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61. 发明授权

US07923253B2 Method for identifying type I diabetes mellitus in humans 有权
标题翻译：用于鉴定人类I型糖尿病的方法
公开(公告)号：US07923253B2
公开(公告)日：2011-04-12
申请号：US12291173
申请日：2008-11-05
申请人： Thomas O Metz , Weijun Qian , Jon M. Jacobs , David G. Camp, II , Richard D. Smith
发明人： Thomas O Metz , Weijun Qian , Jon M. Jacobs , David G. Camp, II , Richard D. Smith
IPC分类号： G01N33/48 , G01N33/68
CPC分类号： G01N33/6893 , G01N2333/4728 , G01N2333/723 , G01N2333/775 , G01N2333/79 , G01N2800/042 , G01N2800/50
摘要： A method and system for classifying subject populations utilizing predictive and diagnostic biomarkers for type I diabetes mellitus. The method including determining the levels of a variety of markers within the serum or plasma of a target organism and correlating this level to general populations as a screen for predisposition or progressive monitoring of disease presence or predisposition.
摘要翻译：一种利用I型糖尿病预测和诊断生物标志物分类受试者群体的方法和系统。该方法包括确定目标生物体的血清或血浆内的各种标志物的水平，并将该水平与一般群体相关联作为疾病存在或倾向性的倾向或逐步监测的屏幕。

62. 发明申请

US20100156151A1 FOLDING MESH CHAIR WITH NESTING HOOPS 有权
标题翻译：折叠式餐桌椅
公开(公告)号：US20100156151A1
公开(公告)日：2010-06-24
申请号：US12422821
申请日：2009-04-13
申请人： Richard D. Smith , Orrin C. Farnsworth
发明人： Richard D. Smith , Orrin C. Farnsworth
IPC分类号： A47D1/02
CPC分类号： A47C4/44 , A47C3/04 , A47C4/28 , A47C4/38 , A47C5/06 , A47C7/002 , A47C7/282
摘要： A folding mesh chair includes a seat and a backrest carried between opposite frame sides. The chair has an unfolded seating position in which the seat pivots to extend from the frame sides and bottoms of front and rear legs move apart, and a folded position in which the seat pivots toward the frame sides and the front and rear legs move together. One or both of the seat and the backrest have a continuous sheet of flexible and elastic mesh or patterned open texture plastic held across and substantially covering an opening in an all-plastic hoop fixed between the frame sides. The hoop includes inner and outer plastic mating hoops with the mesh extending over an outer perimeter of the inner hoop and into an interface between the inner and outer hoops.
摘要翻译：折叠网椅包括座位和靠在相对的框架侧之间的靠背。椅子具有展开的就座位置，其中座椅枢转以从框架侧面延伸，前后腿的底部移动分开，并且座椅朝向框架侧部枢转并且前后腿部一起移动的折叠位置。座椅和靠背中的一个或两个具有连续的柔性和弹性网格片或图案化的开放纹理塑料，其保持横跨并且基本上覆盖固定在框架侧之间的全塑性环箍中的开口。箍包括内部和外部塑料配合箍，其中网状物在内箍的外周延伸并且进入内圈和外箍之间的界面。

63. 发明授权

US07591511B2 Tamper resistant attachment device for a chair backrest 有权
标题翻译：用于椅子靠背的防篡改附件
公开(公告)号：US07591511B2
公开(公告)日：2009-09-22
申请号：US11412002
申请日：2006-04-25
申请人： Richard D. Smith , David J. Laws
发明人： Richard D. Smith , David J. Laws
IPC分类号： A47C5/12
CPC分类号： A47C5/06 , A47C31/023
摘要： A tamper resistant attachment apparatus for attaching a backrest to a chair frame. A flap is foldably coupled to an edge of a chair backrest. The flap is foldable over onto the backrest into a folded position. The flap has a channel that fits around a frame of a chair when the flap is in the folded position. At least one aperture that extends through the flap can receive a corresponding pin that is coupled to the backrest when the flap is in the folded position. The at least one pin is deformable to secure the flap and backrest around the chair frame when the flap is in the folded position.
摘要翻译：一种用于将靠背固定到椅子框架上的防拆装置。翼片可折叠地联接到椅子靠背的边缘。襟翼可折叠到靠背上折叠位置。当襟翼处于折叠位置时，翼片具有适合于椅子框架周围的通道。延伸通过翼片的至少一个孔可以接收当翼片处于折叠位置时联接到靠背的相应销。当翼片处于折叠位置时，至少一个销可变形以将折板和靠背固定在椅子框架周围。

64. 外观设计

USD599127S1 Mesh folding chair 有权
标题翻译：网折叠椅
公开(公告)号：USD599127S1
公开(公告)日：2009-09-01
申请号：US29335295
申请日：2009-04-13
申请人： Richard D. Smith
设计人： Richard D. Smith

65. 发明授权

US07541576B2 Method of multiplexed analysis using ion mobility spectrometer 有权
标题翻译：使用离子迁移谱仪的多重分析方法
公开(公告)号：US07541576B2
公开(公告)日：2009-06-02
申请号：US11701752
申请日：2007-02-01
申请人： Mikhail E. Belov , Richard D. Smith
发明人： Mikhail E. Belov , Richard D. Smith
IPC分类号： H01J49/40
CPC分类号： H01J49/0031 , G01N27/622
摘要： A method for analyzing analytes from a sample introduced into a Spectrometer by generating a pseudo random sequence of a modulation bins, organizing each modulation bin as a series of submodulation bins, thereby forming an extended pseudo random sequence of submodulation bins, releasing the analytes in a series of analyte packets into a Spectrometer, thereby generating an unknown original ion signal vector, detecting the analytes at a detector, and characterizing the sample using the plurality of analyte signal subvectors. The method is advantageously applied to an Ion Mobility Spectrometer, and an Ion Mobility Spectrometer interfaced with a Time of Flight Mass Spectrometer.
摘要翻译：一种用于通过产生调制箱的伪随机序列来分析从引入到光谱仪中的样品的分析物的方法，将每个调制箱组织成一系列的子调制箱，由此形成扩频的伪随机序列的子调制箱，将分析物在一系列分析物分组进入光谱仪，从而产生未知的原始离子信号矢量，检测检测器处的分析物，并使用多个分析物信号子矢量表征样品。该方法有利地应用于离子移动光谱仪和与飞行时间质谱仪接口的离子迁移光谱仪。

66. 外观设计

USD513456S1 Stacking chair 有权
公开(公告)号：USD513456S1
公开(公告)日：2006-01-10
申请号：US29218410
申请日：2004-12-01
申请人： Richard D. Smith
设计人： Richard D. Smith

67. 发明授权

US06498340B2 Method for calibrating mass spectrometers 失效
标题翻译：校准质谱仪的方法
公开(公告)号：US06498340B2
公开(公告)日：2002-12-24
申请号：US09760248
申请日：2001-01-12
申请人： Gordon A. Anderson , Michael D. Brands , James E. Bruce , Ljiljana Pasa-Tolic , Richard D. Smith
发明人： Gordon A. Anderson , Michael D. Brands , James E. Bruce , Ljiljana Pasa-Tolic , Richard D. Smith
IPC分类号： H01J4900
CPC分类号： H01J49/0009
摘要： A method whereby a mass spectra generated by a mass spectrometer is calibrated by shifting the parameters used by the spectrometer to assign masses to the spectra in a manner which reconciles the signal of ions within the spectra having equal mass but differing charge states, or by reconciling ions having known differences in mass to relative values consistent with those known differences. In this manner, the mass spectrometer is calibrated without the need for standards while allowing the generation of a highly accurate mass spectra by the instrument.
摘要翻译：通过移动光谱仪使用的参数来校准光谱仪产生的质谱的方法来校准光谱仪产生的质谱，方法是以质量相同但不同电荷状态的光谱中的离子信号进行协调，或通过调和具有与已知差异一致的质量与相对值之间的已知差异的离子。以这种方式，质谱仪被校准，而不需要标准，同时允许通过仪器产生高精度的质谱。

68. 发明授权

US06187190B1 Apparatus for molecular weight separation 失效
标题翻译：分子量分离装置
公开(公告)号：US06187190B1
公开(公告)日：2001-02-13
申请号：US09474851
申请日：1999-12-30
申请人： Richard D. Smith , Chuanliang Liu
发明人： Richard D. Smith , Chuanliang Liu
IPC分类号： B01D6128
CPC分类号： B01D61/243 , B01D61/28 , G01N2001/4016
摘要： The present invention relates generally to an apparatus and method for separating high molecular weight molecules from low molecular weight molecules. More specifically, the invention relates to the use of microdialysis for removal of the salt (low molecular weight molecules) from a nucleotide sample (high molecular weight molecules) for ESI-MS analysis. The dialysis or separation performance of the present invention is improved by (1) increasing dialysis temperature thereby increasing desalting efficiency and improving spectrum quality; (2) adding piperidine and imidazole to the dialysis buffer solution and reducing charge states and further increasing detection sensitivity for DNA; (3) using low concentrations (0-2.5 mM NH4OAc) of dialysis buffer and shifting the DNA negative ions to higher charge states, producing a nearly 10-fold increase in detection sensitivity and a slightly decreased desalting efficiency, (4) conducting a two-stage separation or (5) any combination of (1), (2), (3) and (4).
摘要翻译：本发明一般涉及从低分子量分子中分离高分子量分子的装置和方法。更具体地，本发明涉及使用微量透析从ESI-MS分析的核苷酸样品（高分子量分子）中除去盐（低分子量分子）。通过（1）增加透析温度从而提高脱盐效率和提高光谱质量，提高本发明的透析或分离性能; （2）向透析缓冲液中加入哌啶和咪唑，降低电荷状态，进一步提高DNA的检测灵敏度; （3）使用透析缓冲液的低浓度（0-2.5mM NH 4 OAc），并将DNA负离子转移到较高的电荷状态，检测灵敏度增加近10倍，脱盐效率稍微降低，（4）级分离或（5）（1），（2），（3）和（4）的任何组合。

69. 发明授权

US6107628A Method and apparatus for directing ions and other charged particles generated at near atmospheric pressures into a region under vacuum 失效
标题翻译：将在接近大气压下产生的离子和其他带电粒子引导到真空区域的方法和装置
公开(公告)号：US6107628A
公开(公告)日：2000-08-22
申请号：US90896
申请日：1998-06-03
申请人： Richard D. Smith , Scott A. Shaffer
发明人： Richard D. Smith , Scott A. Shaffer
IPC分类号： H01J49/42
CPC分类号： H01J49/066
摘要： A method and apparatus for focusing dispersed charged particles. More specifically, a series of elements within a region maintained at a pressure between 10.sup.-1 millibar and 1 bar, each having successively larger apertures forming an ion funnel, wherein RF voltages are applied to the elements so that the RF voltage on any element has phase, amplitude and frequency necessary to define a confinement zone for charged particles of appropriate charge and mass in the interior of the ion funnel, wherein the confinement zone has an acceptance region and an emmitance region and where the acceptance region area is larger than the emmitance region area.
摘要翻译：用于聚焦分散的带电粒子的方法和装置。更具体地，区域内的一系列元件保持在10-1毫巴和1巴之间的压力，每个元件具有连续更大的孔形成离子漏斗，其中RF电压施加到元件，使得任何元件上的RF电压具有在离子漏斗的内部限定适当电荷和质量的带电颗粒的限制区所需的相位，幅度和频率，其中限制区具有接受区域和发射区域，并且接受区域面积大于发射区域区域。

70. 发明授权

US5160503A Water-soluble blends of active methylene compounds and polyhydric alcohols as formaldehyde scavengers 失效
标题翻译：活性亚甲基化合物和多元醇的水溶性共混物作为甲醛清除剂
公开(公告)号：US5160503A
公开(公告)日：1992-11-03
申请号：US436142
申请日：1989-11-13
申请人： Richard D. Smith
发明人： Richard D. Smith
IPC分类号： B27N1/00 , D06M13/224 , D06M15/423
CPC分类号： D06M13/224 , B27N1/003 , D06M15/423 , Y10T428/31957
摘要： A composition for a formaldehyde scavenger is provided which consists of a water-soluble blend of a substituted or unsubstituted polyhydric alcohol and an active methylene compound selected from the group consisting of dialkyl malonate and alkylacetoacetate.
摘要翻译：提供了一种用于甲醛清除剂的组合物，其由取代或未取代的多元醇和选自丙二酸二烷基酯和烷基乙酰乙酸酯的活性亚甲基化合物的水溶性共混物组成。

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