专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

71. 发明公开

EP1272637A4 A METHOD FOR SCREENING FOR AUTOIMMUNE DISEASE BY IDENTIFYING POLYMORPHISMS IN IL-12 p40 审中-公开
标题翻译：用于筛选自身免疫疾病的由IL-12 P40多态性的鉴定
公开(公告)号：EP1272637A4
公开(公告)日：2004-09-08
申请号：EP01916738
申请日：2001-03-27
申请人： INST MEDICAL W & E HALL
发明人： MORAHAN GRANT
IPC分类号： C12N15/09 , A61K38/20 , A61K39/395 , A61K45/00 , A61K48/00 , A61P3/10 , A61P37/02 , C12N15/24 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： A method of screening mammals for an autoimmune disease or a predisposition to said disease (e.g diabeties). The method consists of identifying polymorphisms in IL-12 p40 and linking them to the disease condition.

72. 发明公开

EP1265985A4 PANCREATIC ISLET CELL GROWTH FACTORS 审中-公开
标题翻译：胰腺岛细胞生长因子
公开(公告)号：EP1265985A4
公开(公告)日：2004-06-23
申请号：EP01905503
申请日：2001-02-16
申请人： INST MEDICAL W & E HALL
发明人： HARRISON LEONARD C , JIANG FANG-XU , STANLEY EDOUARD G , GONEZ LEONEL JORGE
IPC分类号： A61K35/12 , A61K35/39 , A61K38/00 , A61K38/18 , A61K38/22 , A61K45/00 , A61P3/10 , A61P35/00 , C07K14/51 , C07K14/78 , C12N5/071 , A61P5/48
CPC分类号： A61K38/1875 , A61K35/12 , C07K14/51 , C07K14/78 , C12N5/0676 , C12N2501/15 , C12N2501/155 , C12N2501/16 , C12N2501/58
摘要： The present invention relates generally to growth factors and more particularly to growth factors which are capable of stimulating or otherwise facilitating formation of insulin-secreting cells. The identification of these growth factors permits the development of protocols to culture cells in vitro for transplantation into mammalian and in particular human subjects with insulin-dependent type 1 diabetes or related conditions. It is further contemplated that the endogenous expression of growth factors required for the development of insulin-producing cells may be manipulated in vivo, by the appropriate administration of agents including genetic agents capable of regulating the expression of growth factors in pancreatic duct epithelial cells. The growth factors ray also be administered to subjects with type 1 diabetes to stimulate the proliferation and differentiation of pancreatic cells into insulin-secreting cells. The present invention also provides modulators of growth factor-mediated pancreatic cell differentiation. Such modulators are useful in the treatment inter alia of beta cell tumors and/or pancreatic cancer.

73. 发明公开

EP0134799A4 EXPRESSION OF PLASMODIUM FALCIPARUM POLYPEPTIDES FROM CLONED cDNA. 失效
标题翻译：从克隆的C-DNA表达恶性疟原虫多肽。
公开(公告)号：EP0134799A4
公开(公告)日：1985-07-30
申请号：EP84900598
申请日：1984-01-27
申请人： INST MEDICAL W & E HALL
发明人： KEMP DAVID JAMES , ANDERS ROBIN FREDRIC , COPPEL ROSS LEON , BROWN GRAHAM VALLANCEY , SAINT ROBERT BRYCE , COWMAN ALAN FREDERICK , MITCHELL GRAHAM FRANK
IPC分类号： A61K39/015 , A61K20060101 , A61K39/00 , A61K39/002 , A61P31/04 , C07G99/00 , C07H21/04 , C07K14/00 , C07K14/44 , C07K14/445 , C07K19/00 , C12N20060101 , C12N1/20 , C12N1/21 , C12N15/00 , C12N15/09 , C12P21/02 , C12R1/19 , C12R1/90 , F02B75/02
CPC分类号： C07K14/445 , A61K39/00 , C07K2319/00 , C07K2319/40 , F02B2075/027
摘要： DNA molecules comprising artificially constructed polynucleotide sequences substantially corresponding to all or a portion of Plasmodium falciparum messenger RNA (mRNA) or genomic DNA (gDNA). Especially DNA molecules comprising artificially constructed polynucleotide sequences coding for the whole or part of one or more proteins occuring in P. falciparum, or a precursor or modification thereof. Such DNA molecules are capable of being expressed as a polypeptide(s). Synthetic peptides or polypeptides displaying the antigenicity of all or a portion of at least one P. falciparum antigen. Compositions for stimulating immune responses against P. falciparum antigens in a mammal, comprising at least one polypeptide displaying the antigenicity of a P. falciparum antigen, together with a pharmaceutically acceptable carrier therefor.

74. 发明申请

WO2015006811A3 DIAGNOSTIC METHODS 审中-公开
标题翻译：诊断方法
公开(公告)号：WO2015006811A3
公开(公告)日：2016-06-23
申请号：PCT/AU2014000730
申请日：2014-07-18
申请人： INST MEDICAL W & E HALL , MURDOCH CHILDRENS RES INST
发明人： BLEWITT MARNIE , HARRISON LEONARD CHARLES , MAKSIMOVIC JOVANA , NASELLI GAETANO , OSHLACK ALICIA , ZHANG YUXIA
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881
摘要： A method for identifying the level of T-regulatory cell activity in a test biological sample comprising immune cells, the method comprising screening a test sample for the methylation profiles of a pre-selected genetic locus/loci selected from the list consisting of: (i) at least one genetic locus or at least two genetic Loci defined m one or more of Table 1 to Table 5; (ii) at least one genetic locus or at least two genetic loci defined in one or more of Table 6 to Table 10; and (iii) at least two genetic loci defined in one or more of Table 1 to Table 5, and one or more of Table 6 to Table 10; and determining the degree of concordance between the test methylation profiles and a reference methylation profile, wherein the degree of concordance identifies the level of T-regulatory cell activity in the sample.
摘要翻译：一种用于鉴定包含免疫细胞的测试生物样品中T调节细胞活性水平的方法，所述方法包括筛选预先选择的遗传基因座/位点的甲基化谱的测试样品，所述选择的遗传基因座/位点选自：（i ）至少一个遗传基因座或至少两个定义在表1至表5中的一个或多个的遗传基因座; （ii）在表6至表10中的一个或多个中定义的至少一个遗传基因座或至少两个遗传基因座; 和（iii）在表1至表5中的一个或多个中定义的至少两个遗传基因座，以及表6至表10中的一个或多个; 并确定测试甲基化谱与参考甲基化谱之间的一致程度，其中一致度确定样品中T调节细胞活性的水平。

75. 发明申请

WO2009143246A3 ARYLSULFONAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：芳香酰胺化合物，组合物和使用方法
公开(公告)号：WO2009143246A3
公开(公告)日：2010-04-29
申请号：PCT/US2009044680
申请日：2009-05-20
申请人： GENENTECH INC , INST MEDICAL W & E HALL , BAELL JONATHAN , LESSENE GUILLAUME LAURENT , SLEEBS BRAD EDMUND , FAIRBROTHER WAYNE , FLYGARE WAYNE , KOEHLER MICHAEL
发明人： BAELL JONATHAN , LESSENE GUILLAUME LAURENT , SLEEBS BRAD EDMUND , FAIRBROTHER WAYNE , FLYGARE WAYNE , KOEHLER MICHAEL
IPC分类号： C07D215/38 , A61K31/517 , A61P35/02
CPC分类号： C07D215/38
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti apoptotic protein family member.
摘要翻译：公开了抑制抗凋亡蛋白家族成员的活性的化合物，含有该化合物的组合物和该化合物用于制备治疗疾病的药物的用途，其中发生表达一种或多种抗凋亡蛋白家族成员。

76. 发明申请

WO2010093742A8 METHODS AND COMPOSITIONS FOR IDENTIFYING, CLASSIFYING AND MONITORING SUBJECT HAVING BCL-2 FAMILY INHIBITOR-RESISTANT TUMORS AND CANCERS 审中-公开
标题翻译：用于鉴定，分类和监测具有BCL-2家族阻抑性肿瘤和癌症的受试者的方法和组合物
公开(公告)号：WO2010093742A8
公开(公告)日：2011-08-11
申请号：PCT/US2010023818
申请日：2010-02-11
申请人： ABBOTT LAB , INST MEDICAL W & E HALL , SEMIZAROV DIMITRI , UZIEL TAMAR , HUANG DAVID , VAN DELFT MARK F , TSE CHRISTIN , LESNIEWSKI RICHARD R
发明人： SEMIZAROV DIMITRI , UZIEL TAMAR , HUANG DAVID , VAN DELFT MARK F , TSE CHRISTIN , LESNIEWSKI RICHARD R
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , G01N33/57496 , G01N2333/4703
摘要： The invention is directed to methods and kits that allow for identifying, classifying, and monitoring cancer patients for Bcl-2 family inhibitor therapies. The methods and compositions of the invention are directed to determining amplification of BcI-XL and in cancer or tumor cells, or elevated BcI-XL polypeptide expression.
摘要翻译：本发明涉及允许鉴定，分类和监测癌症患者Bcl-2家族抑制剂疗法的方法和试剂盒。本发明的方法和组合物涉及确定BcI-XL和癌症或肿瘤细胞中的扩增或升高的BcI-XL多肽表达。

77. 发明申请

WO2008061208A3 ARYLSULFONAMIDE COMPOUNDS 审中-公开
标题翻译：芳香酰胺化合物
公开(公告)号：WO2008061208A3
公开(公告)日：2008-07-03
申请号：PCT/US2007084873
申请日：2007-11-15
申请人： GENENTECH INC , INST MEDICAL W & E HALL , BAELL JONATHAN BAYLDON , LESSENE GUILLAUME LAURENT , SLEEBS BRAD EDMUND , FAIRBROTHER WAYNE J , FLYGARE JOHN A , KOEHLER MICHAEL F T
发明人： BAELL JONATHAN BAYLDON , LESSENE GUILLAUME LAURENT , SLEEBS BRAD EDMUND , FAIRBROTHER WAYNE J , FLYGARE JOHN A , KOEHLER MICHAEL F T
IPC分类号： C07D239/94 , A61K31/517 , A61P43/00
CPC分类号： C07D239/94
摘要： The invention relates generally to small molecules that mimic the biological activity of certain peptides and proteins, to compositions containing them and to their use. In particular, the invention relates to compounds of the general formula (I) that mimic the biological activity of BH3-only proteins and are capable of binding to and neutralising prosurvival Bcl-2 proteins: wherein A 1 , A 2 , B 1, B 2 , B 3 , X, Z, R 1 , R 2 , R 3 and t are as described herein. The invention also relates to processes of preparing the benzenesulfonamide compounds that mimic portions of peptides and proteins, and to the use of such compounds in the regulation of cell death and the treatment and/or prophylaxis of diseases or conditions associated with the deregulation of cell death.
摘要翻译：本发明一般涉及模拟某些肽和蛋白质的生物学活性的小分子，含有它们的组合物及其用途。特别地，本发明涉及模拟仅含BH3蛋白的生物学活性的通式（I）的化合物，并且能够结合并中和前病毒Bcl-2蛋白：其中A 1， B 1，B 2，B 3，X 3，Z 1，R 2， R 2，R 3和R 3如本文所述。本发明还涉及制备模仿肽和蛋白质的一部分的苯磺酰胺化合物的方法，以及这些化合物在调节细胞死亡中的用途以及治疗和/或预防与细胞死亡调节相关的疾病或病症。

78. 发明申请

WO03023404A8 A METHOD OF DIAGNOSIS AND TREATMENT AND AGENTS USEFUL FOR SAME 审中-公开
标题翻译：一种诊断和治疗的方法以及适用于该方法的药剂
公开(公告)号：WO03023404A8
公开(公告)日：2003-05-08
申请号：PCT/AU0201246
申请日：2002-09-12
申请人： INST MEDICAL W & E HALL , VISVADER JANE ELLEN , LINDEMAN GEOFFREY JOHN , SUM ELEANOR Y M , O'REILLY LORRAINE ANN
发明人： VISVADER JANE ELLEN , LINDEMAN GEOFFREY JOHN , SUM ELEANOR Y M , O'REILLY LORRAINE ANN
IPC分类号： G01N33/53 , A61K45/00 , A61K49/00 , A61P1/00 , A61P7/00 , A61P11/00 , A61P13/12 , A61P15/00 , A61P17/00 , A61P25/00 , A61P27/02 , A61P35/00 , A61P35/02 , C07K16/18 , C07K16/30 , C07K16/46 , C12N5/10 , C12N15/02 , C12N15/09 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/574 , G01N33/577 , A61K39/395 , A61K49/16 , C12N5/12
CPC分类号： G01N33/57415 , C07K16/30 , C07K16/3015
摘要： The present invention relates generally to a method for detecting an aberrant cell, and more particularly an aberrant epithelial cell, in a subject or in a biological sample from said subject and agents useful for same. More particularly, the present invention relates to a method of deleting an aberrant mammary epithelial cell. The presence of the aberrant cell or group of aberrant cells provides an indication of a particular disease or condition or a propensity for development of a disease or condition. More particularly, the present invention contemplates a method for detecting a cell associated with breast cancer or having a propensity to develop into a breast cancer in a subject or in a biological sample from said subject by determining the relative increase in the presence of the LM04 protein or a related protein or a relative increase in LM04 activity or a relative increase in the presence of expression products from a gene encoding the LM04 protein or a related protein. The present invention further provides a method for diagnosing the presence of a cancer or cancerous-like growth, in particular breast cancer in a subject or in a biological sample from said subject by screening for up-regulation of LM04 or a related protein in a cell or group of cells or an up-regulation in the presence of expression products of genetic sequences encoding LM04 or a related protein. The present invention provides diagnostic agents useful for detecting LM04 or expression products of genetic material encoding LM04. Such diagnostic agents include immunointeractive molecules, such as antibodies, and genetic probes for detecting expression products of LM04 genes. The present invention further provides genetically modified animals exhibiting altered levels of LM04. Such animals are useful models for screening for anti-cancer agents. The present invention still further relates generally to a method of modulating LM04 related cellular proliferation and to agents useful for same. More particularly, the present invention contemplates a method of modulating breast cell proliferation by modulating LM04 nucleic acid expression and/or LM04 functioning. The method of the present invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by aberrant, unwanted or otherwise inappropriate LM04 regulated cellular proliferation. The present invention is further directed to methods for identifying and/or designing agents capable of modulating LM04 regulated cellular proliferation.
摘要翻译：本发明一般涉及用于检测受试者或来自所述受试者的生物样品中的异常细胞，更特别是异常上皮细胞的方法以及用于其的试剂。更具体地说，本发明涉及一种删除异常乳房上皮细胞的方法。异常细胞或一组异常细胞的存在提供了特定疾病或病症或疾病或病症发展倾向的指征。更特别地，本发明考虑了一种用于检测与乳腺癌相关的细胞或在受试者中或在来自所述受试者的生物样品中具有发展成乳腺癌倾向的细胞的方法，其通过测定LM04蛋白质存在的相对增加或相关蛋白质或LM04活性的相对增加或来自编码LM04蛋白质或相关蛋白质的基因的表达产物的存在的相对增加。本发明进一步提供了通过筛选细胞中LM04或相关蛋白质的上调来诊断受试者或来自所述受试者的生物样品中癌症或癌样生长特别是乳腺癌的存在的方法或在存在编码LM04或相关蛋白的基因序列表达产物的情况下上调的细胞组。本发明提供了用于检测LM04或编码LM04的遗传物质的表达产物的诊断剂。这样的诊断剂包括免疫相互作用分子如抗体，以及用于检测LM04基因表达产物的基因探针。本发明进一步提供显示LM04水平改变的基因修饰动物。这些动物是筛选抗癌剂的有用模型。本发明还进一步涉及调节LM04相关细胞增殖的方法和涉及用于其的试剂。更特别地，本发明考虑通过调节LM04核酸表达和/或LM04功能来调节乳房细胞增殖的方法。本发明的方法尤其可用于治疗和/或预防以异常，不需要的或其他不适当的LM04调节的细胞增殖为特征的病症。本发明还涉及鉴定和/或设计能够调节LM04调节的细胞增殖的试剂的方法。

79. 发明申请

WO9955849A8 TYROSINE PHOSPHATASE IA-2, GAD AND ROTAVIRUS VP7 IMMUNITY 审中-公开
标题翻译：酪氨酸磷酸酶IA-2，GAD和ROTAVIRUS VP7免疫
公开(公告)号：WO9955849A8
公开(公告)日：2000-05-25
申请号：PCT/AU9900314
申请日：1999-04-27
申请人： INST MEDICAL W & E HALL , UNIV MELBOURNE , HONEYMAN MARGO CAROLE , COULSON BARBARA SUE , HARRISON LEONARD CHARLES
发明人： HONEYMAN MARGO CAROLE , COULSON BARBARA SUE , HARRISON LEONARD CHARLES
IPC分类号： A61K39/00 , C07K14/725 , C12N9/16 , G01N33/68 , C12N9/12 , A61K39/15 , C07K7/00 , A61K37/02
CPC分类号： G01N33/6878 , A61K39/00 , C12N9/16
摘要： The present invention provides T cell epitopes from IA-2. The present invention also relates to the use of these epitopes in diagnosis and therapy. The present invention further provides rotavirus vaccines.
摘要翻译：本发明提供了来自IA-2的T细胞表位。本发明还涉及这些表位在诊断和治疗中的用途。本发明进一步提供轮状病毒疫苗。

80. 发明申请

WO2013053008A3 MOLECULES WHICH BIND CLEC9A 审中-公开
标题翻译：分子结合CLEC9A
公开(公告)号：WO2013053008A3
公开(公告)日：2013-06-20
申请号：PCT/AU2012001233
申请日：2012-10-12
申请人： INST MEDICAL W & E HALL
发明人： COLMAN PETER MALCOLM , COPPEL ROSS LEON , CZABOTAR PETER EDWARD , LAHOUD MIREILLE HANNA , NICOLA NICOS ANTHONY , POLICHENI ANTONIA NATALIE , SHORTMAN KENNETH DOUGLAS , TULLETT KIRSTEEN MCINNES , ZHANG JIAN-GUO , BAUM JACOB , WONG WILSON
IPC分类号： C07K14/435 , A61K38/17 , A61P37/00 , C12N5/0784 , C12N15/12
CPC分类号： C12N9/93 , C07K14/4716 , C07K14/7056 , C07K19/00 , C07K2319/43 , C07K2319/70
摘要： The present invention relates to the identification of molecules which bind the dendritic cell marker known as Clec9A. The present invention provides new compounds for targeting therapeutic agents such as antigens to dendritic cells. Also provided are methods of modulating a humoral and/or T-cell mediated immune response to the antigen, methods of delivery of a cytotoxic agent to dendritic cells thereof involved in diseased states, methods of modulating the uptake and/or clearance of cells with a disrupted cell membrane, cells infected with a pathogen, dying cells or dead cells, or a portion thereof, and methods of modulating antigen recognition, processing and/or presentation, as well as immune responses to material derived from cells with a disrupted cell membrane, cells infected with a pathogen, dying cells or dead cells, or a portion thereof.
摘要翻译：本发明涉及结合被称为Clec9A的树突细胞标记的分子的鉴定。本发明提供了用于将治疗剂如抗原靶向树突细胞的新化合物。还提供了调节对抗原的体液和/或T细胞介导的免疫应答的方法，将细胞毒剂递送至涉及患病状态的树突细胞的方法，调节细胞摄取和/或清除的方法破坏的细胞膜，被病原体感染的细胞，将死的细胞或死亡的细胞或其一部分，以及调节抗原识别，加工和/或呈递以及对源自具有破坏的细胞膜的细胞的物质的免疫应答的方法，感染病原体的细胞，将死的细胞或死细胞或其部分。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式