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    • 3. 发明申请
    • NOVEL BISHETEROCYCLIC DERIVATIVE OR SALT THEREOF
    • 新型双相异构衍生物或其盐
    • WO1993003021A1
    • 1993-02-18
    • PCT/JP1992000954
    • 1992-07-28
    • YAMANOUCHI PHARMACEUTICAL CO., LTD.NIIGATA, KunihiroTAKAHASHI, TakumiYONEDA, TakashiNOSHIRO, OsamuKOIKE, ReikoSHIMAYA, Akiyoshi
    • YAMANOUCHI PHARMACEUTICAL CO., LTD.
    • C07D263/44
    • C07D263/44C07D277/20C07D277/34C07D493/04Y02P20/55
    • A bisheterocyclic compound represented by general formula (I), stereoisomers thereof, tautomers thereof, a pharmaceutically acceptable salt or a pharmaceutically acceptable solvate thereof, a pharmaceutical composition containing the same, and a process for the production thereof. In formula (I), R and R may be the same or different from each other and each represents (II) or (III), R represents hydrogen or a protective group, X, Y and Y may be the same or different from one another and each represents oxygen or sulfur, B and B represent each phenylene, B represents phenylene, naphthylene, cyclohexylene or furo[3,2-b]furanylene, L and L represent each -(O)n-A-, n represents 0 or 1, and A represents a single bond or lower alkylene, provided that when n is 1, A represents alkylene and the oxygen atom of each of L and L is bonded to B . The above compounds are useful as a hypoglycemic drug based on the activity of enhancing insulin sensitivity.
    • 由通式(I)表示的双杂环化合物,其立体异构体,其互变异构体,其药学上可接受的盐或其药学上可接受的溶剂合物,含有它们的药物组合物及其制备方法。 在式(I)中,R 1和R 2可以彼此相同或不同,并且各自表示(II)或(III),R 3表示氢或保护基,X,Y' 1>和Y 2可以相同或不同,各自表示氧或硫,B 1和B 2表示各个亚苯基,B 3表示亚苯基,亚萘基,亚环己基或呋喃并[3 ,2-b]呋喃,L 1和L 2表示 - (O)n - ,n表示0或1,A表示单键或低级亚烷基,条件是当n为1时,A表示 亚烷基和L 1和L 2各自的氧原子与B 3键合。 基于提高胰岛素敏感性的活性,上述化合物可用作降血糖药物。