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1. 发明申请

WO0163241A9 MICROFLUIDIC DEVICES AND METHODS 审中-公开
标题翻译：微流体装置和方法
公开(公告)号：WO0163241A9
公开(公告)日：2003-08-28
申请号：PCT/US0105963
申请日：2001-02-23
申请人： ZYOMYX INC , JEDRZEJEWSKI PAUL , NOCK STEFFEN , WAGNER PETER , INDERMUHLE PIERRE F , ZAUGG FRANK G
发明人： JEDRZEJEWSKI PAUL , NOCK STEFFEN , WAGNER PETER , INDERMUHLE PIERRE F , ZAUGG FRANK G
IPC分类号： G01N33/53 , B01J19/00 , B01L3/00 , B01L3/02 , B01L99/00 , B81B1/00 , C40B40/10 , C40B60/14 , G01N35/04 , G01N35/10 , G01N37/00 , F15C1/04 , G01N27/26 , G01N27/447
CPC分类号： B01L3/0244 , B01J19/0046 , B01J2219/00317 , B01J2219/00351 , B01J2219/00367 , B01J2219/00369 , B01J2219/00382 , B01J2219/00497 , B01J2219/00504 , B01J2219/00509 , B01J2219/00585 , B01J2219/00587 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00664 , B01J2219/00677 , B01J2219/00702 , B01J2219/00725 , B01L3/0241 , B01L3/0248 , B01L3/0262 , B01L3/5085 , B01L3/5088 , B01L2300/0809 , B01L2300/0848 , B01L2400/022 , B01L2400/0688 , B33Y80/00 , B82Y30/00 , C40B40/10 , C40B60/14 , Y10T436/11 , Y10T436/114165 , Y10T436/117497 , Y10T436/118339 , Y10T436/143333 , Y10T436/156666 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： Embodiments of the invention are directed to microfluidic devices. In one embodiment, a microanalysis chip comprises a body having at least one transfer-separation channel with a channel bottom that has a bottom opening. The transfer-separation channel terminates in a discharge aperture.
摘要翻译：本发明的实施例涉及微流体装置。在一个实施例中，微量分析芯片包括具有至少一个具有底部开口的通道底部的转移分离通道的主体。转印分离通道终止于排出孔。

2. 发明申请

WO0163241A3 MICROFLUIDIC DEVICES AND METHODS 审中-公开
标题翻译：微流体装置和方法
公开(公告)号：WO0163241A3
公开(公告)日：2002-10-17
申请号：PCT/US0105963
申请日：2001-02-23
申请人： ZYOMYX INC , JEDRZEJEWSKI PAUL , NOCK STEFFEN , WAGNER PETER , INDERMUHLE PIERRE F , ZAUGG FRANK G
发明人： JEDRZEJEWSKI PAUL , NOCK STEFFEN , WAGNER PETER , INDERMUHLE PIERRE F , ZAUGG FRANK G
IPC分类号： G01N33/53 , B01J19/00 , B01L3/00 , B01L3/02 , B01L99/00 , B81B1/00 , C40B40/10 , C40B60/14 , G01N35/04 , G01N35/10 , G01N37/00 , F15C1/04 , G01N27/26 , G01N27/447
CPC分类号： B01L3/0244 , B01J19/0046 , B01J2219/00317 , B01J2219/00351 , B01J2219/00367 , B01J2219/00369 , B01J2219/00382 , B01J2219/00497 , B01J2219/00504 , B01J2219/00509 , B01J2219/00585 , B01J2219/00587 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00664 , B01J2219/00677 , B01J2219/00702 , B01J2219/00725 , B01L3/0241 , B01L3/0248 , B01L3/0262 , B01L3/5085 , B01L3/5088 , B01L2300/0809 , B01L2300/0848 , B01L2400/022 , B01L2400/0688 , B33Y80/00 , B82Y30/00 , C40B40/10 , C40B60/14 , Y10T436/11 , Y10T436/114165 , Y10T436/117497 , Y10T436/118339 , Y10T436/143333 , Y10T436/156666 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： Embodiments of the invention are directed to microfluidic devices. In one embodiment, a microanalysis chip comprises a body having at least one transfer-separation channel with a channel bottom that has a bottom opening. The transfer-separation channel terminates in a discharge aperture.
摘要翻译：本发明的实施例涉及微流体装置。在一个实施例中，微量分析芯片包括具有至少一个具有底部开口的通道底部的转移分离通道的主体。转印分离通道终止于排出孔。

3. 发明申请

WO2005118143A3 METHODS AND APPARATUS FOR LABEL-INDEPENDENT MONITORING OF BIOLOGICAL INTERACTIONS ON SENSITIZED SUBSTRATES 审中-公开
标题翻译：敏感基质生物相互作用的标签独立监测方法与装置
公开(公告)号：WO2005118143A3
公开(公告)日：2006-10-05
申请号：PCT/US2005019691
申请日：2005-06-03
申请人： ZYOMYX INC , INDERMUEHLE PIERRE , HEIDECKER MANFRED , FOLLONIER STEPHANE , WAGNER PETER
发明人： INDERMUEHLE PIERRE , HEIDECKER MANFRED , FOLLONIER STEPHANE , WAGNER PETER
IPC分类号： G01N21/29 , B01L3/00 , B01L3/12 , G01N21/21
CPC分类号： G01N21/211 , B01L3/5085 , B01L2300/0654 , B01L2300/0819 , B01L2300/0877 , Y10T156/10
摘要： Sensor interrogation systems (400) based on optical phase changes are configured to quantify analytes. Sensor chips (408) and wells (122) can include light scattering regions, light absorbing regions, or tilted regions to reduce or eliminate unwanted portions of an interrogation optical beam. In some examples, a spatial phase modulation is used to compensate static birefringence or to provide a selected sensor bias point. Phase changes can be detected based on polarization using interferometry. Optical resonator structures can be used to enhance phase changes to simplify detection of optical phase changes.
摘要翻译：基于光学相位变化的传感器询问系统（400）被配置为量化分析物。传感器芯片（408）和阱（122）可以包括光散射区域，光吸收区域或倾斜区域，以减少或消除询问光束的不期望的部分。在一些示例中，使用空间相位调制来补偿静态双折射或提供所选择的传感器偏置点。基于使用干涉测量的极化可以检测相位变化。可以使用光学谐振器结构来增强相位变化，以简化光学相位变化的检测。

4. 发明申请

WO2004017042A3 METHODS AND REAGENTS FOR SURFACE FUNCTIONALIZATION 审中-公开
标题翻译：表面功能化的方法和试剂
公开(公告)号：WO2004017042A3
公开(公告)日：2004-12-09
申请号：PCT/US0325927
申请日：2003-08-18
申请人： ZYOMYX INC , CICERO RONALD , FORMAN JONATHAN , KERNEN PETER , LU HONGBO , QUINCY DAVID , SCHWEISER STEFAN , WAGNER PETER
发明人： CICERO RONALD , FORMAN JONATHAN , KERNEN PETER , LU HONGBO , QUINCY DAVID , SCHWEISER STEFAN , WAGNER PETER
IPC分类号： G01N33/547 , C12M1/00 , C12N15/09 , G01N20060101 , G01N33/543 , G01N37/00
CPC分类号： G01N33/54353 , B82Y30/00
摘要： Reagents and method for making arrays of affinity agents are disclosed. Methods of using the arrays of affinity agents also are disclosed. The arrays are particularly useful for high throughput drug screening and clinical diagnostics applications.
摘要翻译：公开了用于制造亲和试剂阵列的试剂和方法。还公开了使用亲和剂阵列的方法。阵列对于高通量药物筛选和临床诊断应用特别有用。

5. 发明申请

WO2009076235A2 CELL ASSAY KIT AND METHOD 审中-公开
标题翻译：细胞测定试剂盒和方法
公开(公告)号：WO2009076235A2
公开(公告)日：2009-06-18
申请号：PCT/US2008085737
申请日：2008-12-05
申请人： ZYOMYX INC , ZAUGG FRANK , TOBIAS RENEE , KERNEN PETER , RUIZ-TAYLOR LAURENCE , WAGNER PETER
发明人： ZAUGG FRANK , TOBIAS RENEE , KERNEN PETER , RUIZ-TAYLOR LAURENCE , WAGNER PETER
IPC分类号： C12Q1/06 , C12M1/00 , G01N33/53 , G01N33/569
CPC分类号： G01N33/54326 , G01N33/491 , G01N33/538 , G01N33/54313 , G01N33/56972
摘要： A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell- collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.
摘要翻译：公开了用于测定细胞样品中存在至少一个给定类型的至少一个阈值数目的细胞的方法和试剂盒。该试剂盒包括具有用于接收细胞样品的样品室和包含选定密度和/或粘度介质并且沿其长度具有多个细胞收集区域的细长收集室的测定装置和能够特异性附着于所选择的细胞类型的细胞，并且当附着于细胞时是有效的，以增加细胞的密度或磁化率。在操作中，细胞样品中的颗粒结合的细胞和颗粒在重力或选定的离心或磁场力的影响下通过细长收集室被拉伸，直到颗粒结合的细胞和颗粒完全填充连续的细胞收集区域收集室。与至少一个收集区域相关联的标记表示所选择类型的细胞的浓度有效至少部分地填充该收集区域。

6. 发明申请

WO2008156491A2 DEVICES AND METHODS FOR ANALYSIS OF SAMPLES WITH DEPLETION OF ANALYTE CONTENT 审中-公开
标题翻译：用于分析分析样品的装置和方法，分析分析内容
公开(公告)号：WO2008156491A2
公开(公告)日：2008-12-24
申请号：PCT/US2007080108
申请日：2007-10-01
申请人： ZYOMYX INC , WAGNER PETER , ZAUGG FRANK , MITCHNIK MARK
发明人： WAGNER PETER , ZAUGG FRANK , MITCHNIK MARK
IPC分类号： G01N33/53
CPC分类号： G01N33/54366 , B01F5/061 , B01F5/0646 , B01F5/0647 , B01F5/0655 , B01F13/0059 , B01F2005/0621 , B01F2005/0636 , B01L3/5023 , B01L3/502746 , B01L2300/0636 , B01L2300/0867 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , B01L2400/086
摘要： A system and method for determining the presence and/or concentration of one or more analytes in a sample that comprises a fluid, the system comprising a solid substrate comprising a sample inlet or inlets and one or more analyte determination flow paths, each analyte determination flow path comprising a defined beginning and a defined terminus and comprising at least one capture zone containing a capture agent for an analyte, the capture agent or agents being immobilized along a portion of the flow path or paths, the flow path or paths being designed so that the one or more analytes are depleted from the sample and bound in a non-linear manner to the portion of the flow path or paths containing immobilized capture agent or agents, producing an analyte depletion end region for each analyte between the beginning and the terminus of the analyte determination flow path.
摘要翻译：一种用于确定包含流体的样品中一种或多种分析物的存在和/或浓度的系统和方法，所述系统包括固体基质，其包含样品入口或入口以及一个或多个分析物确定流动路径，每个分析物确定流程路径，其包含限定的起始点和限定的末端，并且包含至少一个包含分析物的捕获剂的捕获区域，所述捕获剂或试剂沿所述流动路径或路径的一部分被固定，所述流动路径或路径被设计成使得一个或多个分析物从样品中耗尽，并以非线性方式结合到包含固定化捕获剂或试剂的流动路径或路径的部分，从而在每个分析物的起始和终点之间产生分析物耗尽末端区域分析物确定流路。

7. 发明申请

WO2004081983A2 SUBSTRATE PROCESSING APPARATUS AND METHOD FOR THE CONTROLLED FORMATION OF LAYERS INCUDING SELF-ASSEMBLED MONOLYAERS 审中-公开
标题翻译：基质处理装置和控制形成自发组合单体的层的方法
公开(公告)号：WO2004081983A2
公开(公告)日：2004-09-23
申请号：PCT/US2004006851
申请日：2004-03-03
申请人： ZYOMYX INC , HASSELBLATT MARKUS , WAGNER PETER , KERNEN PETER , ZAUGG FRANK , DE LA SALLE OLIVIER
发明人： HASSELBLATT MARKUS , WAGNER PETER , KERNEN PETER , ZAUGG FRANK , DE LA SALLE OLIVIER
IPC分类号： B01L9/00 , C40B60/14 , G01N1/34 , H01L21/00 , H01L51/00 , H01L51/40 , H01L
CPC分类号： B82Y30/00 , B01J2219/00281 , B01J2219/00353 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01L9/52 , B01L2300/0803 , B01L2300/0822 , B82Y40/00 , C40B60/14 , G01N1/405 , H01L21/67028 , H01L21/67034 , H01L21/67057 , H01L51/0002
摘要： Substrate processing methods and apparatuses are disclosed. One embodiment of the invention is directed to a substrate processing apparatus for processing an analytical substrate. The apparatus includes a substrate holder for holding a substrate and a processing chamber including an opening for receiving the substrate holder and the substrate. A fluid inlet and a fluid outlet are in the processing chamber. A washing device adapted to supply a wash liquid to the substrate while the substrate is in the processing chamber. A liquid removal device adapted to dry the substrate when the substrate is being withdrawn from the processing chamber.
摘要翻译：公开了基板处理方法和装置。本发明的一个实施例涉及用于处理分析基板的基板处理装置。该装置包括用于保持基板的基板保持件和包括用于接收基板保持件和基板的开口的处理室。流体入口和流体出口在处理室中。一种洗涤装置，适于在衬底处于处理室的同时向衬底提供洗涤液体。一种液体去除装置，适于在衬底从处理室中取出时干燥衬底。

8. 发明申请

WO2009076235A3 CELL ASSAY KIT AND METHOD 审中-公开
公开(公告)号：WO2009076235A3
公开(公告)日：2009-10-15
申请号：PCT/US2008085737
申请日：2008-12-05
申请人： ZYOMYX INC , ZAUGG FRANK , TOBIAS RENEE , KERNEN PETER , RUIZ-TAYLOR LAURENCE , WAGNER PETER
发明人： ZAUGG FRANK , TOBIAS RENEE , KERNEN PETER , RUIZ-TAYLOR LAURENCE , WAGNER PETER
IPC分类号： G01N33/49 , G01N33/543 , G01N33/569
CPC分类号： G01N33/54326 , G01N33/491 , G01N33/538 , G01N33/54313 , G01N33/56972
摘要： A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell- collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.

9. 发明申请

WO03073089A9 METHOD AND DEVICE FOR PERFORMING IMPEDANCE SPECTROSCOPY 审中-公开
标题翻译：用于执行阻抗谱的方法和装置
公开(公告)号：WO03073089A9
公开(公告)日：2004-10-21
申请号：PCT/US0305810
申请日：2003-02-25
申请人： ZYOMYX INC
发明人： WAGNER PETER , WIEGAND GERALD
IPC分类号： G01N27/02 , G01N33/543
CPC分类号： G01N27/026 , G01N33/48728
摘要： A highly time resolved impedance spectroscopy that enhances the measurement of the dynamics of non-stationary systems with enhanced time resolution. The highly time resolved impedance spectroscopy includes an optimized, frequency rich a.c., or transient, voltage signal is used as the perturbation signal, non-stationary time to frequency transformation algorithms are used when processing the measured time signals of the voltage and current to determine impedance spectra which are localized in time; and the system-characterizing quantities are determined from the impedance spectra using equivalent circuit fitting in a time-resolution-optimized form. Methods and apparatus for processing impedance spectra data are also provided.
摘要翻译：高度时间分辨阻抗光谱学，增强了时间分辨率增强的非平稳系统的动态测量。高度时间分辨阻抗谱包括优化的，富含频率的交流或瞬态电压信号作为扰动信号，当处理所测量的电压和电流的时间信号以确定阻抗时使用非平稳的时间到频率变换算法时间上定位的光谱; 并且使用时间分辨率优化形式的等效电路拟合从阻抗谱确定系统表征量。还提供了用于处理阻抗谱数据的方法和设备。

10. 发明公开

EP1261689A4 CHIPS HAVING ELEVATED SAMPLE SURFACES 审中-公开
标题翻译： CHIPS MITERHöHTERPROBENOBERFLäCHE
公开(公告)号：EP1261689A4
公开(公告)日：2005-06-29
申请号：EP01914480
申请日：2001-02-23
申请人： ZYOMYX INC
发明人： INDERMUHLE PIERRE F , ZAUGG FRANK G , WAGNER PETER , NOCK STEFFEN
IPC分类号： G01N33/53 , B01J19/00 , B01L3/00 , B01L3/02 , B01L99/00 , B81B1/00 , C40B40/10 , C40B60/14 , G01N35/04 , G01N35/10 , G01N37/00 , C12M1/18
CPC分类号： B01L3/0244 , B01J19/0046 , B01J2219/00317 , B01J2219/00351 , B01J2219/00367 , B01J2219/00369 , B01J2219/00382 , B01J2219/00497 , B01J2219/00504 , B01J2219/00509 , B01J2219/00585 , B01J2219/00587 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00664 , B01J2219/00677 , B01J2219/00702 , B01J2219/00725 , B01L3/0241 , B01L3/0248 , B01L3/0262 , B01L3/5085 , B01L3/5088 , B01L2300/0809 , B01L2300/0848 , B01L2400/022 , B01L2400/0688 , B33Y80/00 , B82Y30/00 , C40B40/10 , C40B60/14 , Y10T436/11 , Y10T436/114165 , Y10T436/117497 , Y10T436/118339 , Y10T436/143333 , Y10T436/156666 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： A test device is disclosed having a base (22) that is a non-sample surface and sample structures (25 (a,b)) comprising pillars (20 (a,b)).
摘要翻译：公开了一种测试装置，其具有作为非样本表面的基部（22）和包括柱（20（a，b））的样品结构（25（a，b）），其中每个柱包括样品表面（24 a，b））和侧表面（18（a，b）），并且其中每个支柱的样品表面（24（a，b，））和基底（23）的表面具有相同的涂层。

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