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71. 发明授权

US08292938B2 Placement of multiple intraluminal medical devices within a body vessel 有权
标题翻译：多个管腔内医疗器械放置在体内容器内
公开(公告)号：US08292938B2
公开(公告)日：2012-10-23
申请号：US11210999
申请日：2005-08-24
申请人： Brian C. Case
发明人： Brian C. Case
IPC分类号： A61M29/00
CPC分类号： A61F2/962 , A61F2/01 , A61F2/013 , A61F2/2412 , A61F2/2436 , A61F2/2475 , A61F2/95 , A61F2/966 , A61F2002/011 , A61F2002/826 , A61F2002/9522 , A61F2230/0006
摘要： Medical device delivery systems and related kits and methods for placing multiple expandable medical devices within a body vessel are provided. A delivery system includes first and second expandable medical devices having the same or different dimensions. Placement of the first and second expandable medical devices in a body vessel can be achieved without requiring withdrawal of one or more components of the delivery system and insertion of secondary components.
摘要翻译：提供用于将多个可扩展医疗装置放置在体内容器内的医疗装置输送系统和相关工具包和方法。递送系统包括具有相同或不同尺寸的第一和第二可扩张医疗装置。可以实现第一和第二可扩张医疗装置在身体容器中的放置，而不需要撤回输送系统的一个或多个部件和次要部件的插入。

72. 发明授权

US08021417B2 Prosthetic valve that permits retrograde flow 有权
标题翻译：允许逆行流动的假体瓣膜
公开(公告)号：US08021417B2
公开(公告)日：2011-09-20
申请号：US12139836
申请日：2008-06-16
申请人： Thomas A. Osborne , Brian C. Case , Mark W. Bleyer , Ram H. Paul
发明人： Thomas A. Osborne , Brian C. Case , Mark W. Bleyer , Ram H. Paul
IPC分类号： A61F2/24
CPC分类号： A61F2/2475 , A61F2/2412 , A61F2/2418 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/0026 , A61F2230/0095
摘要： A prosthetic valve for regulating fluid flow through a body vessel is provided. The valve includes an expandable support frame and a valve leaflet, and includes at least one opening that permits a controlled amount of retrograde flow through the valve when the valve is in a closed configuration. A flap disposed adjacent the opening is able to temporarily and substantially close the opening to contribute to the regulation of retrograde flow proceeding through the valve.
摘要翻译：提供了一种用于调节通过身体容器的流体流动的人造瓣膜。阀包括可膨胀的支撑框架和瓣膜小叶，并且包括至少一个开口，当阀处于关闭构型时允许通过阀的受控量的逆行流动。邻近开口设置的翼片能够暂时且基本上关闭开口，以有助于调节通过阀门的逆行流。

73. 发明授权

US07563276B2 Intraluminal medical device with cannula for controlled retrograde flow 有权
标题翻译：管腔内医疗器械带套管用于控制逆行流
公开(公告)号：US07563276B2
公开(公告)日：2009-07-21
申请号：US11260981
申请日：2005-10-28
申请人： Thomas A. Osborne , Charles W. Agnew , Brian C. Case
发明人： Thomas A. Osborne , Charles W. Agnew , Brian C. Case
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0016 , A61F2220/0058 , A61F2220/0075 , A61F2230/0026 , A61F2230/0067 , A61F2230/0095
摘要： Prosthetic valves for regulating fluid flow through a body vessel are described. The valves include a valve member that includes at least a portion that is capable of moving to selectively permit and substantially prevent fluid flow through the body vessel, either alone or with one or more additional valve members. A cannula is associated with the valve and permits a controlled amount of fluid flow through the valve, such as retrograde flow while the valve member substantially prevents fluid flow through the body vessel.
摘要翻译：描述了用于调节通过身体血管的流体流动的假体瓣膜。阀包括阀构件，该阀构件包括至少一部分，其能够移动以选择性地允许和基本上防止流体流过身体容器，单独地或与一个或多个附加的阀构件。套管与阀相关联并且允许受控量的流体流过阀，例如逆流，同时阀构件基本上防止流体流过身体血管。

74. 发明申请

US20090177275A1 SENSING DELIVERY SYSTEM FOR INTRALUMINAL MEDICAL DEVICES 审中-公开
标题翻译：感染输送系统用于内科医疗器械
公开(公告)号：US20090177275A1
公开(公告)日：2009-07-09
申请号：US12406678
申请日：2009-03-18
申请人： Brian C. Case
发明人： Brian C. Case
IPC分类号： A61F2/24 , A61B5/05
CPC分类号： A61B5/1076 , A61B5/0215 , A61B2090/3784 , A61F2/2412 , A61F2/2436 , A61F2/2475 , A61F2/95 , A61F2002/011
摘要： Delivery systems and methods of treatment are described. The delivery systems facilitate visualization, monitoring, or sensing of body vessel parameters, blood parameters, or an intraluminal medical device included in the delivery system prior to, during, or after deployment in a body vessel. A sensing apparatus associated with the delivery systems provide information relating to the body vessel and/or fluid within the body vessel that can be used for verification of placement, confirmation of intraluminal medical device function, and/or determination of the need for additional delivery steps, among other purposes. The information can also be used for verification of initial vessel sizing information.
摘要翻译：描述了递送系统和治疗方法。递送系统便于在部署在体内血管之前，期间或之后的体内血管参数，血液参数或包括在输送系统中的管腔内医疗装置的可视化，监测或感测。与输送系统相关联的感测装置提供与身体容器和/或身体容器内的流体相关的信息，其可用于验证放置，确认管腔内医疗装置的功能和/或确定需要额外的输送步骤，其他目的。该信息也可用于验证初始容器尺寸信息。

75. 发明授权

US07524332B2 Vascular valve with removable support component 有权
标题翻译：具有可拆卸支撑部件的血管瓣
公开(公告)号：US07524332B2
公开(公告)日：2009-04-28
申请号：US10549437
申请日：2004-03-17
申请人： Thomas A. Osborne , Brian C. Case , David R. Lessard , Neal E. Fearnot
发明人： Thomas A. Osborne , Brian C. Case , David R. Lessard , Neal E. Fearnot
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2427 , A61F2/243 , A61F2/2475 , A61F2220/0016 , A61F2220/005 , A61F2220/0075 , A61F2230/0026 , A61F2230/0095
摘要： Described are vascular valve devices having valve elements formed of flexible material and at least one removable frame element. Also described are methods for using such devices in the vascular system and in particular in the venous system to treat venous insufficiency.
摘要翻译：描述了具有由柔性材料形成的阀元件和至少一个可拆卸框架元件的血管瓣膜装置。还描述了在血管系统中，特别是在静脉系统中使用这种装置来治疗静脉功能不全的方法。

76. 发明授权

US07449027B2 Modifying fluid flow in a body vessel lumen to promote intraluminal flow-sensitive processes 有权
标题翻译：修改体内血管腔内的流体流动，以促进腔内流感敏感过程
公开(公告)号：US07449027B2
公开(公告)日：2008-11-11
申请号：US11093401
申请日：2005-03-29
申请人： James B. Hunt , Brian C. Case
发明人： James B. Hunt , Brian C. Case
IPC分类号： A61F2/06
CPC分类号： A61F2/2403 , A61B17/12022 , A61B17/12036 , A61B17/1204 , A61B17/12109 , A61B17/12131 , A61B50/30 , A61B2017/00783 , A61F2/2412 , A61F2/2475 , A61F2002/068 , A61F2250/006 , Y10S623/903
摘要： The present invention, in one embodiment, provides an implantable intraluminal fluid flow control system comprising an interface and a flow-modifying device positioned at a flow-modifying effective distance from the interface within the lumen of a body vessel. In one embodiment, the invention relates to maintaining, regulating or varying the fluid flow within a body vessel to preserve, promote, alter or enhance remodeling of tissue at the interface. Remodeling can include the resorption and replacement of implanted remodelable material with autologous tissue. The interface can comprise remodelable material such as small intestine submucosa. In one embodiment, one or more interfaces are positioned at flow-modifying effective distances from one or more flow-modifying devices. Related medical devices, kits and methods of treatment are also provided in some embodiments.
摘要翻译：本发明在一个实施例中提供了一种植入式管腔内流体流动控制系统，其包括界面和流动修改装置，所述界面和流动修改装置以与主体容器的内腔内的界面有效距离的流动修改方式定位。在一个实施方案中，本发明涉及维持，调节或改变体内容器内的流体流动以保持，促进，改变或增强组织在界面处的重塑。重塑可以包括用自体组织吸收和替换植入的可重塑材料。界面可以包括可重塑的材料，例如小肠粘膜下层。在一个实施例中，一个或多个接口被定位成与一个或多个流量修改设备的流动修改有效距离。在一些实施例中也提供了相关的医疗装置，套件和治疗方法。

77. 发明申请

US20080255580A1 MEDICAL DEVICE DELIVERY SYSTEM WITH SHEATH SEPARATION 有权
标题翻译：医疗器械输送系统与分离
公开(公告)号：US20080255580A1
公开(公告)日：2008-10-16
申请号：US12059241
申请日：2008-03-31
申请人： GRANT T. HOFFMAN , Brian C. Case
发明人： GRANT T. HOFFMAN , Brian C. Case
IPC分类号： A61B17/00
CPC分类号： A61F2/95 , A61F2/958 , A61F2/97
摘要： Medical device delivery systems and associated methods are provided. Delivery systems according to the invention include an elongated tubular member and a body member, such as a dilator, disposed therein. An intraluminal medical device is disposed on the dilator and within the tubular member prior to deployment. The delivery system includes a means for separating two or more portions of the distal end of the tubular member that aids in deploying the intraluminal medical device from the delivery system by separating two or more portions of the tubular member from each other to facilitate release of the intraluminal medical device from the body member. Various structures can be used for means for separating, including a cutting ring, activateable material on the tubular member, or other suitable structure. The provided devices and methods reduce friction occuring from relative movement between the sheath and dilator during deployment.
摘要翻译：提供医疗器械输送系统及相关方法。根据本发明的递送系统包括细长的管状构件和设置在其中的诸如扩张器的主体构件。在展开之前，将管腔内医疗装置设置在扩张器上并在管状构件内。递送系统包括用于分离管状构件的远端的两个或更多个部分的装置，其通过将管状构件的两个或更多个部分彼此分离来有助于将管腔内医疗装置从输送系统展开以便于释放管腔内医疗器械从身体成员。各种结构可以用于分离的装置，包括切割环，管状构件上的可激活材料或其他合适的结构。所提供的装置和方法减少在展开期间由护套和扩张器之间的相对运动发生的摩擦力。

78. 发明申请

US20080058955A1 PROSTHETIC TESTICLE 审中-公开
标题翻译：假药
公开(公告)号：US20080058955A1
公开(公告)日：2008-03-06
申请号：US11844198
申请日：2007-08-23
申请人： Gary Bradford Shirley , Ram H. Paul , Brian C. Case
发明人： Gary Bradford Shirley , Ram H. Paul , Brian C. Case
IPC分类号： A61F2/02 , A46B11/00
CPC分类号： A61L27/56 , A61F2/0059 , A61F2/022 , A61F2230/0076 , A61F2250/0068 , A61L27/34 , A61L27/3641 , C08L75/04
摘要： A prosthetic testicle is provided that is able to mimic the movement and feel of a natural testicle while at the same time being able to remodel itself into native tissue. Additionally, the prosthetic testicle is able to provide long-term delivery of drugs into the patient.
摘要翻译：提供了一种能够模仿天然睾丸运动和手感的假体睾丸，同时能够将自身改造成天然组织。此外，假体睾丸能够向患者提供药物的长期输送。

79. 发明授权

US10413652B2 Systems and methods for use and control of an automated separator with adsorption columns 有权
公开(公告)号：US10413652B2
公开(公告)日：2019-09-17
申请号：US14110587
申请日：2011-04-13
申请人： John T. Foley , Jonathan Prendergast , Lan T. Nguyen , Brian C. Case
发明人： John T. Foley , Jonathan Prendergast , Lan T. Nguyen , Brian C. Case
IPC分类号： A61M1/36
摘要： Blood treatment systems and methods are provided for combining a blood separation system and an adsorption device. The blood separation system is configured to separate a blood component from blood, while the adsorption device is configured to receive at least a portion of the separated blood component and process it. The blood separation system includes a fluid flow element and a controller. The fluid flow element is configured for flowing the separated blood component into the adsorption device. The controller controls the fluid flow element based at least in part on one or more processing parameters. The processing parameters include a maximum flow rate of the separated blood component flowed into the adsorption device, a maximum pressure of the separated blood component flowed into the adsorption device, and/or the volume of fluid in a location of the system.

80. 发明授权

US09533089B2 Centrifugation system with red blood cell barrier 有权
标题翻译：具有红细胞屏障的离心系统
公开(公告)号：US09533089B2
公开(公告)日：2017-01-03
申请号：US14008651
申请日：2012-03-28
申请人： Kyungyoon Min , Richard I. Brown , John T. Foley , Brian C. Case
发明人： Kyungyoon Min , Richard I. Brown , John T. Foley , Brian C. Case
IPC分类号： A61M1/36 , B04B5/04
CPC分类号： A61M1/3693 , A61M1/3696 , A61M2205/128 , A61M2205/3331 , A61M2205/3337 , B04B5/0442 , B04B2005/045 , C12N5/0634 , C12N5/0641 , C12N5/0644
摘要： Centrifugation systems and methods are provided for separating blood into its constituent parts. Inner and outer walls of a centrifuge each include a projection which extends toward the other wall. A separation chamber is received in the centrifuge between the walls, with the chamber including an inlet port for flowing blood into the chamber, a plasma outlet port for flowing plasma out of the chamber, and a red cell outlet port for flowing red blood cells out of the chamber. With the chamber received in the centrifuge between the walls, the first projection extends into the path of separated blood components flowing toward the plasma outlet port and prevents cellular blood components from flowing into the plasma outlet port. The second projection extends into the path of separated blood components flowing toward the red cell outlet port and prevents plasma from flowing into the red cell outlet port.
摘要翻译：提供离心系统和方法用于将血液分离成其组成部分。离心机的内壁和外壁各自包括朝向另一壁延伸的突起。分离室被容纳在离心机之间的壁之间，其中腔室包括用于使血液进入腔室的入口端口，用于使等离子体流出腔室的等离子体出口和用于使红细胞流出的红细胞出口的房间。随着室中的离心机容纳在壁之间，第一突出部延伸到分离的血液成分流向等离子体出口端口的路径中，并防止细胞血液成分流入等离子体出口。第二突出部延伸到朝向红细胞出口流动的分离的血液成分的路径中，并防止血浆流入红细胞出口。

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