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71. 发明申请

US20120129675A1 CENTRIFUGE 有权
公开(公告)号：US20120129675A1
公开(公告)日：2012-05-24
申请号：US13209226
申请日：2011-08-12
申请人： John E. Nash , William T. Fisher
发明人： John E. Nash , William T. Fisher
IPC分类号： B04B1/06 , B04B7/08 , B01D21/26 , B04B7/16 , B04B11/05 , B04B11/00 , B04B15/00 , B04B7/12
CPC分类号： B04B5/0442 , A61M1/3693 , A61M1/3696 , B01D21/245 , B01D21/262 , B01D21/34 , B01D2221/10 , B04B1/02 , B04B5/0407 , B04B7/08 , B04B11/04 , B04B2005/0485
摘要： Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) and or platelet poor plasma (PPP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma into separate receivers while retaining the platelets and other factors in the centrifuge chamber. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants.

72. 发明申请

US20090292276A1 SYSTEM AND METHOD OF USE FOR AGENT DELIVERY AND REVASCULARIZING OF GRAFTS AND VESSELS 有权
标题翻译：用于送货和运输的货物和船只的系统和方法
公开(公告)号：US20090292276A1
公开(公告)日：2009-11-26
申请号：US12468753
申请日：2009-05-19
申请人： John E. Nash , William T. Fisher , Charles W. Dodson, JR.
发明人： John E. Nash , William T. Fisher , Charles W. Dodson, JR.
IPC分类号： A61B17/22 , A61M37/00 , A61B18/20
CPC分类号： A61B17/320758 , A61B17/32037 , A61B2017/22048 , A61B2017/22067 , A61B2217/005 , A61B2217/007 , A61M1/0058 , A61M1/0084 , A61M5/14232 , A61M2025/1095 , A61M2205/05
摘要： A system and method for opening a lumen in an occluded blood vessel, e.g., a coronary bypass graft, of a living being. The system comprises an atherectomy catheter having a working head, e.g., a rotary impacting impeller, and a debris extraction sub-system. The atherectomy catheter is located within a guide catheter. The working head is arranged to operate on, e.g., impact, the occlusive material in the occluded vessel to open a lumen therein, whereupon some debris may be produced. The debris extraction sub-system introduces an infusate liquid at a first flow rate adjacent the working head and withdraws that liquid and some blood at a second and higher flow rate, through the guide catheter to create a differential flow adjacent the working head, whereupon the debris is withdrawn in the infusate liquid and blood for collection outside the being's body. The introduction of the infusate liquid may also be used to establish an unbalanced flow adjacent the working head to enable the atherectomy catheter to be steered hydrodynamically. A guide wire having an inflatable balloon on its distal end may be used with the atherectomy catheter to block the flow of debris distally, while enabling distal tissues to be perfused with an oxygenating liquid. At least one flow control port may be provided in the guide catheter to prevent collapse of the vessel being revascularized. A cradle is provided to fix the guide catheter and guide wire in position within the body of the being while enabling the atherectomy catheter to be advanced along the guide wire and through the guide catheter.
摘要翻译：一种用于打开活体的封闭血管（例如冠状动脉旁路移植物）中的内腔的系统和方法。该系统包括具有工作头的动脉粥样硬化切除术导管，例如旋转冲击叶轮和碎片提取子系统。粥样斑块切除术导管位于引导导管内。工作头被布置成操作例如冲击闭塞的容器中的封闭材料以在其中打开内腔，于是可能产生一些碎屑。碎片提取子系统以邻近工作头的第一流速引入输注液体，并通过引导导管以第二和较高流速抽出该液体和一些血液，以在工作头附近形成差动流，残留的液体和血液被收集在身体外部。输注液体的引入也可用于在工作头附近建立不平衡的流动，以使动脉粥样硬化切除术导管能够流体动力学转向。在其远端具有可膨胀气囊的导丝可以与粥样斑块切除术导管一起使用，以阻止碎片向远处流动，同时使远端组织能够用含氧液体灌注。可以在引导导管中设置至少一个流量控制端口，以防止血运重建的血管的塌陷。提供支架以将引导导管和导丝固定在身体内的适当位置，同时使得粥样斑块切除导管能够沿导丝并通过引导导管前进。

73. 发明授权

US06936056B2 Intravascular system for occluded blood vessels and guidewire for use therein 失效
公开(公告)号：US06936056B2
公开(公告)日：2005-08-30
申请号：US10355754
申请日：2003-01-31
申请人： John E. Nash , William T. Fisher , Charles W. Dodson, Jr. , John Michael Henderson , Joseph W. Kaufmann
发明人： John E. Nash , William T. Fisher , Charles W. Dodson, Jr. , John Michael Henderson , Joseph W. Kaufmann
IPC分类号： A61B17/00 , A61B17/22 , A61B17/32 , A61D1/02 , A61M1/00 , A61M31/00
CPC分类号： A61B17/320758 , A61B2017/00845 , A61B2017/00853 , A61B2017/22038 , A61B2217/005 , A61B2217/007 , A61M1/0058
摘要： A system and method for opening a lumen in an occluded blood vessel, e.g., a coronary bypass graft, of a living being. The system comprises an atherectomy catheter having a working head, e.g., a rotary impacting impeller, and a debris extraction sub-system. The atherectomy catheter is located within a guide catheter. The working head is arranged to operate on, e.g., impact, the occlusive material in the occluded vessel to open a lumen therein, whereupon some debris may be produced. The debris extraction sub-system introduces an infusate liquid at a first flow rate adjacent the working head and withdraws that liquid and some blood at a second and higher flow rate, through the guide catheter to create a differential flow adjacent the working head, whereupon the debris is withdrawn in the infusate liquid and blood for collection outside the being's body. The introduction of the infusate liquid may also be used to establish an unbalanced flow adjacent the working head to enable the atherectomy catheter to be steered hydrodynamically. A guide wire having an inflatable balloon on its distal end may be used with the atherectomy catheter to block the flow of debris distally, while enabling distal tissues to be perfused with an oxygenating liquid. At least one flow control port may be provided in the guide catheter to prevent collapse of the vessel being revascularized. A cradle is provided to fix the guide catheter and guide wire in position within the body of the being while enabling the atherectomy catheter to be advanced along the guide wire and through the guide catheter. The guide catheter includes a wear resistant coating and is constructed so that its distal end includes plural sections of different outside diameters, with the distal most section being of the smallest outside diameter. A control console is provided to establish various modes of operation of the system based on manual inputs via switches or voice commands via voice recognition circuitry. A video panel displays the various modes of operation and instructions to the operator.

74. 发明授权

US06905505B2 System and method of use for agent delivery and revascularizing of grafts and vessels 失效
标题翻译：用于药剂递送和移植物和血管血运重建的系统和方法
公开(公告)号：US06905505B2
公开(公告)日：2005-06-14
申请号：US10121192
申请日：2002-04-12
申请人： John E. Nash , William T. Fisher , Charles W. Dodson, Jr.
发明人： John E. Nash , William T. Fisher , Charles W. Dodson, Jr.
IPC分类号： A61B17/22 , A61B17/32 , A61D1/02 , A61F2/06 , A61M1/00 , A61M29/02 , A61M31/00
CPC分类号： A61B17/320758 , A61B17/32037 , A61B2017/22048 , A61B2017/22067 , A61B2217/005 , A61B2217/007 , A61M1/0058 , A61M1/0084 , A61M5/14232 , A61M2025/1095 , A61M2205/05
摘要： A system and method for opening a lumen in an occluded blood vessel, e.g., a coronary bypass graft, of a living being. The system comprises an atherectomy catheter having a working head, e.g., a rotary impacting impeller, and a debris extraction sub-system. The atherectomy catheter is located within a guide catheter. The working head is arranged to operate on, e.g., impact, the occlusive material in the occluded vessel to open a lumen therein, whereupon some debris may be produced. The debris extraction sub-system introduces an infusate liquid at a first flow rate adjacent the working head and withdraws that liquid and some blood at a second and higher flow rate, through the guide catheter to create a differential flow adjacent the working head, whereupon the debris is withdrawn in the infusate liquid and blood for collection outside the being's body. The introduction of the infusate liquid may also be used to establish an unbalanced flow adjacent the working head to enable the atherectomy catheter to be steered hydrodynamically. A guide wire having an inflatable balloon on its distal end may be used with the atherectomy catheter to block the flow of debris distally, while enabling distal tissues to be perfused with an oxygenating liquid. At least one flow control port may be provided in the guide catheter to prevent collapse of the vessel being revascularized. A cradle is provided to fix the guide catheter and guide wire in position within the body of the being while enabling the atherectomy catheter to be advanced along the guide wire and through the guide catheter.
摘要翻译：一种用于打开活体的封闭血管（例如冠状动脉旁路移植物）中的内腔的系统和方法。该系统包括具有工作头的动脉粥样硬化切除术导管，例如旋转冲击叶轮和碎片提取子系统。粥样斑块切除术导管位于引导导管内。工作头被布置成操作例如冲击闭塞的容器中的封闭材料以在其中打开内腔，于是可能产生一些碎屑。碎片提取子系统以邻近工作头的第一流速引入输注液体，并通过引导导管以第二和较高流速抽出该液体和一些血液，以在工作头附近形成差动流，残留的液体和血液被收集在身体外部。输注液体的引入也可用于在工作头附近建立不平衡的流动，以使动脉粥样硬化切除术导管能够流体动力学转向。在其远端具有可膨胀气囊的导丝可以与粥样斑块切除术导管一起使用，以阻止碎片向远处流动，同时使远端组织能够用含氧液体灌注。可以在引导导管中设置至少一个流量控制端口，以防止血运重建的血管的塌陷。提供支架以将引导导管和导丝固定在身体内的适当位置，同时使得粥样斑块切除导管能够沿导丝并通过引导导管前进。

75. 发明授权

US06569151B1 Device for connecting a catheter or other tubular member onto a guide-wire without access to the ends of the guide-wire 有权
标题翻译：用于将导管或其它管状构件连接到导丝上而不接近导丝末端的装置
公开(公告)号：US06569151B1
公开(公告)日：2003-05-27
申请号：US09523077
申请日：2000-03-10
申请人： John E. Nash , William T. Fisher , H. Michael Cunningham , Gregory Walters
发明人： John E. Nash , William T. Fisher , H. Michael Cunningham , Gregory Walters
IPC分类号： A61M2516
CPC分类号： A61M25/0169 , A61M25/00 , A61M25/0068 , A61M25/007 , A61M25/0074 , A61M25/09041 , A61M2025/0177 , A61M2025/018 , A61M2025/0186 , A61M2025/09008 , A61M2025/09125 , A61M2025/1056 , A61M2025/1095
摘要： A tubular instrument, e.g., a catheter including a hollow wall portion forming the distal end of the instrument and terminating at a distal opening, having a connector arranged to be used with a guide-wire. The guide wire has a distal end portion and a proximal end portion, the distal end portion of the guide-wire being arranged to be extended to some interior position within the body of a living being, with the proximal end portion of the guide-wire being located outside the being's body. The connector is located at the distal end of the instrument and is arranged to be readily manipulated by a twisting action to connect the instrument onto the guide-wire for sliding movement therealong. In particular, the connector establishes a path into which a portion of the guide-wire can be inserted from a lateral direction by merely twisting the instrument, without requiring access to either end of the guide-wire. In one embodiment the path is a spiral channel formed in the hollow wall portion of the instrument. In another embodiment the connector is a spiral member located on the outside of the distal end of the instrument, spaced slightly from the outer surface of the instrument to form the path or channel into which the guide-wire is inserted.
摘要翻译：管状器械，例如导管，其包括形成器械的远端并终止于远侧开口的中空壁部分，具有布置成与导丝一起使用的连接器。导丝具有前端部和近端部，导线的前端部被配置为延伸到活体的主体内的一些内部位置，导丝的基端部位于身体的外面。连接器位于仪器的远端，并且被布置成易于通过扭转动作操作，以将仪器连接到导丝上，以便沿着其滑动运动。特别地，连接器建立了一条路径，通过仅仅扭转仪器，导线的一部分可以从横向方向插入到该路径中，而不需要进入导线的任一端。在一个实施例中，路径是形成在仪器的中空壁部分中的螺旋通道。在另一个实施例中，连接器是位于仪器远端外侧的螺旋构件，与仪器的外表面稍微间隔开，以形成引导线插入其中的路径或通道。

76. 发明申请

US20120004601A1 Interventional procedure drive and control system 有权
标题翻译：介入程序驱动和控制系统
公开(公告)号：US20120004601A1
公开(公告)日：2012-01-05
申请号：US13211015
申请日：2011-08-16
申请人： John E. Nash , Gregory Walters , Stephen Heiman , Jim Barnitz , Pete Fatone
发明人： John E. Nash , Gregory Walters , Stephen Heiman , Jim Barnitz , Pete Fatone
IPC分类号： A61M5/168 , A61M1/00
CPC分类号： A61M1/0058 , A61M1/0035
摘要： A pumping system for use in medical applications where liquids must be infused and aspirated from a mammalian patient, and whose economics are such that it is cost effective to simply dispose of it after a single use. The system features positive displacement pump(s) such as reciprocating pump(s) containing a damping mechanism to dampen out the peaks and valleys in the fluid pressure that is pumped, which is important for preventing cavitation. The system furthermore features a shut-off valve on the extraction side so that certain injected fluids such as contrast medium, are not immediately pumped out of the patient. In a preferred embodiment, the system also features means for independently controlling the fluid pressure/volume on the infusion and extraction sides, self-priming capability, a continuous fluid path, and visual air bubble detection, with viewports located at important points in the fluid path, such as at pumps and valves.
摘要翻译：一种用于医疗应用的泵送系统，其中液体必须从哺乳动物患者输注和吸入，并且其经济性使得在一次使用后简单处置它具有成本效益。该系统具有容积式泵，例如包含阻尼机构的往复泵，以阻止所泵送的流体压力中的峰和谷，这对于防止空化是重要的。该系统还具有在提取侧的截止阀，使得某些注射的流体（例如造影剂）不会立即泵出患者体内。在优选实施例中，系统还具有用于独立地控制输液和抽出侧的流体压力/体积，自吸能力，连续流体路径和视觉气泡检测的装置，其中视口位于流体中的重要点路径，如泵和阀门。

77. 发明授权

US07833239B2 System and method of use for revascularizing stenotic bypass grafts and other blood vessels 有权
标题翻译：用于血管狭窄性旁路移植物和其他血管的系统和方法
公开(公告)号：US07833239B2
公开(公告)日：2010-11-16
申请号：US11627628
申请日：2007-01-26
申请人： John E. Nash
发明人： John E. Nash
IPC分类号： A61B17/22
CPC分类号： A61B17/320758 , A61B17/22 , A61B17/32037 , A61B2017/22048 , A61B2017/22067 , A61B2017/320775 , A61B2217/005 , A61B2217/007 , A61M1/0058 , A61M1/0084 , A61M5/14232 , A61M2025/1095 , A61M2205/05
摘要： A system and method for opening a lumen in an occluded blood vessel, e.g., a coronary bypass graft, of a living being's vascular system. The system introduces an infusate liquid at a first flow rate to the occluded portion of the blood vessel, and withdraws that liquid and some blood at a second and higher flow rate. This action creates a differential flow in the occluded blood vessel portion and thereby prevent particles of occlusive material from flowing into any upstream blood vessel or downstream blood vessel in said living being's vascular system.
摘要翻译：用于打开活体血管系统的封闭血管（例如冠状动脉旁路移植物）中的内腔的系统和方法。该系统以第一流量向血管的闭塞部分引入输注液体，并以第二和较高流速抽出该液体和一些血液。这种作用在闭塞的血管部分中产生不同的流动，从而防止闭塞性物质的颗粒流入所述活体血管系统中的任何上游血管或下游血管。

78. 发明授权

US5681334A Apparatus and methods of use for preventing blood seepage at a percutaneous puncture site 失效
标题翻译：用于预防经皮穿刺部位渗血的装置和方法
公开(公告)号：US5681334A
公开(公告)日：1997-10-28
申请号：US612350
申请日：1996-03-07
申请人： Douglas Evans , John E. Nash
发明人： Douglas Evans , John E. Nash
IPC分类号： A61B17/00 , A61B17/04 , A61B17/06 , A61B17/12
CPC分类号： A61B17/0057 , A61B17/0469 , A61B17/0401 , A61B17/0482 , A61B17/06066 , A61B2017/00004 , A61B2017/00637 , A61B2017/00654 , A61B2017/00659 , A61B2017/00663 , A61B2017/0458 , A61B2017/0464 , A61B2017/047 , A61B2017/0472 , A61B2017/06042 , A61B2017/06057
摘要： Apparatus and methods of use for reducing bleeding from the situs of a percutaneous arterial puncture in a living being, with the opening in the arterial wall having been closed by a closure including at least one portion of a suture extending out of the puncture. The apparatus basically comprising a mass of material which inhibits the flow of blood therethrough, e.g., collagen, a carrier for carrying the suture portion through the mass of material, and means for holding the mass of material with respect to the suture portion so that it closely engages tissue contiguous with the puncture tract. The means for holding may comprise a knot in the suture portion, or can be a releasably securable member for location on the suture portion. In one embodiment the carrier comprises a piercing member, e.g., a needle, arranged for location within the interior of the artery for passage thereout through the wall of the artery and through the mass of material to carry the suture portion therethrough. In another embodiment the carrier comprises an elongated member, e.g., a flexible filament, arranged to selectively grasp the suture portion to carry it through the mass of material. A housing is provided for retaining the mass of material while the carrier extends the suture portion through it. A tamper may be provided for tamping the mass of material into intimate engagement with the contiguous tissue.
摘要翻译：用于减少活体内经皮动脉穿刺部位出血的装置和方法，其中动脉壁中的开口被封闭件封闭，包括至少一部分延伸出穿刺的缝合线。该装置基本上包含一定量的阻止血液通过其中的物质，例如胶原蛋白，用于通过物料传送缝合部分的载体，以及用于相对于缝线部分保持材料块的装置，使得其紧密接合与穿刺道相邻的组织。用于保持的装置可以包括在缝线部分中的结，或者可以是用于在缝线部分上定位的可释放地固定的构件。在一个实施例中，载体包括穿刺构件，例如针，布置成位于动脉内部，用于通过动脉壁通过，并且穿过该物质的物质以将缝线部分穿过其中。在另一个实施例中，载体包括细长构件，例如柔性细丝，布置成选择性地抓住缝合线部分以将其运送穿过大量的材料。提供用于保持材料块的壳体，同时载体通过其延伸缝合部分。可以提供捣固材料以将物质块与邻接的组织紧密接合。

79. 发明授权

US5441517A Hemostatic puncture closure system and method of use 失效
标题翻译：止血穿刺闭合系统及使用方法
公开(公告)号：US5441517A
公开(公告)日：1995-08-15
申请号：US154882
申请日：1993-11-18
申请人： Kenneth Kensey , John E. Nash , Douglas Evans
发明人： Kenneth Kensey , John E. Nash , Douglas Evans
IPC分类号： A61B17/12 , A61B17/00 , A61B17/03 , A61B17/04 , A61B19/00 , A61F2/06 , A61M25/00 , A61M37/00 , F16G11/04 , F16G11/10
CPC分类号： A61B17/0057 , F16G11/108 , A61B2017/00004 , A61B2017/00637 , A61B2017/00654 , A61B2017/00659 , A61B2017/00672 , A61B2017/00898 , A61B2017/0496 , A61B2090/032 , A61B2090/0811 , A61B90/03 , A61B90/39 , Y10S604/90
摘要： A system, a closure, and method of use for determining the position of a blood vessel via a percutaneous puncture and for sealing the percutaneous puncture in the blood vessel. The system includes an introducer sheath and associated positioning device, a hemostatic puncture closure, and a deployment instrument. The positioning device enables the introducer sheath to be positioned at a desired position within the vessel. The deployment instrument includes a tubular carrier storing the closure. The carrier has a distally located free end to be extended via an introducer through the puncture and its associated tract. The closure comprises a radiopaque rigid anchor, a compressed collagen plug, and a thin filament connecting the two in a pulley-like arrangement. The carrier ejects the anchor through the introducer and puncture and then draws it against the free end of the introducer. The instrument and introducer are then withdrawn together to pull the anchor against the tissue contiguous with the puncture inside the artery. Further withdrawl draws the plug out of the carrier into the puncture tract, whereupon the plug moves with respect to the anchor into engagement with the outside of artery wall to seal the puncture or incision. A tensioning device limits the force applied to the filament. The carrier also includes a tamper which is used to mechanically deform the plug within the tract. Once positioned hemostasis occurs rapidly, thereby locking the closure in place.
摘要翻译：一种用于通过经皮穿刺确定血管位置并用于密封血管中经皮穿刺的系统，闭合件和方法。该系统包括引导器护套和相关联的定位装置，止血穿刺闭合器和展开装置。定位装置使引导器护套能够定位在容器内的期望位置。展开仪器包括一个储存封闭件的管状载体。载体具有远端定位的自由端，通过穿刺器穿过穿刺器及其相关的管道延伸。闭合件包括不透射线的刚性锚固件，压缩的胶原塞，以及以滑轮状布置连接两者的细丝。托架通过导引器弹出锚固件并穿刺，然后将其拉到导引器的自由端。然后将仪器和引导器一起拉出以将锚固件靠在与动脉内的穿刺相邻的组织上。进一步撤出将塞子从载体中抽出到穿刺管中，于是塞子相对于锚移动，与动脉壁的外侧接合以密封穿刺或切口。张紧装置限制施加到细丝上的力。载体还包括用于使塞子在管道内机械变形的篡改。一旦定位，止血快速发生，从而将闭合件锁定就位。

80. 发明授权

US5282827A Hemostatic puncture closure system and method of use 失效
标题翻译：止血穿刺闭合系统及使用方法
公开(公告)号：US5282827A
公开(公告)日：1994-02-01
申请号：US846322
申请日：1992-03-05
申请人： Kenneth Kensey , John E. Nash , Douglas Evans
发明人： Kenneth Kensey , John E. Nash , Douglas Evans
IPC分类号： A61B17/12 , A61B17/00 , A61B17/03 , A61B17/04 , A61B19/00 , A61F2/06 , A61M25/00 , A61M37/00 , F16G11/04 , F16G11/10
CPC分类号： A61B17/0057 , F16G11/108 , A61B2017/00004 , A61B2017/00637 , A61B2017/00654 , A61B2017/00659 , A61B2017/00672 , A61B2017/00898 , A61B2017/0496 , A61B2090/032 , A61B2090/0811 , A61B90/03 , A61B90/39 , Y10S604/90
摘要： A system, a closure, and method of use for determining the position of a blood vessel via a percutaneous puncture and for sealing the percutaneous puncture in the blood vessel. The system includes an introducer sheath and associated positioning device, a hemostatic puncture closure, and a deployment instrument. The positioning device enables the introducer sheath to be positioned at a desired position within the vessel. The deployment instrument includes a tubular carrier storing the closure. The carrier has a distally located free end to be extended via an introducer through the puncture and its associated tract. The closure comprises a radiopaque rigid anchor, a compressed collagen plug, and a thin filament connecting the two in a pulley-like arrangement. The carrier ejects the anchor through the introducer and puncture and then draws it against the free end of the introducer. The instrument and introducer are then withdrawn together to pull the anchor against the tissue contiguous with the puncture inside the artery. Further withdrawl draws the plug out of the carrier into the puncture tract, whereupon the plug moves with respect to the anchor into engagement with the outside of artery wall to seal the puncture or incision. A tensioning device limits the force applied to the filament. The carrier also includes a tamper which is used to mechanically deform the plug within the tract. Once positioned hemostasis occurs rapidly, thereby locking the closure in place.
摘要翻译：一种用于通过经皮穿刺确定血管位置并用于密封血管中经皮穿刺的系统，闭合件和方法。该系统包括引导器护套和相关联的定位装置，止血穿刺闭合器和展开装置。定位装置使引导器护套能够定位在容器内的期望位置。展开仪器包括一个储存封闭件的管状载体。载体具有远端定位的自由端，通过穿刺器穿过穿刺器及其相关的管道延伸。闭合件包括不透射线的刚性锚固件，压缩的胶原塞，以及以滑轮状布置连接两者的细丝。托架通过导引器弹出锚固件并穿刺，然后将其拉到导引器的自由端。然后将仪器和引导器一起拉出以将锚固件靠在与动脉内的穿刺相邻的组织上。进一步撤出将塞子从载体中抽出到穿刺管中，于是塞子相对于锚移动，与动脉壁的外侧接合以密封穿刺或切口。张紧装置限制施加到细丝上的力。载体还包括用于使塞子在管道内机械变形的篡改。一旦定位，止血快速发生，从而将闭合件锁定就位。

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