distance between said track grooves formed in the inner ring and those formed in the outer ring is determined so that the balls are fitted in the grooves between the ring and the inner ring with a predetermined interference, while leaving an axial clearance between the pockets of the cage and the balls. Thus, the balls can roll smoothly with little play in the direction of rotation.
摘要翻译：等动力接头具有内圈和外圈，其形成有彼此相对的轴向轨道槽，容纳在轨道槽中的滚珠，安装在内圈和外圈之间并具有容纳各个球的凹部的保持架，由此通过球在内圈和外圈之间传递扭矩，使得内圈和外圈将以相同的速度旋转。形成在内圈中的所述轨道槽和形成在外圈中的轨道槽之间的距离被确定为使得球以预定的干涉装配在环和内圈之间的槽中，同时在凹槽之间留下轴向间隙笼子和球。因此，滚珠能够在旋转方向上平滑地滚动。

9. 发明授权

US07098226B2 TNF-α production inhibitors 有权
标题翻译： TNF-α产生抑制剂
公开(公告)号：US07098226B2
公开(公告)日：2006-08-29
申请号：US10168777
申请日：2001-05-31
申请人： Masakazu Ban , Hiroshi Suhara , Masato Horiuchi , Noriyoshi Yamamoto , Hiroshi Enomoto , Hiroyuki Inoue
发明人： Masakazu Ban , Hiroshi Suhara , Masato Horiuchi , Noriyoshi Yamamoto , Hiroshi Enomoto , Hiroyuki Inoue
IPC分类号： A61K31/44 , C07D213/06
CPC分类号： C07D213/56 , C07D213/30 , C07D213/32 , C07D213/38 , C07D213/40 , C07D213/68 , C07D213/75 , C07D401/06
摘要： A purpose of the present invention is to provide TNF-α production inhibitors being useful as therapeutic agents for autoimmune diseases such as rheumatoid arthritis. Novel compounds having the structure represented by the general formula [1] or salts thereof according to the present invention have excellent TNF-α production inhibitory activities, wherein “A” is —(NR4)—, —(CR5R6)— or —O—, “B” is alkylene or alkenylene, R1, R2, R4, R5 and R6 are hydrogen, alkyl, alkenyl, adamantyl or the like, R3 is aryl or an unsaturated heterocycle, and “X” is oxygen or sulfer respectively.
摘要翻译：本发明的目的是提供TNF-α产生抑制剂，其可用作自身免疫疾病如类风湿性关节炎的治疗剂。具有本发明的通式[1]所示结构或其盐的新化合物具有优异的TNF-α产生抑制活性，其中“A”为 - （NR 4 - ） - ， - （CR 5）6 - 或-O-，“B”是亚烷基或亚烯基，R 1，R 2， R 4，R 5，R 6和R 6是氢，烷基，烯基，金刚烷基等，R 3 芳基或不饱和杂环，“X”分别是氧或硫。

10. 发明授权

US08802869B2 3-hydroxy-6H-benzo [c] chromene-6-one derivative and manufacturing method thereof 有权
标题翻译： 3-羟基-6H-苯并[c]色烯-6-酮衍生物及其制备方法
公开(公告)号：US08802869B2
公开(公告)日：2014-08-12
申请号：US13982534
申请日：2012-02-08
申请人： Kazuhiro Kudou , Noriyoshi Yamamoto , Masakazu Ban , Atsushi Ohno
发明人： Kazuhiro Kudou , Noriyoshi Yamamoto , Masakazu Ban , Atsushi Ohno
IPC分类号： C07D311/78
CPC分类号： C07D311/80 , C07C231/12 , C07C233/54
摘要： A method of manufacturing a compound or a salt thereof expressed with a formula (III) below, characterized by causing a compound or a salt thereof expressed with a formula (I) below and a compound or a salt thereof expressed with a formula (II) below to react in the presence of carbonate and copper salt or in the presence of hydroxide salt, carbonate, and copper salt.
摘要翻译：一种以下式（III）表示的化合物或其盐的制造方法，其特征在于使由下式（Ⅰ）表示的化合物或其盐及式（Ⅱ）表示的化合物或其盐，在碳酸盐和铜盐的存在下或在氢氧化物盐，碳酸盐和铜盐的存在下反应。

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