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1. 发明申请

WO2003066109A1 NITRIC OXIDE IN A PATHOGEN INACTIVATION PROCESS 审中-公开
标题翻译：硝酸氧化酶在病毒灭活过程中
公开(公告)号：WO2003066109A1
公开(公告)日：2003-08-14
申请号：PCT/US2003/004009
申请日：2003-02-10
申请人： GAMBRO, INC.
发明人： EDRICH, Richard, Alan 2754 S. Ingalls Way , GOODRICH, Laura , DEPPISCH, Reinhold , HLAVINKA, Dennis, J. , LOCKERBIE, Robert, Owen , BECK, Werner
IPC分类号： A61L2/00
CPC分类号： A61L2/0047 , A61K41/0019 , A61K41/0057 , A61L2/0082 , A61L2/08 , A61L2/10 , A61L2/16 , A61L2202/22 , A61M1/0272 , A61M1/3681 , A61M1/3683 , A61M1/3686 , A61M2202/0275
摘要： This invention provides methods and compositions for using nitric oxide in a photoradiation pathogen inactivation process for whole blood and blood components to improve pathogen kill and to improve preservation of the quality of the blood components. This invention provides methods for using nitric oxide in combination with oxygen, photosensitizers, quencher and/or glycolysis inhibitor, and compositions comprising blood components decontaminated by these methods. Nitric oxide is provided using nitric oxide gas, or nitric oxide generators such as L-arginine, and/or N-acetyl-cysteine. This invention also provides compositions suitable for photoradiation pathogen inactivation that include fluid comprising a blood component, a photosensitizer, and dissolved nitric oxide. This invention provides decontamination systems useful for performing the methods of this invention and methods for making the decontamination systems. This invention also provides methods for decontaminating fluids and methods for increasing the storage life and quality of photochemically decontaminated platelets.
摘要翻译：本发明提供了在全血和血液成分的光辐射病原体失活过程中使用一氧化氮以改善病原体杀伤并改善血液成分质量的保存的方法和组合物。本发明提供了使用一氧化氮与氧，光敏剂，猝灭剂和/或糖酵解抑制剂组合的方法，以及包含通过这些方法去污染的血液成分的组合物。使用一氧化氮气体或一氧化氮生成剂如L-精氨酸和/或N-乙酰半胱氨酸来提供一氧化氮。本发明还提供适用于光辐射病原体灭活的组合物，其包括含有血液成分，光敏剂和溶解的一氧化氮的流体。本发明提供了用于执行本发明方法的净化系统和用于制造去污系统的方法。本发明还提供了用于净化流体的方法和用于增加光化学去污血小板的储存寿命和质量的方法。

2. 发明申请

WO2004018471A1 NUCLEIC ACID DAMAGE USING RIBOFLAVIN AND LIGHT 审中-公开
标题翻译：使用RIBOFLAVIN和LIGHT的核酸损伤
公开(公告)号：WO2004018471A1
公开(公告)日：2004-03-04
申请号：PCT/US2003/026770
申请日：2003-08-25
申请人： GAMBRO, INC.
发明人： LOCKERBIE, Robert, Owen , KUMAR, Vijay , KEIL, Shawn, D. , GOODRICH, Raymond, P.
IPC分类号： C07D475/14
CPC分类号： A61L2/0082 , A61K41/0019 , A61L2/0011 , A61M1/3681 , A61M1/3683
摘要： A process for damaging and maintaining damage to the nucleic acids of pathogens such as white blood cells, bacteria and viruses which may be contained in blood or blood components. This process comprises adding to the blood or blood component containing pathogens an effective amount of riboflavin, and exposing the fluid to light of an appropriate wavelength to damage the nucleic acid of the pathogen and to substantially maintain the damage to the pathogenic nucleic acids to allow for subsequent transfusion into a recipient.
摘要翻译：一种损害和维护可能包含在血液或血液成分中的病原体核酸如白细胞，细菌和病毒的损害的过程。该方法包括向含有病原体的血液或血液成分中加入有效量的核黄素，并将该液体暴露于适当波长的光以损害病原体的核酸，并且基本维持致病性核酸的损伤，以允许随后输血到接受者。

3. 发明申请

WO2003090794A1 SOLUTION CONTAINING PLATELET ACTIVATION INHIBITORS FOR PATHOGEN REDUCING AND STORING BLOOD PLATELETS 审中-公开
标题翻译：包含板激活抑制剂用于病原体减少和储存血液平板的解决方案
公开(公告)号：WO2003090794A1
公开(公告)日：2003-11-06
申请号：PCT/US2003/013224
申请日：2003-04-28
申请人： GAMBRO, INC.
发明人： GOODRICH, Laura , GOODRICH, Raymond, P. , GAMPP, Deanna , LOCKERBIE, Robert, Owen
IPC分类号： A61L2/00
CPC分类号： A61K31/557 , A01N1/02 , A01N1/0215 , A61K31/352 , A61K31/52 , A61K35/19 , A61L2/0011 , A61L2/0088
摘要： This invention relates to the addition of platelet activation inhibitors to solutions used in the pathogen reduction an subsequent storage of platelets. More particularly, the invention relates the addition of adenylate cyclase stimulators and phosphodiesterase inhibitors to a platelet pathogen reduction and storage solution.
摘要翻译：本发明涉及将血小板活化抑制剂添加到用于病原体还原的溶液中，随后储存血小板。更具体地，本发明涉及将腺苷酸环化酶刺激剂和磷酸二酯酶抑制剂添加到血小板病原体还原和储存溶液中。

4. 发明公开

EP1530571A1 NUCLEIC ACID DAMAGE USING RIBOFLAVIN AND LIGHT 有权转让
标题翻译： NUKLEINSÄURE-SCHÄDENVERURSACHT DURCH RIBOFLAVIN UND LICHT
公开(公告)号：EP1530571A1
公开(公告)日：2005-05-18
申请号：EP03751901.4
申请日：2003-08-25
申请人： Gambro, Inc.
发明人： LOCKERBIE, Robert, Owen , KUMAR, Vijay , KEIL, Shawn, D. , GOODRICH, Raymond, P.
IPC分类号： C07D475/14 , A61L2/00 , A61L2/08 , A61L2/10
CPC分类号： A61L2/0082 , A61K41/0019 , A61L2/0011 , A61M1/3681 , A61M1/3683
摘要： A process for damaging and maintaining damage to the nucleic acids of pathogens such as white blood cells, bacteria and viruses which may be contained in blood or blood components. This process comprises adding to the blood or blood component containing pathogens an effective amount of riboflavin, and exposing the fluid to light of an appropriate wavelength to damage the nucleic acid of the pathogen and to substantially maintain the damage to the pathogenic nucleic acids to allow for subsequent transfusion into a recipient.
摘要翻译：一种损害和维护病原体核酸如血液或血液成分中可能含有的白细胞，细菌和病毒的损害的方法。该方法包括向含有病原体的血液或血液成分中加入有效量的核黄素，并将该液体暴露于适当波长的光以损害病原体的核酸，并基本维持致病性核酸的损伤，以允许随后输血到接受者。

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