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71. 发明授权

US07833474B2 Sterile device and method for producing same 有权
标题翻译：无菌装置及其制造方法
公开(公告)号：US07833474B2
公开(公告)日：2010-11-16
申请号：US12405840
申请日：2009-03-17
申请人： Aaron J. Swanson , Jennifer M. Reynolds , Rajiv Shah
发明人： Aaron J. Swanson , Jennifer M. Reynolds , Rajiv Shah
IPC分类号： G01N27/00 , B08B17/00 , A61L2/00 , A61L9/00 , B05D5/12 , A61F2/48 , A61F2/70 , B65B55/02 , B65D85/84 , A61N1/18 , G01F1/64
CPC分类号： A61L2/18 , A61B5/1486 , A61B5/1495 , A61L2/08 , A61L2/206 , A61L2202/24 , Y10S422/905
摘要： A sterile device immersed in a sterile buffer and a method for providing same. The sterile device may be a medical device such as a biosensor having a biomolecule as a sensing element such as, for example, a glucose oxidase enzyme. The buffer may be a bicarbonate solution. Both the device and the buffer may be packaged and stored over long term while maintaining sterilization. The sterilization method may comprise a combination of gaseous, liquid and light sterilization.
摘要翻译：浸在无菌缓冲液中的无菌装置及其提供方法。无菌装置可以是诸如生物传感器的医疗装置，其具有生物分子作为感测元件，例如葡萄糖氧化酶。缓冲液可以是碳酸氢盐溶液。设备和缓冲液都可以长期包装和储存，同时保持灭菌。灭菌方法可以包括气体，液体和光灭菌的组合。

72. 发明申请

US20100285084A1 Antimicrobial coatings for medical devices and methods for making and using them 有权
标题翻译：医疗器械的抗微生物涂层及其制造和使用方法
公开(公告)号：US20100285084A1
公开(公告)日：2010-11-11
申请号：US11983930
申请日：2007-11-13
申请人： Zhongping Yang , Eunjoo Jin , Laura Christoferson , Rajiv Shah
发明人： Zhongping Yang , Eunjoo Jin , Laura Christoferson , Rajiv Shah
IPC分类号： A61F2/00 , B05D1/36 , A61K38/44 , A61P31/00 , A61N1/05
CPC分类号： A61L27/34 , A61L27/54 , A61L2300/11 , A61L2300/208
摘要： Embodiments of the invention provide methods for using compositions to inhibit microbial growth on a surface of a medical device having the composition applied thereto, to medical devices having the composition applied to a surface thereof and to methods for using the compositions to coat medical devices.
摘要翻译：本发明的实施方案提供使用组合物抑制其施用组合物的医疗装置的表面上的微生物生长的方法，以及将组合物施用于其表面的医疗装置以及使用该组合物涂覆医疗装置的方法。

73. 发明申请

US20100280347A1 BIOSENSORS AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：生物传感器及其使用方法
公开(公告)号：US20100280347A1
公开(公告)日：2010-11-04
申请号：US12784220
申请日：2010-05-20
申请人： Rajiv Shah , Gopikrishnan Soundararajan , Rebecca K. Gottlieb , Udo Hoss , Eric A. Grovender , Shaun M. Pendo
发明人： Rajiv Shah , Gopikrishnan Soundararajan , Rebecca K. Gottlieb , Udo Hoss , Eric A. Grovender , Shaun M. Pendo
IPC分类号： A61B5/1473 , B65D71/00 , G01N27/26 , G01N27/30
CPC分类号： C12Q1/006
摘要： Embodiments of the invention provide analyte sensors having optimized permselective membranes and methods for making and using such sensors. Embodiments of the invention also provide analyte sensors such as those having porous matrices coated with an analyte sensing composition and methods for making and using such sensors. Illustrative embodiments include electrochemical glucose sensors having glucose oxidase coatings.
摘要翻译：本发明的实施例提供具有优化的选择渗透膜的分析物传感器以及用于制造和使用这种传感器的方法。本发明的实施例还提供分析物传感器，例如具有涂覆有分析物感测组合物的多孔基质的分析物传感器以及用于制造和使用这种传感器的示例性实施方案包括具有葡萄糖氧化酶涂层的电化学葡萄糖传感器。

74. 发明申请

US20100279377A1 BIOSENSORS AND METHODS FOR MAKING AND USING THEM 审中-公开
公开(公告)号：US20100279377A1
公开(公告)日：2010-11-04
申请号：US12784233
申请日：2010-05-20
申请人： Rajiv Shah , Gopikrishnan Soundararajan , Rebecca K. Gottlieb , Udo Hoss , Eric A. Grovender , Shaun M. Pendo
发明人： Rajiv Shah , Gopikrishnan Soundararajan , Rebecca K. Gottlieb , Udo Hoss , Eric A. Grovender , Shaun M. Pendo
IPC分类号： C12N11/08
CPC分类号： C12Q1/006
摘要： Embodiments of the invention provide analyte sensors having optimized permselective membranes and methods for making and using such sensors. Embodiments of the invention also provide analyte sensors such as those having porous matrices coated with an analyte sensing composition and methods for making and using such sensors. Illustrative embodiments include electrochemical glucose sensors having glucose oxidase coatings.

75. 发明授权

US07813780B2 Biosensors and methods for making and using them 有权
标题翻译：生物传感器和制造和使用它们的方法
公开(公告)号：US07813780B2
公开(公告)日：2010-10-12
申请号：US11301512
申请日：2005-12-13
申请人： Rajiv Shah , Gopikrishnan Soundararajan , Rebecca K. Gottlieb , Udo Hoss , Eric A. Grovender , Shaun M. Pendo
发明人： Rajiv Shah , Gopikrishnan Soundararajan , Rebecca K. Gottlieb , Udo Hoss , Eric A. Grovender , Shaun M. Pendo
IPC分类号： A61B5/05
CPC分类号： C12Q1/006
摘要： Embodiments of the invention provide analyte sensors having optimized permselective membranes and methods for making and using such sensors. Embodiments of the invention also provide analyte sensors such as those having porous matrices coated with an analyte sensing composition and methods for making and using such sensors. Illustrative embodiments include electrochemical glucose sensors having glucose oxidase coatings.
摘要翻译：本发明的实施例提供具有优化的选择渗透膜的分析物传感器以及用于制造和使用这种传感器的方法。本发明的实施例还提供分析物传感器，例如具有涂覆有分析物感测组合物的多孔基质的分析物传感器以及用于制造和使用这种传感器的示例性实施方案包括具有葡萄糖氧化酶涂层的电化学葡萄糖传感器。

76. 发明授权

US07781328B2 Multilayer substrate 有权
标题翻译：多层基板
公开(公告)号：US07781328B2
公开(公告)日：2010-08-24
申请号：US11868898
申请日：2007-10-08
申请人： Rajiv Shah , Shaun Pendo , Edward B. Babiricki
发明人： Rajiv Shah , Shaun Pendo , Edward B. Babiricki
IPC分类号： H01L21/4763
CPC分类号： H01L21/4857 , H01L2924/0002 , H05K1/092 , H05K3/4061 , H05K3/4647 , H05K3/4667 , H05K3/467 , H05K2201/0179 , H05K2203/0278 , H01L2924/00
摘要： A multilayer substrate device formed from a base substrate and alternating metalization layers and dielectric layers. Each layer is formed without firing. Vias may extend through one of the dielectric layers such that two metalization layers surrounding the dielectric layers make contact with each other. The vias may be formed by placing pillars on top of a metalization layer, forming a dielectric layer on top of the metalization layer and surrounding the pillars, and removing the pillars. Dielectric layers may be followed by other dielectric layers and metalization layers may be followed by other metalization layers. Vias in the substrate may be filled by forming an assembly around the substrate, the assembly including printing sheets containing a conductive ink and pressure plates for applying pressure. A vacuum may be applied to remove air in the ink. Pressure may then be applied to the printing sheets through the pressure plates. The conductive ink in the printing sheets is pushed through the vias when pressure is applied by the pressure plates.
摘要翻译：由基底基板和交替的金属化层和电介质层形成的多层衬底器件。每层形成而不烧制。通孔可以延伸穿过介电层之一，使得围绕电介质层的两个金属化层彼此接触。可以通过将金属化层顶部放置柱子形成通孔，在金属化层的顶部上形成电介质层并围绕柱子，并移除支柱。电介质层之后可以是其它电介质层，金属化层之后可以是其它金属化层。可以通过在基板周围形成组件来填充基板中的通孔，该组件包括含有导电油墨的印刷纸和用于施加压力的压力板。可以施加真空以除去油墨中的空气。然后可以通过压力板将压力施加到印刷纸上。当通过压力板施加压力时，打印纸中的导电油墨被推过通孔。

77. 发明授权

US07736309B2 Implantable sensor method and system 有权
标题翻译：植入式传感器方法和系统
公开(公告)号：US07736309B2
公开(公告)日：2010-06-15
申请号：US10334686
申请日：2002-12-31
申请人： Michael E. Miller , Rajiv Shah
发明人： Michael E. Miller , Rajiv Shah
IPC分类号： A61B5/00 , A61B5/05
CPC分类号： A61B5/6847 , A61B5/0031 , A61B5/04 , A61B5/145 , A61B5/14503 , A61B5/14532 , A61B5/14552 , A61B5/14865 , A61B5/6882 , A61B17/3468 , A61M1/1698 , A61M5/14276 , A61M5/1723 , A61M2230/20 , A61M2230/201 , G06F19/00
摘要： Systems and methods for non-vascular sensor implantation and for measuring physiological parameters in areas of a body where the physiological parameters are heterogeneous. An implant unit is implanted in an area of a body and a foreign body capsule is allowed to form around the implant unit area. A sensor may be directed into a body cavity such as, for example, the peritoneal space, subcutaneous tissues, the foreign body capsule, or other area. A subcutaneous area of the body may be tunneled for sensor placement. Spatially separated sensing elements may be used for detecting individual amounts of the physiological parameter. An overall amount of the physiological parameter may be determined by calculating a statistical measurement of the individual sensed amounts in the area. Another embodiment of the invention, a multi-analyte measuring device, may include a substrate having an electrode array on one side and an integrated circuit on another side.
摘要翻译：用于非血管传感器植入和用于测量生理参数异质的身体的生理参数的系统和方法。植入单元植入身体的一个区域，允许在植入单元区域周围形成异物胶囊。传感器可以被引导到诸如腹膜空间，皮下组织，异物胶囊或其他区域的体腔中。身体的皮下区域可以被隧道用于传感器放置。空间分离的感测元件可用于检测生理参数的各个量。生理参数的总量可以通过计算该区域中各个感测量的统计测量来确定。本发明的多分析物测量装置的另一实施例可以包括在一侧具有电极阵列的基板和在另一侧上的集成电路。

78. 发明授权

US07725148B2 Sensor with layered electrodes 有权
标题翻译：带层状电极的传感器
公开(公告)号：US07725148B2
公开(公告)日：2010-05-25
申请号：US11234523
申请日：2005-09-23
申请人： Rajiv Shah , Rebecca K. Gottlieb
发明人： Rajiv Shah , Rebecca K. Gottlieb
IPC分类号： A61B5/05 , A61B5/00 , G01N31/00 , G01N33/50 , G01N27/26 , C12M1/00 , C12Q1/00
CPC分类号： A61B5/14865 , A61B5/0004 , A61B5/0017 , A61B5/14532 , A61B5/6848 , A61B5/6849 , C12Q1/006 , C23C14/20 , C23C14/3414 , G01N27/307 , G01N27/3273 , G01N27/4166 , Y10T29/49002 , Y10T29/49005 , Y10T29/49007 , Y10T29/49117 , Y10T29/49155
摘要： A thin film sensor, such as a glucose sensor, is provided for transcutaneous placement at a selected site within the body of a patient. The sensor includes several sensor layers that include conductive layers and includes a proximal segment defining conductive contacts adapted for electrical connection to a suitable monitor, and a distal segment with sensor electrodes for transcutaneous placement. The sensor electrode layers are disposed generally above each other, for example with the reference electrode above the working electrode and the working electrode above the counter electrode. The electrode layers are separated by dielectric layer.
摘要翻译：提供薄膜传感器，例如葡萄糖传感器，用于经皮放置在患者体内的选定部位。传感器包括几个传感器层，其包括导电层，并且包括限定适于与合适的监视器电连接的导电触点的近端段，以及具有用于经皮放置的传感器电极的远端段。传感器电极层大致彼此上下设置，例如，在工作电极上方的参考电极和对置电极上方的工作电极。电极层由电介质层分离。

79. 发明授权

US07659194B2 High reliability multilayer circuit substrates and methods for their formation 有权
标题翻译：高可靠性多层电路基板及其形成方法
公开(公告)号：US07659194B2
公开(公告)日：2010-02-09
申请号：US11395457
申请日：2006-03-31
申请人： Rajiv Shah , Shaun Pendo
发明人： Rajiv Shah , Shaun Pendo
IPC分类号： H01L21/4763
CPC分类号： H05K3/467 , H01L21/4857 , H01L21/4867 , H01L2924/0002 , H01L2924/19107 , H05K1/162 , H05K3/048 , H05K3/4053 , H05K3/4061 , H05K3/4664 , H05K2201/0179 , H05K2203/0278 , H05K2203/085 , H05K2203/1476 , H05K2203/308 , H01L2924/00
摘要： A multilayer circuit substrate for multi-chip modules or hybrid circuits includes a dielectric base substrate, conductors formed on the base substrate and a vacuum deposited dielectric thin film formed over the conductors and the base substrate. The vacuum deposited dielectric thin film is patterned using sacrificial structures formed by shadow mask techniques. Substrates formed in this manner enable significant increases in interconnect density and significant reduction of over-all substrate thickness.
摘要翻译：用于多芯片模块或混合电路的多层电路衬底包括电介质基底，形成在基底衬底上的导体和形成在导体和基底衬底上的真空沉积的电介质薄膜。使用由荫罩技术形成的牺牲结构对真空沉积的电介质薄膜进行图案化。以这种方式形成的基板能够显着增加互连密度并显着降低总体衬底厚度。

80. 发明申请

US20090299301A1 Needle protective device for subcutaneous sensors 有权
标题翻译：用于皮下传感器的针头保护装置
公开(公告)号：US20090299301A1
公开(公告)日：2009-12-03
申请号：US12154935
申请日：2008-05-28
申请人： Rebecca K. Gottlieb , Rajiv Shah , Katherine T. Wolfe , Eric Allan Larson
发明人： Rebecca K. Gottlieb , Rajiv Shah , Katherine T. Wolfe , Eric Allan Larson
IPC分类号： A61M5/32 , A61B5/055
CPC分类号： A61B5/14532 , A61B5/1473 , A61B5/6849 , A61B17/3496 , A61M5/158 , A61M5/3243 , A61M25/0612 , A61M37/0069 , A61M2005/1585 , A61M2005/3247
摘要： An introducer is provided for introducing a sensor into the body of a patient. The introducer connects to a sensor hub. When the sensor hub and introducer are connected, the introducer needle is exposed. When the sensor hub and introducer are disconnected, a needle cover and the needle move with respect to each other so that the needle cover substantially covers the needle, protecting a user from being injured by the needle.
摘要翻译：提供导引器用于将传感器引入患者体内。导引器连接到传感器集线器。当传感器毂和导引器连接时，导引针被暴露。当传感器毂和导引器断开时，针盖和针相对于彼此移动，使得针盖基本上覆盖针，保护使用者免受针受伤。

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