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71. 发明申请

WO2003090795A1 APPARATUS AND METHOD FOR IRRADIATING AND MIXING FLUIDS IN CONTAINERS 审中-公开
标题翻译：装置和容器中混合流体的方法
公开(公告)号：WO2003090795A1
公开(公告)日：2003-11-06
申请号：PCT/US2003/013278
申请日：2003-04-28
申请人： GAMBRO, INC.
发明人： HLAVINKA, Dennis, J. , MARTINEZ, Michael, A.
IPC分类号： A61L2/08
CPC分类号： B01F5/0682 , A61L2/0011 , A61L2/0088 , A61L2/08 , A61L2/084 , A61L2/10 , A61L2202/22 , A61M1/025 , A61M1/0277 , A61M1/3683 , B01F5/0683 , B01F5/0688 , B01F9/0014 , B01F11/0065 , B01F13/0001 , B01F13/001
摘要： A mixing system, apparatus and/or method. Pathogen reduction of and/or mixing storage solutions into blood or blood components are useful purposes for these. Squeezing or clapping devices may be used to activate the mixing process, as may rotational devices or laterally movable, rotational and/or orbital devices. Constriction elements may also be used to create useful vortex mixing actions. Photoradiation may be provided while the components continue to be mixed together for pathogen reduction of blood or blood components.
摘要翻译：混合系统，装置和/或方法。病原体减少和/或将储存溶液混合到血液或血液成分中是有用的。压缩或拍打装置可以用于激活混合过程，如旋转装置或横向可移动，旋转和/或轨道装置。收缩元件也可用于产生有用的涡流混合动作。可以提供光引发剂，同时组分继续混合在一起用于血液或血液成分的病原体减少。

72. 发明申请

WO2003089027A3 BLOOD COMPONENT PROCESSING SYSTEM, APPARATUS AND METHOD 审中-公开
公开(公告)号：WO2003089027A3
公开(公告)日：2003-10-30
申请号：PCT/US2003/011764
申请日：2003-04-16
申请人： GAMBRO, INC.
发明人： HOGBERG, Niclas , PIHLSTEDT, Peter , HOLMES, Brian, M. , VAN WAEG, Geert , HALLGREN, Emanuel , PERSSON, Lars , STRANDBERG, Lars , CORBIN, Frank, III
IPC分类号： A61M1/36
摘要： A system and method are used in connection with processing of blood components. The processing of blood components may involve centrifugal separation and/or filtering of the blood components. In some examples, at least some blood components are centrifugally separated in a chamber and then filtered via a filter (31) rotating along with a centrifuge rotor (1), wherein the filter is located closer than the chamber to an axis of rotation of the rotor. The filter may include a porous filtration medium configured to filter leukocytes, platelets, and/or red blood cells. Some examples include a pressure sensor sensing pressure of pumped blood components. The sensed pressure may be used in connection with controlling the pumping of the blood products and/or in connection with determining the location of an interface associated with the blood products. Other uses of the sensed pressure are also possible.

73. 发明申请

WO2003089027A2 BLOOD COMPONENT PROCESSING SYSTEM, APPARATUS AND METHOD 审中-公开
标题翻译：血液组分处理系统，装置和方法
公开(公告)号：WO2003089027A2
公开(公告)日：2003-10-30
申请号：PCT/US2003/011764
申请日：2003-04-16
申请人： GAMBRO, INC.
发明人： HOGBERG, Niclas , PIHLSTEDT, Peter , HOLMES, Brian, M. , VAN WAEG, Geert , HALLGREN, Emanuel , PERSSON, Lars , STRANDBERG, Lars , CORBIN, Frank, III
IPC分类号： A61M1/36
CPC分类号： B04B13/00 , A61M1/0209 , A61M1/0218 , A61M1/025 , A61M1/26 , A61M1/262 , A61M1/3633 , A61M1/3639 , A61M1/3641 , A61M1/3693 , A61M1/3696 , A61M1/3698 , A61M2205/331 , B04B5/0428 , B04B5/0442 , B04B2005/045 , B04B2005/0478 , B04B2013/006
摘要： A system and method are used in connection with processing of blood components. The processing of blood components may involve centrifugal separation and/or filtering of the blood components. In some examples, at least some blood components are centrifugally separated in a chamber and then filtered via a filter rotating along with a centrifuge rotor, wherein the filter is located closer than the chamber to an axis of rotation of the rotor. The filter may include a porous filtration medium configured to filter leukocytes, platelets, and/or red blood cells. Some examples include a pressure sensor sensing pressure of pumped blood components. The sensed pressure may be used in connection with controlling the pumping of the blood products and/or in connection with determining the location of an interface associated with the blood products. Other uses of the sensed pressure are also possible.
摘要翻译：与血液成分的处理有关的系统和方法。血液成分的处理可能涉及血液成分的离心分离和/或过滤。在一些实例中，至少一些血液成分在室中离心分离，然后通过与离心机转子一起旋转的过滤器过滤，其中过滤器位于离转子更靠近转动轴的位置。过滤器可以包括被配置为过滤白细胞，血小板和/或红细胞的多孔过滤介质。一些示例包括感测泵送的血液成分的压力的压力传感器。感测到的压力可以与控制血液制品的泵送和/或与确定与血液制品相关联的界面的位置的结合一起使用。感测压力的其他用途也是可能的。

74. 发明申请

WO2003082181A3 CONTAINER AND METHOD OF SEALING 审中-公开
公开(公告)号：WO2003082181A3
公开(公告)日：2003-10-09
申请号：PCT/US2003/009731
申请日：2003-03-28
申请人： GAMBRO, INC.
发明人： MANICA, Keith , HLAVINKA, Dennis, J.
IPC分类号： A61J1/00
摘要： A method and apparatus for use in inactivating pathogens in fluids such as blood or blood components. The apparatus includes a container having a main body portion and at least one tubing extending into the main body portion of the container. The apparatus also includes a container having a main body portion, at least one port and tubing extending from the port into the main body portion. The method includes flowing the fluid to be inactivated into the container via the port, and sealing the port off from the main body portion of the container through the container, without sealing the main body portion of the container.

75. 发明申请

WO03050536A3 METHODS AND APPARATUS FOR SEPARATION OF BLOOD COMPONENTS 审中-公开
标题翻译：用于分离血液成分的方法和装置
公开(公告)号：WO03050536A3
公开(公告)日：2003-09-25
申请号：PCT/US0238566
申请日：2002-12-04
申请人： GAMBRO INC
发明人： ANTWILER GLEN DELBERT , TAYLOR LINDA A
IPC分类号： A61M1/02 , A61M1/36 , B01D17/038 , B04B5/04 , G01N33/49 , G01N33/50
CPC分类号： G01N33/491 , A61M1/0218 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M2202/0439 , B01D21/262 , B01D2221/10 , B04B5/0442 , B04B2005/0471
摘要： The present invention is directed to a method and system that separates first particles from second particles, or white blood cells from red blood cells, by sedimentation in a fluid chamber with debulking of one of the first or second particles or red blood cells through the inlet of the fluid chamber. The method and system further includes fractionation of the remaining particles or white blood cells into selected subsets. In one embodiment of the instant invention a blood product containing white blood cells is loaded in a separation chamber, a diluting or sedimenting agent is added to encourage rouleaux formation of any red blood cells, the cells are sedimented and the red blood cells are removed.
摘要翻译：本发明涉及一种方法和系统，该方法和系统通过在第一或第二颗粒或红细胞中的一个通过入口的减压而在流体室中沉淀来分离第一颗粒与第二颗粒或白细胞的红细胞，的流体室。该方法和系统还包括将剩余的颗粒或白细胞分级成选定的子集。在本发明的一个实施方案中，将含有白细胞的血液制品装载在分离室中，加入稀释或沉降剂以促进任何红细胞的形成，细胞沉淀并除去红细胞。

76. 发明申请

WO2003066109A1 NITRIC OXIDE IN A PATHOGEN INACTIVATION PROCESS 审中-公开
标题翻译：硝酸氧化酶在病毒灭活过程中
公开(公告)号：WO2003066109A1
公开(公告)日：2003-08-14
申请号：PCT/US2003/004009
申请日：2003-02-10
申请人： GAMBRO, INC.
发明人： EDRICH, Richard, Alan 2754 S. Ingalls Way , GOODRICH, Laura , DEPPISCH, Reinhold , HLAVINKA, Dennis, J. , LOCKERBIE, Robert, Owen , BECK, Werner
IPC分类号： A61L2/00
CPC分类号： A61L2/0047 , A61K41/0019 , A61K41/0057 , A61L2/0082 , A61L2/08 , A61L2/10 , A61L2/16 , A61L2202/22 , A61M1/0272 , A61M1/3681 , A61M1/3683 , A61M1/3686 , A61M2202/0275
摘要： This invention provides methods and compositions for using nitric oxide in a photoradiation pathogen inactivation process for whole blood and blood components to improve pathogen kill and to improve preservation of the quality of the blood components. This invention provides methods for using nitric oxide in combination with oxygen, photosensitizers, quencher and/or glycolysis inhibitor, and compositions comprising blood components decontaminated by these methods. Nitric oxide is provided using nitric oxide gas, or nitric oxide generators such as L-arginine, and/or N-acetyl-cysteine. This invention also provides compositions suitable for photoradiation pathogen inactivation that include fluid comprising a blood component, a photosensitizer, and dissolved nitric oxide. This invention provides decontamination systems useful for performing the methods of this invention and methods for making the decontamination systems. This invention also provides methods for decontaminating fluids and methods for increasing the storage life and quality of photochemically decontaminated platelets.
摘要翻译：本发明提供了在全血和血液成分的光辐射病原体失活过程中使用一氧化氮以改善病原体杀伤并改善血液成分质量的保存的方法和组合物。本发明提供了使用一氧化氮与氧，光敏剂，猝灭剂和/或糖酵解抑制剂组合的方法，以及包含通过这些方法去污染的血液成分的组合物。使用一氧化氮气体或一氧化氮生成剂如L-精氨酸和/或N-乙酰半胱氨酸来提供一氧化氮。本发明还提供适用于光辐射病原体灭活的组合物，其包括含有血液成分，光敏剂和溶解的一氧化氮的流体。本发明提供了用于执行本发明方法的净化系统和用于制造去污系统的方法。本发明还提供了用于净化流体的方法和用于增加光化学去污血小板的储存寿命和质量的方法。

77. 发明申请

WO2003063930A1 WHOLE BLOOD COLLECTION AND PROCESSING METHOD 审中-公开
标题翻译：全血采集和处理方法
公开(公告)号：WO2003063930A1
公开(公告)日：2003-08-07
申请号：PCT/US2003/003305
申请日：2003-02-03
申请人： GAMBRO, INC.
发明人： CORBIN, Frank, III , URDAHL, Steven, Gage
IPC分类号： A61M1/38
CPC分类号： A61M1/387 , A61M1/0209 , A61M1/0218 , A61M1/3633 , A61M2202/0439
摘要： A method is disclosed for collecting and processing whole blood. Whole blood is collected at several remote donor sites and transported to a central blood-processing center, where information regarding demand for blood products is used to direct processing of whole blood into blood products. Whole blood is initially collected in collection bags unattached to satellite bags instead of commonly used multiple bag sets. When the determination is made at the blood processing center as to which blood products are to be made, the appropriate satellite bags and/or other system components are sterile docked to the blood-collection bag and the whole blood is processed. The use of blood-collection bags initially unattached to satellite bags eliminates waste and simplifies the transportation and processing of whole blood. Also disclosed are blood collection systems that remove leukocytes and collect whole blood into blood-collection bags unattached to satellite bags.
摘要翻译：公开了一种用于收集和处理全血的方法。全血在几个远距离的捐赠站点收集并运送到一个中央血液处理中心，其中有关血液制品需求的信息用于将全血直接加工成血液制品。全血最初收集在不附带卫星袋的收集袋中，而不是常用的多个袋装。当在血液处理中心做出关于哪些血液制品的确定时，将合适的卫星袋和/或其它系统部件与血液收集袋无菌地对接，并且全血被处理。首先使用不附带卫星袋的采血袋消除浪费，简化了全血的运输和加工。还公开了采血系统，其将白血球除去并将全血收集到未附着于卫星袋的血液收集袋中。

78. 发明申请

WO2003063915A1 REDUCTION OF CONTAMINANTS IN BLOOD AND BLOOD PRODUCTS USING PHOTOSENSITIZERS AND PEAK WAVELENGTHS OF LIGHT 审中-公开
标题翻译：使用光敏剂和峰值波长减少血液和血液中的污染物
公开(公告)号：WO2003063915A1
公开(公告)日：2003-08-07
申请号：PCT/US2003/003359
申请日：2003-02-03
申请人： GAMBRO, INC.
发明人： HLAVINKA, Dennis, J. , GOODRICH, Raymond, P. , GOODRICH, Laura , MCGRAW, Daniel
IPC分类号： A61L2/00
CPC分类号： A61L2/0047 , A61K35/18 , A61K41/0057 , A61K41/0071 , A61L2/0076 , A61L2/0088 , A61L2/24 , A61L2/26 , A61L2202/22 , A61M1/3681 , A61M1/3683 , A61M2205/053 , A61M2205/75 , C12N13/00
摘要： Methods and apparatuses are provided for inactivation of pathogens in fluids containing blood products. Preferred methods include the steps of adding an effective, non-toxic amount of a photosensitizer such as riboflavin to the blood product and exposing the fluid to light having a peak wavelength.
摘要翻译：提供了用于在含有血液制品的流体中灭活病原体的方法和装置。优选的方法包括将有效的无毒量的光敏剂如核黄素添加到血液制品中并将流体暴露于具有峰值波长的光的步骤。

79. 发明申请

WO2003063902A2 INACTIVATION OF WEST NILE VIRUS AND MALARIA USING PHOTOSENSITIZERS 审中-公开
标题翻译：利用光敏剂灭活西尼尔病毒和疟疾
公开(公告)号：WO2003063902A2
公开(公告)日：2003-08-07
申请号：PCT/US2003/003358
申请日：2003-02-03
申请人： GAMBRO, INC.
发明人： REDDY, Heather , GOODRICH, Raymond, P.
IPC分类号： A61K41/00
CPC分类号： A61K41/0057 , A61K41/0019
摘要： Methods and apparatuses are provided for inactivation of microorganisms in fluids or on surfaces. Preferably the fluids contain blood or blood products and comprise biologically active proteins. Preferred methods include the steps of adding an effective, non-toxic amount of a photosensitizer to a fluid and exposing the fluid to photoradiation sufficient to activate the photosensitizer whereby microorganisms are inactivated.
摘要翻译：提供了用于灭活流体中或表面上的微生物的方法和设备。优选地，流体含有血液或血液制品并包含生物活性蛋白质。优选的方法包括以下步骤：向流体中加入有效的无毒量的光敏剂，并使流体暴露于足以激活光敏剂的光辐射，从而使微生物失活。

80. 发明申请

WO2003054176A3 PREPARATION OF VACCINES USING PHOTOSENSITIZER AND LIGHT 审中-公开
公开(公告)号：WO2003054176A3
公开(公告)日：2003-07-03
申请号：PCT/US2002/040923
申请日：2002-12-20
申请人： GAMBRO, INC.
发明人： GOODRICH, Raymond, P.
IPC分类号： C12N7/04
摘要： Methods are provided for treating a vaccine containing infectious particles which may be viral, bacterial, and/or cellular in nature. Preferred methods include the steps of adding an effective, non-toxic amount of an endogenous photosensitizer to the fluid and exposing the fluid to photoradiation sufficient to inactivate the infectious particles but not enough to damage the antigenic characteristics of the infectious particles.

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