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71. 发明授权

US09265774B2 Methods, compounds and pharmaceutical compositions for treating anxiety and mood disorders 有权
标题翻译：用于治疗焦虑和情绪障碍的方法，化合物和药物组合物
公开(公告)号：US09265774B2
公开(公告)日：2016-02-23
申请号：US14112016
申请日：2012-04-13
申请人： Eric A. Stone , Lin Yan , David Quartermain , Yasmeen Sarfraz
发明人： Eric A. Stone , Lin Yan , David Quartermain , Yasmeen Sarfraz
IPC分类号： A61K31/573 , A61K31/24 , A61K31/35 , A61K31/13 , A61K31/137 , A61K31/138 , A61K45/06 , A61K31/135
CPC分类号： A61K31/573 , A61K31/13 , A61K31/135 , A61K31/137 , A61K31/138 , A61K31/24 , A61K45/06 , A61K2300/00
摘要： Pharmaceutical compositions containing a cocktail of inhibitors of central stress nuclei are provided. The pharmaceutical compositions are useful for the prevention and treatment of a variety of conditions in mammals including humans, including anxiety and mood disorders such as depression.
摘要翻译：提供含有中枢应激核的抑制剂混合物的药物组合物。药物组合物可用于预防和治疗包括人在内的哺乳动物中的各种病症，包括焦虑和情绪障碍如抑郁症。

72. 发明申请

US20130289003A1 DIAZENIUMDIOLATE HETEROCYCLIC DERIVATIVES 有权
标题翻译：二氮杂环戊烷杂环衍生物
公开(公告)号：US20130289003A1
公开(公告)日：2013-10-31
申请号：US13881929
申请日：2011-10-25
申请人： Amjad Ali , Michael Man-Chu Lo , Robert K. Baker , Zhiqiang Guo , Brent Whitehead , Timothy J. Henderson , Edward Metzger , Lin Yan , Shrenik K. Shah , James Dellureficio , Jun Wang
发明人： Amjad Ali , Michael Man-Chu Lo , Robert K. Baker , Zhiqiang Guo , Brent Whitehead , Timothy J. Henderson , Edward Metzger , Lin Yan , Shrenik K. Shah , James Dellureficio , Jun Wang
IPC分类号： C07D207/12 , C07D205/04 , C07D413/10 , C07D403/10 , C07D307/20 , C07D309/12 , C07D211/44 , C07D401/04
CPC分类号： C07D211/44 , A61K31/655 , C07D205/04 , C07D207/12 , C07D207/16 , C07D207/273 , C07D307/20 , C07D309/12 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/10 , C07D413/04 , C07D413/10 , C07D417/04
摘要： A compound having the structure: useful for treating hypertension, Pulmonary Arterial Hypertension (PAH), congestive heart failure, conditions resulting from excessive water retention, cardiovascular disease, diabetes, oxidative stress, endothelial dysfunction, cirrhosis, pre-eclampsia, osteoporosis or nephropathy.
摘要翻译：具有以下结构的化合物：用于治疗高血压，肺动脉高压（PAH），充血性心力衰竭，由过度保水引起的病症，心血管疾病，糖尿病，氧化应激，内皮功能障碍，肝硬化，先兆子痫，骨质疏松症或肾病。

73. 发明授权

US08361994B2 Primary amine diazeniumdiolate heterocyclic derivatives 有权
标题翻译：伯胺二氮烯鎓二醇杂环衍生物
公开(公告)号：US08361994B2
公开(公告)日：2013-01-29
申请号：US13412032
申请日：2012-03-05
申请人： Amjad Ali , Michael Man-Chu Lo , Zhiqiang Guo , Brent Whitehead , Timothy J. Henderson , Lin Yan , Shrenik K. Shah
发明人： Amjad Ali , Michael Man-Chu Lo , Zhiqiang Guo , Brent Whitehead , Timothy J. Henderson , Lin Yan , Shrenik K. Shah
IPC分类号： C07D205/04 , C07D207/12 , C07D211/44 , C07D309/10 , C07D401/02 , C07D401/04 , C07D401/14 , C07D403/02 , A61K31/655 , A61P9/12
CPC分类号： C07D211/46 , C07D207/12 , C07D207/273 , C07D207/48 , C07D211/96 , C07D223/08 , C07D309/12 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/12
摘要： A compound having the structure useful for treating hypertension, Pulmonary Arterial Hypertension (PAH), congestive heart failure, conditions resulting from excessive water retention, cardiovascular disease, diabetes, oxidative stress, endothelial dysfunction, cirrhosis, pre-eclampsia, osteoporosis or nephropathy.
摘要翻译：具有用于治疗高血压，肺动脉高压（PAH），充血性心力衰竭，由过度保水引起的病症，心血管疾病，糖尿病，氧化应激，内皮功能障碍，肝硬化，先兆子痫，骨质疏松症或肾病的结构的化合物。

74. 发明申请

US20090312307A1 HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION 审中-公开
标题翻译：钾离子通道功能的杂环抑制剂
公开(公告)号：US20090312307A1
公开(公告)日：2009-12-17
申请号：US12538955
申请日：2009-08-11
申请人： John Lloyd , Yoon T. Jeon , Heather Finlay , Lin Yan , Michael F. Gross , Serge Beaudoin
发明人： John Lloyd , Yoon T. Jeon , Heather Finlay , Lin Yan , Michael F. Gross , Serge Beaudoin
IPC分类号： A61K31/55 , C07D409/04 , A61K31/4535 , A61K31/497 , C07D401/06 , A61K31/4725 , C07D401/12 , A61P9/00
CPC分类号： C07D211/26 , C07D211/34 , C07D211/62 , C07D211/64 , C07D211/96 , C07D223/04 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Novel heterocyclo compounds useful as inhibitors of potassium channel function (especially inhibitors of the Kv1 subfamily of voltage gated K+ channels, especially inhibitors Kv1.5 which has been linked to the ultra-rapidly activating delayed rectifier K+ current IKur), methods of using such compounds in the prevention and treatment of arrhythmia and IKur-associated conditions, and pharmaceutical compositions containing such compounds.
摘要翻译：可用作钾通道功能抑制剂的新型杂环化合物（特别是电压门控K +通道的Kv1亚族抑制剂，特别是与超快速活化延迟整流剂K +当前IKur连接的抑制剂Kv1.5），使用这些化合物的方法在预防和治疗心律失常和IKur相关病症中，以及含有这些化合物的药物组合物。

75. 发明授权

US07494714B2 Surfaces that resist the adsorption of biological species 有权
公开(公告)号：US07494714B2
公开(公告)日：2009-02-24
申请号：US11825998
申请日：2007-07-09
申请人： Robert G. Chapman , Emanuele Ostuni , Michael N. Liang , Lin Yan , George M. Whitesides
发明人： Robert G. Chapman , Emanuele Ostuni , Michael N. Liang , Lin Yan , George M. Whitesides
IPC分类号： B32B9/04
CPC分类号： B82Y30/00 , A61L15/42 , A61L27/34 , A61L27/50 , A61L31/10 , B32B27/06 , B82Y5/00 , Y10T428/26 , Y10T428/265 , Y10T428/268 , Y10T428/269 , Y10T428/31504 , Y10T428/31678 , Y10T428/31681 , Y10T428/31725 , Y10T428/31855
摘要： The present invention provides articles resistant to the adsorption of proteins, cells and bacteria. The articles can either have a chemical chain bonded thereon where the chemical chain can comprise a terminal group free of a hydrogen bond donor or where a hydrogen bond donor is sufficiently buried such that an exposed surface of the article including the chemical chain is free of a hydrogen bond donor. The chemical chain, or plurality of chemical chains, can comprise a monolayer such as a self-assembled monolayer (SAM) which can be homogeneous (one type of SAM) or mixed, i.e. or more different types of SAMs. Other more specific examples of chemical chains are provided. The plurality of chemical chains can comprise a polymer such as a polyamine. In many aspects, the plurality of chemical chains is sufficiently free of cross-linking or branching. The present invention also provides an article capable of specific binding of a desired biomolecule while preventing non-specific binding of biomolecules.

76. 发明申请

US20090042954A1 2-(Aryl)Azacyclylmethyl Carboxylates, Sulfonates, Phosphonates, Phosphinates and Heterocycles as S1p Receptor Antagonists 失效
标题翻译：作为S1p受体拮抗剂的2-（芳基）氮杂环丙基甲基羧酸盐，磺酸盐，膦酸盐，磷酸盐和杂环
公开(公告)号：US20090042954A1
公开(公告)日：2009-02-12
申请号：US11665046
申请日：2005-10-18
申请人： Jeffrey John Hale , Lin Yan
发明人： Jeffrey John Hale , Lin Yan
IPC分类号： A61K31/4245 , C07D413/10 , A61P11/00 , A61P37/06
CPC分类号： C07D413/10 , C07D413/14
摘要： The present invention encompasses compounds of Formula I: as well as the pharmaceutically acceptable salts thereof. The compounds are S1P1/Edg1 receptor agonists and thus have immunosuppressive, anti-inflammatory and hemostatic activities by modulating leukocyte trafficking, sequestering lymphocytes in secondary lymphoid tissues, and enhancing vascular integrity. The invention is also directed to pharmaceutical compositions containing such compounds and methods of treatment or prevention.
摘要翻译：本发明包括式I的化合物及其药学上可接受的盐。化合物是S1P1 / Edg1受体激动剂，因此通过调节白细胞运输，隔离淋巴细胞在次级淋巴组织中并增强血管完整性具有免疫抑制，抗炎和止血活性。本发明还涉及含有这些化合物和治疗或预防方法的药物组合物。

77. 发明申请

US20070264505A1 Surfaces that resist the adsorption of biological species 有权
公开(公告)号：US20070264505A1
公开(公告)日：2007-11-15
申请号：US11825998
申请日：2007-07-09
申请人： Robert Chapman , Emanuele Ostuni , Michael Liang , Lin Yan , George Whitesides
发明人： Robert Chapman , Emanuele Ostuni , Michael Liang , Lin Yan , George Whitesides
IPC分类号： B32B9/04
CPC分类号： B82Y30/00 , A61L15/42 , A61L27/34 , A61L27/50 , A61L31/10 , B32B27/06 , B82Y5/00 , Y10T428/26 , Y10T428/265 , Y10T428/268 , Y10T428/269 , Y10T428/31504 , Y10T428/31678 , Y10T428/31681 , Y10T428/31725 , Y10T428/31855
摘要： The present invention provides articles resistant to the adsorption of proteins, cells and bacteria. The articles can either have a chemical chain bonded thereon where the chemical chain can comprise a terminal group free of a hydrogen bond donor or where a hydrogen bond donor is sufficiently buried such that an exposed surface of the article including the chemical chain is free of a hydrogen bond donor. The chemical chain, or plurality of chemical chains, can comprise a monolayer such as a self-assembled monolayer (SAM) which can be homogeneous (one type of SAM) or mixed, i.e. or more different types of SAMs. Other more specific examples of chemical chains are provided. The plurality of chemical chains can comprise a polymer such as a polyamine. In many aspects, the plurality of chemical chains is sufficiently free of cross-linking or branching. The present invention also provides an article capable of specific binding of a desired biomolecule while preventing non-specific binding of biomolecules.

78. 发明申请

US20060019309A1 Self-assembling peptide surfaces for cell patterning and interactions 审中-公开
公开(公告)号：US20060019309A1
公开(公告)日：2006-01-26
申请号：US11068936
申请日：2005-02-28
申请人： Shuguang Zhang , Alexander Rich , Lin Yan , George Whitesides
发明人： Shuguang Zhang , Alexander Rich , Lin Yan , George Whitesides
IPC分类号： C40B20/02 , C12M1/34
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00382 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00626 , B01J2219/0063 , B01J2219/00635 , B01J2219/00637 , B01J2219/00659 , B01J2219/00725 , B01J2219/00743 , B82Y5/00 , B82Y10/00 , B82Y40/00 , C07K2/00 , C07K7/08 , C07K17/14 , C12N5/0068 , C12N2535/10 , C40B40/10 , C40B60/14 , G01N33/54353 , G01N2610/00 , G03F7/0002 , G03F7/165
摘要： This invention describes self assembled monolayers (SAMs) manufactured by imprinting reactive peptides onto solid supports. The invention further relates to methods of preparing and using these improved SAMs.

79. 发明授权

US06828777B2 Fixture for test cards of testing machine 失效
标题翻译：测试机测试夹具
公开(公告)号：US06828777B2
公开(公告)日：2004-12-07
申请号：US10634569
申请日：2003-08-04
申请人： Chun-Nan Ou , Tai Ping Zhou , Lin Yan , Ga Lei Hu , Yao Qing Zhao
发明人： Chun-Nan Ou , Tai Ping Zhou , Lin Yan , Ga Lei Hu , Yao Qing Zhao
IPC分类号： G01R104
CPC分类号： G01R31/2808
摘要： A fixture for test cards of testing machine includes an actuator (1), a self-adjusting unit (3), and a testing unit (5). The self-adjusting unit includes a first connecting plate (30) and a second connecting plate (32). The first connecting plate is attached to the actuator. A first through hole (301) is defined in each corner of the first connecting plate. A second through hole (321) is defined in each corner of the second connecting plate. A plurality of coil springs (36) is received in the first and second through holes respectively. A plurality of bolts (34) is extended through the second through holes and the coil springs, and engages in the first through holes respectively. The bolts are movable relative to the second connecting plate. The testing unit is attached to the second connecting plate, and adapted for receiving test cards (90).
摘要翻译：用于测试机的测试卡的夹具包括致动器（1），自动调节单元（3）和测试单元（5）。自调整单元包括第一连接板（30）和第二连接板（32）。第一连接板连接到致动器。在第一连接板的每个角部限定第一通孔（301）。在第二连接板的每个角部限定第二通孔（321）。多个螺旋弹簧（36）分别容纳在第一和第二通孔中。多个螺栓（34）延伸穿过第二通孔和螺旋弹簧，分别接合在第一通孔中。螺栓可相对于第二连接板移动。测试单元附接到第二连接板，并适于接收测试卡（90）。

80. 发明授权

US06368877B1 Self-assembling peptide surfaces for cell patterning and interactions 失效
标题翻译：自组装肽表面用于细胞图案化和相互作用
公开(公告)号：US06368877B1
公开(公告)日：2002-04-09
申请号：US08882415
申请日：1997-06-25
申请人： Shuguang Zhang , Alexander Rich , Lin Yan , George Whitesides
发明人： Shuguang Zhang , Alexander Rich , Lin Yan , George Whitesides
IPC分类号： G01N33552
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00382 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00626 , B01J2219/0063 , B01J2219/00635 , B01J2219/00637 , B01J2219/00659 , B01J2219/00725 , B01J2219/00743 , B82Y5/00 , B82Y10/00 , B82Y40/00 , C07K2/00 , C07K7/08 , C07K17/14 , C12N5/0068 , C12N2535/10 , C40B40/10 , C40B60/14 , G01N33/54353 , G01N2610/00 , G03F7/0002 , G03F7/165
摘要： This invention describes self assembled monolayers (SAMs) manufactured by imprinting reactive peptides onto solid supports. The invention further relates to methods of preparing and using these improved SAMs.
摘要翻译：本发明描述了通过将反应性肽印迹到固体支持物上制造的自组装单层（SAM）。本发明还涉及制备和使用这些改进的SAM的方法。

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