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61. 发明申请

WO1994014796A1 NOVEL N-(PYRIDYLCARBONYL)BENZAZEPINE DERIVATIVE AND INTERMEDIATE THEREFOR 审中-公开
标题翻译：新型N-（吡咯烷基）苯并噻吩衍生物及其中间体
公开(公告)号：WO1994014796A1
公开(公告)日：1994-07-07
申请号：PCT/JP1993001838
申请日：1993-12-17
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , MATSUMOTO, Yuzo , TANAKA, Akihiro , MATSUHISA, Akira , KIKUCHI, Kazumi , SAKAMOTO, Ken-ichiro , YATSU, Takeyuki , YANAGISAWA, Isao
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： C07D401/06
CPC分类号： C07D401/06
摘要： An N-(pyridylcarbonyl)benzazepine derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof, useful for preventing and treating cardiac failure, hyponatremia, syndrome of inappropriate secretion of vasopressin (SIADH), hypertension, renal failure, edema, water metabolism disorder, and the like on the basis of arginine vasopressin receptor antagonism; and a benzazepinylcarbonylpyridine derivative represented by general formula (II) or a salt thereof, useful as an intermediate for the production of the compound (I) and so forth, wherein R represents hydrogen, lower alkyl, lower alkoxy, halogen, or phenyl which may be substituted by lower alkyl; X represents -NHCO- or -CON(R )-; n represents 0 or 1; and R represents hydrogen or (a) wherein R is as defined above, wherein n is as defined above; and Y represents COOH, activated carboxy, protected carboxy, or optionally protected HN(R )-.
摘要翻译：用于预防和治疗心力衰竭，低钠血症，加压素分泌不良综合征（SIADH），高血压，肾衰竭，水肿，水分的通式（I）表示的N-（吡啶基羰基）苯并氮杂衍生物或其药学上可接受的盐代谢障碍等，基于精氨酸加压素受体拮抗作用; 和由通式（II）表示的苯并氮杂基羰基吡啶衍生物或其盐，可用作制备化合物（I）等的中间体，其中R表示氢，低级烷基，低级烷氧基，卤素或苯基，被低级烷基取代; X表示-NHCO-或-CON（R 1） - ; n表示0或1; 并且R 1表示氢或（a）其中R如上定义，其中n如上所定义; 和Y代表COOH，活化的羧基，保护的羧基或任选被保护的HN（R 1） - 。

62. 发明申请

WO1993024053A1 K-FILTER FOR SERIAL HIGH-SPEED ROTATOGRAPHY, AND APPARATUS FOR THE ROTATOGRAPHY 审中-公开
标题翻译：用于串行高速旋转的K过滤器和旋转装置
公开(公告)号：WO1993024053A1
公开(公告)日：1993-12-09
申请号：PCT/JP1993000693
申请日：1993-05-25
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , KUMAZAKI, Tatsuo , YAMADA, Hifumi
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： A61B06/03
CPC分类号： G21K1/04 , A61B6/548 , G21K1/10
摘要： A K-filter (1) is the one attached to an apparatus for serial high-speed rotatography for photographing a specimen by use of X rays. The filter comprises two K-containers (5a and 5b) in which a space is defined for fluidly containing a fluid substance transmitting no radiation, and a radiation permeable region (2) formed between the two K-containers (5a and 5b). The K-containers (5a and 5b) are pivotally supported by a supporting member (1a) and are of an inversion type which allows the radiation permeable region sides of the K-containers to move. Therefore, when this apparatus is rotated at a high speed to more than 180 DEG , it is possible to conduct filtering under any conditions such as an inclined posture, not the horizontal posture, under which potographing is started.
摘要翻译： K过滤器（1）是连接到用于通过X射线拍摄样品的串行高速旋转设备的装置。过滤器包括两个K容器（5a和5b），其中限定了用于流体地容纳不发射辐射的流体物质的空间，以及形成在两个K容器（5a和5b）之间的辐射透过区域（2）。 K容器（5a和5b）由支撑构件（1a）可枢转地支撑，并且是允许K容器的可辐射透过区域侧移动的反转型。因此，当该装置以高速旋转至大于180度时，可以在任何条件下进行过滤，例如倾斜姿势，而不是水平姿势，在此条件下，开始拍摄。

63. 发明申请

WO1993017710A1 PHARMACEUTICAL PREPARATION FOR PERCUTANEOUS ADMINISTRATION 审中-公开
标题翻译：用于治疗晚期行政管理的药物制剂
公开(公告)号：WO1993017710A1
公开(公告)日：1993-09-16
申请号：PCT/JP1992000285
申请日：1992-03-10
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , KYUKYU PHARMACEUTICAL CO., LTD. , KONNO, Yutaka , TAKIGUCHI, Nobuyuki , NAKATA, Katsunori , SAITO, Katsumi , SAWAI, Yoshihiro , TAKAYANAGI, Hitoshi , SUDEJI, Kazuyoshi , NAGATA, Kiyonori
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , KYUKYU PHARMACEUTICAL CO., LTD.
IPC分类号： A61K47/10
CPC分类号： A61K47/44 , A61K47/10
摘要： A pharmaceutical preparation for percutaneous administration comprising a drug having a relatively high solubility in triethylene glycol, triethylene glycol, and a terpene, and further containing, if necessary, ethanol or isopropanol. The preparation is excellent in the skin permeation of drug and is further improved in the permeation through the panniculus adiposus because it contains ethanol and/or isopropanol.
摘要翻译：一种用于经皮给药的药物制剂，其包含在三甘醇，三甘醇和萜烯中具有较高溶解度的药物，并且如果需要，还含有乙醇或异丙醇。该制剂在药物的皮肤渗透性方面是优异的，并且由于含有乙醇和/或异丙醇，通过脂肪球蛋白的渗透进一步改善。

64. 发明申请

WO1993012069A1 NOVEL AMINO ALCOHOL DERIVATIVE OR SALT THEREOF 审中-公开
标题翻译：新型氨基醇衍生物或其盐
公开(公告)号：WO1993012069A1
公开(公告)日：1993-06-24
申请号：PCT/JP1992001629
申请日：1992-12-15
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , MATSUDA, Koyo , HARADA, Hironori , TSUZUKI, Ryuji , MORIHIRA, Koichiro , ITO, Noriki , KAKUTA, Hirotoshi , IIZUMI, Yuichi
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： C07C217/58
CPC分类号： C07D285/135 , C07C217/58 , C07C217/84 , C07C255/58 , C07C2602/08 , C07C2602/10 , C07D207/34 , C07D207/50 , C07D213/38 , C07D231/38 , C07D241/12 , C07D241/20 , C07D249/14 , C07D261/14 , C07D275/03 , C07D277/42 , C07D303/22 , C07D333/36 , C07D417/04
摘要： A compound represented by general formula (I), a pharmaceutical composition containing the same, and a process for producing the same, wherein R : hydrogen, lower alkyl, lower alkanoyl or aralkyl; R : optionally hydroxylated lower alkyl or (a); ring B: benzene ring or five- or six-membered heterocycle bearing 1 to 3 heteroatoms selected among N, O and S; R : hydrogen, lower alkyl, lower alkenyl, lower alkanoyl, lower alkoxycarbonyl or aryl; R : lower alkyl; R , R and R may be the same or different from each other and each represents hydrogen, halogen, alkyl, lower alkoxy, aryloxy or cyano, provided that two adjacent groups among R , R and R may be combined together to represent -(CH2)4-, -(CH2)3-, -CH=CH-CH-CH- or (b); and n: an integer of 0 to 3. This compound (I) has a squalene epoxidase inhibiting activity and is useful for preventing and treating various diseases caused by cholesterol, such as arteriosclerosis.
摘要翻译：由通式（I）表示的化合物，含有该化合物的药物组合物及其制备方法，其中R 1：氢，低级烷基，低级烷酰基或芳烷基; R 2：任选羟基化的低级烷基或（a）; 环B：苯环或含有1至3个选自N，O和S的杂原子的五或六元杂环; R 3：氢，低级烷基，低级烯基，低级烷酰基，低级烷氧基羰基或芳基; R 4：低级烷基; R 5，R 6和R 7可以彼此相同或不同，并且各自表示氢，卤素，烷基，低级烷氧基，芳氧基或氰基，条件是R 5， R 6和R 7可以一起组合以表示 - （CH 2）4 - ， - （CH 2）3 - ， - CH = CH-CH-CH-或（b）; n为0〜3的整数。该化合物（I）具有角鲨烯环氧酶抑制活性，可用于预防和治疗诸如动脉硬化等胆固醇引起的各种疾病。

65. 发明申请

WO1993005027A1 TRIAZOLYLATED TERTIARY AMINE COMPOUND OR SALT THEREOF 审中-公开
标题翻译：三唑化合物或其盐
公开(公告)号：WO1993005027A1
公开(公告)日：1993-03-18
申请号：PCT/JP1992001089
申请日：1992-08-27
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , OKADA, Minoru , KAWAMINAMI, Eiji , YODEN, Toru , KUDO, Masafumi , ISOMURA, Yasuo
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： C07D249/08
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： A triazolylated tertiary amine compound represented by general formula (I) or a salt thereof, having an aromatase inhibitory activity and being useful for preventing and treating breast cancer, mastopathy, endometriosis, prostatomegaly, etc., wherein A represents a single bond, lower alkylene or carbonyl; B represents lower alkyl, aryl, a 5- or 6-membered heterocyclic group, or a bicyclic fused heterocyclic group; D represents aryl, a 5- or 6-membered heterocyclic group, or a bicyclic fused heterocyclic group; and E represents 4H-1,2,4-triazolyl, 1H-1,2,4-triazolyl or 1H-1,2,3-triazolyl.
摘要翻译：由通式（I）表示的三唑基化叔胺化合物或其盐具有芳香酶抑制活性，可用于预防和治疗乳腺癌，乳腺病，子宫内膜异位症，前列腺肥大等，其中A表示单键，低级亚烷基或羰基; B表示低级烷基，芳基，5或6元杂环基或双环稠合杂环基; D表示芳基，5或6元杂环基或双环稠合杂环基; E表示4H-1,2,4-三唑基，1H-1,2,4-三唑基或1H-1,2,3-三唑基。

66. 发明申请

WO1993003021A1 NOVEL BISHETEROCYCLIC DERIVATIVE OR SALT THEREOF 审中-公开
标题翻译：新型双相异构衍生物或其盐
公开(公告)号：WO1993003021A1
公开(公告)日：1993-02-18
申请号：PCT/JP1992000954
申请日：1992-07-28
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , NIIGATA, Kunihiro , TAKAHASHI, Takumi , YONEDA, Takashi , NOSHIRO, Osamu , KOIKE, Reiko , SHIMAYA, Akiyoshi
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： C07D263/44
CPC分类号： C07D263/44 , C07D277/20 , C07D277/34 , C07D493/04 , Y02P20/55
摘要： A bisheterocyclic compound represented by general formula (I), stereoisomers thereof, tautomers thereof, a pharmaceutically acceptable salt or a pharmaceutically acceptable solvate thereof, a pharmaceutical composition containing the same, and a process for the production thereof. In formula (I), R and R may be the same or different from each other and each represents (II) or (III), R represents hydrogen or a protective group, X, Y and Y may be the same or different from one another and each represents oxygen or sulfur, B and B represent each phenylene, B represents phenylene, naphthylene, cyclohexylene or furo[3,2-b]furanylene, L and L represent each -(O)n-A-, n represents 0 or 1, and A represents a single bond or lower alkylene, provided that when n is 1, A represents alkylene and the oxygen atom of each of L and L is bonded to B . The above compounds are useful as a hypoglycemic drug based on the activity of enhancing insulin sensitivity.
摘要翻译：由通式（I）表示的双杂环化合物，其立体异构体，其互变异构体，其药学上可接受的盐或其药学上可接受的溶剂合物，含有它们的药物组合物及其制备方法。在式（I）中，R 1和R 2可以彼此相同或不同，并且各自表示（II）或（III），R 3表示氢或保护基，X，Y' 1＆gt;和Y 2可以相同或不同，各自表示氧或硫，B 1和B 2表示各个亚苯基，B 3表示亚苯基，亚萘基，亚环己基或呋喃并[3 ，2-b]呋喃，L 1和L 2表示 - （O）n - ，n表示0或1，A表示单键或低级亚烷基，条件是当n为1时，A表示亚烷基和L 1和L 2各自的氧原子与B 3键合。基于提高胰岛素敏感性的活性，上述化合物可用作降血糖药物。

67. 发明申请

WO1992013828A1 NOVEL BENZANILIDE DERIVATIVE OR SALT THEREOF 审中-公开
标题翻译：新的苯甲酰胺衍生物或其盐
公开(公告)号：WO1992013828A1
公开(公告)日：1992-08-20
申请号：PCT/JP1992000121
申请日：1992-02-06
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , MASE, Toshiyasu , IGARASHI, Susumu , NODA, Ichio , KIMURA, Takenori , KOUTOKU, Hiroshi
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： C07C235/56
CPC分类号： C07C235/64 , C07C235/56
摘要： A benzanilide derivative represented by general formula (I), which has a testosterone 5 alpha reductase inhibitory activity, a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof, and a process for producing the same.
摘要翻译：由通式（I）表示的具有睾酮5α还原酶抑制活性的苯甲酰苯胺衍生物及其药学上可接受的盐，其药物组合物及其制备方法。

68. 发明申请

WO1992007819A1 TRI(LOWER ALKOXY)BENZENE DERIVATIVE 审中-公开
标题翻译： TRI（低级烷基）苯甲衍生物
公开(公告)号：WO1992007819A1
公开(公告)日：1992-05-14
申请号：PCT/JP1991001429
申请日：1991-10-18
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , HARA, Hiromu , MARUYAMA, Tatsuya , SAITO, Munetoshi , MASE, Toshiyasu
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： C07C237/06
CPC分类号： C07D295/13 , C07C237/20 , C07C275/34 , C07D295/145
摘要： A tri(lower alkoxy)benzene derivative represented by general formula (I), its salt, its optically active isomer, its solvate, a medicinal composition containing the same, and a process for the production thereof, wherein R?1, R2 and R3¿ may be the same or different from one another and each represents lower alkyl; A represents (a) or (b); and R?4 and R5¿ may be the same or different from each other and each represents lower alkyl, aralkyl or aryl, or alternatively R?4 and R5¿ may be combined with each other to form, together with the adjacent nitrogen atom, pyrrolidinyl, piperidino, morpholino, thiomorpholino, or piperazino which may be substituted with lower alkyl at the 4-position. This compound is useful as a secretagogue for pulmonary surfactants.

69. 发明申请

WO1992001714A1 NON-A NON-B HEPATITIS VIRUS ANTIGEN 审中-公开
标题翻译：非N型乙型肝炎病毒抗原
公开(公告)号：WO1992001714A1
公开(公告)日：1992-02-06
申请号：PCT/JP1991000964
申请日：1991-07-19
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , SHIMIZU, Yasuaki , IMAI, Takeshi , ISHIDA, Junko , YANO, Emiko , YASUDA, Syuhei , MORINAGA, Tetsuo , ARIMA, Terukatu
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： C07K13/00
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/24222
摘要： Non-A non-B hepatitis virus antigen polypeptide groups Y19 and Y22 or fragments thereof; complex antigen polypeptides prepared by fusing two or more antigens selected from the above polypeptides; and antigen polypeptides having an epitope contained in a group Y19 or Y22 polypeptide. A method of detecting a non-A non-B hepatitis virus antigen by determining an immunological conjugate formed by the reaction of a non-A non-B hepatitis virus antibody with one or a mixture of these antigens.
摘要翻译：非A型非乙型肝炎病毒抗原多肽组Y19和Y22或其片段; 通过融合选自上述多肽的两种或多种抗原制备的复合抗原多肽; 和具有包含在Y19或Y22组多肽中的表位的抗原多肽。通过测定通过非A非乙型肝炎病毒抗体与这些抗原中的一种或其混合物的反应形成的免疫缀合物来检测非A非乙型肝炎病毒抗原的方法。

70. 发明申请

WO1991017674A1 WHITE LAVER 审中-公开
标题翻译：白雪皑皑
公开(公告)号：WO1991017674A1
公开(公告)日：1991-11-28
申请号：PCT/JP1991000611
申请日：1991-05-08
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , KIRIYAMA, Shuhachi
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： A23L01/337
CPC分类号： A61K36/04 , A23L17/60 , A61K2300/00
摘要： The invention relates to a white laver obtained by treating a marine alga belonging to the genus Porphyra through the step of decoloration, especially treatment with protease, and the step of treating with an organic solvent or a watery organic solvent; a reddish violet laver obtained in one of the steps for preparing a white laver; a process for preparing a white laver, and so forth. The white laver is widely utilized as a food itself, a component of various food, drink and favorite food, and a drug, while also the reddish violet laver is utilized as a food itself or a component of various food, drink and favorite food.

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