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71. 发明申请

US20070141116A1 Glaucoma Implant Device 审中-公开
标题翻译：青光眼植入装置
公开(公告)号：US20070141116A1
公开(公告)日：2007-06-21
申请号：US11561958
申请日：2006-11-21
申请人： Leonard Pinchuk , Jean-Marie Parel , Francisco Fantes
发明人： Leonard Pinchuk , Jean-Marie Parel , Francisco Fantes
IPC分类号： A61F2/16
CPC分类号： A61F9/00781 , A61F2210/0071
摘要： An aqueous humor drainage device having an elongate duct structure that provides a fluid passageway for diverting aqueous humor from the anterior chamber of the eye and at least one fixation member that extends from the elongate duct structure. In one embodiment, the fixation member is realized by a tab that is spaced apart from the two ends of the elongate duct structure. In another embodiment, the fixation member is realized by a pair of tines that extend in traverse directions relative to the central axis of the elongate duct structure. The tines are spaced apart for positioning on opposite sides of the sclera of the eye during use. The elongate duct structure and the at least one fixation member are preferably formed from a biocompatible elastomeric material comprising polyisobutylene and a glassy segment.
摘要翻译：一种房水引流装置，其具有细长的管道结构，其提供用于将房水从眼睛的前房转向的流体通道和从细长管道结构延伸的至少一个固定构件。在一个实施例中，固定构件通过与细长管道结构的两个端部间隔开的突片来实现。在另一个实施例中，固定构件通过相对于细长管道结构的中心轴线在横向方向上延伸的一对尖齿实现。在使用期间，齿相间隔开定位在眼睛的巩膜的相对两侧。细长管道结构和至少一个固定构件优选由包含聚异丁烯和玻璃质区段的生物相容弹性体材料形成。

72. 发明申请

US20070118210A1 Trileaflet Heart Valve 审中-公开
标题翻译： Trileaflet心脏瓣膜
公开(公告)号：US20070118210A1
公开(公告)日：2007-05-24
申请号：US11561069
申请日：2006-11-17
申请人： Leonard Pinchuk
发明人： Leonard Pinchuk
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2415 , A61F2220/0075 , A61F2250/0039 , A61L27/34 , A61L27/48 , A61L27/56 , C08L53/02 , C08L67/02
摘要： A prosthetic heart valve is described that includes three leaflet members which open and close in unison with the flowing of blood through the aorta. The leaflets are made of a composite multilayer polymer material that includes a central porous material such as polyethylene terephthalate sandwiched between two other polymer layers. The two polymer layers are made up of block co-polymers that contain polyisobutylene. The composite multilayer may be formed by dip coating the porous material into a solution of the block co-polymer or by compression molding of the porous material between two layers of the block co-polymer. The composite multilayer polymer material is biocompatible and durable in bodily implant applications.
摘要翻译：描述了一种假体心脏瓣膜，其包括与通过主动脉的血液流动一致地打开和关闭的三个小叶构件。传单由复合多层聚合物材料制成，其包括中心多孔材料，例如夹在两个其它聚合物层之间的聚对苯二甲酸乙二醇酯。两个聚合物层由含有聚异丁烯的嵌段共聚物组成。复合多层可以通过将多孔材料浸渍到嵌段共聚物的溶液中或者通过在两层嵌段共聚物之间压缩多孔材料来形成。复合多层聚合物材料在体外植入应用中是生物相容性和耐久性的。

73. 发明申请

US20070118066A1 Glaucoma Implant Device 有权
标题翻译：青光眼植入装置
公开(公告)号：US20070118066A1
公开(公告)日：2007-05-24
申请号：US11561956
申请日：2006-11-21
申请人： Leonard Pinchuk , Jean-Marie Parel , Francisco Fantes
发明人： Leonard Pinchuk , Jean-Marie Parel , Francisco Fantes
IPC分类号： A61M5/00
CPC分类号： A61F9/00781 , A61F2210/0071
摘要： An aqueous humor drainage device having an elongate structure that provides a fluid passageway for diverting aqueous humor from the anterior chamber of the eye. The device is formed from a biocompatible soft polymeric material with a hardness less than Shore 80A. Preferably, the polymeric material includes polyisobutylene and a glassy segment. The device preferably includes at least one fixation member that extends from the elongate structure. In one embodiment, the fixation member is realized by a tab that is spaced apart from the two ends of the elongate structure. In another embodiment, the fixation member is realized by a pair of tines that extend in traverse directions relative to the central axis of the elongate structure. The tines are spaced apart for positioning on opposite sides of the sclera of the eye during use.
摘要翻译：一种房水引流装置，其具有细长结构，其提供用于将房水从眼睛前房转向的流体通道。该装置由硬度小于肖氏80A的生物相容性软聚合材料形成。优选地，聚合物材料包括聚异丁烯和玻璃质部分。该装置优选地包括从细长结构延伸的至少一个固定构件。在一个实施例中，固定构件通过与细长结构的两个端部间隔开的突片来实现。在另一个实施例中，固定构件通过相对于细长结构的中心轴线在横向方向上延伸的一对齿来实现。在使用期间，齿相间隔开定位在眼睛的巩膜的相对两侧。

74. 发明申请

US20070118065A1 Glaucoma Implant Device 审中-公开
标题翻译：青光眼植入装置
公开(公告)号：US20070118065A1
公开(公告)日：2007-05-24
申请号：US11561954
申请日：2006-11-21
申请人： Leonard Pinchuk , Jean-Marie Parel , Francisco Fantes
发明人： Leonard Pinchuk , Jean-Marie Parel , Francisco Fantes
IPC分类号： A61M5/00
CPC分类号： A61F9/00781
摘要： A surgical tool for supporting an aqueous humor drainage device and for inserting a distal portion of the device into the anterior chamber of the eye. The aqueous humor drainage device has an elongate duct and preferably at least one fixation member that extends from the elongate duct structure. In one embodiment, the fixation member is realized by a tab that is spaced apart from the two ends of the elongate duct structure. In another embodiment, the fixation member is realized by a pair of tines that extend in traverse directions relative to the central axis of the elongate duct structure. The tool includes a hollow support member that supports a portion of the device and preferably a guide slot for guided deployment of the device.
摘要翻译：一种用于支撑房水引流装置并用于将装置的远端部分插入眼睛前房的手术工具。房水引流装置具有细长导管，优选地，至少一个从细长管道结构延伸的固定构件。在一个实施例中，固定构件通过与细长管道结构的两个端部间隔开的突片来实现。在另一个实施例中，固定构件通过相对于细长管道结构的中心轴线在横向方向上延伸的一对尖齿实现。该工具包括中空支撑构件，该中空支撑构件支撑装置的一部分，并且优选地用于引导装置的引导部分。

75. 发明申请

US20060189929A1 Methods and Apparatus for Sclerosing the Wall of a Varicose Vein 审中-公开
公开(公告)号：US20060189929A1
公开(公告)日：2006-08-24
申请号：US11381370
申请日：2006-05-03
申请人： Banning Lary , Leonard Pinchuk , Saul Gottlieb , Charles Slater
发明人： Banning Lary , Leonard Pinchuk , Saul Gottlieb , Charles Slater
IPC分类号： A61M29/00
CPC分类号： A61M25/10 , A61B17/320725 , A61B2017/22038 , A61B2017/22067 , A61B2017/22082 , A61M25/1011 , A61M2025/0004 , A61M2025/0175 , A61M2025/105 , A61M2025/1052 , A61M2025/1068
摘要： A preferred apparatus for delivering an intravascular drug such as a sclerosing agent (or a microfoam sclerosing agent) to a varicose vein includes a catheter having three concentric tubes. The innermost tube has a guide wire lumen and an inflation lumen. The distal end of the innermost tube has an integral inflatable occlusion balloon in fluid communication with the inflation lumen. The intermediate tube has a lumen through which the innermost tube extends. The distal end of the intermediate tube has a self-expanding balloon with a plurality of fluid pores in fluid communication with the intermediate tube lumen. The outer tube has a lumen through which the intermediate tube extends. Sclerosing agent is dispensed through the intermediate tube to pores located at the distal end of the intermediate tube or in the self-expanding balloon. Veins are sclerosed as the self-expanding balloon is pulled through and ultimately out of the vein.

76. 发明申请

US20050055075A1 Methods for the manufacture of porous prostheses 审中-公开
标题翻译：制造多孔假体的方法
公开(公告)号：US20050055075A1
公开(公告)日：2005-03-10
申请号：US10657544
申请日：2003-09-08
申请人： Leonard Pinchuk , Yasushi Kato
发明人： Leonard Pinchuk , Yasushi Kato
IPC分类号： A61L27/34 , A61L27/56 , A61L31/10 , A61L31/14 , A61F2/06
CPC分类号： A61L31/146 , A61L27/34 , A61L27/56 , A61L31/10 , C08L53/02
摘要： A method for the manufacture of a biocompatible porous prosthesis comprising the steps of applying a solution to a porous support structure for a prosthesis, said solution comprising a biocompatible block copolymer including one or more elastomeric blocks and one or more thermoplastic blocks, and a first solvent capable of dissolving said copolymer; and applying a second solvent capable of dissolving said first solvent but incapable of dissolving said copolymer to the surfaces of said prosthesis and thereby causing said copolymer to precipitate onto said support structure.
摘要翻译：一种用于制造生物相容性多孔假体的方法，包括以下步骤：将溶液施用于假体的多孔支撑结构，所述溶液包含生物相容性嵌段共聚物，其包含一个或多个弹性体嵌段和一个或多个热塑性嵌段，以及第一溶剂能够溶解所述共聚物; 以及施加能够溶解所述第一溶剂的第二溶剂，但不能将所述共聚物溶解到所述假体的表面，从而使所述共聚物沉淀到所述载体结构上。

77. 发明授权

US06860900B2 Stent and stent-graft for treating branched vessels 失效
标题翻译：支架和支架移植物用于治疗分枝血管
公开(公告)号：US06860900B2
公开(公告)日：2005-03-01
申请号：US10607741
申请日：2003-06-27
申请人： Claude O. Clerc , Paul F. Chouinard , Leonard Pinchuk , Paul J. Thompson
发明人： Claude O. Clerc , Paul F. Chouinard , Leonard Pinchuk , Paul J. Thompson
IPC分类号： A61F2/90 , A61F2/06
CPC分类号： A61F2/90 , A61F2/07 , A61F2/856 , A61F2002/061 , A61F2002/065 , A61F2002/075 , A61F2220/0016 , A61F2230/0008
摘要： An implantable stent and stent-graft for treating a patient having a relatively healthy first aorta portion upstream from a renal artery branch, and a diseased aorta portion downstream from the renal artery branch. One embodiment of the device includes a fixation section, a renal artery branch section and a diseased aorta section, all of which can be tubular, radially compressible and self-expandable structures formed from a plurality of filaments which are helically wound in a braided configuration. When the device is implanted and in its expanded state, the fixation section engages the first aorta portion upstream from a renal artery branch to provide substantial anchoring support. The diseased aorta section engages the portion of the aorta downstream from the renal artery branch and extends across the diseased portion of the aorta for purposes of treatment. The renal artery branch section extends across the renal artery branch and connects the diseased aorta section to the fixation section while allowing blood flow between the aorta and renal artery branch.
摘要翻译：一种可植入支架和支架移植物，用于治疗患有在肾动脉分支上游具有相对健康的第一主动脉部分的患者，以及在肾动脉分支下游的患病主动脉部分。该装置的一个实施例包括固定部分，肾动脉分支部分和患病主动脉部分，所有这些部分都可以是由以编织构造螺旋缠绕的多根细丝形成的管状，径向可压缩和自扩张结构。当装置植入并处于其膨胀状态时，固定部分与肾动脉分支上游的第一主动脉部分接合以提供实质的锚定支撑。患病的主动脉段与肾动脉分支下游的主动脉的部分接合，并延伸穿过主动脉的患病部分以用于治疗。肾动脉分支部分延伸穿过肾动脉分支，并将患病主动脉部分连接到固定部分，同时允许主动脉和肾动脉分支之间的血液流动。

78. 发明授权

US06500148B1 Balloons for medical devices and fabrication thereof 有权
标题翻译：用于医疗设备的气球及其制造
公开(公告)号：US06500148B1
公开(公告)日：2002-12-31
申请号：US09618499
申请日：2000-07-18
申请人： Leonard Pinchuk , Robert S. Shonk , Thomas Trotta
发明人： Leonard Pinchuk , Robert S. Shonk , Thomas Trotta
IPC分类号： A61M2900
CPC分类号： A61M25/1029 , A61B2017/00783 , A61L29/06 , A61M25/1034 , A61M25/1038 , A61M25/104 , A61M29/02 , A61M2025/1086 , C08L77/06
摘要： Dilation balloons and catheters including same are provided. The balloons are fabricated of a material such as a nylon or a polyamide material, and they have an inflated, non-distended working profile as well as a stretched inflated profile which is achieved by applying pressure through a dilatation catheter or the like that is in excess of that needed to achieve the inflated, non-distended profile and which is adequate to effect dilatation or the like up to a maximum pre-bursting pressure application. The maximum pre-bursting size of the balloon can be tailored depending upon the needs of the particular balloon within a wide range of possible maximum pre-bursting sizes.
摘要翻译：提供了包括气囊和导管的包括气囊和导管。气球由诸如尼龙或聚酰胺材料的材料制成，并且它们具有膨胀的，不扩张的加工轮廓以及拉伸的膨胀轮廓，其通过将压力施加在膨胀导管等中而实现，实现膨胀的，不扩张的轮廓所需的足够多的，并且其足以实现扩张等直到最大的预破裂压力应用。可以根据特定气球在可能的最大预爆破尺寸的宽范围内的需要来调整气囊的最大预爆破尺寸。

79. 发明授权

US06500146B1 Balloons for medical devices and fabrication thereof 有权
公开(公告)号：US06500146B1
公开(公告)日：2002-12-31
申请号：US09648197
申请日：2000-08-25
申请人： Leonard Pinchuk , Robert S. Shonk , Thomas Trotta
发明人： Leonard Pinchuk , Robert S. Shonk , Thomas Trotta
IPC分类号： A61M2900
CPC分类号： A61M25/1029 , A61B2017/00783 , A61L29/06 , A61M25/1034 , A61M25/104 , A61M29/02 , A61M2025/1086 , C08L77/06
摘要： Dilatation balloons and catheters including same are provided. The balloons are fabricated of a material such as a nylon or a polyamide material, and they have an inflated, non-distended working profile as well as a stretched inflated profile which is achieved by applying pressure through a dilatation catheter or the like that is in excess of that needed to achieve the inflated, non-distended profile and which is adequate to effect dilatation or the like up to a maximum pre-bursting pressure application. The maximum pre-bursting size of the balloon can be tailored depending upon the needs of the particular balloon within a wide range of possible maximum pre-bursting sizes.

80. 发明授权

US5804318A Lubricious hydrogel surface modification 失效
标题翻译：润滑水凝胶表面改性
公开(公告)号：US5804318A
公开(公告)日：1998-09-08
申请号：US548827
申请日：1995-10-26
申请人： Leonard Pinchuk , Yasushi P. Kato
发明人： Leonard Pinchuk , Yasushi P. Kato
IPC分类号： A61L27/34 , A61L27/52 , A61L29/08 , A61L29/14 , A61L31/10 , A61L31/14 , A61L33/00 , B05D1/18 , B05D3/10 , C08J7/04 , B32B15/08 , B05D5/08 , B32B27/08 , B32B27/30
CPC分类号： B82Y30/00 , A61L27/34 , A61L27/52 , A61L29/085 , A61L29/145 , A61L31/10 , A61L31/145 , A61L33/0011 , B05D1/185 , B05D3/101 , B82Y40/00 , C08J7/047 , C08J2433/00 , Y10S623/901 , Y10T428/3154 , Y10T428/31576 , Y10T428/31663 , Y10T428/31667 , Y10T428/31699 , Y10T428/3175 , Y10T428/31797 , Y10T428/31928 , Y10T428/31935
摘要： New and improved lubrifying coatings for reducing the coefficients of friction of surfaces on medical devices include hydrophilic copolymers derived monoethylenically-unsaturated monomers including some monomers having pendant primary amine functionality and some monomers having pendant tertiary amine functionality. The lubricious hydrogel coatings are covalently bondable to epoxy functionalized surfaces on the medical equipment to provide firmly adherent hydrogel coatings that are slippery when wet. Epoxy functionalized surfaces are provided by epoxy functional or epoxy group containing silane coupling agents. The pendant tertiary amine moieties are readily convertible at alkaline pH to quaternary ammonium cations to which anionic anti-thrombogenic agents may be bonded. Three dimensional copolymer matrices may also be provided as coatings on the surfaces by crosslinking the copolymers before or after attachment to the surface being treated.
摘要翻译：用于降低医疗装置表面的摩擦系数的新的和改进的润滑涂层包括衍生的单烯属不饱和单体的亲水共聚物，包括一些具有侧链官能度侧基的单体和一些具有侧胺官能团侧基的单体。润滑的水凝胶涂层与医疗设备上的环氧官能化表面共价结合，以提供在湿润时滑动的牢固粘附的水凝胶涂层。环氧官能化表面由环氧官能或环氧基硅烷偶联剂提供。侧链叔胺部分可以在碱性pH下容易地转化成能与阴离子抗血栓形成剂结合的季铵阳离子。也可以通过在连接到被处理表面之前或之后使共聚物交联而在表面上提供三维共聚物基质作为涂层。

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