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    • 73. 发明授权
    • Transdermal therapeutic formulation and a method of administration
thereof
    • 透皮治疗剂型及其施用方法
    • US5744162A
    • 1998-04-28
    • US929044
    • 1992-08-13
    • Hideaki OkabeIchiro TsuchidaTakanori Saito
    • Hideaki OkabeIchiro TsuchidaTakanori Saito
    • A61K9/70A61K47/32A61K9/14
    • A61K9/7061A61K47/32
    • A transdermal therapeutic formulation is made of a composition comprising a polymer and ingredients mixed with the polymer which are a pharmacologically active substance, an alcohol, a percutaneous absorption promoter utilized according to necessity and water utilized according to necessity. The polymer comprises lipophilic monomer units and hydrophilic monomer units in a specific ratio. The alcohol, the percutaneous absorption promoter and water are mixed with the polymer in specific amounts. The transdermal therapeutic formulation has excellent percutaneous absorption, has many kinds of applicable pharmacologically active substances, shows good stability of percutaneous absorption with time because of absence of crystallization of the pharmacologically active substance, has good adhesive strength and thus favorably utilized as transdermal therapeutic plaster.
    • 透皮治疗制剂由包含聚合物和与聚合物混合的成分组成的组合物制成,所述组合物是药理活性物质,醇,根据需要使用的经皮吸收促进剂和根据需要使用的水。 聚合物包含亲脂性单体单元和具有特定比例的亲水性单体单元。 将醇,经皮吸收促进剂和水与特定量的聚合物混合。 透皮治疗剂具有优异的经皮吸收性,具有多种适用的药理活性物质,由于不存在药理活性物质的结晶,显示出良好的经皮吸收稳定性,具有良好的粘合强度,因此有利地用作透皮治疗膏药。
    • 74. 发明授权
    • Composite body having a blister-free pressure-sensitive adhesive sheet
attached thereto
    • 具有附着于其上的无水泡粘合片的复合体
    • US5229195A
    • 1993-07-20
    • US899048
    • 1992-06-16
    • Shigenobu MaruokaIchiro TsuchidaTakanori Saito
    • Shigenobu MaruokaIchiro TsuchidaTakanori Saito
    • C09J7/02C09J133/08C09J155/00
    • C09J133/08C09J155/005C09J7/0217C09J2201/606Y10T428/2887Y10T428/31507Y10T428/31928Y10T428/31935
    • The pressure-sensitive adhesive sheet of the invention is free from the troubles of forming blisters due to the gas emission from the substrate surface to which the adhesive sheet is applied and bonded by using a unique pressure-sensitive adhesive to form the adhesive layer on a base sheet. The principal ingredient of the pressure-sensitive adhesive used in the present invention is a copolymer having a specified molecular weight and a specified glass transition temperature and composed of (a) from 50 to 85% by weight of a first monomeric moiety of an acrylic ester, e.g., 2-ethylhexyl acrylate, (b) from 1 to 30% by weight of a second monomeric moiety of an acrylic compound having a polar group, e.g., acrylic acid, and (c) from 5 to 40% by weight of a third monomeric moiety of a macromonomer having a polymeric molecular chain of styrene units and/or methyl methacrylate units and having a polymerizable functional group, e.g., methacryloyl group, at the molecular chain end.
    • 本发明的压敏粘合片由于通过使用独特的压敏粘合剂在粘合剂层的基材表面上产生气泡而形成泡罩而形成粘合剂层,因此不存在 基板。 本发明中使用的压敏粘合剂的主要成分是具有特定分子量和规定的玻璃化转变温度的共聚物,由(a)50-85重量%的丙烯酸酯的第一单体部分 ,例如丙烯酸2-乙基己酯,(b)1至30重量%的具有极性基团的丙烯酸化合物(例如丙烯酸)的第二单体部分,和(c)5-40重量% 在分子链末端具有苯乙烯单元和/或甲基丙烯酸甲酯单元的聚合物分子链和具有可聚合官能团例如甲基丙烯酰基的大分子单体的第三单体部分。