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1. 发明申请

WO2004017042A2 METHODS AND REAGENTS FOR SURFACE FUNCTIONALIZATION 审中-公开
标题翻译：表面功能化的方法和试剂
公开(公告)号：WO2004017042A2
公开(公告)日：2004-02-26
申请号：PCT/US2003/025927
申请日：2003-08-18
申请人： ZYOMYX, INC. , CICERO, Ronald , FORMAN, Jonathan , KERNEN, Peter , LU, Hongbo , QUINCY, David , SCHWEISER, Stefan , WAGNER, Peter
发明人： CICERO, Ronald , FORMAN, Jonathan , KERNEN, Peter , LU, Hongbo , QUINCY, David , SCHWEISER, Stefan , WAGNER, Peter
IPC分类号： G01N
CPC分类号： G01N33/54353 , B82Y30/00
摘要： Reagents and method for making arrays of affinity agents are disclosed. Methods of using the arrays of affinity agents also are disclosed. The arrays are particularly useful for high throughput drug screening and clinical diagnostics applications.
摘要翻译：公开了用于制备亲和剂阵列的试剂和方法。还公开了使用亲和剂阵列的方法。阵列对于高通量药物筛选和临床诊断应用特别有用。

2. 发明申请

WO2009076235A4 CELL ASSAY KIT AND METHOD 审中-公开
公开(公告)号：WO2009076235A4
公开(公告)日：2009-06-18
申请号：PCT/US2008/085737
申请日：2008-12-05
申请人： ZYOMYX, INC. , ZAUGG, Frank , TOBIAS, Renee , KERNEN, Peter , RUIZ-TAYLOR, Laurence , WAGNER, Peter
发明人： ZAUGG, Frank , TOBIAS, Renee , KERNEN, Peter , RUIZ-TAYLOR, Laurence , WAGNER, Peter
IPC分类号： G01N33/543 , G01N33/49 , G01N33/569
摘要： A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell- collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.

3. 发明申请

WO2004081983A3 SUBSTRATE PROCESSING APPARATUS AND METHOD FOR THE CONTROLLED FORMATION OF LAYERS INCUDING SELF-ASSEMBLED MONOLYAERS 审中-公开
公开(公告)号：WO2004081983A3
公开(公告)日：2004-09-23
申请号：PCT/US2004/006851
申请日：2004-03-03
申请人： ZYOMYX INC. , HASSELBLATT, Markus , WAGNER, Peter , KERNEN, Peter , ZAUGG, Frank , DE LA SALLE, Olivier
发明人： HASSELBLATT, Markus , WAGNER, Peter , KERNEN, Peter , ZAUGG, Frank , DE LA SALLE, Olivier
IPC分类号： B32B27/04
摘要： Substrate processing methods and apparatuses are disclosed. One embodiment of the invention is directed to a substrate processing apparatus for processing an analytical substrate. The apparatus includes a substrate holder for holding a substrate and a processing chamber including an opening for receiving the substrate holder and the substrate. A fluid inlet and a fluid outlet are in the processing chamber. A washing device adapted to supply a wash liquid to the substrate while the substrate is in the processing chamber. A liquid removal device adapted to dry the substrate when the substrate is being withdrawn from the processing chamber.

4. 发明申请

WO2008156491A3 DEVICES AND METHODS FOR ANALYSIS OF SAMPLES WITH DEPLETION OF ANALYTE CONTENT 审中-公开
公开(公告)号：WO2008156491A3
公开(公告)日：2008-12-24
申请号：PCT/US2007/080108
申请日：2007-10-01
申请人： ZYOMYX, INC. , WAGNER, Peter , ZAUGG, Frank , MITCHNIK, Mark
发明人： WAGNER, Peter , ZAUGG, Frank , MITCHNIK, Mark
IPC分类号： C12M1/34
摘要： A system and method for determining the presence and/or concentration of one or more analytes in a sample that comprises a fluid, the system comprising a solid substrate comprising a sample inlet or inlets and one or more analyte determination flow paths, each analyte determination flow path comprising a defined beginning and a defined terminus and comprising at least one capture zone containing a capture agent for an analyte, the capture agent or agents being immobilized along a portion of the flow path or paths, the flow path or paths being designed so that the one or more analytes are depleted from the sample and bound in a non-linear manner to the portion of the flow path or paths containing immobilized capture agent or agents, producing an analyte depletion end region for each analyte between the beginning and the terminus of the analyte determination flow path.

5. 发明申请

WO2005118143A2 METHODS AND APPARATUS FOR LABEL-INDEPENDENT MONITORING OF BIOLOGICAL INTERACTIONS ON SENSITIZED SUBSTRATES 审中-公开
标题翻译：敏感基质生物相互作用的标签独立监测方法与装置
公开(公告)号：WO2005118143A2
公开(公告)日：2005-12-15
申请号：PCT/US2005/019691
申请日：2005-06-03
申请人： ZYOMYX, INC. , INDERMUEHLE, Pierre , HEIDECKER, Manfred , FOLLONIER, Stephane , WAGNER, Peter
发明人： INDERMUEHLE, Pierre , HEIDECKER, Manfred , FOLLONIER, Stephane , WAGNER, Peter
IPC分类号： B01L3/12
CPC分类号： G01N21/211 , B01L3/5085 , B01L2300/0654 , B01L2300/0819 , B01L2300/0877 , Y10T156/10
摘要： Sensor interrogation systems based on optical phase changes are configured to quantify analytes. Sensor chips and wells can include light scattering regions, light absorbing regions, or tilted regions to reduce or eliminate unwanted portions of an interrogation optical beam. In some examples, a spatial phase modulation is used to compensate static birefringence or to provide a selected sensor bias point. Phase changes can be detected based on state of polarization using interferometry. Optical resonator structures can be used to enhance phase changes to simplify detection of optical phase changes.
摘要翻译：基于光学相位变化的传感器询问系统被配置为量化分析物。传感器芯片和阱可以包括光散射区域，光吸收区域或倾斜区域，以减少或消除询问光束的不需要的部分。在一些示例中，使用空间相位调制来补偿静态双折射或提供所选择的传感器偏置点。可以基于使用干涉测量的偏振态来检测相位变化。可以使用光学谐振器结构来增强相位变化，以简化光学相位变化的检测。

6. 发明申请

WO2009123592A1 DEVICE AND METHOD FOR ANALYSIS OF SAMPLES WITH DEPLETION OF ANALYTE CONTENT 审中-公开
标题翻译：用于分析分析样品的装置和方法，分析分析内容
公开(公告)号：WO2009123592A1
公开(公告)日：2009-10-08
申请号：PCT/US2008/004372
申请日：2008-04-03
申请人： ZYOMYX, INC. , WAGNER, Peter , ZAUGG, Frank , MITCHNIK, Mark
发明人： WAGNER, Peter , ZAUGG, Frank , MITCHNIK, Mark
IPC分类号： C12Q1/00
CPC分类号： G01N33/558 , G01N33/54366
摘要： A system and method for determining the presence and/or concentration of one or more analytes in a sample that comprises a fluid, the system comprising a substrate comprising a sample inlet or inlets and one or more analyte determination flow paths, each analyte determination flow path comprising a defined beginning and a defined terminus and comprising at least one capture zone containing a capture agent for an analyte, the capture agent or agents being immobilized along a portion of the flow path or paths, the flow path or paths being designed so that the one or more analytes are depleted from the sample and bound to the portion of the flow path or paths containing immobilized capture agent or agents, producing an analyte depletion end region for each analyte between the beginning and the terminus of the analyte determination flow path.
摘要翻译：一种用于确定样品中一种或多种分析物在含有流体的存在和/或浓度的系统和方法，所述系统包括含有样品入口或入口以及一个或多个分析物确定流路的基底，每个分析物确定流路包括限定的起始点和限定的末端，并且包含至少一个含有分析物的捕获剂的捕获区，所述捕获剂或试剂沿所述流动路径或路径的一部分被固定，所述流路或路径被设计成使得一个或多个分析物从样品中消耗并且结合到含有固定化捕获剂或试剂的流动路径或路径的部分，为分析物确定流路的开始和终点之间的每个分析物产生分析物耗尽端区。

7. 发明申请

WO2003073089A1 METHOD AND DEVICE FOR PERFORMING IMPEDANCE SPECTROSCOPY 审中-公开
标题翻译：用于执行阻抗谱的方法和装置
公开(公告)号：WO2003073089A1
公开(公告)日：2003-09-04
申请号：PCT/US2003/005810
申请日：2003-02-25
申请人： ZYOMYX, INC.
发明人： WAGNER, Peter , WIEGAND, Gerald
IPC分类号： G01N27/02
CPC分类号： G01N27/026 , G01N33/48728
摘要： A highly time resolved impedance spectroscopy that enhances the measurement of the dynamics of non-stationary systems with enhanced time resolution. The highly time resolved impedance spectroscopy includes an optimized, frequency rich a.c., or transient, voltage signal is used as the perturbation signal, non-stationary time to frequency transformation algorithms are used when processing the measured time signals of the voltage and current to determine impedance spectra which are localized in time; and the system-characterizing quantities are determined from the impedance spectra using equivalent circuit fitting in a time-resolution-optimized form. Methods and apparatus for processing impedance spectra data are also provided.
摘要翻译：高度时间分辨的阻抗谱，增强了时间分辨率提高的非固定系统的动态测量。高度时间分辨的阻抗谱包括优化的频率丰富的交流或瞬态电压信号用作扰动信号，当处理测量的电压和电流的时间信号以确定阻抗时，使用非平稳的时间到频率变换算法时间局部化的光谱; 并且使用以时间分辨率优化形式的等效电路拟合从阻抗谱确定系统特征量。还提供了用于处理阻抗谱数据的方法和装置。

8. 发明授权

EP2229591B1 CELL ASSAY KIT AND METHOD 有权转让
标题翻译： ZELLTESTSET和程序
公开(公告)号：EP2229591B1
公开(公告)日：2012-05-16
申请号：EP08860287.5
申请日：2008-12-05
申请人： Zyomyx, Inc.
发明人： ZAUGG, Frank , TOBIAS, Renee , MCMANUS-MUNOZ, Silvia , KERNEN, Peter , RUIZ-TAYLOR, Laurence , WAGNER, Peter
IPC分类号： G01N33/543 , G01N33/49 , G01N33/569
CPC分类号： G01N33/54326 , G01N33/491 , G01N33/538 , G01N33/54313 , G01N33/56972
摘要： A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell- collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.

9. 发明公开

EP1294513A1 SITE-SPECIFIC, COVALENT BIOCONJUGATION OF PROTEINS 审中-公开
标题翻译：局部化特异性共价蛋白质生物偶联
公开(公告)号：EP1294513A1
公开(公告)日：2003-03-26
申请号：EP01926445.6
申请日：2001-03-27
申请人： Zyomyx, Inc.
发明人： WAGNER, Peter , MA, Lifu , NOCK, Steffen , WILSON, David , SYDOR, Jens
IPC分类号： B23B25/00 , C07H21/00 , C07K1/113 , C08H1/00 , C09D189/00 , G01N33/00
CPC分类号： G01N33/54353 , B82Y30/00 , G01N33/52
摘要： Heterofunctional crosslinking groups are provided having the formula (I) wherein W is a covalent core component; L?1, L2 and L3¿ are independently linking groups; X is a non-covalent or reversibly covalent protein tag binder; Y is a activatable covalent linking group; and Z is a protected or unprotected covalent crosslinking group.

10. 发明公开

EP1261689A1 CHIPS HAVING ELEVATED SAMPLE SURFACES 审中-公开
标题翻译：具有增加的样品表面CHIPS
公开(公告)号：EP1261689A1
公开(公告)日：2002-12-04
申请号：EP01914480.7
申请日：2001-02-23
申请人： Zyomyx, Inc.
发明人： INDERMUHLE, Pierre F. , ZAUGG, Frank G. , WAGNER, Peter , NOCK, Steffen
IPC分类号： C12M1/18
CPC分类号： B01L3/0244 , B01J19/0046 , B01J2219/00317 , B01J2219/00351 , B01J2219/00367 , B01J2219/00369 , B01J2219/00382 , B01J2219/00497 , B01J2219/00504 , B01J2219/00509 , B01J2219/00585 , B01J2219/00587 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00664 , B01J2219/00677 , B01J2219/00702 , B01J2219/00725 , B01L3/0241 , B01L3/0248 , B01L3/0262 , B01L3/5085 , B01L3/5088 , B01L2300/0809 , B01L2300/0848 , B01L2400/022 , B01L2400/0688 , B33Y80/00 , B82Y30/00 , C40B40/10 , C40B60/14 , Y10T436/11 , Y10T436/114165 , Y10T436/117497 , Y10T436/118339 , Y10T436/143333 , Y10T436/156666 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： A test device is disclosed having a base (22) that is a non-sample surface and sample structures (25 (a,b)) comprising pillars (20 (a,b)).

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