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61. 发明申请

US20180172700A1 Affinity Plate for Haptoglobin Phenotype Determination, Kit Comprising It, and Method of Haptoglobin Phenotype Determination by Means of Affinity Plates in Combination with Desorption Ionization Mass Spectrometry Techniques 审中-公开
公开(公告)号：US20180172700A1
公开(公告)日：2018-06-21
申请号：US15736855
申请日：2016-06-16
申请人： Petr Novak , Michael Volny , Petr Pompach , Viktor Ruzicka
发明人： Petr Novak , Michael Volny , Petr Pompach , Viktor Ruzicka
IPC分类号： G01N33/68 , C12P21/06 , C07K14/47
CPC分类号： G01N33/6851 , C07K14/4717 , C12P21/06 , G01N33/6848 , G01N33/6893 , G01N2333/4713 , G01N2560/00 , H01J49/0418
摘要： The invention relates to the affinity plate for haptoglobin phenotype determination, the kit comprising it, and the method of haptoglobin phenotype determination by detection of its a subunits by means of mass spectrometry desorption ionization techniques after preceding preconcentration of haptoglobin on the surface of the affinity plate with immobilized anti-haptoglobin antibody that was deposited onto this surface from gas phase after preceding electrospray ionization and heat desolvation. Then the signals of mass spectra corresponding to α1 and/or α2 subunits can be found and thus determined the haptoglobin phenotype, whereas only al subunit exists in phenotype 1-1, both the subunits a1 and α2 exist in phenotype 2-1, and only α2 subunit exists in phenotype

62. 发明授权

US09924728B2 Food compositions comprising one or both of recombinant beta-lactoglobulin protein and recombinant alpha-lactalbumin protein 有权
公开(公告)号：US09924728B2
公开(公告)日：2018-03-27
申请号：US15438273
申请日：2017-02-21
申请人： Perfect Day, Inc.
发明人： Ryan Pandya , Perumal Gandhi , Shaowen Ji , Derek Beauchamp , Louis Hom
IPC分类号： C07K14/00 , A23C11/08 , A23C9/123 , A23C19/055 , A23C9/13 , A23J3/10 , C07K14/47
CPC分类号： A23C11/08 , A23C9/123 , A23C9/1307 , A23C9/1315 , A23C9/1512 , A23C11/04 , A23C15/12 , A23C19/053 , A23C19/055 , A23J3/10 , A23L9/22 , A23V2002/00 , C07K14/00 , C07K14/4717 , C07K14/4732 , C07K14/76 , A23V2200/264 , A23V2250/54246
摘要： Disclosed herein are methods and compositions including casein, and methods for making these compositions.

63. 发明申请

US20170049141A1 PRODUCTION OF PROTEIN-POLYSACCHARIDE CONJUGATES 审中-公开
标题翻译：生产蛋白多糖结合物
公开(公告)号：US20170049141A1
公开(公告)日：2017-02-23
申请号：US15342545
申请日：2016-11-03
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION
发明人： John A. Lucey , Dani Zhu , Srinivasan Damodaran
IPC分类号： A23L29/30 , C08B37/02 , A23L2/66 , A23C21/08 , A23J3/08 , C08H1/00 , C07K14/47
CPC分类号： A23L29/30 , A23C21/08 , A23J3/08 , A23L2/66 , A23L5/00 , A23L27/60 , A23L27/84 , A23L29/10 , A23L33/125 , A23V2002/00 , A61K35/20 , C07K14/4717 , C08B37/0021 , C08H1/00 , A23V2200/222 , A23V2250/54252 , A23V2250/5042 , A23V2250/54246 , A23V2200/304 , A23V2200/16
摘要： The present invention provides novel compositions and methods for producing protein-polysaccharide conjugates in aqueous solutions. Also provided are methods for limiting the Maillard reaction to the very initial stage, the formation of the Schiff base. Provided are methods to obtain a simple product of Schiff base with white color, and compositions obtained using the methods of the present invention.
摘要翻译：本发明提供了用于在水溶液中生产蛋白质 - 多糖缀合物的新型组合物和方法。还提供了将美拉德反应限制在初始阶段，形成希夫碱的方法。提供了获得具有白色的席夫碱的简单产品的方法，以及使用本发明的方法获得的组合物。

64. 发明申请

US20160367690A1 CURCUMIN-PEPTIDE CONJUGATES AND FORMULATIONS 审中-公开
公开(公告)号：US20160367690A1
公开(公告)日：2016-12-22
申请号：US15187393
申请日：2016-06-20
申请人： John Robert Chancey
发明人： John Robert Chancey
IPC分类号： A61K47/48 , A61K31/12 , C07K14/47
CPC分类号： C07K14/47 , A61K31/12 , A61K47/542 , A61K47/64 , C07K14/4717 , C07K14/76
摘要： Disclosed here are compositions comprising a curcuminoid-peptide complex. Also disclosed are therapeutic compositions comprising a curcuminoid-peptide complex as described and a pharmaceutically acceptable excipient, diluent, or carrier.
摘要翻译：这里公开的是包含姜黄素 - 肽复合物的组合物。还公开了包含所述的姜黄素 - 肽复合物和药学上可接受的赋形剂，稀释剂或载体的治疗组合物。

65. 发明授权

US09145448B2 Method for the isolation of haptoglobin 有权
标题翻译：分离触珠蛋白的方法
公开(公告)号：US09145448B2
公开(公告)日：2015-09-29
申请号：US11577478
申请日：2005-10-19
申请人： Joan Dalton , Adrian Podmore , Peter Kumpalume
发明人： Joan Dalton , Adrian Podmore , Peter Kumpalume
IPC分类号： C07K1/18 , C07K14/00 , A61K38/16 , C07K14/47 , A61K38/17 , B01D15/36
CPC分类号： C07K14/47 , A61K38/1722 , B01D15/363 , C07K1/18 , C07K14/4717
摘要： The invention provides a method for the isolation of haptoglobin from a sample comprising Cohn fraction V, wherein said method comprises anion exchange chromatography of said sample. The product may be further purified and/or subjected to one or more virus inactivation or reduction steps. The isolated haptoglobin may then be formulated for pharmaceutical use.
摘要翻译：本发明提供了从包含Cohn馏分V的样品中分离触珠蛋白的方法，其中所述方法包括所述样品的阴离子交换层析。产物可以进一步纯化和/或进行一个或多个病毒灭活或还原步骤。然后将分离的触珠蛋白配制成药物用途。

66. 发明申请

US20130004490A1 DELIVERY OF TRANSTHYRETIN ACROSS THE BLOOD-BRAIN BARRIER AS A TREATMENT FOR ALZHEIMER'S DISEASE 审中-公开
标题翻译：作为治疗阿尔茨海默病的血脑屏障的血液透析递送
公开(公告)号：US20130004490A1
公开(公告)日：2013-01-03
申请号：US13515050
申请日：2010-12-14
申请人： Juan Jose Marugan , Wei Zheng , Silvia Muro-Galindo
发明人： Juan Jose Marugan , Wei Zheng , Silvia Muro-Galindo
IPC分类号： A61K39/395 , C07K16/18 , A61K39/44 , C12N15/62 , A61P25/28 , C12N1/21 , C08G63/91 , C12P21/02 , C12N15/63 , C12N1/19 , C12N5/10 , A61K38/17 , C07K19/00
CPC分类号： C07K14/70525 , A61K38/00 , A61K47/6811 , A61K47/6849 , C07K14/4717 , C07K2319/33
摘要： The invention provides a composition comprising transthyretin and an ICAM-1 targeting agent, wherein the transthyretin and ICAM-1 targeting agent are coupled together, as well as methods of preparing such compositions. The invention further provides a diabody capable of binding specifically to ICAM-1 and transthyretin. The invention also provides a method of use of such composition in the manufacture of a medicament for treating an amyloid-β related neurodegenerative disease, comprising administering to a subject a composition comprising transthyretin coupled to an ICAM-1 targeting agent in an amount effective to treat the neurodegenerative disease, wherein the composition is administered to the subject outside of the blood-brain barrier.
摘要翻译：本发明提供了包含转甲状腺素蛋白和ICAM-1靶向剂的组合物，其中转甲状腺素蛋白和ICAM-1靶向剂偶联在一起，以及制备这种组合物的方法。本发明还提供能够特异性结合ICAM-1和转甲状腺素蛋白的双抗体。本发明还提供了一种使用这种组合物在制备用于治疗淀粉样蛋白的药物中的方法。包括向受试者施用包含与有效治疗神经变性疾病的量的ICAM-1靶向剂偶联的转甲状腺素蛋白的组合物，其中所述组合物在所述血脑屏障外给予受试者。

67. 发明授权

US07825292B1 Desmin gene having novel point mutation causative of dilated cardiomyopathy 失效
标题翻译： Desmin基因具有引起扩张型心肌病的新型点突变
公开(公告)号：US07825292B1
公开(公告)日：2010-11-02
申请号：US11975760
申请日：2007-10-22
申请人： Aiji Sakamoto
发明人： Aiji Sakamoto
IPC分类号： A01K67/00 , A01K67/033
CPC分类号： C12N15/8509 , A01K2217/05 , A01K2227/10 , A01K2267/03 , A01K2267/0375 , C07K14/4717 , C07K16/18 , C12Q1/6883 , C12Q2600/156
摘要： The present invention is intended to elucidate the cause of severe cardiomyopathy in subline (T) not manifesting the macroscopic cardiac hypertrophy, which has been separated from a hamster (B) with hypertrophic cardiomyopathy and clarify the pathogenic cause of dilated cardiomyopathy, thereby establishing a method of detecting and identifying dilated cardiomyopathy and a method of preventing and treating the same. The present invention relates to a desmin gene having a point mutation at the site corresponding to the 571-position of the base sequence in the cDNA translation region of Syrian hamster; a polypeptide thereof; and an oligonucleotide consisting of 5 to 250 bases including the point mutation site or an oligonucleotide having a sequence complementary thereto. Moreover, the present invention relates to a method of detecting and identifying the point mutation at the site corresponding to the 571-position of the base sequence in the cDNA translation region of Syrian hamster to judge whether or not it is a gene causative of hereditary cardiomyopathy.
摘要翻译：本发明旨在阐明不显示与肥厚性心肌病的仓鼠（B）分离的宏观心脏肥大的亚系（T）中严重心肌病的原因，并阐明扩张型心肌病的致病原因，从而建立方法检测和鉴别扩张型心肌病及其预防和治疗方法。本发明涉及在对应于叙利亚仓鼠的cDNA翻译区的碱基序列的571位的位点处具有点突变的结蛋白基因; 其多肽; 以及包含5〜250个碱基的寡核苷酸，包括点突变位点或与其互补的序列的寡核苷酸。此外，本发明涉及一种检测和鉴定在叙利亚仓鼠cDNA翻译区的碱基序列的571位相应位点处的点突变的方法，以判断其是否是遗传性心肌病的基因。

68. 发明申请

US20060216330A1 Peptides having an ace inhibiting effect 审中-公开
标题翻译：具有抑制抑制作用的肽
公开(公告)号：US20060216330A1
公开(公告)日：2006-09-28
申请号：US10555626
申请日：2004-04-23
申请人： Johannes Janssen , Johannes Schalk
发明人： Johannes Janssen , Johannes Schalk
IPC分类号： A61K38/08 , C12P21/06 , A61K47/00
CPC分类号： C07K14/4717 , A23C9/1307 , A23C21/02 , A23J3/343 , A23L33/18 , A61K38/1709
摘要： Use of the pentapeptide IIAEK, the pentapeptide IPAVF and/or the hexapeptide IPAVFK and salts thereof for the preparation of an angiotensin-converting enzyme inhibitor.
摘要翻译：五肽IIAEK，五肽IPAVF和/或六肽IPAVFK及其盐在制备血管紧张素转换酶抑制剂中的用途。

69. 发明申请

US20050155092A1 Desmin gene having novel point mutation causative of dilated cardiomyopathy 失效
标题翻译： Desmin基因具有引起扩张型心肌病的新型点突变
公开(公告)号：US20050155092A1
公开(公告)日：2005-07-14
申请号：US10495409
申请日：2002-10-11
申请人： Aiji Sakamoto
发明人： Aiji Sakamoto
IPC分类号： A01K67/027 , C07K14/47 , C07K16/18 , C12N15/09 , C12N15/12 , C12N15/85 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , C07H21/04 , C07K14/705
CPC分类号： C12N15/8509 , A01K2217/05 , A01K2227/10 , A01K2267/03 , A01K2267/0375 , C07K14/4717 , C07K16/18 , C12Q1/6883 , C12Q2600/156
摘要： The present invention is intended to elucidate the cause of severe cardiomyopathy in subline (T) not manifesting the macroscopic cardiac hypertrophy, which has been separated from a hamster (B) with hypertrophic cardiomyopathy and clarify the pathogenic cause of dilated cardiomyopathy, thereby establishing a method of detecting and identifying dilated cardiomyopathy and a method of preventing and treating the same. The present invention relates to a desmin gene having a point mutation at the site corresponding to the 571-position of the base sequence in the cDNA translation region of Syrian hamster; a polypeptide thereof; and an oligonucleotide consisting of 5 to 250 bases including the point mutation site or an oligonucleotide having a sequence complementary thereto. Moreover, the present invention relates to a method of detecting and identifying the point mutation at the site corresponding to the 571-position of the base sequence in the cDNA translation region of Syrian hamster to judge whether or not it is a gene causative of hereditary cardiomyopathy.
摘要翻译：本发明旨在阐明不显示与肥厚性心肌病的仓鼠（B）分离的宏观心脏肥大的亚系（T）中严重心肌病的原因，并阐明扩张型心肌病的致病原因，从而建立方法检测和鉴别扩张型心肌病及其预防和治疗方法。本发明涉及在对应于叙利亚仓鼠的cDNA翻译区的碱基序列的571位的位点处具有点突变的结蛋白基因; 其多肽; 以及包含5〜250个碱基的寡核苷酸，包括点突变位点或与其互补的序列的寡核苷酸。此外，本发明涉及一种检测和鉴定在叙利亚仓鼠cDNA翻译区的碱基序列的571位相应位点处的点突变的方法，以判断其是否是遗传性心肌病的基因。

70. 发明申请

US20050064474A1 Methods and compositions for targeted cleavage and recombination 有权
标题翻译：用于靶向切割和重组的方法和组合物
公开(公告)号：US20050064474A1
公开(公告)日：2005-03-24
申请号：US10912932
申请日：2004-08-06
申请人： Fyodor Urnov , Michael Holmes , Jeffrey Miller , Carl Pabo
发明人： Fyodor Urnov , Michael Holmes , Jeffrey Miller , Carl Pabo
IPC分类号： C07K14/435 , C07K14/47 , C07K14/715 , C12N9/14 , C12N9/22 , C12N15/62 , C12P19/34 , C12Q1/68
CPC分类号： A61K35/12 , C07K14/43595 , C07K14/4717 , C07K14/715 , C07K2319/00 , C07K2319/09 , C07K2319/81 , C12N9/14 , C12N9/22 , C12N15/62 , C12N15/85 , C12N2800/80
摘要： Disclosed herein are methods and compositions for targeted cleavage of a genomic sequence, targeted alteration of a genomic sequence, and targeted recombination between a genomic region and an exogenous polynucleotide homologous to the genomic region. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered zinc finger domain and polynucleotides encoding same. Methods for targeted cleavage include introduction of such fusion proteins, or polynucleotides encoding same, into a cell. Methods for targeted recombination additionally include introduction of an exogenous polynucleotide homologous to a genomic region into cells comprising the disclosed fusion proteins.
摘要翻译：本文公开了用于基因组序列的靶向切割，基因组序列的靶向改变以及基因组区域和与该基因组区域同源的外源多核苷酸之间的靶向重组的方法和组合物。组合物包括包含切割结构域（或切割半结构域）和工程化锌指结构域的融合蛋白和编码它们的多核苷酸。用于靶向切割的方法包括将这种融合蛋白或其编码的多核苷酸引入细胞。用于靶向重组的方法另外包括将与基因组区域同源的外源多核苷酸引入包含所公开的融合蛋白的细胞中。

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