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81. 发明专利

JP2020089368A トランスジェニック生物における多不飽和脂肪酸の製造方法审中-公开
公开(公告)号：JP2020089368A
公开(公告)日：2020-06-11
申请号：JP2020000076
申请日：2020-01-06
申请人： BASF PLANT SCIENCE GMBH
发明人： ZANK THORSTEN , BAUER JOERG , CIRPUS PETRA , ABBADI AMINE , HEINZ ERNST , QIU XIAO , VRINTEN PATRICIA , SPERLING PETRA , DOMERGUE FREDERIC , MEYER ASTRID , KIRSCH JELENA
IPC分类号： C12N15/53 , A01H5/00 , A01K67/027 , A23D9/00 , A23K20/158 , A23L33/105 , A23L33/115 , A61K8/36 , A61K8/97 , A61K31/201 , A61K31/202 , A61K36/00 , A61P3/06 , A61P9/00 , A61P9/04 , A61P9/12 , A61P19/02 , A61P29/00 , A61P37/02 , A61Q1/00 , A61Q19/00 , C11B1/02 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12N9/10 , C12N15/63 , C12N15/82 , C12P7/64
摘要：【課題】生物における多不飽和脂肪酸の製造方法、及び、長鎖多不飽和脂肪酸の含量が上昇した油及び/又はトリアシルグリセリドの製造方法の提供。【解決手段】有利には、タラッシオシラ、ユーグレナ又はオストレオコッカスに由来する、Δ5—エロンガーゼ活性、さらにはΔ6—デサチュラーゼ、Δ5—デサチュラーゼ、Δ4—デサチュラーゼ、Δ12—デサチュラーゼ及び/又はΔ6—エロンガーゼ活性を有するポリペプチドをコードする核酸を生物に導入することによる、生物における多不飽和脂肪酸の製造方法。トランスジェニック生物は、好ましくは、トランスジェニック植物又はトランスジェニック微生物である。【選択図】なし

82. 发明专利

JP2014128269A Method for production of multiply-unsaturated fatty acids in transgenic organisms 有权
标题翻译：在转基因生物中生产多余不饱和脂肪酸的方法
公开(公告)号：JP2014128269A
公开(公告)日：2014-07-10
申请号：JP2013270709
申请日：2013-12-27
申请人： Basf Plant Science Gmbh , ビーエーエスエフプラントサイエンスゲーエムベーハー
发明人： ZANK THORSTEN , BAUER JOERG , CIRPUS PETRA , ABBADI AMINE , HEINZ ERNST , QIU XIAO , VRINTEN PATRICIA , SPERLING PETRA , DOMERGUE FREDERIC , MEYER ASTRID , KIRSCH JELENA
IPC分类号： C12N15/09 , A01H5/00 , A01K67/027 , A23D9/00 , A23K1/16 , A23L1/30 , A61K8/36 , A61K8/37 , A61K31/202 , A61K31/232 , A61P3/06 , C11B1/02 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12N9/10 , C12N15/82 , C12P7/64
CPC分类号： C12N15/8247 , A23D9/00 , A23D9/02 , A23L33/115 , A23V2002/00 , C11B1/00 , C12N9/0071 , C12N9/0083 , C12N9/0093 , C12N9/1029 , C12P7/6409 , C12P7/6427 , C12P7/6463 , C12P7/6472 , C12Y114/19 , C12Y114/19003 , C12Y203/01199 , Y02P20/52
摘要： PROBLEM TO BE SOLVED: To provide a method for producing multiply-unsaturated fatty acids in an organism into which nucleic acids have been introduced, the nucleic acids encoding polypeptides with Δ-5 elongase activity.SOLUTION: The method for the production of an oil and/or triacylglyceride which has increased content of long chain multiply-unsaturated fatty acids employs a vector with an isolated nucleic acid sequence encoding a polypeptide having Δ-6 desaturase, a Δ-5 desaturase, Δ-4 desaturase and/or Δ-6 elongase activity derived from Thalassiosira, Euglena, or Ostreococcus, and enzymes of an introduced transgenic organism: a microorganism, a nonhuman animal or a plant.
摘要翻译：要解决的问题：提供一种在已经引入了核酸的生物体中生产多不饱和脂肪酸的方法，编码具有＆Dgr-5延伸酶活性的多肽的核酸。解决方案：生产油的方法具有增加的长链多不饱和脂肪酸含量的甘油三酯和/或三酰基甘油酯使用具有分离的核酸序列的载体，所述分离的核酸序列编码具有＆Dgr; -6去饱和酶，＆Dgr; -5去饱和酶，Dgr-4去饱和酶和/ 衍生自Thalassiosira，Euglena或Ostreococcus的延长酶活性和引入的转基因生物的酶：微生物，非人动物或植物。

83. 发明专利

JP2011087578A Method for production of multiple-unsaturated fatty acid in transgenic organism 审中-公开
标题翻译：在转基因生物中生产多种不饱和脂肪酸的方法
公开(公告)号：JP2011087578A
公开(公告)日：2011-05-06
申请号：JP2010232883
申请日：2010-10-15
申请人： Basf Plant Science Gmbh , ビーエーエスエフプラントサイエンスゲーエムベーハー
发明人： ZANK THORSTEN , BAUER JOERG , CIRPUS PETRA , ABBADI AMINE , HEINZ ERNST , QIU XIAO , VRINTEN PATRICIA , SPERLING PETRA , DOMERGUE FREDERIC , MEYER ASTRID , KIRSCH JELENA
IPC分类号： C12N15/09 , A01H5/00 , A01K67/027 , A23D9/00 , A23L1/30 , A61K8/36 , A61K8/37 , A61K31/202 , A61K31/232 , A61P3/06 , C11B1/02 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/02 , C12N9/10 , C12N15/82 , C12P7/64
CPC分类号： C12N15/8247 , A23D9/00 , A23D9/02 , A23L33/115 , A23V2002/00 , C11B1/00 , C12N9/0071 , C12N9/0083 , C12N9/0093 , C12N9/1029 , C12P7/6409 , C12P7/6427 , C12P7/6463 , C12P7/6472 , C12Y114/19 , C12Y114/19003 , C12Y203/01199 , Y02P20/52
摘要： PROBLEM TO BE SOLVED: To provide a method for producing a multiple-unsaturated fatty acid in an organism, into which a nucleic acid coding for a polypeptide having Δ-5 elongase activity is introduced. SOLUTION: There are provided a nucleic acid sequence coding for Δ-6 desaturase, Δ-5 desaturase, Δ-4 desaturase and/or Δ-6 elongase activity and derived from Thalassiosira, Euglena or Ostreococcus, and a genetic construction containing the nucleic acid sequence. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供在生物体中制备多不饱和脂肪酸的方法，其中引入编码具有Δ-5延伸酶活性的多肽的核酸。解决方案：提供了编码Δ-6去饱和酶，Δ-5去饱和酶，Δ-4去饱和酶和/或Δ-6延伸酶活性的核酸序列，并且衍生自海水藻，欧洲淋巴细胞球菌或油球藻，以及含有核酸序列。版权所有（C）2011，JPO＆INPIT

84. 发明专利

JP2014064571A Ahas mutants 审中-公开
标题翻译： AHAS MUTANT
公开(公告)号：JP2014064571A
公开(公告)日：2014-04-17
申请号：JP2013220236
申请日：2013-10-23
申请人： Basf Plant Science Gmbh , ビーエーエスエフプラントサイエンスゲーエムベーハー
发明人： MCELVER JOHN A , BIJAY SINGH
IPC分类号： C12N15/09 , A01H1/00 , A01H1/02 , A01H5/00 , C12N9/88
CPC分类号： C12N15/8274 , A01H1/02 , A01N43/50 , C12N9/88 , C12N15/8278 , C12Q1/6895 , C12Q2600/13 , C12Q2600/156
摘要： PROBLEM TO BE SOLVED: To provide mutants of the acetohydroxyacid synthase (AHAS) large subunit comprising at least two mutations, which are useful for producing transgenic or non-transgenic plants with improved levels of tolerance to imidazolinone herbicides and sulfonylurea herbicides, which are AHAS-inhibiting herbicides.SOLUTION: Provided are expression vectors, cells and plants which include polynucleotides encoding AHAS large subunit double and triple mutants, plants including two or more AHAS large subunit single mutant polypeptides, and methods of making and using them.
摘要翻译：要解决的问题：提供包含至少两个突变的乙酰羟酸合酶（AHAS）大亚基的突变体，其可用于产生具有改善的对咪唑啉酮除草剂和磺酰脲除草剂的耐受性的转基因植物或非转基因植物，其为AHAS- 抑制除草剂。方法：提供包括编码AHAS大亚基双重和三重突变体的多核苷酸的表达载体，细胞和植物，包括两个或多个AHAS大亚单位单突变体多肽的植物，以及制备和使用它们的方法。

85. 发明专利

JP2007536918A Its use in a method for the achievement of the pathogen resistance in the novel nucleic acid sequences and the plant 审中-公开
公开(公告)号：JP2007536918A
公开(公告)日：2007-12-20
申请号：JP2007512034
申请日：2005-05-06
申请人：ビーエーエスエフプラントサイエンスゲゼルシャフトミットベシュレンクテルハフツングBASF Plant Science GmbH
发明人：フランクマルクス , シュミットラルフ−ミヒャエル
IPC分类号： C12N15/09 , A01H5/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N15/82
CPC分类号： C12N15/8279
摘要：植物、又はこの器官、組織、又は細胞における葉肉細胞浸透性病原体に対する耐性の向上のための方法であって、前記植物、又はこの器官、組織、又は細胞におけるカロース合成酵素活性が、この対照植物と比較して減少していることを特徴とする、耐性の向上のための方法。

86. 发明申请

WO2010069847A1 PLANTS HAVING ENHANCED YIELD-RELATED TRAITS AND/OR ABIOTIC STRESS TOLERANCE AND A METHOD FOR MAKING THE SAME 审中-公开
标题翻译：具有增强的相关行为和/或抗生素耐力的植物及其制造方法
公开(公告)号：WO2010069847A1
公开(公告)日：2010-06-24
申请号：PCT/EP2009/066777
申请日：2009-12-10
申请人： BASF PLANT SCIENCE GMBH , SANZ MOLINERO, Ana Isabel , FRANKARD, Valerie , HATZFELD, Yves , REUZEAU, Christophe
发明人： SANZ MOLINERO, Ana Isabel , FRANKARD, Valerie , HATZFELD, Yves , REUZEAU, Christophe
IPC分类号： C07K14/415 , C12N15/82
CPC分类号： C12N15/8261 , C07K14/415 , C12N15/8271 , C12N15/8273 , Y02A40/146
摘要： The present application is directed to modification of yield related traits by modulating the expression of a Cofactor Required for SP1 activation (CRSP), Myb related CAB promoter binding protein (MCB), Sirtuin 2 (SRT2) or SPX-RING. Furthermore, the application is directed to improved abiotic stress tolerance by modulating the expression of YRP2, YRP3 or YRP4.
摘要翻译：本申请涉及通过调节SP1活化所需的辅因子（CRSP），Myb相关的CAB启动子结合蛋白（MCB），Sirtuin 2（SRT2）或SPX-RING的表达来修饰产量相关性状。此外，该应用旨在通过调节YRP2，YRP3或YRP4的表达来改善非生物胁迫耐受性。

87. 发明申请

WO2009068564A8 PLANTS HAVING ENHANCED YIELD-RELATED TRAITS AND A METHOD FOR MAKING THE SAME 审中-公开
标题翻译：具有增强的相关旅行者的植物及其制造方法
公开(公告)号：WO2009068564A8
公开(公告)日：2010-06-24
申请号：PCT/EP2008066237
申请日：2008-11-26
申请人： BASF PLANT SCIENCE GMBH , SANZ MOLINERO ANA ISABEL , REUZEAU CHRISTOPHE , FRANKARD VALERIE , MULET SALORT JOSE MIGUEL , SALOM RAMON SERRANO
发明人： SANZ MOLINERO ANA ISABEL , REUZEAU CHRISTOPHE , FRANKARD VALERIE , MULET SALORT JOSE MIGUEL , SALOM RAMON SERRANO
IPC分类号： C07K14/415 , C12N15/82
CPC分类号： C12N15/8261 , C07K14/415 , Y02A40/146
摘要： The present invention concerns a method for enhancing yield-related traits in plants by modulating expression in a plant of a nucleic acid encoding a PATL (PATELLIN) polypeptide, or a PRP38 (Precursor RNA Processing factor 38) polypeptide, or an ADA2 (Adaptor 2) polypeptide. The present invention also concerns a method for increasing Thousand Kernel Weight, total weight of seeds and/or number of filled seeds, by modulating expression in a plant of a nucleic acid sequence encoding a GATA-like polypeptide. The invention also concerns a method for increasing various plant yield-related traits by, increasing expression in a plant of a nucleic acid sequence encoding a WD40 repeat (WDR) 23-like polypeptide. The invention also provides hitherto unknown PATL nucleic acids and constructs useful in the methods of the invention.
摘要翻译：本发明涉及通过调节植物中编码PATL（PATELLIN）多肽或PRP38（前体RNA加工因子38）多肽或ADA2（适配器2）的核酸的表达来增强植物中产量相关性状的方法）多肽。本发明还涉及通过调节植物中编码GATA样多肽的核酸序列表达来增加千粒重，种子总重量和/或填充种子数量的方法。本发明还涉及通过增加植物中编码WD40重复（WDR）23样多肽的核酸序列的表达来增加各种植物产量相关性状的方法。本发明还提供了迄今未知的PATL核酸和可用于本发明方法的构建体。

88. 发明申请

WO2010066703A2 DESATURASES AND PROCESS FOR THE PRODUCTION OF POLYUNSATURATED FATTY ACIDS IN TRANSGENIC ORGANISMS 审中-公开
标题翻译：在转基因生物体中生产多不饱和脂肪酸的脱盐和方法
公开(公告)号：WO2010066703A2
公开(公告)日：2010-06-17
申请号：PCT/EP2009/066569
申请日：2009-12-08
申请人： BASF PLANT SCIENCE GMBH , SENGER, Toralf , BAUER, Jörg , NAPIER, Johnathan A.
发明人： NAPIER, Johnathan A.
IPC分类号： C12N15/82 , C12N9/02 , C12N15/53 , C12P7/64 , A01H5/00
CPC分类号： C12P7/6409 , C12N9/0071 , C12N9/0083 , C12N15/8247 , C12P7/6427 , C12P7/6472 , C12P7/6481 , C12Y114/19001
摘要： The present invention relates to polynucleotides from Cochliobolus heterostrophus C5, Cyanothece sp. CCY0110, Mycocentrospora acerina and Hyaloperonospora parasitica, which code for desaturases and which can be employed for the recom bi nant production of polyunsaturated fatty acids. The invention furthermore relates to vectors, host cells and transgenic nonhuman organisms which comprise the polynucleotides according to the invention, and to the polypeptides encoded by the polynucleotides. The invention furthermore relates to antibodies against the polypeptides according to the invention. Finally, the invention also relates to production processes for the polyunsaturated fatty acids and for oil, lipid and fatty acid compositions and to their use as drugs, cosmetics, foodstuffs, feedstuffs, preferably fish food, or food supplements.
摘要翻译：本发明涉及来自旋毛虫异旋藻C5，Cyanothece sp。的多核苷酸。 CCY0110，Mycocentrospora acerina和寄生透明单胞菌，其编码去饱和酶并可用于多不饱和脂肪酸的重组生产。本发明还涉及包含根据本发明的多核苷酸的载体，宿主细胞和转基因非人生物体，并涉及由多核苷酸编码的多肽。本发明还涉及针对根据本发明的多肽的抗体。最后，本发明还涉及用于多不饱和脂肪酸和油，脂质和脂肪酸组合物的生产方法以及它们作为药物，化妆品，食品，饲料，优选鱼食或食品补充剂的用途。

89. 发明申请

WO2010046221A1 PLANTS WITH INCREASED YIELD (NUE) 审中-公开
标题翻译：植物增加（NUE）
公开(公告)号：WO2010046221A1
公开(公告)日：2010-04-29
申请号：PCT/EP2009/062798
申请日：2009-10-02
申请人： BASF PLANT SCIENCE GMBH , SCHÖN, Hardy , THIMM, Oliver , RITTE, Gerhard , BLÄSING, Oliver , BRUYNSEELS, Koen , HATZFELD, Yves , FRANKARD, Valerie , SANZ MOLINERO, Ana Isabel , REUZEAU, Christophe , VANDENABEELE, Steven
发明人： SCHÖN, Hardy , THIMM, Oliver , RITTE, Gerhard , BLÄSING, Oliver , BRUYNSEELS, Koen , HATZFELD, Yves , FRANKARD, Valerie , SANZ MOLINERO, Ana Isabel , REUZEAU, Christophe , VANDENABEELE, Steven
IPC分类号： C12N15/82 , A01H5/00
CPC分类号： C12N15/8273 , C12N15/8261 , Y02A40/146
摘要： A method for producing a plant with increased yield as compared to a corresponding wild type plant whereby the method comprises at least the following step: increasing or generating in a plant or a part thereof one or more activities selected from the group consisting of 17.6 kDa class I heat shock protein, 26.5 kDa class I small heat shock protein, 26S protease subunit, 2-Cys peroxiredoxin, 3-dehydroquinate synthase, 5-keto-D-gluconate-5-reductase, asparagine synthetase A, aspartate 1-decarboxylase precursor, ATP-dependent RNA helicase, B0567-protein, B1088-protein, B1289-protein, B2940-protein, calnexin homolog, CDS5399-protein, chromatin structure-remodeling complex protein, D-amino acid dehydrogenase, D-arabinono-1,4-lactone oxidase, Delta 1-pyrroline-5-carboxylate reductase, glycine cleavage complex lipoylprotein, ketodeoxygluconokinase, lipoyl synthase, low-molecular-weight heat-shock protein, Microsomal cytochrome b reductase, mitochondrial ribosomal protein, mitotic check point protein, monodehydroascorbate reductase, paraquat-inducible protein B, phosphatase, Phosphoglucosamine mutase, protein disaggregation chaperone, protein kinase, pyruvate decarboxylase, recA family protein, rhodanese-related sulfurtransferase, ribonuclease P protein component, ribosome modulation factor, sensory histidine kinase, serine hydroxymethyltransferase, SLL1280-protein, SLL1797-protein, small membrane lipoprotein, Small nucleolar ribonucleoprotein complex subunit, Sulfatase, transcription initiation factor subunit, tretraspanin, tRNA ligase, xyloglucan galactosyltransferase, YKL130C-protein, YLR443W-protein, YML096W-protein, and zinc finger family protein - activity.
摘要翻译：与相应的野生型植物相比，生产具有增加的产量的植物的方法，其中所述方法至少包括以下步骤：在植物或其部分中增加或产生一种或多种选自17.6kDa类的活性 I热休克蛋白，26.5 kDa I类小型热休克蛋白，26S蛋白酶亚基，2-Cys过氧化还原酶，3-脱氢秋水仙碱合酶，5-酮-D-葡萄糖酸-5-还原酶，天冬酰胺合成酶A，天冬氨酸1-脱羧酶前体， ATP依赖性RNA解旋酶，B0567蛋白，B1088蛋白，B1289蛋白，B2940蛋白，钙粘蛋白同源物，CDS5399蛋白，染色质结构重塑复合蛋白，D-氨基酸脱氢酶，D-阿拉伯聚糖-1,4- 内酯氧化酶，1-吡咯啉-5-羧酸还原酶，甘氨酸裂解复合物，脂酰基蛋白，酮脱氧葡萄糖激酶，脂酰基合成酶，低分子量热休克蛋白，微粒体细胞色素b还原酶，线粒体核糖体蛋白，有丝分裂检查点蛋白质，单脱氢抗坏血酸还原酶，百草枯诱导蛋白B，磷酸酶，磷酸葡糖胺变位酶，蛋白质解聚分子伴侣，蛋白激酶，丙酮酸脱羧酶，recA家族蛋白，罗丹斯相关硫转移酶，核糖核酸酶P蛋白成分，核糖体调节因子，感觉组氨酸激酶，丝氨酸羟甲基转移酶，SLL1280蛋白，SLL1797蛋白，小膜脂蛋白，小核仁核糖核蛋白复合子亚基，硫酸酯酶，转录起始因子亚基，tretraspanin，tRNA连接酶，木葡聚糖半乳糖基转移酶，YKL130C-蛋白，YLR443W蛋白，YML096W蛋白和锌指家族蛋白质 - 活性。

90. 发明申请

WO2010034672A1 PLANTS WITH INCREASED YIELD (LT) 审中-公开
标题翻译：植物增加（LT）
公开(公告)号：WO2010034672A1
公开(公告)日：2010-04-01
申请号：PCT/EP2009/062132
申请日：2009-09-18
申请人： BASF Plant Science GmbH , THIMM, Oliver , RITTE, Gerhard , SCHÖN, Hardy , BLÄSING, Oliver
发明人： THIMM, Oliver , RITTE, Gerhard , SCHÖN, Hardy , BLÄSING, Oliver
IPC分类号： C12N15/82 , C07K14/245 , A01H5/00
CPC分类号： C12N15/8261 , C07K14/245 , Y02A40/146
摘要： A method for producing a plant with increased yield as compared to a corresponding wild type plant comprising at least the following step: increasing or generating in a plant or a part thereof one or more activities selected from the group consisting of 3-phosphoglycerate dehydrogenase, Adenylate kinase, B2758-protein, Cyclic nucleotide phosphodiesterase, cysteine synthase, Exopolyphosphatase, geranylgeranyl reductase, Mating hormone A- factor precursor, mitochondrial succinate-fumarate transporter, modification methylase HemK family protein, Myo-inositol transporter, oxidoreductase subunit, peptidy-prolyl-cis- trans-isomerase, protein kinase, Ribose-5-phosphate isomerase, slr1293-protein, YDR049W-protein, YJL181 W-protein, and YPL109C-protein -activity.
摘要翻译：与相应的野生型植物相比，生产具有增加的产量的植物的方法，其包括至少以下步骤：在植物或其部分中增加或产生一种或多种选自3-磷酸甘油酸脱氢酶，腺苷酸激酶，B2758蛋白，环核苷酸磷酸二酯酶，半胱氨酸合成酶，外多磷酸酶，香叶基香叶基还原酶，交配激素A-因子前体，线粒体琥珀酸 - 富马酸转运蛋白，修饰甲基化酶HemK家族蛋白，肌醇转运蛋白，氧化还原酶亚基，肽 - 脯氨酰 - - 反式异构酶，蛋白激酶，核糖-5-磷酸异构酶，slr1293蛋白，YDR049W蛋白，YJL181W蛋白和YPL109C-蛋白活性。

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