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71. 发明申请

US20050009155A1 Polyhydroxyalkanoate synthase and gene encoding the same enzyme 失效
公开(公告)号：US20050009155A1
公开(公告)日：2005-01-13
申请号：US10914187
申请日：2004-08-10
申请人： Tetsuya Yano , Takeshi Imamura , Sakae Suda , Tsutomu Honma
发明人： Tetsuya Yano , Takeshi Imamura , Sakae Suda , Tsutomu Honma
IPC分类号： C12N1/21 , C12N9/10 , C12P7/62 , C07H21/04 , C12N9/04 , C12N9/18
CPC分类号： C12N9/1025 , C12P7/625
摘要： A novel polyhydroxyalkanoate (PHA) synthase derived from a microorganism capable of producing a PHA having a novel side-chain structure and a DNA encoding the amino acid sequence for the synthase are provided. Two PHA synthase proteins (SEQ ID NOs: 1 and 3) derived from Pseudomonas cichorii YN2 (FERM BP-7375) and PHA synthase genes encoding these PHA synthases are provided, respectively (SEQ ID NOs: 2 and 4). A recombinant microorganism is endowed with a PHA producing ability.

72. 发明授权

US06803220B2 Polyhydroxyalkanoate synthase and gene encoding the same enzyme 失效
标题翻译：聚羟基链烷酸酯合成酶和编码相同酶的基因
公开(公告)号：US06803220B2
公开(公告)日：2004-10-12
申请号：US10259632
申请日：2002-09-30
申请人： Tetsuya Yano , Takeshi Imamura , Sakae Suda , Tsutomu Honma
发明人： Tetsuya Yano , Takeshi Imamura , Sakae Suda , Tsutomu Honma
IPC分类号： C12N902
CPC分类号： C12P7/625 , C12N9/1025
摘要： A novel polyhydroxyalkanoate (PHA) synthase derived from a microorganism capable of producing a PHA having a novel side-chain structure and a DNA encoding the amino acid sequence for the synthase are provided. Two PHA synthase proteins (SEQ ID NOs. 1 and 3) derived from Pseudomonas cichorii H45 (FERM BP-7374) and PHA synthase genes encoding these PHA synthases are provided, respectively (SEQ ID NOs. 2 and 4). A recombinant microorganism is endowed with a PHA producing ability.
摘要翻译：提供了源自能够产生具有新型侧链结构的PHA的微生物和编码合成酶的氨基酸序列的DNA的新型聚羟基链烷酸酯（PHA）合酶。分别提供了两种衍生自Cseudomonas cichorii H45（FERM BP-7374）的PHA合成酶蛋白（SEQ ID NO.1和3）和编码这些PHA合成酶的PHA合酶基因（SEQ ID NO.2和4）。重组微生物具有PHA产生能力。

73. 发明授权

US06803219B2 Polyhydroxyalkanoate synthase and gene encoding the same enzyme 失效
标题翻译：聚羟基链烷酸酯合成酶和编码相同酶的基因
公开(公告)号：US06803219B2
公开(公告)日：2004-10-12
申请号：US10253509
申请日：2002-09-25
申请人： Tetsuya Yano , Takeshi Imamura , Sakae Suda , Tsutomu Honma
发明人： Tetsuya Yano , Takeshi Imamura , Sakae Suda , Tsutomu Honma
IPC分类号： C12N902
CPC分类号： C12N9/1025 , C12P7/625
摘要： A novel polyhydroxyalkanoate (PHA) synthase derived from a microorganism capable of producing a PHA having a novel side-chain structure and a DNA encoding the amino acid sequence for the synthase are provided. Two PHA synthase proteins (SEQ ID NOs. 1 and 3) derived from Pseudomonas cichorii YN2 (FERM BP-7375) and PHA synthase genes encoding these PHA synthases are provided, respectively (SEQ ID NOs. 2 and 4). A recombinant microorganism is endowed with a PHA producing ability.
摘要翻译：提供了源自能够产生具有新型侧链结构的PHA的微生物和编码合成酶的氨基酸序列的DNA的新型聚羟基链烷酸酯（PHA）合酶。分别提供了两种衍生自奇异假单胞菌YN2（FERM BP-7375）的PHA合成酶蛋白（SEQ ID NO.1和3）和编码这些PHA合成酶的PHA合酶基因（SEQ ID NO.2和4）。重组微生物具有PHA产生能力。

74. 发明授权

US06485951B2 Polyhydroxyalkanoate synthase and gene encoding the same enzyme 失效
标题翻译：聚羟基链烷酸酯合成酶和编码相同酶的基因
公开(公告)号：US06485951B2
公开(公告)日：2002-11-26
申请号：US09821016
申请日：2001-03-30
申请人： Tetsuya Yano , Takeshi Imamura , Sakae Suda , Tsutomu Honma
发明人： Tetsuya Yano , Takeshi Imamura , Sakae Suda , Tsutomu Honma
IPC分类号： C12N904
CPC分类号： C12N9/1025 , C12P7/625
摘要： A novel polyhydroxyalkanoate (PHA) synthase derived from a microorganism capable of producing a PHA having a novel side-chain structure and a DNA encoding the amino acid sequence for the synthase are provided. Two PHA synthase proteins (SEQ ID Nos. 1 and 3) derived from Pseudomonas jessenii P161 (FERM BP-7376) and PHA synthase genes encoding these PHA synthases are provided, respectively (SEQ ID Nos. 2 and 4). A recombinant microorganism is endowed with a PHA producing ability.
摘要翻译：提供了源自能够产生具有新型侧链结构的PHA的微生物和编码合成酶的氨基酸序列的DNA的新型聚羟基链烷酸酯（PHA）合酶。分别提供了两种衍生自琼脂糖假单胞菌P161（FERM BP-7376）的PHA合酶蛋白（SEQ ID No.1和3）和编码这些PHA合成酶的PHA合酶基因（SEQ ID No.2和4）。重组微生物具有PHA产生能力。

75. 发明申请

US20110294987A1 COMPOSITE PARTICLE, CONTRAST AGENT FOR PHOTOACOUSTIC IMAGING, AND METHOD FOR PRODUCING THE COMPOSITE PARTICLE 失效
标题翻译：复合颗粒，用于光电成像的对比剂，以及用于生产复合颗粒的方法
公开(公告)号：US20110294987A1
公开(公告)日：2011-12-01
申请号：US13115276
申请日：2011-05-25
申请人： Kengo Kanazaki , Tsutomu Honma , Fumio Yamauchi , Satoshi Ogawa , Sachiko Inoue
发明人： Kengo Kanazaki , Tsutomu Honma , Fumio Yamauchi , Satoshi Ogawa , Sachiko Inoue
IPC分类号： C07K17/00
CPC分类号： C07K17/08 , C07K17/14 , G01N33/533 , G01N33/54313
摘要： The present invention provides a composite particle having a high molar absorption coefficient for detection with higher detection sensitivity in photoacoustic imaging. In the present invention, a composite particle having a particle, a single-chain antibody which includes an antigen recognition region and a region other than the antigen recognition region and which is conjugated with the particle, and an organic dye conjugated with the single-chain antibody, in which the region other than the antigen recognition region of the single-chain antibody has thiol group, and a functional group of the particle is bound to the thiol group, is provided.
摘要翻译：本发明提供一种具有高摩尔吸光系数的复合颗粒，用于检测光电成像中较高的检测灵敏度。在本发明中，具有包含抗原识别区域和抗原识别区域以外的区域的粒子，单链抗体与该颗粒结合的复合粒子和与单链结合的有机染料抗体，其中除了单链抗体的抗原识别区域以外的区域具有硫醇基，并且该颗粒的官能团与硫醇基团结合。

76. 发明授权

US6080249A Method for adhering a member and apparatus for adhering a member 失效
标题翻译：用于粘附构件的方法和用于粘附构件的装置
公开(公告)号：US6080249A
公开(公告)日：2000-06-27
申请号：US990934
申请日：1997-12-15
申请人： Tsutomu Honma , Yoshiaki Yanagida
发明人： Tsutomu Honma , Yoshiaki Yanagida
IPC分类号： B05D1/26 , B05C5/00 , B05C5/02 , B05C11/00 , G11B5/187 , G11B5/31 , G11B5/39 , H05K13/04 , B32B31/00 , B05B5/00 , B05C1/00 , G11B5/127
CPC分类号： B05C5/02 , B24B37/04 , G11B5/1871 , G11B5/3103 , B05C5/0216 , G11B5/3116 , G11B5/3163 , G11B5/3967 , Y10T156/1798 , Y10T29/49027 , Y10T29/49032 , Y10T29/4905 , Y10T29/49055 , Y10T29/49059
摘要： A method for adhering a member and an apparatus for adhering the member to a base is useful for preventing warping of the member and non-uniformity of the strength of adhesion. After the adhesive application unit is positioned at a first position at a fixed distance from an initial application position of the base, movement of the unit is started from the first position with the moving unit while the action of discharging adhesive of the application unit is started. Next, the action of discharging adhesive of the application unit is completed at the final application position of the base and the movement is stopped at a second position at a fixed distance from the final application position of the base. This results in movement of the application unit at a constant speed from the initial application position to the final application position of the block. Therefore, non-uniformity of the adhesive layer at the initial application position and the final application position of the block can be prevented.
摘要翻译：用于将构件和用于将构件粘附到基座的装置的方法可用于防止构件的翘曲和粘合强度的不均匀性。在粘合剂施加单元位于与基座的初始施加位置相距一定距离的第一位置处，当施加单元的粘合剂的排出作用开始时，单元的移动从具有移动单元的第一位置开始。接下来，在基座的最终施加位置处完成排出施加单元的粘合剂的动作，并且在与基座的最终施加位置固定的距离处的移动停止在第二位置。这导致应用单元从初始应用位置到块的最终应用位置的恒定速度移动。因此，可以防止在初始施加位置处的粘合剂层的不均匀性和块的最终施加位置。

77. 发明申请

US20080057561A1 CELL CULTURE TREATMENT APPARATUS AND CELL CULTURE TREATMENT METHOD 审中-公开
标题翻译：细胞培养装置和细胞培养处理方法
公开(公告)号：US20080057561A1
公开(公告)日：2008-03-06
申请号：US11843564
申请日：2007-08-22
申请人： Atsushi Takahashi , Tsutomu Honma , Takahisa Ibii
发明人： Atsushi Takahashi , Tsutomu Honma , Takahisa Ibii
IPC分类号： C12N1/00 , C12M1/12
CPC分类号： C12M23/12 , C12M23/38 , C12M25/04
摘要： The present invention provides a cell culture treatment device for culturing, treating and collecting cells, which includes a flow path, a cell-retaining section, a solution inlet, a solution outlet, a cell collection port and a lid. The present invention also provides an device for easily, efficiently separating and collecting the cells thereby in a short period of time, and provides a method therefor.
摘要翻译：本发明提供一种培养，处理和收集细胞的细胞培养处理装置，其包括流路，细胞保持部，溶液入口，溶液出口，细胞收集口和盖。本发明还提供了一种用于在短时间内容易地，有效地分离和收集电池的装置，并提供了一种方法。

78. 发明授权

US4050605A Panel assembled tank 失效
标题翻译：面板组装槽
公开(公告)号：US4050605A
公开(公告)日：1977-09-27
申请号：US690819
申请日：1976-05-27
申请人： Hiroshi Wakana , Isamu Harada , Tsutomu Honma
发明人： Hiroshi Wakana , Isamu Harada , Tsutomu Honma
IPC分类号： B65D90/02 , B65D90/08 , F16S1/10 , B65D7/24 , B65D7/46
CPC分类号： B65D90/023 , B65D90/08
摘要： A high pressure resistant and water tight panel assembled tank consisting of unit panels, each unit panel is formed with a protrusion portion in the form of a pyramid or truncated pyramid progressively increasing its height toward a center of the square wall surface of the panel and has securing flanges at the peripheries of the panel. The unit panels consist of (a) bottom wall panels of which securing flanges are folded in a direction opposite to the extending direction of the protrusion portion and (b) side wall panels of which securing flanges are folded in a direction the same as that of the protrusion portion and having partially thicker portions, and the securing flanges of the wall panels embracing sealing seats therebetween are clamped together outside of the tank to form the assembled tank. Assembled tie rods and panels for mounting supply and drain pipings are incorporated in the tank to improve the pressure resistance of the tank and to facilitate assembling, settling, piping and cleaning of the tank.
摘要翻译：由单元面板组成的高耐压防水面板组装槽，每个单元面板形成有金字塔形或截顶棱锥形状的突出部分，逐渐增加其朝向面板方形壁表面中心的高度，并具有固定法兰在面板的周边。单元面板包括（a）底壁板，其固定凸缘在与突出部分的延伸方向相反的方向上折叠，并且（b）侧壁板的固定凸缘沿着与突出部分并且具有部分较厚的部分，并且包围其间的密封座的壁板的固定凸缘被夹在一起在罐外面以形成组装的罐。用于安装供水管和排水管的组合式拉杆和板被并入罐中，以改善罐的耐压性，并且便于罐的组装，沉降，管道和清洁。

79. 发明申请

US20080314197A1 SCREW TIGHTENING APPARATUS 审中-公开
标题翻译：螺丝紧固装置
公开(公告)号：US20080314197A1
公开(公告)日：2008-12-25
申请号：US12202695
申请日：2008-09-02
申请人： Tsutomu Honma
发明人： Tsutomu Honma
IPC分类号： B23Q16/00
CPC分类号： B23P19/066 , B25B21/00 , B25B23/08 , B25B23/14 , B25B23/147 , G01L5/24 , Y10T74/1412
摘要： A screw tightening apparatus includes a sleeve that surrounds a leading end of the bit; and a first adjustment member and a second adjustment member that adjust a position of a tip end of the sleeve with respect to the leading end of the bit in an axial direction of the sleeve and the bit. When the first and second adjustment members are operated by a same amount, an adjusted amount of the position of the tip end of the sleeve by the second adjustment member is smaller than an adjusted amount of the position of the tip end of the sleeve by the first adjustment member. The screw tightening apparatus is capable of easily and highly precisely adjusting (setting) a protruding amount of the leading end of the bit from the tip end of the sleeve.
摘要翻译：螺钉紧固装置包括围绕钻头的前端的套筒; 以及第一调节构件和第二调节构件，其在套筒和钻头的轴向方向上调节套筒的顶端相对于钻头的前端的位置。当第一调节构件和第二调节构件以相同的量操作时，通过第二调节构件的套筒的前端的位置的调整量小于套筒的顶端的位置的调整量第一调整成员。螺杆紧固装置能够从套筒的前端容易且高精度地调整（设定）钻头前端的突出量。

80. 发明申请

US20080227664A1 CELL ARRAY STRUCTURAL BODY AND CELL ARRAY 审中-公开
标题翻译：细胞阵列结构体和细胞阵列
公开(公告)号：US20080227664A1
公开(公告)日：2008-09-18
申请号：US12038304
申请日：2008-02-27
申请人： Tsutomu Honma , Atsushi Takahashi , Takahisa Ibii
发明人： Tsutomu Honma , Atsushi Takahashi , Takahisa Ibii
IPC分类号： C40B60/12
CPC分类号： C40B60/12 , C12M23/12 , C12M41/12 , C40B40/02
摘要： The present invention provides a cell array structural body containing a substrate, a plurality of micropores piercing the substrate from one surface to another surface, through which a sample cell can pass, and a capture/release unit for the sample cell on a wall surface of each micropore, as well as a cell array with such structural body detachably immobilizing sample cells in its micropores. In using the cell array structural body and the cell array for drug evaluations or the like, handling of a culture medium or a drug solution, or washing procedure is easy, and harvest of a desired cell from the cell array is easy and trustworthy.
摘要翻译：本发明提供了一种电池阵列结构体，其包含基板，多个微孔，从一个表面穿透基板至另一个表面，样品池可以通过该多个微孔，以及用于样品池的捕获/释放单元每个微孔，以及具有这种结构体的电池阵列，其可拆卸地将样品池固定在其微孔中。在使用细胞阵列结构体和细胞阵列进行药物评价等时，容易地处理培养基或药物溶液或洗涤程序，并且从细胞阵列收集所需细胞容易且值得信赖。

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