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    • 74. 发明申请
    • METHODS FOR PURIFYING ANTIBODIES USING CERAMIC HYDROXYAPATITE
    • 使用陶瓷羟基磷灰石来治疗抗体的方法
    • US20100234577A1
    • 2010-09-16
    • US12304782
    • 2007-06-13
    • Gregory J. MazzolaThomas M. Smith
    • Gregory J. MazzolaThomas M. Smith
    • C07K1/22C07K16/00
    • C07K1/20C07K1/18C07K16/065
    • This invention relates to the purification of monoclonal antibodies from mammalian cell culture fluid utilizing sequential, orthogonal chromatography and filtration techniques resulting in material of high purity and quality that is suitable for human administration. The method involves capturing an IgG product using immobilized protein A affinity chromatography, followed by at least one ion exchange technique prior to adsorbing the IgG to hydroxyapatite and selectively eluting the product in a single isocratic step to achieve purification from impurities and simultaneously reducing multiple types of impurities including but not limited to IgG aggregates, residual protein A, non-IgG proteins, host cell proteins, viral particles, and DNA
    • 本发明涉及使用顺序,正交色谱和过滤技术从哺乳动物细胞培养液中纯化单克隆抗体,产生适于人类施用的高纯度和高质量的材料。 该方法包括使用固定化蛋白A亲和色谱法捕获IgG产物,接着在将IgG吸附到羟基磷灰石之前进行至少一种离子交换技术,并在单个等度梯度步骤中选择性洗脱产物,以实现纯化从杂质中同时降低多种类型 杂质包括但不限于IgG聚集体,残留蛋白A,非IgG蛋白,宿主细胞蛋白,病毒颗粒和DNA
    • 75. 发明申请
    • Synchronous Transmission of Data with Network Remote Control
    • 网络远程控制数据同步传输
    • US20080153477A1
    • 2008-06-26
    • US12045089
    • 2008-03-10
    • Jocelyn CloutierAllen E. MilewskiThomas M. Smith
    • Jocelyn CloutierAllen E. MilewskiThomas M. Smith
    • H04M3/00
    • H04N21/41407H04L12/5692H04M3/42H04M2203/1016H04M2207/18H04N7/17318H04N21/242H04N21/4227H04N21/4781
    • A novel method and apparatus is disclosed for synchronously delivering complementary data to two devices. Complementary data is used herein to designate at least two streams of related data that, when combined, form an organic whole. In one embodiment of the disclosed invention, a command is received through a network for the synchronous transmission of complementary data. Subsequently, first data is transmitted through the network to a first device synchronized with transmission of second data to a second device, wherein the first and second data are complementary data.In one embodiment of the invention, a mobile and/or hand-held device such as a PDA is used to control another device remotely through one or more networks, such that complementary, synchronous streams of data that are intended for observation in combination by users and/or entities, can be transmitted to each of the PDA and the device. The flexibility of such an arrangement, wherein the PDA can be carried to different locations to control different devices for synchronous transmission of complementary data, allows the provision of a multitude of services not heretofore available.
    • 公开了一种用于将补充数据同时传送到两个装置的新颖的方法和装置。 这里使用互补数据来表示当组合时形成有机整体的至少两个相关数据流。 在所公开的发明的一个实施例中,通过网络接收命令以进行互补数据的同步传输。 随后,第一数据通过网络发送到与第二数据的传输同步的第一设备到第二设备,其中第一和第二数据是互补数据。 在本发明的一个实施例中,诸如PDA之类的移动和/或手持设备被用于通过一个或多个网络远程控制另一个设备,使得用于由用户组合观察的互补的同步数据流 和/或实体可以被发送到PDA和设备中的每一个。 这种布置的灵活性,其中PDA可以被携带到不同的位置以控制用于互补数据的同步传输的不同设备,允许提供迄今为止不可用的大量服务。
    • 77. 发明授权
    • Merchandisers with central heating and control mechanisms and methods for manufacturing and reconfiguring such merchandisers
    • US06627855B2
    • 2003-09-30
    • US09901132
    • 2001-07-10
    • Melissa M. HohlerPeter J. KoopmanRobert T. WoodThomas M. Smith
    • Melissa M. HohlerPeter J. KoopmanRobert T. WoodThomas M. Smith
    • A21B126
    • A47J36/2483A47F3/001A47F3/0434A47F3/0443A47J36/2488
    • A merchandiser for displaying food products and holding such food products at a controlled temperature has a well divided into three or more well sections, wherein each of the well sections receives a serving tray and wherein the serving trays collectively have a center line. A rear access door, a pair of side plates, and a transparent front plate, together with the well, define a food product holding cavity. A pair of supporting brackets position a merchandiser heating and control device above the well. The merchandiser heating and control device has a heating compartment, which positions three or more heating elements and three or more illuminating elements substantially above the center line of the serving trays, wherein the heating compartment includes three or more circulating fans for circulating heated air from the heating compartment into the holding cavity. The merchandiser heating and control device also has a retaining bracket for receiving an upper edge of the rear access door and has an enclosed guide surface. Further, the merchandiser heating and control device has a control compartment positioned above the retaining bracket and containing control elements for controlling heating elements and illuminating elements and having a rear control panel, wherein the control compartment includes a cooling fan for cooling the control elements and a plurality of vents formed in the control panel for drawing cooling air into the control compartment from outside the holding cavity and for exhausting heated air outside the holding cavity. Moreover, the merchandiser heating and control device has a securing bracket for mounting an upper edge of the transparent front plate. Methods for manufacturing such merchandisers permit them to be readily reconfigured during manufacture or at a customer site.
    • 78. 发明授权
    • Telephone voice-ringing using a transmitted voice announcement
    • 使用传输的语音通知来电话语音
    • US06519326B1
    • 2003-02-11
    • US09072785
    • 1998-05-06
    • Allen E. MilewskiThomas M. Smith
    • Allen E. MilewskiThomas M. Smith
    • H04M164
    • H04M19/041H04M3/02H04M3/06H04M7/0057H04M7/12
    • A voice-ringing system is provided. The traditional telephone ring for notifying a called party of an incoming phone call is replaced by a short verbal announcement that is provided by the calling party when placing the phone call. In a manner similar to traditional telephone ringing, the announcement is repeated until the call is answered or until the caller abandons the unanswered call. One implementation for the voice-ringing system is to utilize the Internet as a signaling channel. The calling party establishes a call by utilizing a communications device that is connected to both the Internet and to a voice network. The verbal announcement is sent to the called party as a signal transmitted over the Internet. The called party hears the voice ring on a communications device that is also connected to both the Internet and a voice network. When the called party indicates that the call should be accepted, a return signal is sent to the calling party's communication device. The calling party's communication device then establishes an end-to-end call on the voice network.
    • 提供语音铃声系统。 用于通知被叫方的来电电话的传统电话铃代替由主叫方在拨打电话时提供的短语言通知。 以类似于传统电话振铃的方式,重复通知直到呼叫被应答或者直到主叫方放弃未应答的呼叫。 语音振铃系统的一个实现是利用互联网作为信令信道。 呼叫方利用连接到因特网和语音网络的通信设备来建立呼叫。 口头公告作为通过互联网传输的信号发送给被叫方。 被叫方在也连接到互联网和语音网络的通信设备上听到语音环。 当被叫方指示该呼叫应被接受时,返回信号被发送到呼叫方的通信设备。 呼叫方的通信设备然后在语音网络上建立端到端呼叫。
    • 79. 发明授权
    • Message sender status monitor
    • 消息发送者状态监视器
    • US06501834B1
    • 2002-12-31
    • US09990233
    • 2001-11-21
    • Allen E. MilewskiDavid R. MillenThomas M. SmithDavid M. Weimer
    • Allen E. MilewskiDavid R. MillenThomas M. SmithDavid M. Weimer
    • H04M1100
    • H04L51/18H04L51/043H04L51/08H04L51/36
    • A message sender status monitor is used to determine the communication status of the sender of an electronic message. In the case of email, upon the recipient opening an email, a query is launched to a “status registry” to determine if the sender of the email is currently logged in to the communication network, or if the sender is currently on the telephone, or currently using a cell phone, etc. This status information is then used by the recipient of the email to determine the communication medium used to send a reply to the email sender. For example, if the status information indicates that the message sender is currently logged in to the data network, the recipient can respond using “instant messaging” (considered, therefore, to be a more efficient type of response that merely responding with an email message).
    • 消息发送者状态监视器用于确定电子消息的发送者的通信状态。 在电子邮件的情况下,在收件人打开电子邮件时,将向“状态注册表”发送查询以确定电子邮件的发件人当前是否登录到通信网络,或者如果发件人当前在电话上, 或当前正在使用手机等。该状态信息然后由电子邮件的接收方使用以确定用于向电子邮件发送者发送回复的通信介质。 例如,如果状态信息指示消息发送者当前登录到数据网络,则接收方可以使用“即时消息”进行响应(因此,认为是仅仅响应于电子邮件消息的更有效的响应类型 )。
    • 80. 发明授权
    • Merchandisers with central heating and control mechanisms and methods for manufacturing and reconfiguring such merchandisers
    • 具有中央供暖和控制机制的商人以及用于制造和重新配置这种商品的方法
    • US06259065B1
    • 2001-07-10
    • US09560135
    • 2000-04-28
    • Melissa M. HohlerPeter J. KoopmanRobert T. WoodThomas M. Smith
    • Melissa M. HohlerPeter J. KoopmanRobert T. WoodThomas M. Smith
    • A21B126
    • A47J36/2483A47F3/001A47F3/0434A47F3/0443A47J36/2488
    • A merchandiser for displaying food products and holding such food products at a controlled temperature has a well divided into three or more well sections, wherein each of the well sections receives a serving tray and wherein the serving trays collectively have a center line. A rear access door, a pair of side plates, and a transparent front plate, together with the well, define a food product holding cavity. A pair of supporting brackets position a merchandiser heating and control device above the well. The merchandiser heating and control device has a heating compartment, which positions three or more heating elements and three or more illuminating elements substantially above the center line of the serving trays, wherein the heating compartment includes three or more circulating fans for circulating heated air from the heating compartment into the holding cavity. The merchandiser heating and control device also has a retaining bracket for receiving an upper edge of the rear access door and has an enclosed guide surface. Further, the merchandiser heating and control device has a control compartment positioned above the retaining bracket and containing control elements for controlling heating elements and illuminating elements and having a rear control panel, wherein the control compartment includes a cooling fan for cooling the control elements and a plurality of vents formed in the control panel for drawing cooling air into the control compartment from outside the holding cavity and for exhausting heated air outside the holding cavity. Moreover, the merchandiser heating and control device has a securing bracket for mounting an upper edge of the transparent front plate. Methods for manufacturing such merchandisers permit them to be readily reconfigured during manufacture or at a customer site.
    • 用于在受控温度下展示食品并且保持这种食品的商品广告商被分为三个或更多个井段,其中每个井段都接收一个托盘,其中该托盘共同具有中心线。 一个后检修门,一对侧板和一个透明的前板与井一起限定一个食品容纳腔。 一对支撑支架将商品采暖和控制装置定位在井上。 商品采暖控制装置具有加热室,该加热室将三个或更多个加热元件和三个或更多个照明元件定位在基本上在服务托盘的中心线上方,其中加热室包括三个或更多个循环风扇,用于将来自 加热室进入保持腔。 商品采暖控制装置还具有用于接收后通道门的上边缘并具有封闭的引导表面的固定支架。 另外,商品采暖控制装置具有位于保持支架上方的控制室,并且包含用于控制加热元件和照明元件的控制元件,并具有后控制面板,其中控制室包括用于冷却控制元件的冷却风扇和 多个通风口形成在控制面板中,用于将冷却空气从保持腔的外部抽吸到控制室中,并且用于将加热的空气排出到保持腔外部。 此外,商品采暖控制装置具有用于安装透明前板的上边缘的固定支架。 制造这种商品的方法允许它们在制造期间或在客户现场容易地重新配置。