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71. 发明授权

US06936275B2 Amino acid modulated extended release dosage form 失效
公开(公告)号：US06936275B2
公开(公告)日：2005-08-30
申请号：US10364793
申请日：2003-02-11
申请人： A. Reza Fassihi , Thomas Dürig
发明人： A. Reza Fassihi , Thomas Dürig
IPC分类号： A61K9/16 , A61K9/20 , A61K9/22 , A61K9/26 , A61K47/00
CPC分类号： A61K9/2077 , A61K9/1617 , A61K9/1652 , A61K9/2013 , A61K9/205 , Y10S514/96 , Y10S514/961 , Y10S514/964 , Y10S514/965 , Y10S514/972
摘要： Disclosed herein is a oral extended release dosage form comprising a plurality of granules of an effective amount of a pharmaceutically active compound, at least one amino acid, and an intragranular polymer in which the granule is dispersed within a hydrophilic extragranular polymer matrix which is more rapidly hydrating than the intragranular polymer. The amino acid is selected for hydropathy characteristics depending on solubility characteristics of the active compound.

72. 发明授权

US06893658B1 Soft capsules 失效
标题翻译：软胶囊
公开(公告)号：US06893658B1
公开(公告)日：2005-05-17
申请号：US10069755
申请日：2000-08-31
申请人： Yoshimitsu Iida , Yutaka Ogawa
发明人： Yoshimitsu Iida , Yutaka Ogawa
IPC分类号： A61K9/48 , A61K31/593
CPC分类号： A61K31/593 , A61K9/4858 , Y10S514/962 , Y10S514/972
摘要： An object of the present invention is to provide soft capsule formulations of active vitamins D, well-suited to practical production with easy discrimination of active ingredient levels, in which stability of the active vitamins D3 to light and heat is ensured, and which material is highly safe to the human body. According to the present invention, soft capsule formulations of active vitamins D3 can be obtained-wherein the capsule shell contains a white pigment and yellow iron oxide and/or red iron oxide, or titanium oxide and caramel, or yellow iron oxide.
摘要翻译：本发明的目的是提供活性维生素D的软胶囊制剂，其非常适合实际生产，容易区分活性成分水平，其中活性维生素D 3对光和/ 确保了热量，哪种材料对人体高度安全。根据本发明，可以获得活性维生素D 3 N的软胶囊制剂，其中胶囊壳包含白色颜料和黄色氧化铁和/或红色氧化铁，或氧化钛和焦糖，或黄色氧化铁。

73. 发明申请

US20020146387A1 STABILIZED ACTIVE MATERIALS 失效
标题翻译：稳定活性材料
公开(公告)号：US20020146387A1
公开(公告)日：2002-10-10
申请号：US09828040
申请日：2001-04-06
发明人： Darryl F. Klassen , David J. Muir
IPC分类号： A01N025/00
CPC分类号： A01N37/02 , A01N25/22 , A01N61/00 , Y10S514/963 , Y10S514/964 , Y10S514/97 , Y10S514/972 , A01N25/28 , A01N31/08 , A01N2300/00
摘要： A stabilized insect mating disruption pheromone compositions comprising an insect pheromone and 2,2null-Methylenebis(6-t-butyl-p-cresol). Methods of use and microcapsules containing these compositions are also provided.
摘要翻译：包含昆虫信息素和2,2'-亚甲基双（6-叔丁基对甲酚）的稳定的昆虫交配破坏信息素组合物。还提供了使用方法和含有这些组合物的微胶囊。

74. 发明申请

US20020041853A1 Cosmetic composition 有权
公开(公告)号：US20020041853A1
公开(公告)日：2002-04-11
申请号：US09873398
申请日：2001-06-05
申请人： SHOWA DENKO K.K.
发明人： Nobuaki Ishii , Junko Futami , Kouichi Wada , Michihiro Takama
IPC分类号： A61K007/42 , A61K007/021
CPC分类号： B82Y30/00 , A61K8/29 , A61K8/731 , A61K8/732 , A61K8/733 , A61K8/8147 , A61Q1/02 , A61Q17/04 , C01P2002/82 , C01P2002/84 , C01P2004/04 , C01P2004/62 , C01P2004/64 , C01P2004/82 , C01P2004/86 , C01P2006/60 , C09C1/043 , C09C1/3661 , Y10S514/972
摘要： A cosmetic composition comprising titanium oxide coated with one or both of silica and alumina or zinc oxide coated with one or both of silica and alumina, and a thickening polymer having a carboxyl group in the side chain, preferably a carboxyvinyl polymer, wherein when 10% by mass of silica- and/or alumina-coated titanium oxide or silica- and/or alumina-coated zinc oxide is dispersed in an aqueous solution containing 0.133% by mass of a carboxyvinyl polymer, the viscosity after the passing of 100 hours is 50% or more of the initial viscosity. A cosmetic composition comprising titanium oxide coated with one or both silica and alumina or zinc oxide coated with one or both of silica and alumina, and a thickening polymer having a carboxyl group in the side chain of the invention, can maintain emulsion stability by thickening of polymer for a long period of time and can be widely and suitably used for ultraviolet shielding cosmetic materials or the like having preparation form stability.

75. 发明授权

US06210657B1 Use of isoindolinone derivatives as stabilizers for organic materials 失效
标题翻译：异吲哚啉酮衍生物作为有机材料的稳定剂的使用
公开(公告)号：US06210657B1
公开(公告)日：2001-04-03
申请号：US09207624
申请日：1998-12-09
申请人： Thorsten Habeck , Sylke Haremza , Hubert Trauth , Volker Schehlmann , Horst Westenfelder
发明人： Thorsten Habeck , Sylke Haremza , Hubert Trauth , Volker Schehlmann , Horst Westenfelder
IPC分类号： A61K742
CPC分类号： A61K31/4035 , C08K5/3417 , C09D7/48 , C09K15/30 , Y10S514/844 , Y10S514/97 , Y10S514/972
摘要： Isoindolinone derivatives of the formula I, in which the variables have the following meanings: R1 is hydrogen, COOR4, COR4, CONR4R5, CN, C1-C20-alkyl, C2-C10-alkenyl, C3-C10-cycloalkyl, C3-C10-cycloalkenyl, aryl or heteroaryl, substituted or unsubstituted; R1 and R2 together are C7-C10-bicycloalkyl or C7-C10-bicycloalkenyl; R3 is hydrogen, C1-C20-alkyl, C2-C10-alkenyl, C3-C10-cycloalkyl, C3-C10-cycloalkenyl, C1-C12-alkoxy, C1-C20-alkoxycarbonyl, C1-C12-alkylamino, C1-C12-dialkylamino, aryl or heteroaryl, substituted or unsubstituted, substituents which confer solubility in water, selected from the group consisting of carboxylate, sulfonate or ammonium radicals; R4 and R5 independently of one another are hydrogen, C1-C20-alkyl, C2-C10-alkenyl, C3-C10-cycloalkyl, C3-C10-cycloalkenyl; aryl or heteroaryl, substituted or unsubstituted; are used as stabilizers for organic materials.
摘要翻译：式I的异吲哚啉酮衍生物，其中变量具有以下含义：R1是氢，COOR4，COR4，CONR4R5，CN，C1-C20-烷基，C2-C10-烯基，C3-C10-环烷基，C3-C10- 环烯基，芳基或杂芳基，取代或未取代的; R1和R2一起是C7-C10-双环烷基或C7-C10-双环烯基; R3是氢，C1-C20-烷基，C2-C10-烯基，C3-C10-环烷基，C3 -C 10 - 环烯基，C 1 -C 12 - 烷氧基，C 1 -C 20 - 烷氧基羰基，C 1 -C 12 - 烷基氨基，C 1 -C 12 - 二烷基氨基，芳基或杂芳基，取代或未取代的赋予水溶性的取代基，羧酸酯，磺酸酯或铵基; R 4和R 5彼此独立地是氢，C 1 -C 20 - 烷基，C 2 -C 10 - 烯基，C 3 -C 10 - 环烷基，C 3 -C 10 - 环烯基; 芳基或杂芳基，取代或未取代的;被用作有机材料的稳定剂。

76. 发明授权

US6113950A Process for coating biological pesticides and compositions therefrom 失效
标题翻译：用于涂覆生物农药及其组合物的方法
公开(公告)号：US6113950A
公开(公告)日：2000-09-05
申请号：US284003
申请日：1999-04-05
申请人： James Perry Foster
发明人： James Perry Foster
IPC分类号： A01N25/26 , A01N25/22 , A01N59/00 , A01N59/06 , A01N63/00 , A01N59/16 , A01N25/00 , C07H21/00 , C12N7/00
CPC分类号： A01N59/00 , A01N59/06 , A01N63/00 , Y10S424/08 , Y10S514/951 , Y10S514/972
摘要： A pesticidal composition comprising particles of biological pesticides and particles of durable TiO.sub.2 in an amount sufficient to substantially coat the particles of biological pesticides and process for the preparation thereof are disclosed.
摘要翻译： PCT No.PCT / US97 / 17393 Sec。 371日期1999年4月5日 102（e）日期1999年4月5日PCT 1997年9月29日PCT公布。第WO98 / 15183号公报日期1998年04月16日公开了一种杀虫组合物，其包含生物农药颗粒和耐用TiO 2颗粒，其量足以基本上涂覆生物农药颗粒并用于其制备方法。

77. 发明授权

US6017556A Liposomogenic UV absorbers 失效
标题翻译：脂质体紫外线吸收剂
公开(公告)号：US6017556A
公开(公告)日：2000-01-25
申请号：US931392
申请日：1997-09-16
申请人： Helmut Luther , Dietmar Huglin , Robert Hochberg
发明人： Helmut Luther , Dietmar Huglin , Robert Hochberg
IPC分类号： C07D249/20 , A61K8/00 , A61K8/14 , A61K8/37 , A61K8/40 , A61K8/49 , A61Q5/00 , A61Q5/02 , A61Q5/04 , A61Q5/06 , A61Q5/08 , A61Q5/10 , A61Q17/00 , A61Q17/04 , C07D251/14 , C07D251/24 , C09K3/00 , A61K9/127 , A61K7/06
CPC分类号： B82Y30/00 , A61K8/14 , A61K8/37 , A61K8/496 , A61K8/4966 , A61Q17/04 , A61Q5/00 , B82Y5/00 , C07D251/24 , A61K2800/57 , Y10S514/88 , Y10S514/881 , Y10S514/944 , Y10S514/972
摘要： The use of liposomogenic UV absorbers for protecting human hair from the damaging effect of UV radiation is described. The liposomogenic UV absorbers comprise a hydrophilic head group (=Z), a spacer (=W), a UV chromophore (Q) having an absorption in the range from 285 to 400 nm and at least one hydrophobic tail group (=A). They have the formula ##STR1## in which A.sub.1 and A.sub.2 independently of one another are a hydrophobic radical;Q is a UV chromophore;W is an organic radical;Z.sub.1 and Z.sub.2 independently of one another are a hydrophilic radical; n.sub.1 and n.sub.2 independently of one another are a number from 0 to 4, where n.sub.1 =n.sub.2 = is not included;p is 1 or 2;q is a number from 0 to 3;r.sub.1 is 1 or 2;r.sub.2 is 0 or 1; ands.sub.1 is a number from 1 to 3.The liposomogenic UV absorbers are capable of self-organization into bimolecular layers, and can as a result penetrate into the stratum corneum to a high degree and are extremely resistant to washing out there.
摘要翻译：描述了使用脂质体UV吸收剂来保护人的头发免受UV辐射的破坏作用。脂质体UV吸收剂包括亲水性头基（= Z），间隔基（= W），具有285至400nm范围内的吸收的UV发色团（Q）和至少一个疏水性尾基（= A）。它们具有其中A1和A2彼此独立的是疏水基团的式子; Q是紫外发色团; W是有机基团; Z 1和Z 2彼此独立地是亲水基团; n1和n2彼此独立的是0至4的数，其中n1 = n2 =不包括在内; p为1或2; q是从0到3的数字; r1为1或2; r2为0或1; s1是从1到3的数字。脂质体UV吸收剂能够自组织成双分子层，并且因此可以高度渗透到角质层中并且非常耐洗涤。

78. 发明授权

US06001346A Aqueous emulsion comprising biodegradable carrier for insect pheromones and methods for controlled release thereof 失效
标题翻译：包含用于昆虫信息素的可生物降解的载体的水乳液及其控制释放的方法
公开(公告)号：US06001346A
公开(公告)日：1999-12-14
申请号：US711159
申请日：1996-09-09
申请人： Michael Delwiche , John M. Krochta , Richard E. Rice , Cynthia Atterholt
发明人： Michael Delwiche , John M. Krochta , Richard E. Rice , Cynthia Atterholt
IPC分类号： A01N25/18 , A01N25/02 , A01N25/00 , A01N25/08 , A01N25/30
CPC分类号： A01N25/18 , Y10S514/937 , Y10S514/938 , Y10S514/939 , Y10S514/94 , Y10S514/941 , Y10S514/942 , Y10S514/943 , Y10S514/964 , Y10S514/97 , Y10S514/971 , Y10S514/972 , Y10S514/973 , Y10S514/975
摘要： A sprayable or solid biodegradable wax carrier for insect pheromones and a method for constant release rate of the pheromone from the biodegradable wax. A composition comprising a pheromone and paraffin wax formulated as an aqueous emulsion or a solid suitable for application to a surface of a tree or crop for mating disruption of insect pests. Pheromone is released by diffusion or by partitioning from the biodegradable wax carrier or by pheromone exposure due to the biodegradable wax carrier degradation.
摘要翻译：用于昆虫信息素的可喷雾或固体可生物降解的蜡载体和来自可生物降解的蜡的信息素的恒定释放速率的方法。一种组合物，其包含被配制为水性乳液的信息素和石蜡，或适用于树或作物的表面用于交配中断害虫的固体。由于可生物降解的蜡载体降解，信息素通过扩散或通过分解从可生物降解的蜡载体或信息素暴露释放。

79. 发明授权

US5929053A Pesticidal composition and method for controlling pests using the same 失效
标题翻译：杀虫剂组合物及其使用方法
公开(公告)号：US5929053A
公开(公告)日：1999-07-27
申请号：US767300
申请日：1996-12-16
申请人： Miwa Murakami , Masao Ogawa , Izumi Fujimoto , Toshiro Ohtsubo
发明人： Miwa Murakami , Masao Ogawa , Izumi Fujimoto , Toshiro Ohtsubo
IPC分类号： A01N25/28 , A01N57/02 , A01N57/16 , A01N25/26
CPC分类号： A01N57/02 , A01N25/28 , A01N57/16 , Y10S424/11 , Y10S514/951 , Y10S514/963 , Y10S514/972
摘要： A pesticidal composition comprising microcapsules, each microencapsulating an organophosphorus compound having a melting point of at least 15.degree. C., a proportion (A) of aromatic ring structure in microcapsule wall material being not more than 40% by weight, and a ratio of (A) to (average diameter/wall thickness) of the microcapsules being not less than 0, but not more than 0.8, causes less color change to applied area even if applied outdoors.
摘要翻译：一种杀虫组合物，其包含微胶囊，每个微胶囊包封熔点至少为15℃的有机磷化合物，微胶囊壁材料中芳族环结构的比例（A）不超过40重量％，（ A）至微胶囊的（平均直径/壁厚）不小于0但不大于0.8，即使在室外施用也会使施涂区域的颜色变化较小。

80. 发明授权

US5788955A Screening cosmetic composition containing a mixture of 1,4-benzenedi (3-methylidene-10-camphosulfonic) acid, partially or completely neutralized, and metal oxide nanopigments 失效
标题翻译：筛选含有部分或完全中和的1,4-苯二（3-亚甲基-10--磺基）酸和金属氧化物纳米颗粒的混合物的化妆品组合物
公开(公告)号：US5788955A
公开(公告)日：1998-08-04
申请号：US458192
申请日：1995-06-02
申请人： Martine Eteve , Isabelle Hansenne
发明人： Martine Eteve , Isabelle Hansenne
IPC分类号： A61K8/30 , A61K8/00 , A61K8/04 , A61K8/06 , A61K8/11 , A61K8/18 , A61K8/19 , A61K8/24 , A61K8/25 , A61K8/26 , A61K8/27 , A61K8/28 , A61K8/29 , A61K8/34 , A61K8/35 , A61K8/36 , A61K8/41 , A61K8/44 , A61K8/46 , A61K8/58 , A61K8/64 , A61K8/86 , A61K8/89 , A61K8/891 , A61K8/98 , A61Q1/00 , A61Q1/02 , A61Q1/04 , A61Q1/06 , A61Q1/08 , A61Q1/10 , A61Q1/12 , A61Q5/00 , A61Q5/02 , A61Q5/04 , A61Q5/06 , A61Q5/08 , A61Q5/10 , A61Q17/04 , A61K7/42 , A61K7/00
CPC分类号： A61Q17/04 , A61K8/0241 , A61K8/19 , A61K8/27 , A61K8/28 , A61K8/29 , A61K8/466 , B82Y5/00 , A61K2800/413 , A61K2800/43 , A61Q1/02 , A61Q1/06 , A61Q1/08 , A61Q1/10 , A61Q5/02 , A61Q5/04 , A61Q5/06 , A61Q5/08 , Y10S514/972
摘要： The invention relates to a screening cosmetic composition comprising, in a mixture, 0.5 to 10% by weight of metal oxide nanopigments chosen from titanium, zinc, cerium or zirconium oxide or mixtures thereof, with a mean diameter of less than 100 nm, and 0.1 to 10% by weight of 1,4-benzenedi(3-methylidene-10-camphosulfonic) acid or one of its alkali metal, ammonium, amine, alkanolamine, Ca, Zn, Mg, Ba, Al or Zr salts, in a cosmetically acceptable carrier. This composition is useful as composition for protecting the human epidermis or the hair against UV rays or as make-up.
摘要翻译：本发明涉及一种筛选化妆品组合物，其包含0.5至10重量％的选自钛，锌，铈或氧化锆的金属氧化物纳米颗粒或其混合物，其平均直径小于100nm，和0.1 至10重量％的1,4-苯二（3-亚甲基-10-樟脑磺酸）酸或其碱金属，铵，胺，链烷醇胺，Ca，Zn，Mg，Ba，Al或Zr盐中的一种，在化妆品可接受的载体该组合物可用作用于保护人类表皮或头发免受紫外线或作为化妆品的组合物。

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