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71. 发明申请

US20100197739A1 Stable Suspension Concentrate Formulation for Water-Soluble Compounds 有权
标题翻译：水溶性化合物的稳定悬浮浓缩配方
公开(公告)号：US20100197739A1
公开(公告)日：2010-08-05
申请号：US12445905
申请日：2007-10-16
申请人： Robin W. Dexter , Hong Liu
发明人： Robin W. Dexter , Hong Liu
IPC分类号： A01N43/40 , A01P7/04
CPC分类号： A01N43/50 , A01N25/02 , A01N43/40 , A01N51/00 , A61K47/02 , A61K47/38 , A61L2400/06 , A01N25/04 , A01N59/02 , A01N59/06 , A01N2300/00
摘要： The present invention is directed to an insecticidal water based suspension concentrate formulation comprising a water-soluble insecticide selected from the group consisting of N-cyanomethyl-4-(trifluoromethyl)nicotinamide and (EZ)-1-(6-chloro-3-pyridylmethyl)-N-nitroimidazolidin-2-ylidineamine and at least one water-soluble salt selected from the group consisting of magnesium sulfate (hydrated and anhydrous forms) and sodium sulfate, wherein the water-soluble insecticide is present in an insecticidally effective amount and methods of use.
摘要翻译：本发明涉及一种杀虫水基悬浮液浓缩物制剂，其包含选自N-氰基甲基-4-（三氟甲基）烟酰胺和（EZ）-1-（6-氯-3-吡啶基甲基）-N-硝基咪唑烷-2-基胺和至少一种选自硫酸镁（水合和无水形式）和硫酸钠的水溶性盐，其中水溶性杀虫剂以杀虫有效量存在，并且方法的使用。

72. 发明申请

US20100048541A1 SUBSTITUTED LACTAMS AS INHIBITORS OF ABETA PROTEIN PRODUCTION 审中-公开
标题翻译：作为ABETA蛋白质生产的抑制剂的替代的LACTAMS
公开(公告)号：US20100048541A1
公开(公告)日：2010-02-25
申请号：US12561420
申请日：2009-09-17
申请人： Qi HAN , Hong Liu , Richard E. Olson , Michael G. Yang
发明人： Qi HAN , Hong Liu , Richard E. Olson , Michael G. Yang
IPC分类号： A61K31/5513 , C07D243/24 , C07D401/04
CPC分类号： C07D223/12 , C07D223/18 , C07D243/12 , C07D243/24 , C07D401/04
摘要： This invention relates to novel lactams of Formula (I): having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.
摘要翻译：本发明涉及式（I）的新型内酰胺：具有药物和生物影响性质，其药物组合物和使用方法。这些新化合物抑制淀粉样蛋白前体蛋白的加工，更具体地，抑制Aβ的生成，从而起到防止淀粉样蛋白的神经沉积的形成的作用。更具体地说，本发明涉及与阿尔茨海默病和唐氏综合征等淀粉样蛋白生成相关的神经障碍的治疗。

73. 发明授权

US07662860B2 3D-structure model of SARS coronavirus 3CL protease and anti-SARS drugs 失效
标题翻译： SARS冠状病毒3CL蛋白酶和抗SARS药物的3D结构模型
公开(公告)号：US07662860B2
公开(公告)日：2010-02-16
申请号：US11293847
申请日：2005-12-02
申请人： Jianhua Shen , Hualiang Jiang , Xu Shen , Jianping Zuo , Xiaomin Luo , Donglu Bai , Jingkang Shen , Kaixian Chen , Chunshan Gui , Lili Chen , Jing Chen , Yifu Yang , Xianhan Zhuang , Yiming Yang , Xuchang He , Hong Liu , Bing Xiong , Haibin Luo , Tao Sun , Fei Ye
发明人： Jianhua Shen , Hualiang Jiang , Xu Shen , Jianping Zuo , Xiaomin Luo , Donglu Bai , Jingkang Shen , Kaixian Chen , Chunshan Gui , Lili Chen , Jing Chen , Yifu Yang , Xianhan Zhuang , Yiming Yang , Xuchang He , Hong Liu , Bing Xiong , Haibin Luo , Tao Sun , Fei Ye
IPC分类号： A61K31/165
CPC分类号： C12N9/506 , A61K31/167
摘要： The present invention discloses 3D-structure of SARS-CoV Viral 3CL Protease obtained through molecular simulation. The 3D-structure is used as a drug target for screening the existing medical database CMC (Comprehensive Medicinal Chemistry, MDL Information System, Inc.), and a group of compounds which have the activity of inhibiting SARS-CoV virus 3CL Protease are found. Cinanserin was tested at molecular and viral levels, and it was found to be able to inhibit the SARS-CoV viral 3CL protease and SARS-CoV viruses. Cinanserin analogs were synthesized and tested at molecular and viral levels, they were found to be able to inhibit the SARS-CoV virus 3CL Protease and SARS-CoV viruses, and may be used for treating and/or preventing SARS-CoV virus infection.
摘要翻译：本发明公开了通过分子模拟获得的SARS-CoV病毒3CL蛋白酶的三维结构。使用3D结构作为筛选现有医学数据库CMC（Comprehensive Medicinal Chemistry，MDL Information System，Inc。）的药物靶点，并发现一组具有抑制SARS-CoV病毒3CL蛋白酶活性的化合物。在分子和病毒水平测试了Cinanserin，发现能够抑制SARS-CoV病毒3CL蛋白酶和SARS-CoV病毒。合成Cinanserin类似物并在分子和病毒水平进行测试，发现它们能够抑制SARS-CoV病毒3CL蛋白酶和SARS-CoV病毒，可用于治疗和/或预防SARS-CoV病毒感染。

74. 发明申请

US20100009992A1 AMPK MODULATORS 有权
标题翻译： AMPK调制器
公开(公告)号：US20100009992A1
公开(公告)日：2010-01-14
申请号：US12365671
申请日：2009-02-04
申请人： Neal C. Birnberg , Hong Liu , Qing Ping Weng , Haibo Shang , Pan Yin , Sharanappa B. Rajur , Hwa-Ok Kim , Paresh D. Salgaonkar , Norton P. Peet
发明人： Neal C. Birnberg , Hong Liu , Qing Ping Weng , Haibo Shang , Pan Yin , Sharanappa B. Rajur , Hwa-Ok Kim , Paresh D. Salgaonkar , Norton P. Peet
IPC分类号： A61K31/437 , A61K31/4985 , A61K31/4375 , A61K31/47 , A61K31/404 , C07D498/04 , C07D471/04 , C07D215/20 , C07D209/12 , A61P35/00 , A61P3/10 , A61P3/04
CPC分类号： C07D498/04 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D209/42 , C07D215/54 , C07D215/56 , C07D401/04 , C07D403/04 , C07D471/04
摘要： The present invention relates to compounds and pharmaceutically acceptable salts, esters and prodrugs of Formula (I) or (II): which are useful as AMPK modulators effective in treating diabetes, obesity and cancer in a subject.
摘要翻译：本发明涉及式（I）或（II）的化合物和药学上可接受的盐，酯和前药：其可用作对受试者中有效治疗糖尿病，肥胖和癌症的AMPK调节剂。

75. 发明申请

US20090247517A1 COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY 失效
标题翻译：化合物和组合物作为CANNABINOID受体1活性的抑制剂
公开(公告)号：US20090247517A1
公开(公告)日：2009-10-01
申请号：US11718016
申请日：2005-10-26
申请人： Hong Liu , Xiaohui He , Ha-Soon Choi , Kunyong Yang , David H. Woodmansee , Zhicheng Wang , David Archer Ellis , Baogen Wu , Yun He , Truc Ngoc Nguyen
发明人： Hong Liu , Xiaohui He , Ha-Soon Choi , Kunyong Yang , David H. Woodmansee , Zhicheng Wang , David Archer Ellis , Baogen Wu , Yun He , Truc Ngoc Nguyen
IPC分类号： A61K31/5377 , C07D487/02 , A61K31/519 , C07D471/02 , A61K31/437 , C07D473/30 , A61K31/522 , C07D413/14 , A61K31/496 , C07D413/02 , A61P3/04
CPC分类号： C07D487/04 , C07D471/04 , C07D473/30 , C07D498/04
摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cannabinoid Receptor 1 (CB1).
摘要翻译：本发明提供化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与大麻素受体1（CB1）的活性相关的疾病或病症的方法。

76. 发明申请

US20090088037A1 LAMINATED FABRIC CONSTRUCTION WITH POLYOLEFIN COMPOSITIONS 审中-公开
标题翻译：具有聚烯烃组合物的层压织物结构
公开(公告)号：US20090088037A1
公开(公告)日：2009-04-02
申请号：US12208813
申请日：2008-09-11
申请人： Carmen A. Covelli , Douglas K. Farmer , James M. Lambert , Hong Liu , Robert O. Waldbauer , Young D. Nguyen
发明人： Carmen A. Covelli , Douglas K. Farmer , James M. Lambert , Hong Liu , Robert O. Waldbauer , Young D. Nguyen
IPC分类号： B32B5/18 , C08F210/00 , B32B27/00
摘要： Articles comprising multiple layers are included. The multiple layer articles may include fabrics, foams, films, fiber in combination with a polyolefin composition such as a film, powder, or nonwoven.
摘要翻译：包括多层的物品。多层制品可以包括与聚烯烃组合物如膜，粉末或非织造材料组合的织物，泡沫，膜，纤维。

77. 发明授权

US07412026B2 Phase-contrast x-ray imaging systems and methods 有权
标题翻译：相位对比X射线成像系统和方法
公开(公告)号：US07412026B2
公开(公告)日：2008-08-12
申请号：US11171006
申请日：2005-06-29
申请人： Hong Liu , Xizeng Wu
发明人： Hong Liu , Xizeng Wu
IPC分类号： G01N23/04 , G21K5/08 , H05G1/64
CPC分类号： A61B6/484 , A61B6/4007 , A61B6/4092 , A61B6/4266 , G01N23/04 , G21K2207/005
摘要： The present invention relates systems and methods for phase-contrast x-ray imaging of an object. In one embodiment, the system includes an x-ray source, a detector, and an object-map generator. The x-ray source transmits x-rays, and the detector is positioned so as to receive at least a portion of the x-rays transmitted by the x-ray source and output an image signal indicative of an intensity measurement of the x-rays received. The object is positioned between the x-ray source and the detector. The detector is then used to acquire intensity measurements at two different positions and output the same to the object-map generator. The object-map generator then utilizes the image signals of the detector, along with algorithms, including phase-retrieval algorithms to generate an attenuation-map and a phase-map for the object. The present invention also include systems and methods utilizing a dual-detector arrangement, a multi-source arrangement, and a mosaic source-detector arrangement.
摘要翻译：本发明涉及用于对象的相位对比度X射线成像的系统和方法。在一个实施例中，系统包括x射线源，检测器和对象图生成器。 x射线源透射x射线，并且检测器被定位成接收由x射线源透射的X射线的至少一部分，并输出指示X射线强度测量的图像信号收到了物体位于x射线源和检测器之间。然后检测器用于在两个不同的位置采集强度测量值，并将其输出到对象图生成器。对象图生成器然后利用检测器的图像信号以及包括相位检索算法的算法来生成对象的衰减映射和相位图。本发明还包括利用双检测器装置，多源装置和马赛克源 - 检测器装置的系统和方法。

78. 发明申请

US20080075957A1 BIFUNCTIONAL MAGNETIC CORE-SEMICONDUCTOR SHELL NANOPARTICLES AND MANUFACTURING METHOD THEREOF 有权
标题翻译：双功能核心半导体壳纳米粒子及其制造方法
公开(公告)号：US20080075957A1
公开(公告)日：2008-03-27
申请号：US11860002
申请日：2007-09-24
申请人： Young Kim , Hong Liu , Jun Wu , Ji Min , Ju Lee
发明人： Young Kim , Hong Liu , Jun Wu , Ji Min , Ju Lee
IPC分类号： B32B5/16 , B01D21/01 , B05D5/12
CPC分类号： B82Y25/00 , B22F1/02 , B22F9/24 , B22F2998/00 , C22C2202/02 , H01F1/0054 , Y10T428/2991 , B22F1/0018
摘要： Provided are bifunctional magnetic core-semiconductor shell nanoparticles and a manufacturing method thereof. The method includes mixing magnetic core material precursors and a reducing agent for the core material precursors; preparing a first mixture solution; heating and cooling the first mixture solution and preparing magnetic core materials; mixing the magnetic core materials with semiconductor shell material precursors and a reducing agent for the semiconductor shell material precursors; preparing a second mixture solution; and heating and cooling the second mixture solution and coating the magnetic core materials with the semiconductor shell materials.
摘要翻译：提供双功能磁芯 - 半导体壳纳米粒子及其制造方法。该方法包括混合磁芯材料前体和芯材前体的还原剂; 制备第一混合溶液; 加热冷却第一混合液并制备磁芯材料; 将磁芯材料与半导体外壳材料前体和用于半导体外壳材料前体的还原剂混合; 制备第二混合溶液; 并加热和冷却第二混合物溶液并用半导体外壳材料涂覆磁芯材料。

79. 发明申请

US20080060773A1 All in one soft windows 审中-公开
标题翻译：所有在一个软窗口
公开(公告)号：US20080060773A1
公开(公告)日：2008-03-13
申请号：US11517849
申请日：2006-09-09
申请人： Hong Liu
发明人： Hong Liu
IPC分类号： A47H23/06
CPC分类号： A47H19/00 , A47H2/00 , A47H23/04 , A47H2023/003
摘要： “All in One Soft Windows” is an article, by combining two or all the three elements of panel, sheer and/or valance—mostly made of fabric—together using only one rod, intended to make window decoration easier and convenient for general public. For the article of panel/sheer combination, making the individual piece of window panel and sheer first, then sew the upper part of them together with sheer as the inner part and panel as the outer part, to make one rod pocket or one set of tabs for hanging. For the articles of panel/valance, sheer/valance and panel/sheer/valance combinations, need to do the individual piece of panel, valance and/or sheer first, then sew the upper part of a pair of panels, or sheers, or a pair of panels and sheers and the upper part of a valance together, make the valance the most outer part at the top, panels as the outer part down below and/or sheers as the inner part, to make one rod pocket or one set of tabs for hanging.
摘要翻译： “一体软窗”是一篇文章，通过组合面板，纯粹和/或价值的三个要素，主要由布料组合使用，仅使用一根杆，旨在使窗户装饰更容易，方便普通公众。对于面板/纯粹组合的物品，首先制作单个的窗板和整板，然后将它们的上部作为内部部件和面板作为外部部分缝合在一起，以制成一个棒袋或一组悬挂标签对于面板/价值，纯粹的价格和面板/纯粹/价值组合的文章，首先需要做单独的面板，价值和/或纯粹，然后缝合一对面板，一对面板和薄片和一个价钱的上部组合在一起，使顶部的外部部分的价格最上面，面板作为外部部分向下和/或侧边作为内部部分，以制作一个杆袋或一个套的悬挂标签。

80. 发明申请

US20070213457A1 SOLVENT FREE AQUEOUS POLYURETHANE DISPERSIONS AND ADHESIVE FILMS THEREFROM FOR STRETCH FABRICS 有权
标题翻译：无溶剂的水性聚氨酯分散剂及其用于拉伸织物的粘合膜
公开(公告)号：US20070213457A1
公开(公告)日：2007-09-13
申请号：US11748038
申请日：2007-05-14
申请人： Hong Liu , Carmen Covelli , Douglas Farmer
发明人： Hong Liu , Carmen Covelli , Douglas Farmer
IPC分类号： C08G18/08
CPC分类号： C08G18/0823 , B32B7/12 , B32B27/12 , B32B2255/02 , B32B2255/26 , B32B2307/306 , B32B2307/51 , B32B2437/00 , C08G18/12 , C08G18/4854 , C08G18/6692 , C08G2170/80 , C09J7/38 , C09J175/04 , C09J2475/00 , Y10T428/31551 , Y10T442/162 , Y10T442/164 , Y10T442/198 , Y10T442/20 , Y10T442/2148 , Y10T442/2197 , Y10T442/2246 , Y10T442/2434 , Y10T442/2459 , Y10T442/2492 , Y10T442/2738 , Y10T442/3008 , Y10T442/3016 , Y10T442/3024 , Y10T442/3911 , C08G18/305
摘要： Novel aqueous polyurethane dispersions and adhesive films formed therefrom are provided. The aqueous polyurethane dispersions are provided in solvent-free systems of a prepolymer comprising at least one polyether or polyester polyol, a mixture of MDI isomers, and a diol. The adhesive films from such dispersions can be heat-activated for bonding, lamination, and adhesion of textile fabrics, including stretch fabrics.
摘要翻译：提供了由其形成的新型水性聚氨酯分散体和粘合剂膜。水性聚氨酯分散体提供在包含至少一种聚醚或聚酯多元醇，MDI异构体的混合物和二醇的预聚物的无溶剂体系中。来自这种分散体的粘合剂膜可以被热活化以用于粘合，层压和粘合纺织织物，包括弹力织物。

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