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1. 发明申请

WO03023404A8 A METHOD OF DIAGNOSIS AND TREATMENT AND AGENTS USEFUL FOR SAME 审中-公开
标题翻译：一种诊断和治疗的方法以及适用于该方法的药剂
公开(公告)号：WO03023404A8
公开(公告)日：2003-05-08
申请号：PCT/AU0201246
申请日：2002-09-12
申请人： INST MEDICAL W & E HALL , VISVADER JANE ELLEN , LINDEMAN GEOFFREY JOHN , SUM ELEANOR Y M , O'REILLY LORRAINE ANN
发明人： VISVADER JANE ELLEN , LINDEMAN GEOFFREY JOHN , SUM ELEANOR Y M , O'REILLY LORRAINE ANN
IPC分类号： G01N33/53 , A61K45/00 , A61K49/00 , A61P1/00 , A61P7/00 , A61P11/00 , A61P13/12 , A61P15/00 , A61P17/00 , A61P25/00 , A61P27/02 , A61P35/00 , A61P35/02 , C07K16/18 , C07K16/30 , C07K16/46 , C12N5/10 , C12N15/02 , C12N15/09 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/574 , G01N33/577 , A61K39/395 , A61K49/16 , C12N5/12
CPC分类号： G01N33/57415 , C07K16/30 , C07K16/3015
摘要： The present invention relates generally to a method for detecting an aberrant cell, and more particularly an aberrant epithelial cell, in a subject or in a biological sample from said subject and agents useful for same. More particularly, the present invention relates to a method of deleting an aberrant mammary epithelial cell. The presence of the aberrant cell or group of aberrant cells provides an indication of a particular disease or condition or a propensity for development of a disease or condition. More particularly, the present invention contemplates a method for detecting a cell associated with breast cancer or having a propensity to develop into a breast cancer in a subject or in a biological sample from said subject by determining the relative increase in the presence of the LM04 protein or a related protein or a relative increase in LM04 activity or a relative increase in the presence of expression products from a gene encoding the LM04 protein or a related protein. The present invention further provides a method for diagnosing the presence of a cancer or cancerous-like growth, in particular breast cancer in a subject or in a biological sample from said subject by screening for up-regulation of LM04 or a related protein in a cell or group of cells or an up-regulation in the presence of expression products of genetic sequences encoding LM04 or a related protein. The present invention provides diagnostic agents useful for detecting LM04 or expression products of genetic material encoding LM04. Such diagnostic agents include immunointeractive molecules, such as antibodies, and genetic probes for detecting expression products of LM04 genes. The present invention further provides genetically modified animals exhibiting altered levels of LM04. Such animals are useful models for screening for anti-cancer agents. The present invention still further relates generally to a method of modulating LM04 related cellular proliferation and to agents useful for same. More particularly, the present invention contemplates a method of modulating breast cell proliferation by modulating LM04 nucleic acid expression and/or LM04 functioning. The method of the present invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by aberrant, unwanted or otherwise inappropriate LM04 regulated cellular proliferation. The present invention is further directed to methods for identifying and/or designing agents capable of modulating LM04 regulated cellular proliferation.
摘要翻译：本发明一般涉及用于检测受试者或来自所述受试者的生物样品中的异常细胞，更特别是异常上皮细胞的方法以及用于其的试剂。更具体地说，本发明涉及一种删除异常乳房上皮细胞的方法。异常细胞或一组异常细胞的存在提供了特定疾病或病症或疾病或病症发展倾向的指征。更特别地，本发明考虑了一种用于检测与乳腺癌相关的细胞或在受试者中或在来自所述受试者的生物样品中具有发展成乳腺癌倾向的细胞的方法，其通过测定LM04蛋白质存在的相对增加或相关蛋白质或LM04活性的相对增加或来自编码LM04蛋白质或相关蛋白质的基因的表达产物的存在的相对增加。本发明进一步提供了通过筛选细胞中LM04或相关蛋白质的上调来诊断受试者或来自所述受试者的生物样品中癌症或癌样生长特别是乳腺癌的存在的方法或在存在编码LM04或相关蛋白的基因序列表达产物的情况下上调的细胞组。本发明提供了用于检测LM04或编码LM04的遗传物质的表达产物的诊断剂。这样的诊断剂包括免疫相互作用分子如抗体，以及用于检测LM04基因表达产物的基因探针。本发明进一步提供显示LM04水平改变的基因修饰动物。这些动物是筛选抗癌剂的有用模型。本发明还进一步涉及调节LM04相关细胞增殖的方法和涉及用于其的试剂。更特别地，本发明考虑通过调节LM04核酸表达和/或LM04功能来调节乳房细胞增殖的方法。本发明的方法尤其可用于治疗和/或预防以异常，不需要的或其他不适当的LM04调节的细胞增殖为特征的病症。本发明还涉及鉴定和/或设计能够调节LM04调节的细胞增殖的试剂的方法。

2. 发明公开

EP1436624A4 A METHOD OF DIAGNOSIS AND TREATMENT AND AGENTS USEFUL FOR SAME 有权
标题翻译：诊断和治疗方法及合适的方法
公开(公告)号：EP1436624A4
公开(公告)日：2005-05-25
申请号：EP02753953
申请日：2002-09-12
申请人： INST MEDICAL W & E HALL
发明人： VISVADER JANE ELLEN , LINDEMAN GEOFFREY JOHN , SUM ELEANOR Y M , O'REILLY LORRAINE ANN
IPC分类号： G01N33/53 , A61K45/00 , A61K49/00 , A61P1/00 , A61P7/00 , A61P11/00 , A61P13/12 , A61P15/00 , A61P17/00 , A61P25/00 , A61P27/02 , A61P35/00 , A61P35/02 , C07K16/18 , C07K16/30 , C07K16/46 , C12N5/10 , C12N15/02 , C12N15/09 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/574 , G01N33/577 , A61K39/395 , A61K49/16
CPC分类号： G01N33/57415 , C07K16/30 , C07K16/3015

3. 发明专利

CA2460092A1 A METHOD OF DIAGNOSIS AND TREATMENT AND AGENTS USEFUL FOR SAME 未知
公开(公告)号：CA2460092A1
公开(公告)日：2003-03-20
申请号：CA2460092
申请日：2002-09-12
申请人： INST MEDICAL W & E HALL
发明人： SUM ELEANOR Y M , LINDEMAN GEOFFREY JOHN , O'REILLY LORRAINE ANN , VISVADER JANE ELLEN
IPC分类号： G01N33/53 , A61K45/00 , A61K49/00 , A61P1/00 , A61P7/00 , A61P11/00 , A61P13/12 , A61P15/00 , A61P17/00 , A61P25/00 , A61P27/02 , A61P35/00 , A61P35/02 , C07K16/18 , C07K16/30 , C07K16/46 , C12N5/10 , C12N15/02 , C12N15/09 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/574 , C12N5/12 , A61K39/395 , G01N33/577
摘要： The present invention relates generally to a method for detecting an aberran t cell, and more particularly an aberrant epithelial cell, in a subject or in a biological sample from said subject and agents useful for same. More particularly, the present invention relates to a method of deleting an aberrant mammary epithelial cell. The presence of the aberrant cell or group of aberrant cells provides an indication of a particular disease or conditio n or a propensity for development of a disease or condition. More particularly , the present invention contemplates a method for detecting a cell associated with breast cancer or having a propensity to develop into a breast cancer in a subject or in a biological sample from said subject by determining the relative increase in the presence of the LM04 protein or a related protein o r a relative increase in LM04 activity or a relative increase in the presence of expression products from a gene encoding the LM04 protein or a related protein. The present invention further provides a method for diagnosing the presence of a cancer or cancerous-like growth, in particular breast cancer i n a subject or in a biological sample from said subject by screening for up- regulation of LM04 or a related protein in a cell or group of cells or an up - regulation in the presence of expression products of genetic sequences encoding LM04 or a related protein. The present invention provides diagnosti c agents useful for detecting LM04 or expression products of genetic material encoding LM04. Such diagnostic agents include immunointeractive molecules, such as antibodies, and genetic probes for detecting expression products of LM04 genes. The present invention further provides genetically modified animals exhibiting altered levels of LM04. Such animals are useful models fo r screening for anti-cancer agents. The present invention still further relate s generally to a method of modulating LM04 related cellular proliferation and to agents useful for same. More particularly, the present invention contemplate s a method of modulating breast cell proliferation by modulating LM04 nucleic acid expression and/or LM04 functioning. The method of the present invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by aberrant, unwanted or otherwise inappropriate LM04 regulate d cellular proliferation. The present invention is further directed to methods for identifying and/or designing agents capable of modulating LM04 regulated cellular proliferation.

4. 发明专利

CA2460092C A METHOD OF DIAGNOSIS AND TREATMENT AND AGENTS USEFUL FOR SAME 未知
公开(公告)号：CA2460092C
公开(公告)日：2013-05-21
申请号：CA2460092
申请日：2002-09-12
申请人： INST MEDICAL W & E HALL
发明人： VISVADER JANE ELLEN , LINDEMAN GEOFFREY JOHN , SUM ELEANOR Y M , O'REILLY LORRAINE ANN
IPC分类号： C07K16/30 , G01N33/53 , A61K39/395 , A61K45/00 , A61K49/00 , A61P1/00 , A61P7/00 , A61P11/00 , A61P13/12 , A61P15/00 , A61P17/00 , A61P25/00 , A61P27/02 , A61P35/00 , A61P35/02 , C07K16/18 , C07K16/46 , C12N5/10 , C12N5/12 , C12N15/02 , C12N15/09 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/574 , G01N33/577
摘要： The present invention relates generally to a method for detecting an aberrant cell, and more particularly an aberrant epithelial cell, in a subject or in a biological sample from said subject and agents useful for same. More particularly, the present invention relates to a method of deleting an aberrant mammary epithelial cell. The presence of the aberrant cell or group of aberrant cells provides an indication of a particular disease or condition or a propensity for development of a disease or condition. More particularly, the present invention contemplates a method for detecting a cell associated with breast cancer or having a propensity to develop into a breast cancer in a subject or in a biological sample from said subject by determining the relative increase in the presence of the LM04 protein or a related protein or a relative increase in LM04 activity or a relative increase in the presence of expression products from a gene encoding the LM04 protein or a related protein. The present invention further provides a method for diagnosing the presence of a cancer or cancerous-like growth, in particular breast cancer in a subject or in a biological sample from said subject by screening for up-regulation of LM04 or a related protein in a cell or group of cells or an up-regulation in the presence of expression products of genetic sequences encoding LM04 or a related protein. The present invention provides diagnostic agents useful for detecting LM04 or expression products of genetic material encoding LM04. Such diagnostic agents include immunointeractive molecules, such as antibodies, and genetic probes for detecting expression products of LM04 genes. The present invention further provides genetically modified animals exhibiting altered levels of LM04. Such animals are useful models for screening for anti-cancer agents. The present invention still further relates generally to a method of modulating LM04 related cellular proliferation and to agents useful for same. More particularly, the present invention contemplates a method of modulating breast cell proliferation by modulating LM04 nucleic acid expression and/or LM04 functioning. The method of the present invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by aberrant, unwanted or otherwise inappropriate LM04 regulated cellular proliferation. The present invention is further directed to methods for identifying and/or designing agents capable of modulating LM04 regulated cellular proliferation.

5. 发明专利

NZ569653A A method of diagnosis and treatment of cancer involving LM04 未知
公开(公告)号：NZ569653A
公开(公告)日：2011-03-31
申请号：NZ56965302
申请日：2002-09-12
申请人： INST MEDICAL W & E HALL
发明人： VISVADER JANE ELLEN , LINDEMAN GEOFFREY JOHN , SUM ELEANOR Y M , O'REILLY LORRAINE ANN
IPC分类号： C07K16/18 , A61K39/395 , G01N33/53 , A61K45/00 , A61K49/00 , A61K49/16 , A61P1/00 , A61P7/00 , A61P11/00 , A61P13/12 , A61P15/00 , A61P17/00 , A61P25/00 , A61P27/02 , A61P35/00 , A61P35/02 , C07K16/30 , C07K16/46 , C12N5/10 , C12N15/02 , C12N15/09 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/574 , G01N33/577
摘要： Disclosed is a method of monitoring an aberrant cell or a cell growth or a predisposition to the development of an aberrant cell or a cell growth in a subject. The disclosed method comprises: i. contacting cells or cell extracts in a biological sample from said subject with a molecule having specificity and binding affinity for LM04 or antigenic portion of LM04 or epitope on LM04 and screening for the level of molecule-LM04 complex formation; or ii. screening a biological sample from said subject for the level of a transcription product of a gene encoding LM04; wherein an elevated presence of said complex or said expression product relative to a normal cell or cell extract is indicative of an aberrant cell. (62) Divided Out of 531532

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