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71. 发明申请

WO2009076235A3 CELL ASSAY KIT AND METHOD 审中-公开
公开(公告)号：WO2009076235A3
公开(公告)日：2009-10-15
申请号：PCT/US2008085737
申请日：2008-12-05
申请人： ZYOMYX INC , ZAUGG FRANK , TOBIAS RENEE , KERNEN PETER , RUIZ-TAYLOR LAURENCE , WAGNER PETER
发明人： ZAUGG FRANK , TOBIAS RENEE , KERNEN PETER , RUIZ-TAYLOR LAURENCE , WAGNER PETER
IPC分类号： G01N33/49 , G01N33/543 , G01N33/569
CPC分类号： G01N33/54326 , G01N33/491 , G01N33/538 , G01N33/54313 , G01N33/56972
摘要： A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell- collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.

72. 发明申请

WO2005022151A1 FILM LAYER FOR DETECTION OF IMMOBILIZED ANALYTES 审中-公开
标题翻译：用于检测分析仪的胶片层
公开(公告)号：WO2005022151A1
公开(公告)日：2005-03-10
申请号：PCT/US2004/028007
申请日：2004-08-27
申请人： ZYOMYX, INC. , KIM, Raymond
发明人： KIM, Raymond
IPC分类号： G01N33/53
CPC分类号： G01N33/558
摘要： The present invention provides methods and apparatuses for detecting the presence of immobilized molecular analytes. The invention uses a novel film layer comprising a molecular ligand that is capable of diffusibly migrating to the immobilized molecular analyte. A variety of detection methods are useful in detecting the resulting detectable product.
摘要翻译：本发明提供用于检测固定化分子分析物的存在的方法和装置。本发明使用包含分子配体的新颖膜层，其能够扩散迁移至固定的分子分析物。各种检测方法可用于检测所得到的可检测产物。

73. 发明申请

WO03073089A8 METHOD AND DEVICE FOR PERFORMING IMPEDANCE SPECTROSCOPY 审中-公开
标题翻译：用于执行阻抗谱的方法和装置
公开(公告)号：WO03073089A8
公开(公告)日：2004-07-01
申请号：PCT/US0305810
申请日：2003-02-25
申请人： ZYOMYX INC
发明人： WAGNER PETER , WIEGAND GERALD
IPC分类号： G01N27/02 , G01N33/543
CPC分类号： G01N27/026 , G01N33/48728
摘要： A highly time resolved impedance spectroscopy that enhances the measurement of the dynamics of non-stationary systems with enhanced time resolution. The highly time resolved impedance spectroscopy includes an optimized, frequency rich a.c., or transient, voltage signal is used as the perturbation signal, non-stationary time to frequency transformation algorithms are used when processing the measured time signals of the voltage and current to determine impedance spectra which are localized in time; and the system-characterizing quantities are determined from the impedance spectra using equivalent circuit fitting in a time-resolution-optimized form. Methods and apparatus for processing impedance spectra data are also provided.
摘要翻译：高度时间分辨的阻抗谱，增强了具有增强的时间分辨率的非固定系统的动力学测量。高度时间分辨的阻抗谱包括优化的频率丰富的交流或瞬态电压信号被用作扰动信号，当处理测量的电压和电流的时间信号以确定阻抗时，使用非平稳的时间到频率变换算法时间局部化的光谱; 并且使用以时间分辨率优化形式拟合的等效电路从阻抗谱确定系统特征量。还提供了用于处理阻抗谱数据的方法和装置。

74. 发明申请

WO03061570A3 ENGINEERED BINDING PROTEINS 审中-公开
标题翻译：工程结合蛋白
公开(公告)号：WO03061570A3
公开(公告)日：2003-09-18
申请号：PCT/US0301362
申请日：2003-01-16
申请人： ZYOMYX INC
发明人： WILSON DAVID S , NOCK STEFFEN
IPC分类号： C07K14/195 , C12N9/02 , C12N15/07 , C12N15/10 , A61K38/00 , A61K45/00 , A61K47/00 , C07K1/14 , C07K1/16 , C07K14/00 , C12N15/03 , C12N15/64 , C12N15/65 , G01N33/53 , G01N33/566
CPC分类号： C12N15/1093 , B82Y30/00 , C07K14/195 , C12N9/0095
摘要： Engineered binding proteins are provided. In some cases, the parent protein corresponding to the engineered protein has a three-layer swiveling beta/beta/alpha domain. In other cases, the parent protein corresponding to the engineered protein has a rubredoxin like fold. At least one portion of the primary sequence of the engineered protein is determined by an engineering scheme. In some case, the engineered protein is characterized by an ability to bind to a compound that the parent protein does not bind. In some cases, the parent protein is derived from a domain of a chaperonin or a rubredoxin. One form of engineering scheme used is a randomization scheme. A method for making libraries of engineered proteins, all based on a single parent protein is provided. Methods to identify proteins that bind to compounds of interest in libraries of engineered libraries is provided. An array of engineered proteins immobilized on a support is provided. Each engineered protein in the array is a chaperonin domain or a rubredoxin that has been subjected to an engineering scheme.
摘要翻译：提供工程结合蛋白。在某些情况下，对应于工程化蛋白质的亲本蛋白质具有三层旋转β/β/α结构域。在其他情况下，对应于工程改造的蛋白质的亲本蛋白质具有类似于rubredoxin的折叠。工程化蛋白质的初级序列的至少一部分由工程方案确定。在某些情况下，工程改造的蛋白质的特征在于与母体蛋白不结合的化合物结合的能力。在一些情况下，母体蛋白质衍生自伴侣蛋白或红蛋白的结构域。使用的一种工程方案是一种随机化方案。提供了基于单亲蛋白的制备工程蛋白的文库的方法。提供了在工程化文库库中鉴定与目的化合物结合的蛋白质的方法。提供固定在载体上的工程蛋白阵列。阵列中的每种工程化蛋白质都是经过工程方案的伴侣蛋白结构域或红霉素。

75. 发明申请

WO2003001870A2 METHODS FOR MAKING ANTIBODY FRAGMENTS AND COMPOSITIONS RESULTING THEREFROM 审中-公开
标题翻译：制备抗体片段的方法和由此产生的组合物
公开(公告)号：WO2003001870A2
公开(公告)日：2003-01-09
申请号：PCT/US2002/018573
申请日：2002-06-12
申请人： ZYOMYX, INC. , NOCK, Steffen , WILSON, David, S. , WU, Jiangchun
发明人： NOCK, Steffen , WILSON, David, S. , WU, Jiangchun
IPC分类号： C07K16/06 , C12P21/08
CPC分类号： C07K16/065 , C07K2317/41 , C07K2317/54 , Y10S530/866
摘要： Improved methods for making antibody fragments, preferably F(ab')2 fragments from various classes and subclasses of antibodies is described. Pretreatment of antibodies with deglycosylases or cellular inhibition of glycosylation during expression, yields antibodies having improved susceptibility towards protease cleavage, preferably pepsinolysis, which yields F(ab')2 antibody fragments. Compositions resulting from such methods are further disclosed.
摘要翻译：描述了制备抗体片段的改进方法，优选抗体的各种类别和亚类的F（ab'）2片段。用去糖基化酶预处理抗体或在表达期间细胞抑制糖基化，产生对蛋白酶切割（优选胃蛋白酶解）有改进的易感性的抗体，其产生F（ab'）2抗体片段。进一步公开了由这种方法产生的组合物。

76. 发明申请

WO0163241A3 MICROFLUIDIC DEVICES AND METHODS 审中-公开
标题翻译：微流体装置和方法
公开(公告)号：WO0163241A3
公开(公告)日：2002-10-17
申请号：PCT/US0105963
申请日：2001-02-23
申请人： ZYOMYX INC , JEDRZEJEWSKI PAUL , NOCK STEFFEN , WAGNER PETER , INDERMUHLE PIERRE F , ZAUGG FRANK G
发明人： JEDRZEJEWSKI PAUL , NOCK STEFFEN , WAGNER PETER , INDERMUHLE PIERRE F , ZAUGG FRANK G
IPC分类号： G01N33/53 , B01J19/00 , B01L3/00 , B01L3/02 , B01L99/00 , B81B1/00 , C40B40/10 , C40B60/14 , G01N35/04 , G01N35/10 , G01N37/00 , F15C1/04 , G01N27/26 , G01N27/447
CPC分类号： B01L3/0244 , B01J19/0046 , B01J2219/00317 , B01J2219/00351 , B01J2219/00367 , B01J2219/00369 , B01J2219/00382 , B01J2219/00497 , B01J2219/00504 , B01J2219/00509 , B01J2219/00585 , B01J2219/00587 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00664 , B01J2219/00677 , B01J2219/00702 , B01J2219/00725 , B01L3/0241 , B01L3/0248 , B01L3/0262 , B01L3/5085 , B01L3/5088 , B01L2300/0809 , B01L2300/0848 , B01L2400/022 , B01L2400/0688 , B33Y80/00 , B82Y30/00 , C40B40/10 , C40B60/14 , Y10T436/11 , Y10T436/114165 , Y10T436/117497 , Y10T436/118339 , Y10T436/143333 , Y10T436/156666 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： Embodiments of the invention are directed to microfluidic devices. In one embodiment, a microanalysis chip comprises a body having at least one transfer-separation channel with a channel bottom that has a bottom opening. The transfer-separation channel terminates in a discharge aperture.
摘要翻译：本发明的实施例涉及微流体装置。在一个实施例中，微量分析芯片包括具有至少一个具有底部开口的通道底部的转移分离通道的主体。转印分离通道终止于排出孔。

77. 发明申请

WO2001098458A3 METHODS FOR IMMOBILIZING POLYPEPTIDES 审中-公开
公开(公告)号：WO2001098458A3
公开(公告)日：2001-12-27
申请号：PCT/US2001/019531
申请日：2001-06-19
申请人： ZYOMYX, INC. , NOCK, Steffen , SYDOR, Jens
发明人： NOCK, Steffen , SYDOR, Jens
IPC分类号： C07K1/02 , C07K1/04 , C07K1/08 , C07K1/13 , C07K17/06 , C07K19/00 , C08G69/10 , C08L89/00 , C12N15/62 , C12P21/00 , C12P21/04
摘要： This invention provides methods for immobilizing polypeptides, for forming arrays of polypeptides arranged on a support, and arrays produced using the methods of the invention. The immobilized polypeptides of the invention are generally in the same orientation, can be full-length and biologically active, and can be readily screened for a desired activity.

78. 发明申请

WO2009076235A2 CELL ASSAY KIT AND METHOD 审中-公开
标题翻译：细胞测定试剂盒和方法
公开(公告)号：WO2009076235A2
公开(公告)日：2009-06-18
申请号：PCT/US2008085737
申请日：2008-12-05
申请人： ZYOMYX INC , ZAUGG FRANK , TOBIAS RENEE , KERNEN PETER , RUIZ-TAYLOR LAURENCE , WAGNER PETER
发明人： ZAUGG FRANK , TOBIAS RENEE , KERNEN PETER , RUIZ-TAYLOR LAURENCE , WAGNER PETER
IPC分类号： C12Q1/06 , C12M1/00 , G01N33/53 , G01N33/569
CPC分类号： G01N33/54326 , G01N33/491 , G01N33/538 , G01N33/54313 , G01N33/56972
摘要： A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell- collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.
摘要翻译：公开了用于测定细胞样品中存在至少一个给定类型的至少一个阈值数目的细胞的方法和试剂盒。该试剂盒包括具有用于接收细胞样品的样品室和包含选定密度和/或粘度介质并且沿其长度具有多个细胞收集区域的细长收集室的测定装置和能够特异性附着于所选择的细胞类型的细胞，并且当附着于细胞时是有效的，以增加细胞的密度或磁化率。在操作中，细胞样品中的颗粒结合的细胞和颗粒在重力或选定的离心或磁场力的影响下通过细长收集室被拉伸，直到颗粒结合的细胞和颗粒完全填充连续的细胞收集区域收集室。与至少一个收集区域相关联的标记表示所选择类型的细胞的浓度有效至少部分地填充该收集区域。

79. 发明申请

WO2008156491A2 DEVICES AND METHODS FOR ANALYSIS OF SAMPLES WITH DEPLETION OF ANALYTE CONTENT 审中-公开
标题翻译：用于分析分析样品的装置和方法，分析分析内容
公开(公告)号：WO2008156491A2
公开(公告)日：2008-12-24
申请号：PCT/US2007080108
申请日：2007-10-01
申请人： ZYOMYX INC , WAGNER PETER , ZAUGG FRANK , MITCHNIK MARK
发明人： WAGNER PETER , ZAUGG FRANK , MITCHNIK MARK
IPC分类号： G01N33/53
CPC分类号： G01N33/54366 , B01F5/061 , B01F5/0646 , B01F5/0647 , B01F5/0655 , B01F13/0059 , B01F2005/0621 , B01F2005/0636 , B01L3/5023 , B01L3/502746 , B01L2300/0636 , B01L2300/0867 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , B01L2400/086
摘要： A system and method for determining the presence and/or concentration of one or more analytes in a sample that comprises a fluid, the system comprising a solid substrate comprising a sample inlet or inlets and one or more analyte determination flow paths, each analyte determination flow path comprising a defined beginning and a defined terminus and comprising at least one capture zone containing a capture agent for an analyte, the capture agent or agents being immobilized along a portion of the flow path or paths, the flow path or paths being designed so that the one or more analytes are depleted from the sample and bound in a non-linear manner to the portion of the flow path or paths containing immobilized capture agent or agents, producing an analyte depletion end region for each analyte between the beginning and the terminus of the analyte determination flow path.
摘要翻译：一种用于确定包含流体的样品中一种或多种分析物的存在和/或浓度的系统和方法，所述系统包括固体基质，其包含样品入口或入口以及一个或多个分析物确定流动路径，每个分析物确定流程路径，其包含限定的起始点和限定的末端，并且包含至少一个包含分析物的捕获剂的捕获区域，所述捕获剂或试剂沿所述流动路径或路径的一部分被固定，所述流动路径或路径被设计成使得一个或多个分析物从样品中耗尽，并以非线性方式结合到包含固定化捕获剂或试剂的流动路径或路径的部分，从而在每个分析物的起始和终点之间产生分析物耗尽末端区域分析物确定流路。

80. 发明申请

WO2004017042A2 METHODS AND REAGENTS FOR SURFACE FUNCTIONALIZATION 审中-公开
标题翻译：表面功能化的方法和试剂
公开(公告)号：WO2004017042A2
公开(公告)日：2004-02-26
申请号：PCT/US2003/025927
申请日：2003-08-18
申请人： ZYOMYX, INC. , CICERO, Ronald , FORMAN, Jonathan , KERNEN, Peter , LU, Hongbo , QUINCY, David , SCHWEISER, Stefan , WAGNER, Peter
发明人： CICERO, Ronald , FORMAN, Jonathan , KERNEN, Peter , LU, Hongbo , QUINCY, David , SCHWEISER, Stefan , WAGNER, Peter
IPC分类号： G01N
CPC分类号： G01N33/54353 , B82Y30/00
摘要： Reagents and method for making arrays of affinity agents are disclosed. Methods of using the arrays of affinity agents also are disclosed. The arrays are particularly useful for high throughput drug screening and clinical diagnostics applications.
摘要翻译：公开了用于制备亲和剂阵列的试剂和方法。还公开了使用亲和剂阵列的方法。阵列对于高通量药物筛选和临床诊断应用特别有用。

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