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71. 发明授权

US06287488B1 Method for injection molding of high quality parts 失效
标题翻译：高品质零件注塑成型方法
公开(公告)号：US06287488B1
公开(公告)日：2001-09-11
申请号：US09240711
申请日：1999-02-02
申请人： Thomas J. Dougherty , Thomas C. Dougherty
发明人： Thomas J. Dougherty , Thomas C. Dougherty
IPC分类号： B29C4556
CPC分类号： B29C45/561 , B29C2045/567 , B29L2011/0016 , B29L2017/005
摘要： A method and apparatus for injection molding of high quality thermoplastic parts is such that a conventional movable mold half is mounted on a movable platen of the injection molding machine, and a special stationary mold half is mounted on the stationary platen. The stationary mold half includes a stationary plate secured to the stationary platen, with the stationary plate including stationary mold inserts. Each stationary mold insert has a stationary mold insert surface. An A-half parting line plate is movably attached to the stationary plate, with the A-half parting line plate being movable with respect to the stationary plate and the stationary mold inserts. A driving device, such as a hydraulic cylinder, is disposed between the stationary plate and the A-half parting line plate, with the driving device driving the A-half parting line plate toward and away from the stationary plate. A control circuit is provided for controlling the driving device to control a movement of the A-half parting line plate with respect to the stationary plate.
摘要翻译：用于注塑成型高品质热塑性部件的方法和装置是这样的：将传统的可移动半模安装在注射成型机的可移动压板上，并且在固定压板上安装特殊的固定半模。固定模具半部包括固定在固定压板上的固定板，固定板包括固定模具插入件。每个固定模具插入件具有固定的模具插入表面。一个半分割线板可移动地连接到固定板上，其中A半分割线板可相对于固定板和固定模具插入件移动。驱动装置如液压缸设置在固定板和A半分割线板之间，驱动装置驱动A-half分型线板朝向和远离固定板。提供控制电路用于控制驱动装置以控制半分离线板相对于固定板的移动。

72. 发明授权

US6076734A Methods and systems for providing human/computer interfaces 失效
公开(公告)号：US6076734A
公开(公告)日：2000-06-20
申请号：US948891
申请日：1997-10-10
申请人： Thomas J. Dougherty , S. Joy Mountford , Jesse L. Dorogusker , James H. Boyden , Philip A. van Allen , Daniel E. Cummings , Brygg A. Ullmer
发明人： Thomas J. Dougherty , S. Joy Mountford , Jesse L. Dorogusker , James H. Boyden , Philip A. van Allen , Daniel E. Cummings , Brygg A. Ullmer
IPC分类号： G06F17/30 , G06K7/00 , G06K7/12 , G06K19/06 , G06K7/10
CPC分类号： G06F17/30876 , G06K19/06037 , G06K7/0008 , G06K7/12 , G06K7/1443
摘要： The present invention teaches a variety of methods and systems for providing computer/human interfaces. According to one method, the user interfaces with an electronic device such as a computer system by engaging a sensor with desired regions of an encoded physical medium. The encoded physical medium is preferably chosen to provide intuitive meaning to the user, and is thus an improved metaphor for interfacing with the computer system. Suitable examples of the encoded physical medium include a data-linked book, magazine, globe, or article of clothing. Some or all of the selected regions have had certain information encoded therein, information suitable for interfacing and controlling the computer system. When the user engages the sensor with a region having certain encoded information, the certain encoded information is interpreted and an appropriate action taken. For example, the sensor or the computer system may provide suitable feedback to the user. The encoded physical medium may have text and/or graphic illustrations that draw the user in or provide meaningful clues or instructions perhaps related to the encoded information. The sensor may have at least one identification number (ID) providing information such as user identity, sensor type, access type, or language type. The sensor can transmit the certain decoded information together with the at least one ID to the computer system.

73. 发明授权

US5681668A Dual wall storage battery system having air passageways in the bottom of the battery 失效
标题翻译：双壁蓄电池系统在电池底部具有空气通道
公开(公告)号：US5681668A
公开(公告)日：1997-10-28
申请号：US466550
申请日：1995-06-06
申请人： Michael E. Reed , Thomas J. Dougherty , Mark S. Inkmann , Debra L. Smith , Michael T. Reher
发明人： Michael E. Reed , Thomas J. Dougherty , Mark S. Inkmann , Debra L. Smith , Michael T. Reher
IPC分类号： H01M2/02 , H01M2/10 , H01M10/50
CPC分类号： H01M2/1072 , H01M10/613 , H01M10/625 , H01M10/6562 , H01M10/6563 , H01M10/658
摘要： A battery shield for a storage battery includes first and second members which are dimensioned to fit around the battery, forming a shield structure, that is open at its top and encloses the battery on all four sides and on the bottom, forming a heat shield for protecting the battery from hot temperatures, the first and second members being hinged to a common base and are adapted to be pivoted about respective hinges outwardly away from another to an open position to facilitate installation of a battery in the shield and to then be moved upwardly and toward one another, in the manner of a "clamshell", to a closed position for enclosing the battery within the battery shield, the bottom of the storage battery having a plurality of transverse channels therein extending between opposing sides for permitting air flow around the bottom of the storage battery when the battery is enclosed within the battery shield.
摘要翻译：用于蓄电池的电池护罩包括第一和第二构件，第一和第二构件的尺寸适于围绕电池，形成屏蔽结构，该屏蔽结构在其顶部开口并且围绕所有四个侧面和底部封装电池，形成用于保护电池免受热的温度影响，第一和第二构件被铰接到共同的基座上并且适于围绕各自的铰链向外远离另一个枢转到打开位置，以便于将电池安装在屏蔽中并且然后向上移动并且以“蛤壳式”的方式朝向彼此相对于封闭位置以将电池封装在电池护罩内，蓄电池的底部具有多个横向通道，其在相对的两侧之间延伸以允许空气流动当电池被封闭在电池护罩内时，蓄电池的底部。

74. 发明授权

US5498710A Alkyl ether analogues of benzoporphyrin derivatives 失效
标题翻译：苯并卟啉衍生物的烷基醚类似物
公开(公告)号：US5498710A
公开(公告)日：1996-03-12
申请号：US231113
申请日：1994-04-22
申请人： Ravindra K. Pandey , Thomas J. Dougherty , Kevin M. Smith , Isabelle Meunier
发明人： Ravindra K. Pandey , Thomas J. Dougherty , Kevin M. Smith , Isabelle Meunier
IPC分类号： C07D487/22
CPC分类号： C07D487/22
摘要： Compounds having properties superior to known photosensitizers defined by the following chemical formula: ##STR1## including R groups R.sup.1, R.sup.2, R.sup.3, and R.sup.4, wherein R.sup.1 and R.sup.2 are methyl or --CH(O--(CH.sub.2).sub.n CH.sub.3)CH.sub.3 or are joined together to form the group D and wherein R.sup.3 and R.sup.4 are methyl or --CH(O--(CH.sub.2).sub.n CH.sub.3)CH.sub.3 or are joined together to form the group D; provided that one of R.sup.1 and R.sup.2 or R.sup.3 and R.sup.4 are joined together to form the group D wherein one of the remaining R groups is methyl and one of the remaining R groups is --CH(O--(CH.sub.2).sub.n CH.sub.3)CH.sub.3, where n is an integer of 5 through 7 and group D is: ##STR2## and R.sub.5 is independently at each occurrence --OR.sub.6 where R.sub.6 is lower alkyl of 1 through 7 carbon atoms or R.sub.6 is an amino acid residue.
摘要翻译：具有优于以下化学式定义的已知光敏剂的性质的化合物：包括R基团R 1，R 2，R 3和R 4的其中R 1和R 2是甲基或-CH（O-（CH 2）n CH 3）一起形成基团D，其中R 3和R 4是甲基或-CH（O-（CH 2）n CH 3）CH 3或连接在一起形成基团D; 条件是R 1和R 2或R 3和R 4中的一个连接在一起形成基团D，其中剩余的R基团之一是甲基，其余的R基团之一是-CH（O-（CH 2）n CH 3）CH 3，其中n 是5〜7的整数，D为：＆lt; IMAGE＆gt; R5各自独立地为-OR 6，其中R 6为1〜7个碳原子的低级烷基或者R6为氨基酸残基。

75. 发明授权

US5404129A Anti-theft battery system for vehicles 失效
标题翻译：汽车防盗电池系统
公开(公告)号：US5404129A
公开(公告)日：1995-04-04
申请号：US97795
申请日：1993-07-27
申请人： David J. Novak , Thomas J. Dougherty
发明人： David J. Novak , Thomas J. Dougherty
IPC分类号： B60R25/04 , H01M2/34
CPC分类号： B60R25/24 , B60R25/04 , B60R25/045 , H01M2/341
摘要： An anti-theft battery system for vehicles includes a control circuit which is connected in the starting circuit and responds to a starting current which exceeds a set point value to interrupt the starting circuit, thereby disconnecting the starter motor from the battery preventing starting of the vehicle, a reset circuit responsive to the control circuit which resets the control circuit after a delay interval to permit the starter motor to be connected to the vehicle battery, and an override circuit for generating an override signal for overriding the control circuit for a preselected interval of time to permit an authorized operator to start the vehicle, the override circuit including a small portable transmitter adapted to be carried by the vehicle operator and a receiver connected to the control circuit.
摘要翻译：用于车辆的防盗电池系统包括控制电路，该控制电路连接在启动电路中并且响应于超过设定值的起动电流以中断启动电路，从而将启动电动机与防止车辆启动的电池断开，响应于所述控制电路的复位电路，所述复位电路在延迟间隔之后复位所述控制电路以允许所述起动电动机连接到所述车辆电池;以及超控电路，用于产生用于超控所述控制电路的预置间隔的超控信号，允许授权操作员启动车辆的时间，该超驰电路包括适于由车辆操作员携带的小型便携式发射器和连接到控制电路的接收器。

76. 发明授权

US5149605A Dual lug battery plate construction 失效
标题翻译：双凸耳电池板结构
公开(公告)号：US5149605A
公开(公告)日：1992-09-22
申请号：US760930
申请日：1991-09-17
申请人： Thomas J. Dougherty
发明人： Thomas J. Dougherty
IPC分类号： H01M2/24 , H01M2/30
CPC分类号： H01M2/24 , H01M2/305
摘要： The present invention relates to a unique battery arrangement including battery plates having a pair of spaced apart battery lugs for both the positive and negative plates. While being spaced apart, the lugs are located generally adjacent one top edge of the plates; on opposite sides for the positive and negative plate constructions. The straps used to electrically connect the lugs are lower in height than those used on current battery designs, providing excellent current collection, efficient fusion with smaller lugs and resistance to vibration caused by separation of the lugs from the straps. The present invention also features plates having greater plate surface area, improved current carrying capability and reduced voltage drop. A weld element couples straps of like polarity, and in the preferred embodiment, at least a portion of the weld element is located intermediate the ends of the straps.
摘要翻译：本发明涉及一种独特的电池装置，其包括具有用于正极板和负极板的一对间隔开的电池接线片的电池板。在间隔开的同时，凸耳大致相邻于板的一个顶部边缘; 在正极和负极板结构的相对两侧。用于电连接凸耳的带子的高度低于当前电池设计中使用的带子，提供优异的电流收集，与较小的接线片的高效融合以及由凸耳与带子分离所产生的抵抗振动。本发明还具有具有更大的板表面积，改善的载流能力和降低的电压降的板。焊接元件连接相似极性的带，并且在优选实施例中，焊接元件的至少一部分位于带的端部之间。

77. 发明授权

US5028621A Drugs comprising porphyrins 失效
标题翻译：药物包括卟啉
公开(公告)号：US5028621A
公开(公告)日：1991-07-02
申请号：US352774
申请日：1989-05-16
申请人： Thomas J. Dougherty , William R. Potter , Kenneth R. Weishaupt
发明人： Thomas J. Dougherty , William R. Potter , Kenneth R. Weishaupt
IPC分类号： A61B5/00 , A61K31/40 , A61K41/00 , A61K49/00 , A61K51/00 , A61N5/06 , A61P35/00 , A61P43/00 , C07D487/22 , C07D519/00 , C09B47/00 , G02B6/04 , G02B6/26 , G02B6/42
CPC分类号： A61K31/40 , A61B5/411 , A61B5/416 , A61K41/0071 , A61N5/0601 , A61N5/062 , C07D519/00 , G02B6/262 , G02B6/4204 , A61B5/0071 , A61B5/0084 , G02B6/4298 , Y10S607/901
摘要： To obtain tumor-selective, photosensitizing drugs useful in the localization of neoplastic tissue and treatment of abnormal neoplastic tissue such as tumors, one of two methods is used. In the first method, a hydrolyzed mixture of the products of reaction of hematoporphyrin with acetic acid and sulfuric acid is cycled through a microporous membrane system to exclude low molecular weight products. In the second method, drugs are synthesized or derived from other pyrrole compounds. The drugs (1) include two covalently bound groups, each with four rings, some of which are pyrroles such as phlorins, porphyrins, chlorins, substituted pyrroles, substituted chlorins or substituted phlorins, each group being arranged in a ring structure, connected covalently to another group and have a triplet energy state above 37.5 kilocalories per mole; (2) are soluble in water, forming an aggregate of over 10,000 molecular weight in water and have an affinity for each other compared to serum protein such that 10 to 100 percent remain self aggregated in serum protein; and (3) are lipophyllic and able to disaggregate and attach to cell plasma, nuclear membrane, mitochondria, lysosomes and tissue. The drug obtained by the first method has an empirical formula of approximately C.sub.68 H.sub.70 N.sub.8 O.sub.11 or C.sub.68 H.sub.66 N.sub.8 O.sub.11 Na.sub.4. Neoplastic tissue retains the drug after it has cleared normal tissues and illumination results in necrosis. Moreover, other photosensitizing materials may be combined with a carrier that enters undesirable tissues and cells of the reticular endothelial system such as macrophages. These photosensitizing materials: (1) must have a triplet energy state above 3.5 kilocalories per mole; (2) cannot be easily oxidized; and (3) not physically quench any required energy state. Preferably, this photosensitizing material should be lipophlic.
摘要翻译：为了获得肿瘤选择性的光敏药物，可用于肿瘤组织的定位和治疗异常肿瘤组织如肿瘤，使用两种方法之一。在第一种方法中，血卟啉与乙酸和硫酸的反应产物的水解混合物循环通过微孔膜系统以排除低分子量产物。在第二种方法中，合成或衍生自其他吡咯化合物的药物。药物（1）包括两个共价结合的基团，每个具有四个环，其中一些是吡咯，例如卟啉，卟啉，二氢卟酚，取代的吡咯，取代的二氢卟酚或取代的藜芦烯，每个组排列成环结构，共价连接到另一组，三重态能量每摩尔高于37.5千卡; （2）可溶于水，与血清蛋白质相比，在水中形成了超过10,000分子量的聚集体，并且与血清蛋白质具有亲和力，使得10％至100％在血清蛋白中保持自我聚集; 和（3）是脂蛋白的并且能够解聚并附着于细胞血浆，核膜，线粒体，溶酶体和组织。通过第一种方法获得的药物具有约C68H70N8O11或C68H66N8O11Na4的经验式。肿瘤组织清除正常组织后保留药物，照明会导致坏死。此外，其它光敏材料可以与进入网状内皮系统的不希望的组织和细胞如巨噬细胞的载体组合。这些光敏材料：（1）必须具有每千克3.5千卡以上的三线态能量状态; （2）不易氧化; 和（3）不能物理地淬灭任何所需的能量状态。优选地，该光敏材料应该是脂肪族的。

78. 发明授权

US4976327A Battery module for the engine compartment of an automobile 失效
标题翻译：汽车发动机舱的电池模块
公开(公告)号：US4976327A
公开(公告)日：1990-12-11
申请号：US311149
申请日：1989-02-14
申请人： David N. Abujudom, II , Thomas J. Dougherty , Mark S. Inkmann , Richard T. Johnson , Neil C. Karolek , David W. Saari
发明人： David N. Abujudom, II , Thomas J. Dougherty , Mark S. Inkmann , Richard T. Johnson , Neil C. Karolek , David W. Saari
IPC分类号： B60K11/00 , B60R16/04
CPC分类号： B60K11/00 , B60R16/04
摘要： A battery module for insulating a battery from the heat of the engine of a motor vehicle, the module including a battery compartment, an air inlet and an air outlet, a first air flow path connecting the air inlet to the air outlet and a second air flow path around the outside of the battery compartment connecting the air inlet to the air outlet, a damper positioned in the housing for movement between a first position wherein the first air flow path is open and the second air flow path is closed and a second position wherein the first air flow path is closed and the second air flow path is open, a shape memory alloy member for moving the damper from the first position to the second position when the ambient temperature exceeds a predetermined minimum and a spring for biasing the damper to the first position when the ambient temperature is less than the predetermined temperature.
摘要翻译：一种用于将电池与机动车辆的发动机的热量隔离的电池模块，所述模块包括电池室，空气入口和空气出口，将空气入口连接到空气出口的第一空气流路和第二空气将空气入口连接到空气出口的电池室外部的流动路径，位于壳体中的阻尼器，用于在第一空气流动路径打开的第一位置与第二空气流动路径关闭的第一位置和第二位置之间移动; 其特征在于，第一空气流通路关闭并且第二空气流动路径打开;形状记忆合金构件，用于当环境温度超过预定最小值时将阻尼器从第一位置移动到第二位置;弹簧，用于将阻尼器偏压到当环境温度低于预定温度时的第一位置。

79. 发明授权

US4968715A Use of purified hematoporphyrin trimers in photodynamic therapy 失效
标题翻译：在光动力学治疗中使用纯化的血卟啉三聚体
公开(公告)号：US4968715A
公开(公告)日：1990-11-06
申请号：US343865
申请日：1989-04-26
申请人： Thomas J. Dougherty , Ravindra K. Pandey
发明人： Thomas J. Dougherty , Ravindra K. Pandey
IPC分类号： C07D487/22 , A61K31/40 , A61K39/44 , A61K41/00 , A61P35/00 , C07D519/00
CPC分类号： C07D519/00 , A61K31/40 , A61K41/0071
摘要： Pure dimer and trimer compounds of hematoporphyrin are prepared and shown to be effective agents in photodynamic therapy. The compounds of the invention are of the formula ##STR1## wherein each X is independently 1-hydroxyethyl or vinyl and wherein R is H or lower alkyl. The compounds of the invention can be conjugated to targeting substances such as immunoglobulins or to labels.
摘要翻译：制备血卟啉的纯二聚体和三聚体化合物，并显示为光动力学治疗中的有效试剂。本发明的化合物具有下式：其中每个X独立地为1-（4-羟基苯基）羟乙基或乙烯基，其中R为H或低级烷基。本发明的化合物可以与靶向物质例如免疫球蛋白缀合，或与标记缀合。

80. 发明授权

US4649151A Drugs comprising porphyrins 失效
标题翻译：药物包括卟啉
公开(公告)号：US4649151A
公开(公告)日：1987-03-10
申请号：US609991
申请日：1984-05-14
申请人： Thomas J. Dougherty , William R. Potter , Kenneth R. Weishaupt
发明人： Thomas J. Dougherty , William R. Potter , Kenneth R. Weishaupt
IPC分类号： A61B5/00 , A61K31/40 , A61K41/00 , A61K49/00 , A61K51/00 , A61N5/06 , A61P35/00 , A61P43/00 , C07D487/22 , C07D519/00 , C09B47/00 , G02B6/04 , G02B6/26 , G02B6/42
CPC分类号： A61K31/40 , A61B5/411 , A61B5/416 , A61K41/0071 , A61N5/0601 , A61N5/062 , C07D519/00 , G02B6/262 , G02B6/4204 , A61B5/0071 , A61B5/0084 , G02B6/4298 , Y10S607/901
摘要： To obtain tumor-selective, photosensitizing drugs useful in the localization of neoplastic tissue and treatment of abnormal neoplastic tissue such as tumors, one of two methods is used. In the first method, a hydrolyzed mixture of the products of reaction of hematoporphyrin with acetic acid and sulfuric acid is cycled through a microporous membrane system to exclude low molecular weight products. In the second method, drugs are synthesized or derived from other pyrrole compounds. The drugs: (1) include two covalently bound groups, each with four rings, some of which are pyrroles such as phlorins, porphyrins, chlorins, substituted pyrroles, substituted chlorins or substituted phlorins, each group being arranged in a ring structure, connected covalently to another group and have a triplet energy state above 37.5 kilocalories per mole; (2) are soluble in water, forming an aggregate of over 10,000 molecular weight in water and have an affinity for each other compared to serum protein such that 10 to 100 percent remain self aggregated in serum protein; and (3) are lipophyllic and able to disaggregate and attach to cell plasma, nuclear membrane, mitochondria, lysosomes and tissue. The drug obtained by the first method has an empirical formula of approximately C.sub.68 H.sub.70 N.sub.8 O.sub.11 or C.sub.68 H.sub.66 N.sub.8 O.sub.11 Na.sub.4.
摘要翻译：为了获得肿瘤选择性的光敏药物，可用于肿瘤组织的定位和治疗异常肿瘤组织如肿瘤，使用两种方法之一。在第一种方法中，血卟啉与乙酸和硫酸的反应产物的水解混合物循环通过微孔膜系统以排除低分子量产物。在第二种方法中，合成或衍生自其他吡咯化合物的药物。药物：（1）包括两个共价结合的基团，每个具有四个环，其中一些是吡咯，例如卟啉，卟啉，二氢卟酚，取代的吡咯，取代的二氢卟酚或取代的藜芦烯，每个组排列成环结构，共价连接到另一组，并具有高于每摩尔37.5千卡的三线态能量状态; （2）可溶于水，与血清蛋白质相比，在水中形成了超过10,000分子量的聚集体，并且与血清蛋白质具有亲和力，使得10％至100％在血清蛋白中保持自我聚集; 和（3）是脂蛋白的并且能够解聚并附着于细胞血浆，核膜，线粒体，溶酶体和组织。通过第一种方法获得的药物具有约C68H70N8O11或C68H66N8O11Na4的经验式。

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