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1. 发明授权

US07524332B2 Vascular valve with removable support component 有权
标题翻译：具有可拆卸支撑部件的血管瓣
公开(公告)号：US07524332B2
公开(公告)日：2009-04-28
申请号：US10549437
申请日：2004-03-17
申请人： Thomas A. Osborne , Brian C. Case , David R. Lessard , Neal E. Fearnot
发明人： Thomas A. Osborne , Brian C. Case , David R. Lessard , Neal E. Fearnot
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2427 , A61F2/243 , A61F2/2475 , A61F2220/0016 , A61F2220/005 , A61F2220/0075 , A61F2230/0026 , A61F2230/0095
摘要： Described are vascular valve devices having valve elements formed of flexible material and at least one removable frame element. Also described are methods for using such devices in the vascular system and in particular in the venous system to treat venous insufficiency.
摘要翻译：描述了具有由柔性材料形成的阀元件和至少一个可拆卸框架元件的血管瓣膜装置。还描述了在血管系统中，特别是在静脉系统中使用这种装置来治疗静脉功能不全的方法。

2. 发明授权

US06881209B2 Medical device including unitary, continuous portion of varying durometer 有权
标题翻译：医疗设备包括单位，连续部分变化的硬度
公开(公告)号：US06881209B2
公开(公告)日：2005-04-19
申请号：US09848742
申请日：2001-05-03
申请人： Scott E. Boatman , David G. Burton , Michael C. Hoffa , Thomas A. Osborne , David A. Drewes, Jr. , David R. Lessard , Maggie A. Z. Hupcey
发明人： Scott E. Boatman , David G. Burton , Michael C. Hoffa , Thomas A. Osborne , David A. Drewes, Jr. , David R. Lessard , Maggie A. Z. Hupcey
IPC分类号： A61L29/06 , C08F283/04 , C08G69/48 , A61M25/00 , B29C45/00 , B29C47/00 , B29D9/00
CPC分类号： A61M25/0009 , A61L29/06 , B29C35/08 , B29K2077/00 , B29L2031/7542 , C08F283/04 , C08G69/48 , Y10T29/4998 , C08L77/00 , C08F218/16
摘要： A medical device (110) including a catheter shaft (111) and a unitarily and continuously formed portion (108) having a varying durometer, and optionally including an expandable balloon (18, 118). One or both of the unitarily and continuously formed portion (108) and the balloon (18, 118) are made from an irradiation cross-linked or cross-linkable mixture of a polyamide elastomer and at least one additional cross-linking reactant. The polyamide elastomer can be a polyester amide, a polyether ester amide or a polyether amide, and is preferably a nylon block copolymer. The aromatic molecule can be 1,3,5 triethyl benzene; 1,2,4 triethyl benzene; and 1,3,5 triisopropyl benzene. The cross-linking reactant can be: (a) a difunctional material, (b) a trifunctional material, (c) a tetrafunctional material, or (d) an aromatic molecule containing at least two ring substituents, each of the ring substituents having labile hydrogens at a benzylic site therein. The cross-linking reactant can also be diallyl phthalate or meta-phenylene dimaleimide.
摘要翻译：一种医疗装置（110），包括导管轴（111）和具有变化的硬度的整体连续形成部分（108），并且可选地包括可膨胀气囊（18,118）。整体和连续形成的部分（108）和球囊（18,118）中的一个或两个由聚酰胺弹性体和至少一种另外的交联反应物的照射交联或可交联混合物制成。聚酰胺弹性体可以是聚酯酰胺，聚醚酯酰胺或聚醚酰胺，优选为尼龙嵌段共聚物。芳族分子可以是1,3,5三乙基苯; 1,2,4三乙苯; 和1,3,5三异丙基苯。交联反应物可以是：（a）双官能材料，（b）三官能材料，（c）四官能材料，或（d）含有至少两个环取代基的芳族分子，每个环取代基具有不稳定性在其苄基位点处的氢。交联反应物也可以是邻苯二甲酸二烯丙酯或间亚苯基二马来酰亚胺。

3. 发明授权

US07722795B2 Medical device including unitary, continuous portion of varying durometer 有权
标题翻译：医疗设备包括单位，连续部分变化的硬度
公开(公告)号：US07722795B2
公开(公告)日：2010-05-25
申请号：US10813415
申请日：2004-03-30
申请人： Scott E. Boatman , David G. Burton , Michael C. Hoffa , Thomas A. Osborne , David A. Drewes, Jr. , David R. Lessard , Maggie A. Z. Hupcey
发明人： Scott E. Boatman , David G. Burton , Michael C. Hoffa , Thomas A. Osborne , David A. Drewes, Jr. , David R. Lessard , Maggie A. Z. Hupcey
IPC分类号： B29C35/08
CPC分类号： A61M25/0009 , A61L29/06 , B29C35/08 , B29K2077/00 , B29L2031/7542 , C08F283/04 , C08G69/48 , Y10T29/4998 , C08L77/00 , C08F218/16
摘要： A medical device (110) including a catheter shaft (111) and a unitarily and continuously formed portion (108) having a varying durometer, and optionally including an expandable balloon (18, 118). One or both of the unitarily and continuously formed portion (108) and the balloon (18, 118) are made from an irradiation cross-linked or cross-linkable mixture of a polyamide elastomer and at least one additional cross-linking reactant. The polyamide elastomer can be a polyester amide, a polyether ester amide or a polyether amide, and is preferably a nylon block copolymer. The aromatic molecule can be 1,3,5 triethyl benzene; 1,2,4 triethyl benzene; and 1,3,5 triisopropyl benzene. The cross-linking reactant can be: (a) a difunctional material, (b) a trifunctional material, (c) a tetrafunctional material, or (d) an aromatic molecule containing at least two ring substituents, each of the ring substituents having labile hydrogens at a benzylic site therein. The cross-linking reactant can also be diallyl phthalate or meta-phenylene dimaleimide.
摘要翻译：一种医疗装置（110），包括导管轴（111）和具有变化的硬度的整体连续形成部分（108），并且可选地包括可膨胀气囊（18,118）。整体和连续形成的部分（108）和球囊（18,118）中的一个或两个由聚酰胺弹性体和至少一种另外的交联反应物的照射交联或可交联混合物制成。聚酰胺弹性体可以是聚酯酰胺，聚醚酯酰胺或聚醚酰胺，优选为尼龙嵌段共聚物。芳族分子可以是1,3,5三乙基苯; 1,2,4三乙苯; 和1,3,5三异丙基苯。交联反应物可以是：（a）双官能材料，（b）三官能材料，（c）四官能材料，或（d）含有至少两个环取代基的芳族分子，每个环取代基具有不稳定性在其苄基位点处的氢。交联反应物也可以是邻苯二甲酸二烯丙酯或间亚苯基二马来酰亚胺。

4. 发明授权

US07713260B2 Catheter having an overmolded hub 有权
标题翻译：导管有一个包覆成型的轮毂
公开(公告)号：US07713260B2
公开(公告)日：2010-05-11
申请号：US10937862
申请日：2004-09-09
申请人： David R. Lessard , Scott E. Eells , Gregory A. Frankland , David A. Drewes, Jr.
发明人： David R. Lessard , Scott E. Eells , Gregory A. Frankland , David A. Drewes, Jr.
IPC分类号： A61M39/10
CPC分类号： A61M25/0009 , A61M25/0028 , A61M25/0032 , A61M25/0097 , A61M25/1036
摘要： Catheters having an overmolded hub are disclosed. The overmolded catheter hubs may include one or more access hubs that are overmolded with an overmold material. The catheter hub may also be formed as a single piece from the overmold material. The overmolded construction can result in a stronger bond between the catheter body and the hub and can provide for access hubs having sufficient clarity for the observation of air bubbles in a contained fluid. The disclosed catheter hubs may also demonstrate improved balloon deflation rates when utilized with a catheter body having a distal balloon.
摘要翻译：公开了具有包覆成型毂的导管。包覆成型的导管套管可以包括一个或多个通过包覆成型材料包覆成型的接入轮毂。导管座也可以从包覆成型材料形成为单件。包覆成型的结构可以导致导管主体和轮毂之间的更牢固的结合，并且可以提供具有足够透明度的接近轮毂，用于观察容纳流体中的气泡。当与具有远端气囊的导管主体一起使用时，所公开的导管套还可以显示改进的气囊放气速率。

5. 发明申请

US20110313403A1 LOCKING MECHANISM FOR A CATHETER 审中-公开
标题翻译：导管的锁定机构
公开(公告)号：US20110313403A1
公开(公告)日：2011-12-22
申请号：US13129906
申请日：2009-11-12
申请人： Amy Lee Hruska , Geoffrey P. Grant , David R. Lessard , Steven D. Anderson , Michael W. Hardert
发明人： Amy Lee Hruska , Geoffrey P. Grant , David R. Lessard , Steven D. Anderson , Michael W. Hardert
IPC分类号： A61M27/00
CPC分类号： A61M25/0097 , A61M25/04 , A61M2025/0163 , A61M2210/1085
摘要： A locking mechanism (15) for a catheter includes a main body (20), a tip (30), and a locking arm (50). The locking arm includes a pivotable portion (56) selectively receivable in a contoured outer surface portion of the main body (24). One end of a tubular member is engageable with the distal end of the tip, and the other end is insertable into a body cavity, e.g., for drainage of fluid therefrom. A tension member (14), e.g. suture, extends through the locking mechanism and the tubular member, and is actuable to maneuver the inserted end of the tubular member into a desired configuration, such as a loop or a pigtail (12). An end of the tension member is receivable along the main body contoured surface following actuation, and is lockable therein upon receipt of the locking arm pivotable portion in the contoured surface, thereby locking the tubular member end in the desired configuration.
摘要翻译：用于导管的锁定机构（15）包括主体（20），尖端（30）和锁定臂（50）。锁定臂包括可选择性地容纳在主体（24）的轮廓外表面部分中的可枢转部分（56）。管状构件的一端可与尖端的远端接合，另一端可插入体腔，例如用于从其中排出流体。张紧构件（14），例如缝合线延伸穿过锁定机构和管状构件，并且可致动以操纵管状构件的插入端部到期望的构造，例如环形或尾纤（12）。张紧构件的端部可沿致动后的主体轮廓表面接收，并且在接收到成形表面中的锁定臂可枢转部分时可锁定在其中，从而将管状构件端部锁定在期望的构造中。

6. 发明授权

US06592550B1 Medical device including improved expandable balloon 有权
公开(公告)号：US06592550B1
公开(公告)日：2003-07-15
申请号：US09663747
申请日：2000-09-15
申请人： Scott E. Boatman , David G. Burton , Michael C. Hoffa , David R. Lessard , David A. Drewes, Jr. , Maggie A. Z. Hupcey
发明人： Scott E. Boatman , David G. Burton , Michael C. Hoffa , David R. Lessard , David A. Drewes, Jr. , Maggie A. Z. Hupcey
IPC分类号： A61M3100
CPC分类号： C08G69/48 , A61L29/06 , C08F283/04 , C08L77/00 , C08F218/16
摘要： A medical device (10) includes a catheter shaft (11) including inner and outer catheter shafts (12 and 14), and an expandable balloon (18) carried by the catheter shaft (11). The balloon (18) is made from an irradiation cross-linked mixture of a polyamide elastomer and at least one additional cross-linking reactant. The polyamide elastomer can be a polyester amide, a polyether ester amide or a polyether amide, and is preferably a nylon block copolymer. The cross-linking reactant can be: (a) a difunctional material, (b) a trifunctional material, (c) a tetrafunctional material, or (d) an aromatic molecule containing at least two ring substituents, each of the ring substituents having labile hydrogens at a benzylic site therein. The cross-linking reactant can also be diallyl phthalate or meta-phenylene dimaleimide. Irradiation is carried out by exposure to an electron beam or to ultraviolet, X- or gamma radiation, preferably at a total fluence of about 0.5 to about 20 megarads. The amount of the cross-linking reactant is selected to avoid the formation of gelling during the process by which the balloon (18) is made, and the amount of the cross-linking agent and the irradiation fluence are selected to give the balloon a strength generally about equal to that which would be obtained by mere irradiation.

7. 发明授权

US07485250B2 Medical device including improved expandable balloon 有权
标题翻译：医疗装置包括改进的可膨胀气囊
公开(公告)号：US07485250B2
公开(公告)日：2009-02-03
申请号：US10463749
申请日：2003-06-16
申请人： Scott E. Boatman , David G. Burton , Michael C. Hoffa , David R. Lessard , David A. Drewes, Jr. , Maggie A. Z. Hupcey
发明人： Scott E. Boatman , David G. Burton , Michael C. Hoffa , David R. Lessard , David A. Drewes, Jr. , Maggie A. Z. Hupcey
IPC分类号： B29C35/08 , D01F1/02 , A61M29/00
CPC分类号： C08G69/48 , A61L29/06 , C08F283/04 , C08L77/00 , C08F218/16
摘要： A medical device (10) includes a catheter shaft (11) including inner and outer catheter shafts (12 and 14), and an expandable balloon (18) carried by the catheter shaft (11). The balloon (18) is made from an irradiation cross-linked mixture of a polyamide elastomer and at least one additional cross-linking reactant. The polyamide elastomer can be a polyester amide, a polyether ester amide or a polyether amide, and is preferably a nylon block copolymer. The cross-linking reactant can be: (a) a difunctional material, (b) a trifunctional material, (c) a tetrafunctional material, or (d) an aromatic molecule containing at least two ring substituents, each of the ring substituents having labile hydrogens at a benzylic site therein. The cross-linking reactant can also be diallyl phthalate or meta-phenylene dimaleimide. Irradiation is carried out by exposure to an electron beam or to ultraviolet, X- or gamma radiation, preferably at a total fluence of about 0.5 to about 20 megarads. The amount of the cross-linking reactant is selected to avoid the formation of gelling during the process by which the balloon (18) is made, and the amount of the cross-linking agent and the irradiation fluence are selected to give the balloon a strength generally about equal to that which would be obtained by mere irradiation.
摘要翻译：医疗装置（10）包括导管轴（11），其包括内导管轴和外导管轴（12和14）和由导管轴（11）承载的可膨胀气囊（18）。球囊（18）由聚酰胺弹性体和至少一种另外的交联反应物的照射交联混合物制成。聚酰胺弹性体可以是聚酯酰胺，聚醚酯酰胺或聚醚酰胺，优选为尼龙嵌段共聚物。交联反应物可以是：（a）双官能材料，（b）三官能材料，（c）四官能材料，或（d）含有至少两个环取代基的芳族分子，每个环取代基具有不稳定性在其苄基位点处的氢。交联反应物也可以是邻苯二甲酸二烯丙酯或间亚苯基二马来酰亚胺。照射通过暴露于电子束或紫外线，X射线或γ射线进行，优选以约0.5至约20兆拉德的总注量。选择交联反应物的量以避免在制备气囊（18）的过程中形成胶凝，并且选择交联剂的量和照射注量以使球囊具有强度通常大约等于仅通过照射获得的能量。

8. 发明授权

US07914841B2 Inline application of coatings 有权
标题翻译：在线应用涂料
公开(公告)号：US07914841B2
公开(公告)日：2011-03-29
申请号：US11700984
申请日：2007-02-01
申请人： Scott E. Eells , David R. Lessard
发明人： Scott E. Eells , David R. Lessard
IPC分类号： B05D3/02 , B05D3/10 , A61M25/00 , B28B3/20 , B29C47/88
CPC分类号： B05D7/02 , B05D2254/00 , B05D2254/02 , B29C37/0092 , B29C47/0023 , B29C47/0066 , B29C47/021 , B29C47/065 , B29C47/882 , B29C47/8895 , B29C65/02 , B29C65/16 , B29C65/48 , B29C66/1142 , B29C66/5221 , B29C2035/046 , B29C2035/0827 , B29C2035/1616 , B29C2793/0027 , B29C2793/009 , B29D23/001 , B29K2027/06 , B29K2027/18 , B29K2075/00 , B29K2077/00 , B29K2079/08 , B29K2995/0092 , B29L2023/007 , B29L2031/7542 , C23C26/00 , B29C65/00
摘要： A method of forming a coated medical device is described. A coating may be applied inline to a continuous tubing formed by extrusion, prior to cutting and secondary operations. Thus, inefficient and labor-intensive steps associated with preparing individual tubes for coating may be avoided. The method may include forcing a flowable material through an exit port of an extruder, depositing a coating onto at least a portion of the continuous length of extruded tubing after the tubing is forced through the exit port, cutting the coated tubing to a desired length after depositing the coating, and performing one or more secondary operations on the coated tube at a temperature in the range of from about 15° C. to about 375° C.
摘要翻译：描述形成涂覆的医疗装置的方法。在切割和二次操作之前，可以将涂层在线施加到由挤出形成的连续管道上。因此，可以避免与准备用于涂覆的各个管相关的低效和劳动密集的步骤。该方法可以包括迫使可流动材料通过挤出机的出口，在管被强制通过出口之后将涂层沉积在连续长度的挤压管道的至少一部分上，之后将涂覆的管道切割成所需长度沉积涂层，并在约15℃至约375℃的温度下对涂覆的管进行一次或多次二次操作。

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