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71. 发明申请

US20140136174A1 System and Method for Patient Specific Modeling of Liver Tumor Ablation 有权
标题翻译：肝脏肿瘤消融患者特异性建模的系统和方法
公开(公告)号：US20140136174A1
公开(公告)日：2014-05-15
申请号：US14071688
申请日：2013-11-05
申请人： Chloe Audigier , Tommaso Mansi , Viorel Mihalef , Ali Kamen , Dorin Comaniciu , Puneet Sharma , Saikiran Rapaka , Herve Delingette , Nicholas Ayache
发明人： Chloe Audigier , Tommaso Mansi , Viorel Mihalef , Ali Kamen , Dorin Comaniciu , Puneet Sharma , Saikiran Rapaka , Herve Delingette , Nicholas Ayache
IPC分类号： G06F19/12
CPC分类号： G16H50/50 , G06F19/00 , G06F19/3481 , G09B23/30
摘要： A method and system for tumor ablation planning and guidance based on a patient-specific model of liver tumor ablation is disclosed. A patient-specific anatomical model of the liver and circulatory system of the liver is estimated from 3D medical image data of a patient. Blood flow in the liver and the circulatory system of the liver is simulated based on the patient-specific anatomical model. Heat diffusion due to ablation is simulated based on a virtual ablation probe position and the simulated blood flow in the liver and the venous system of the liver. Cellular necrosis in the liver is simulated based on the simulated heat diffusion. A visualization of a simulated necrosis region is generated and displayed to the user for decision making and optimal therapy planning and guidance.
摘要翻译：公开了一种基于肝肿瘤消融的患者特异性模型的肿瘤消融计划和指导的方法和系统。根据患者的3D医学图像数据估计肝脏和肝脏循环系统的患者特异性解剖模型。根据患者特异性解剖模型模拟肝脏和肝脏循环系统的血流。基于虚拟消融探针位置和肝脏和肝脏静脉系统中的模拟血流模拟了消融引起的热扩散。基于模拟热扩散模拟肝脏细胞坏死。生成模拟坏死区域的可视化，并向用户显示决策和最佳治疗计划和指导。

72. 发明申请

US20140132293A1 INTEGRATED CIRCUIT WITH DEGRADATION MONITORING 有权
标题翻译：集成电路与降解监测
公开(公告)号：US20140132293A1
公开(公告)日：2014-05-15
申请号：US13956126
申请日：2013-07-31
申请人： Magdy S. Abadir , Puneet Sharma
发明人： Magdy S. Abadir , Puneet Sharma
IPC分类号： G01R31/28 , H03K5/06
CPC分类号： G01R31/2882 , G01R31/31725 , H03K3/0375
摘要： An integrated circuit including a degradation monitoring circuit. The degradation monitoring circuit includes a comparison circuit having a programmable delay element including an input coupled to a data node of a timing path and having an output to provide a delayed signal of a data signal of the data node that is delayed by a programmable amount. The comparison circuit includes a logic comparator that provides a logic comparison between a data signal of the data node and the output of the delay element. The monitoring circuit includes a sampling circuit that provides a sampled signal of the output of the logic comparator that is a sampled with respect to a clock signal of the clock signal line. The monitoring circuit includes a hold circuit that provides a signal indicative of a data signal of the data node transitioning within a predetermined time of an edge transition of a clock signal of the clock signal line.
摘要翻译：一种包括劣化监测电路的集成电路。劣化监视电路包括具有可编程延迟元件的比较电路，该可编程延迟元件包括耦合到定时路径的数据节点的输入，并且具有输出以提供延迟可编程量的数据节点的数据信号的延迟信号。比较电路包括逻辑比较器，其提供数据节点的数据信号和延迟元件的输出之间的逻辑比较。监视电路包括采样电路，该采样电路提供对于时钟信号线的时钟信号采样的逻辑比较器的输出的采样信号。监视电路包括保持电路，该保持电路提供指示在时钟信号线的时钟信号的边沿转换的预定时间内数据节点的数据信号的信号。

73. 发明授权

US08661393B2 Method for analyzing placement context sensitivity of standard cells 有权
标题翻译：分析标准细胞放置上下文敏感度的方法
公开(公告)号：US08661393B2
公开(公告)日：2014-02-25
申请号：US13536694
申请日：2012-06-28
申请人： Robert E. Boone , Puneet Sharma , Matthew A. Thompson
发明人： Robert E. Boone , Puneet Sharma , Matthew A. Thompson
IPC分类号： G06F17/50
CPC分类号： G06F17/5072
摘要： A disclosed method for evaluating placement context sensitivity in the design of an integrated circuit includes accessing a standard cell library comprising a database of standard cells and determining generating boundary data for each of the standard cells. The boundary data for a standard cell indicates the layout of features located within boundary regions of the standard cell. The method includes merging or consolidating boundary data for any two standard cells if their boundary data is the same to determine a canonical or minimal set of boundary regions. The disclosed method further includes enumerating and evaluating all combinations of pairs of the canonical boundary regions and, responsive to identifying of a proximity-based sensitivity or exception, modifying, notating, or otherwise remediating the applicable one or more standard cells that correspond to the boundary region combination that raised the exception.
摘要翻译：用于评估集成电路设计中的放置上下文敏感度的公开的方法包括访问包括标准单元的数据库的标准单元库，并且为每个标准单元确定生成边界数据。标准单元的边界数据表示位于标准单元的边界区域内的特征的布局。该方法包括如果边界数据相同以合并或合并任何两个标准单元的边界数据，以确定边界区域的典型或最小集合。所公开的方法还包括列举和评估规范边界区域对的所有组合，并且响应于识别基于接近度的灵敏度或异常，修改，表示或以其他方式补救对应于边界的可应用的一个或多个标准单元引起异常的区域组合。

74. 发明授权

US08598632B2 Integrated circuit having pitch reduced patterns relative to photoithography features 失效
标题翻译：具有相对于光刻特征的节距减小图案的集成电路
公开(公告)号：US08598632B2
公开(公告)日：2013-12-03
申请号：US13530679
申请日：2012-06-22
申请人： Luan Tran , William T. Rericha , John Lee , Ramakanth Alapati , Sheron Honarkhah , Shuang Meng , Puneet Sharma , Jingyi Bai , Zhiping Yin , Paul Morgan , Mirzafer K. Abatchev , Gurtej S. Sandhu , D. Mark Durcan
发明人： Luan Tran , William T. Rericha , John Lee , Ramakanth Alapati , Sheron Honarkhah , Shuang Meng , Puneet Sharma , Jingyi Bai , Zhiping Yin , Paul Morgan , Mirzafer K. Abatchev , Gurtej S. Sandhu , D. Mark Durcan
IPC分类号： H01L27/118
CPC分类号： H01L21/0338 , H01L21/0337 , H01L21/3086 , H01L21/3088
摘要： An integrated circuit having differently-sized features wherein the smaller features have a pitch multiplied relationship with the larger features, which are of such size as to be formed by conventional lithography.
摘要翻译：具有不同尺寸特征的集成电路，其中较小特征与具有通过常规光刻形成的尺寸的较大特征具有间距倍增关系。

75. 发明申请

US20130243294A1 Method and System for Hemodynamic Assessment of Aortic Coarctation from Medical Image Data 有权
标题翻译：医学图像数据主动脉缩窄血流动力学评估方法与系统
公开(公告)号：US20130243294A1
公开(公告)日：2013-09-19
申请号：US13826307
申请日：2013-03-14
申请人： Kristof Ralovich , Lucian Mihai Itu , Viorel Mihalef , Puneet Sharma , Razvan Ioan Ionasec , Dime Vitanovski , Waldemar Krawtschuk , Dorin Comaniciu
发明人： Kristof Ralovich , Lucian Mihai Itu , Viorel Mihalef , Puneet Sharma , Razvan Ioan Ionasec , Dime Vitanovski , Waldemar Krawtschuk , Dorin Comaniciu
IPC分类号： G06T7/00
CPC分类号： G06T7/0012 , G06T2207/10076 , G06T2207/10096 , G06T2207/30104
摘要： A method and system for non-invasive hemodynamic assessment of aortic coarctation from medical image data, such as magnetic resonance imaging (MRI) data is disclosed. Patient-specific lumen anatomy of the aorta and supra-aortic arteries is estimated from medical image data of a patient, such as contrast enhanced MRI. Patient-specific aortic blood flow rates are estimated from the medical image data of the patient, such as velocity encoded phase-contrasted MRI cine images. Patient-specific inlet and outlet boundary conditions for a computational model of aortic blood flow are calculated based on the patient-specific lumen anatomy, the patient-specific aortic blood flow rates, and non-invasive clinical measurements of the patient. Aortic blood flow and pressure are computed over the patient-specific lumen anatomy using the computational model of aortic blood flow and the patient-specific inlet and outlet boundary conditions.
摘要翻译：公开了一种用于从医学图像数据（如磁共振成像（MRI））数据进行主动脉缩窄的非侵入性血流动力学评估的方法和系统。从患者的医学图像数据估计主动脉和超主动脉血管的患者特异性内腔解剖结构，例如对比度增强的MRI。根据患者的医学图像数据估计患者特异性主动脉血流速率，例如速度编码的相位对比MRI电影图像。基于患者特异性内腔解剖，患者特异性主动脉血流速率和患者的非侵入性临床测量，计算主动脉血流计算模型的患者特异性入口和出口边界条件。使用主动脉血流计算模型和患者特定的入口和出口边界条件，计算患者特异性内腔解剖结构的主动脉血流和压力。

76. 发明申请

US20130132054A1 Method and System for Multi-Scale Anatomical and Functional Modeling of Coronary Circulation 审中-公开
标题翻译：冠状动脉循环多尺度解剖与功能建模方法与系统
公开(公告)号：US20130132054A1
公开(公告)日：2013-05-23
申请号：US13672781
申请日：2012-11-09
申请人： Puneet Sharma , Lucian Mihai Itu , Bogdan Georgescu , Viorel Mihalef , Ali Kamen , Dorin Comaniciu
发明人： Puneet Sharma , Lucian Mihai Itu , Bogdan Georgescu , Viorel Mihalef , Ali Kamen , Dorin Comaniciu
IPC分类号： G06F19/12
CPC分类号： G06F19/12 , G06F19/00 , G06F19/321 , G16H50/30 , G16H50/50
摘要： A method and system for multi-scale anatomical and functional modeling of coronary circulation is disclosed. A patient-specific anatomical model of coronary arteries and the heart is generated from medical image data of a patient. A multi-scale functional model of coronary circulation is generated based on the patient-specific anatomical model. Blood flow is simulated in at least one stenosis region of at least one coronary artery using the multi-scale function model of coronary circulation. Hemodynamic quantities, such as fractional flow reserve (FFR), are computed to determine a functional assessment of the stenosis, and virtual intervention simulations are performed using the multi-scale function model of coronary circulation for decision support and intervention planning.
摘要翻译：公开了一种用于冠状循环多尺度解剖和功能建模的方法和系统。冠状动脉和心脏的患者特异性解剖模型由患者的医学图像数据产生。基于患者特异性解剖模型产生冠状动脉循环的多尺度功能模型。使用冠状动脉循环的多尺度功能模型在至少一个冠状动脉的至少一个狭窄区域中模拟血流量。计算血流动力学量，例如分数流量储备（FFR），以确定狭窄的功能评估，并使用冠状动脉循环的多尺度函数模型进行虚拟干预模拟，以进行决策支持和干预计划。

77. 发明授权

US08224640B2 Method and system for computational modeling of the aorta and heart 有权
标题翻译：主动脉和心脏的计算建模方法和系统
公开(公告)号：US08224640B2
公开(公告)日：2012-07-17
申请号：US12825905
申请日：2010-06-29
申请人： Puneet Sharma , Bogdan Georgescu , Razvan Ioan Ionasec , Dorin Comaniciu
发明人： Puneet Sharma , Bogdan Georgescu , Razvan Ioan Ionasec , Dorin Comaniciu
IPC分类号： G06F19/00 , G06F17/10 , G06G7/58 , G06K9/00
CPC分类号： G06T17/00 , G06F19/00 , G06T7/0012 , G06T2207/10072 , G06T2207/30048 , G16H50/20 , G16H50/50
摘要： A method and system for generating a patient specific anatomical heart model is disclosed. A sequence of volumetric image data, such as computed tomography (CT), echocardiography, or magnetic resonance (MR) image data of a patient's cardiac region is received. A multi-component patient specific 4D geometric model of the heart and aorta estimated from the sequence of volumetric cardiac imaging data. A patient specific 4D computational model based on one or more of personalized geometry, material properties, fluid boundary conditions, and flow velocity measurements in the 4D geometric model is generated. Patient specific material properties of the aortic wall are estimated using the 4D geometrical model and the 4D computational model. Fluid Structure Interaction (FSI) simulations are performed using the 4D computational model and estimated material properties of the aortic wall, and patient specific clinical parameters are extracted based on the FSI simulations. Disease progression modeling and risk stratification are performed based on the patient specific clinical parameters.
摘要翻译：公开了一种用于产生患者特异性解剖心脏模型的方法和系统。接收患者心脏区域的体积图像数据的序列，例如计算机断层摄影（CT），超声心动图或磁共振（MR）图像数据。根据体积心脏成像数据序列估计的心脏和主动脉的多组分患者特定4D几何模型。产生了基于4D几何模型中的个性化几何，材料特性，流体边界条件和流速测量中的一个或多个的患者特定4D计算模型。使用4D几何模型和4D计算模型估计主动脉壁的患者特异性材料性质。使用4D计算模型和主动脉壁的估计材料特性进行流体结构相互作用（FSI）模拟，并且基于FSI模拟提取患者特异性临床参数。疾病进展模型和风险分层是根据患者的具体临床参数进行的。

78. 发明申请

US20120072190A1 Method and System for Non-Invasive Assessment of Coronary Artery Disease 有权
标题翻译：冠状动脉疾病非侵入性评估方法与系统
公开(公告)号：US20120072190A1
公开(公告)日：2012-03-22
申请号：US13226779
申请日：2011-09-07
申请人： Puneet Sharma , Bogdan Georgescu , Viorel Mihalef , Terrence Chen , Dorin Comaniciu
发明人： Puneet Sharma , Bogdan Georgescu , Viorel Mihalef , Terrence Chen , Dorin Comaniciu
IPC分类号： G06G7/60 , G06F17/10 , G06F17/11 , G06G7/57
CPC分类号： A61B5/026 , A61B2576/023 , G06F19/321 , G06F19/3468 , G06T7/0016 , G06T2207/10081 , G06T2207/10096 , G06T2207/10116 , G06T2207/30048 , G06T2207/30104 , G16H20/17 , G16H30/20 , G16H30/40 , G16H50/50
摘要： A method and system for non-invasive patient-specific assessment of coronary artery disease is disclosed. An anatomical model of a coronary artery is generated from medical image data. A velocity of blood in the coronary artery is estimated based on a spatio-temporal representation of contrast agent propagation in the medical image data. Blood flow is simulated in the anatomical model of the coronary artery using a computational fluid dynamics (CFD) simulation using the estimated velocity of the blood in the coronary artery as a boundary condition.
摘要翻译：公开了一种用于冠状动脉疾病非侵入性患者特异性评估的方法和系统。从医学图像数据生成冠状动脉的解剖模型。基于医学图像数据中的造影剂传播的时空表示来估计冠状动脉中的血液速度。使用计算流体动力学（CFD）模拟，使用冠状动脉中血液的估计速度作为边界条件，在冠状动脉的解剖模型中模拟血流。

79. 发明授权

US08073977B2 Internet telephony through hosts 有权
标题翻译：互联网电话通过主机
公开(公告)号：US08073977B2
公开(公告)日：2011-12-06
申请号：US10569569
申请日：2004-09-03
申请人： Jonathan Cox , Andrew B. Kahng , Puneet Sharma
发明人： Jonathan Cox , Andrew B. Kahng , Puneet Sharma
IPC分类号： G06F15/16
CPC分类号： H04L65/1046 , H04L65/1063 , H04L65/1069 , H04L65/1096
摘要： Systems of the invention employ peer-to-peer and centralized server networking to enable POTS/PSTN/PBX phone lines to be shared with other users of the system over the Internet. An example application of the invention is to allow a person, having access to an Internet connection, to receive calls and make calls using his/her home or office telephone, or using the phones of other parties that he/she is authorized to access. In preferred embodiments, the invention can exploit availability of an existing voice modem port on the user's home or office computer, and can require only the installation of software on the home or office computer, and on whatever device (laptop, PDA, computer, mobile phones, etc.) is employed by the user in the remote location. Variant realizations of the invention may also provide any combination of features typically available to phone users, including, for example, the following features: authentication, verification, directory services, directory search, access rights, call forwarding, call answering, voice, mail, missed-call information, call screening, and caller identification.
摘要翻译：本发明的系统采用点对点和集中的服务器网络来使得POTS / PSTN / PBX电话线能够通过因特网与系统的其他用户共享。本发明的示例性应用是允许具有互联网连接的人接收呼叫并使用他/她的家庭或办公室电话或使用他/她被授权访问的其他方的电话。在优选实施例中，本发明可以利用用户的家庭或办公室计算机上的现有语音调制解调器端口的可用性，并且可以仅需要在家庭或办公室计算机上以及在任何设备（膝上型计算机，PDA，计算机，移动设备电话等）由用户在远程位置使用。本发明的变型实现还可以提供通常可用于电话用户的特征的任何组合，包括例如以下特征：认证，验证，目录服务，目录搜索，访问权限，呼叫转移，呼叫应答，语音，邮件，未接来电信息，呼叫筛选和呼叫者识别。

80. 发明申请

US20110292886A1 CHANNEL ASSIGNMENT FOR A WIRELESS NETWORK 有权
标题翻译：无线网络的通道分配
公开(公告)号：US20110292886A1
公开(公告)日：2011-12-01
申请号：US12790814
申请日：2010-05-29
申请人： Jung Gun Lee , Gene Cheung , Sung-Ju Lee , Puneet Sharma
发明人： Jung Gun Lee , Gene Cheung , Sung-Ju Lee , Puneet Sharma
IPC分类号： H04W4/00
CPC分类号： H04W16/04 , H04W28/16 , H04W84/12
摘要： Channel assignment for access points (APs) in a wireless network includes determining at least one of a MaxSum and a MaxMin, and determining a channel assignment for the APs based on at least one of the MaxSum and the MaxMin. The MaxSum is a maximization of a system throughput and the system throughput is a sum of throughput of nodes in the network. The MaxMin is a maximization of a minimum throughput of a set of AP-client links in the network. The AP-client link is a link between an AP and a client associated with the AP.
摘要翻译：无线网络中的接入点（AP）的信道分配包括确定MaxSum和MaxMin中的至少一个，以及基于MaxSum和MaxMin中的至少一个来确定AP的信道分配。 MaxSum是系统吞吐量的最大化，系统吞吐量是网络中节点吞吐量的总和。 MaxMin是网络中一组AP客户端链路的最小吞吐量最大化。 AP-client链路是AP与AP关联的客户端之间的链路。

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