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61. 发明申请

US20120142895A1 HOST CELLS AND METHODS OF USE 审中-公开
标题翻译：宿主细胞和使用方法
公开(公告)号：US20120142895A1
公开(公告)日：2012-06-07
申请号：US13203056
申请日：2010-02-24
申请人： Yong Hwan Jin , James D. Jowett , Alexander H. Taylor , Yuan Zhu
发明人： Yong Hwan Jin , James D. Jowett , Alexander H. Taylor , Yuan Zhu
IPC分类号： C07K14/00 , C12P21/00 , C12N1/19
CPC分类号： C12N15/815 , C07K14/605 , C07K2319/31 , C12N9/1051 , C12N9/60
摘要： The present invention provides genetically modified Pichia strains wherein at least one nucleic acid sequence encoding a functional gene product and/or at least one nucleic acid sequence necessary for expression of at least one functional gene product in said Pichia strain is genetically modified, wherein said gene product is responsible for proteolysis and/or glycosylation in said genetically modified Pichia strain. In particular, Pichia strains are provided wherein nucleic acid sequence encoding a functional gene product or expression of said gene product are genetically modified: PEP4, PRB1, YPS1, YPS2, YMP1, YMP2, YMP3 and PMT4. Also provided herein are genetically modified host cells wherein wild type parent of said genetically modified host cell comprises a gene encoding a polypeptide having at least 60% sequence identity to amino acids 1-865 of SEQ ID NO:4, SEQ ID NO:6 and SEQ ID NO:8 wherein said gene is genetically modified in the genome of said host cell such that the gene product is reduced or eliminated in said genetically modified host cell compared with said wild type host cell.
摘要翻译：本发明提供了遗传修饰的毕赤酵母菌株，其中至少一个编码功能性基因产物的核酸序列和/或在所述毕赤酵母属菌株中表达至少一种功能性基因产物所必需的至少一种核酸序列被遗传修饰，其中所述基因产物负责所述遗传修饰的毕赤酵母菌株中的蛋白水解和/或糖基化。具体而言，提供了编码功能性基因产物的核酸序列或所述基因产物的表达被遗传修饰的毕赤酵母菌株：PEP4，PRB1，YPS1，YPS2，YMP1，YMP2，YMP3和PMT4。本文还提供遗传修饰的宿主细胞，其中所述经遗传修饰的宿主细胞的野生型亲本包含编码与SEQ ID NO：4，SEQ ID NO：6的氨基酸1-865至少60％序列同一性的多肽的基因和 SEQ ID NO：8，其中所述基因在所述宿主细胞的基因组中被遗传修饰，使得与所述野生型宿主细胞相比，在所述遗传修饰的宿主细胞中基因产物被还原或消除。

62. 发明申请

US20120113830A1 ENHANCED NODE B AND METHOD FOR PRECODING WITH REDUCED QUANTIZATION ERROR 有权
标题翻译：增强节点B和减少量化误差预测的方法
公开(公告)号：US20120113830A1
公开(公告)日：2012-05-10
申请号：US13075320
申请日：2011-03-30
申请人： Yuan Zhu , Qinghua Li , Xiaogang Chen
发明人： Yuan Zhu , Qinghua Li , Xiaogang Chen
IPC分类号： H04W24/00
CPC分类号： H04B7/0456 , H04B7/024 , H04B7/0413 , H04B7/0452 , H04B7/0482 , H04B7/0617 , H04B7/0639 , H04B7/0652 , H04L1/009 , H04L1/20 , H04L5/0048 , H04L2001/0093 , H04L2001/0097 , H04W24/10 , H04W40/24 , H04W52/0209 , H04W52/146 , H04W52/34 , H04W52/365 , H04W72/042 , H04W72/0473 , H04W72/06 , Y02D70/00 , Y02D70/1224 , Y02D70/1242 , Y02D70/1262 , Y02D70/1264 , Y02D70/142 , Y02D70/144 , Y02D70/146 , Y02D70/164 , Y02D70/168 , Y02D70/444
摘要： Embodiments of an enhanced Node B (eNB) and method for precoding with reduced quantization error are generally described herein. In some embodiments, first and second precoding-matrix indicator (PMI) reports may be received on an uplink channel and a single subband precoder matrix may be interpolated from precoding matrices indicated by both the PMI reports. Symbols for multiple-input multiple output (MIMO) beamforming may be precoded using the interpolated precoder matrix computed for single subband for a multiple user (MU)-MIMO downlink orthogonal frequency division multiple access (OFDMA) transmission. In some embodiments, each of the first and second PMI reports includes a PMI associated with a same subband that jointly describes a recommended precoder.
摘要翻译：通常在此描述增强型节点B（eNB）的实施例和用于具有减小的量化误差的预编码的方法。在一些实施例中，可以在上行链路信道上接收第一和第二预编码矩阵指示符（PMI）报告，并且可以从由PMI报告指示的预编码矩阵插值单个子带预编码器矩阵。可以使用针对多用户（MU）-MIMO下行链路正交频分多址（OFDMA）传输的单个子带计算的内插预编码器矩阵来对多输入多输出（MIMO）波束形成的符号进行预编码。在一些实施例中，第一和第二PMI报告中的每一个包括与联合描述推荐的预编码器的相同子带相关联的PMI。

63. 发明申请

US20110002263A1 BEAMFORMING USING BASE AND DIFFERENTIAL CODEBOOKS 有权
标题翻译：使用基础和差异代码的波纹管
公开(公告)号：US20110002263A1
公开(公告)日：2011-01-06
申请号：US12639640
申请日：2009-12-16
申请人： Yuan Zhu , Qinghua Li , Xintian E. Lin , Huaning Niu , Alexei Davydov
发明人： Yuan Zhu , Qinghua Li , Xintian E. Lin , Huaning Niu , Alexei Davydov
IPC分类号： G09G3/36 , H04L27/28
CPC分类号： H04B7/0617 , H04B7/0456 , H04B7/0482 , H04B7/0619 , H04B7/0634 , H04B7/0641 , H04L12/66 , H04L25/021 , H04L25/0248 , H04L25/03343 , H04L25/03936 , H04W16/28 , H04W24/02 , H04W48/16 , H04W52/10 , H04W52/146 , H04W72/00 , H04W72/0413 , H04W84/045 , Y02D70/122 , Y02D70/124 , Y02D70/14
摘要： Embodiments of methods and apparatus for determining and/or quantizing a beamforming matrix are disclosed. In some embodiments, the determining and/or quantizing of the beamforming matrix may include the use of a base codebook and a differential codebook. Additional variants and embodiments are also disclosed.
摘要翻译：公开了用于确定和/或量化波束形成矩阵的方法和装置的实施例。在一些实施例中，波束形成矩阵的确定和/或量化可以包括使用基本码本和差分码本。还公开了其它变型和实施方案。

64. 发明申请

US20100329316A1 Techniques for transmission of channel quality data in wireless systems 失效
标题翻译：在无线系统中传输信道质量数据的技术
公开(公告)号：US20100329316A1
公开(公告)日：2010-12-30
申请号：US12459268
申请日：2009-06-26
申请人： Hongmei Sun , Changlong Xu , Qinghua Li , Yuan Zhu , Senjie Zhang , Yang Gao , Jong-Kae J.K. Fwu , Hujun Yin
发明人： Hongmei Sun , Changlong Xu , Qinghua Li , Yuan Zhu , Senjie Zhang , Yang Gao , Jong-Kae J.K. Fwu , Hujun Yin
IPC分类号： H04B1/38
CPC分类号： H04W24/10
摘要： An embodiment of the present invention provides an apparatus, including a transceiver adapted for use in a wireless network using a fast feedback channel design that incorporates a 2-two level adaptive fast feedback channel framework separating uplink (UL) fast feedback channels into primary and secondary UL fast feedback channels.
摘要翻译：本发明的实施例提供了一种装置，其包括适于在使用快速反馈信道设计的无线网络中使用的收发器，所述快速反馈信道设计包含将上行链路（UL）快速反馈信道分成初级和次级的2二级自适应快速反馈信道框架 UL快速反馈通道。

65. 发明申请

US20100227565A1 TRANSMISSION OF CHANNEL QUALITY DATA IN WIRELESS COMMUNICATION SYSTEMS 有权
标题翻译：无线通信系统中信道质量数据的传输
公开(公告)号：US20100227565A1
公开(公告)日：2010-09-09
申请号：US12645830
申请日：2009-12-23
申请人： Hongmei Sun , Changlong Xu , Qinghua Li , Yuan Zhu , Rath Vannithamby , Jong-Kae J.K. Fwu , Senjie Zhang , Yang Y. Gao , Hujun Yin
发明人： Hongmei Sun , Changlong Xu , Qinghua Li , Yuan Zhu , Rath Vannithamby , Jong-Kae J.K. Fwu , Senjie Zhang , Yang Y. Gao , Hujun Yin
IPC分类号： H04B17/00
CPC分类号： H04W68/08 , H04B7/0478 , H04W68/02 , H04W84/045
摘要： Briefly, in accordance with one or more embodiments, data transmitted from a transmitter is received in a downlink channel, and channel quality data is fed back to the transmitter in a first uplink channel or in a second uplink channel. Channel quality data is feedback at a lower rate on the first uplink channel and channel quality data is feedback at a higher rate on the second uplink channel in the event there is a higher amount of data to be fed back. Link adaptation may be utilized to select a transmission rate on the second uplink channel, wherein the transmission rate is selected based at least in part on a channel condition or a user location.
摘要翻译：简而言之，根据一个或多个实施例，在下行链路信道中接收从发射机发送的数据，并且在第一上行链路信道或第二上行链路信道中将信道质量数据反馈给发射机。信道质量数据在第一上行链路信道上以较低的速率进行反馈，并且在存在要反馈的数据量较大的情况下，信道质量数据以较高速率在第二上行链路信道上反馈。可以利用链路自适应来选择第二上行链路信道上的传输速率，其中至少部分地基于信道条件或用户位置来选择传输速率。

66. 发明申请

US20100202376A1 SCHEDULING OF VOICE OVER IP DATA 审中-公开
标题翻译： IP数据调度语音
公开(公告)号：US20100202376A1
公开(公告)日：2010-08-12
申请号：US12669946
申请日：2007-10-10
申请人： Yuan Zhu , Hai Ming Wang , Da Jie Jiang
发明人： Yuan Zhu , Hai Ming Wang , Da Jie Jiang
IPC分类号： H04W8/00
CPC分类号： H04W72/1278 , H04L65/80
摘要： Voice over Internet Protocol (VoIP) transfer is provided over radio links between mobile stations and base stations with a mechanism to schedule initial transmission within voice spurts when semi-persistent allocation of radio resources is employed. The radio link is changed during the voice spurt by allocating different physical resource blocks or by changing transmission parameters with given rescheduling intervals. The scheduling is informed from the base station to involved MS by using data link layer VoIP packet padding bits. The radio link can also be changed per initiative of the MS so that the MS codes a predetermined request into data link layer padding bits of an uplink VoIP packet. The requests from the MS typically involve a change of audio coding mode or informing of the present packet buffer status for VoIP packets at the MS.
摘要翻译：通过无线电链路在移动台和基站之间提供通过因特网协议（VoIP）传送的语音传输，其具有当采用无线电资源的半持续分配时在语音输出内调度初始传输的机制。通过分配不同的物理资源块或通过以给定的重新安排间隔改变传输参数，在语音突发期间改变无线电链路。通过使用数据链路层VoIP数据包填充位将调度从基站通知给相关MS。无线电链路还可以根据MS的主动来改变，使得MS将预定请求编码成上行链路VoIP分组的数据链路层填充比特。来自MS的请求通常涉及音频编码模式的改变或者在MS处通知VoIP分组的当前分组缓冲器状态。

67. 发明申请

US20090207811A1 FREQUENCY QUALITY CRITERIA FOR INTER-FREQUENCY HANDOVER IN A TD-CDMA COMMUNICATION SYSTEM 有权
标题翻译：用于TD-CDMA通信系统中的频率切换的频率质量标准
公开(公告)号：US20090207811A1
公开(公告)日：2009-08-20
申请号：US11631497
申请日：2005-05-25
申请人： Yuan Zhu , Haiming Wang , Jiangeng Kang
发明人： Yuan Zhu , Haiming Wang , Jiangeng Kang
IPC分类号： H04W36/30 , H04W36/00
CPC分类号： H04W36/14 , H04W36/22
摘要： A method for determining whether to perform handover of a UE apparatus to a candidate cell and carrier frequency of a TD-CDMA telecommunications network (such as a TD-SCDMA network) based separately on coverage and capacity, using one decision metric for coverage (e.g. based on received signal code power for the candidate cell and carrier frequency) and a different decision metric for capacity (e.g. based on a quantity proportional to the received signal code power for the candidate cell and carrier frequency and inversely proportional to a measure of total interference in the candidate cell on the carrier frequency. Corresponding equipment and a computer program product are also provided. In deciding whether handover is needed based on capacity, a threshold for received signal code power may be used in addition to the metric for capacity.
摘要翻译：一种用于基于覆盖和容量来分别决定是否执行UE装置到TD-CDMA电信网络（例如TD-SCDMA网络）的候选小区和载频的切换的方法，使用覆盖范围的一个决策度量（例如，基于候选小区和载波频率的接收信号码功率）和不同的容量决定度量（例如，基于与候选小区的接收信号码功率成比例的数量和载波频率，并且与总干扰的测量成反比在载波频率的候选小区中）。还提供相应的设备和计算机程序产品。在基于容量决定是否需要切换时，除了容量的度量之外，也可以使用接收信号码功率的阈值。

68. 发明申请

US20080144530A1 Method, device, system and software product for alternative time division duplex frame structure optimization 失效
标题翻译：方法，设备，系统和软件产品，用于替代时分双工框架结构优化
公开(公告)号：US20080144530A1
公开(公告)日：2008-06-19
申请号：US11982732
申请日：2007-11-02
申请人： Xiangguang Che , Zhi-Chun Honkasalo , Yuan Zhu , Chunye Wang
发明人： Xiangguang Che , Zhi-Chun Honkasalo , Yuan Zhu , Chunye Wang
IPC分类号： H04L12/28
CPC分类号： H04B7/2656
摘要： A method, mobile device, network device, and software product are for forming a time division duplex frame structure, including a downlink pilot timeslot within an initial data timeslot of the frame structure, and also including an uplink pilot timeslot in a further data timeslot of the frame structure. A guard period is located between the initial data timeslot and the further data timeslot.
摘要翻译：一种方法，移动设备，网络设备和软件产品用于形成时分双工帧结构，包括帧结构的初始数据时隙内的下行链路导频时隙，并且还包括在另外的数据时隙中的上行链路导频时隙框架结构。保护周期位于初始数据时隙和其他数据时隙之间。

69. 发明授权

US06350446B1 HAS2 splicing variant HOEFC11: a target in chronic renal failure, inflammatory diseases and myocardial ischemia 失效
标题翻译： HAS2剪接变体HOEFC11：慢性肾功能衰竭，炎性疾病和心肌缺血的靶标
公开(公告)号：US06350446B1
公开(公告)日：2002-02-26
申请号：US09385174
申请日：1999-08-30
申请人： Yuan Zhu , Ponnal Nambi , Mark A Pullen
发明人： Yuan Zhu , Ponnal Nambi , Mark A Pullen
IPC分类号： A61K3843
CPC分类号： C12N9/1051 , A61K38/00
摘要： HOEFC11 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HOEFC11 polypeptides and polynucleotides in the design of protocols for the treatment of chronic renal failure, inflammatory diseases, myocardial ischemia, cancer, rheumatoid arthritis, cirrhotic liver disease, among others, and diagnostic assays for such conditions.
摘要翻译：公开了HOEFC11多肽和多核苷酸以及通过重组技术产生此类多肽的方法。还公开了在设计用于治疗慢性肾功能衰竭，炎性疾病，心肌缺血，癌症，类风湿性关节炎，肝硬化肝病等的方案中用于HOEFC11多肽和多核苷酸的方法以及用于这些病症的诊断测定法。

70. 发明授权

US06291223B1 Mouse aspartic secretase-1 (mASP1) 失效
标题翻译：小鼠天冬氨酸分泌酶-1（mASP1）
公开(公告)号：US06291223B1
公开(公告)日：2001-09-18
申请号：US09717432
申请日：2000-11-21
申请人： Gary Christie , Xiaotong Li , David J. Powell , Yuan Zhu
发明人： Gary Christie , Xiaotong Li , David J. Powell , Yuan Zhu
IPC分类号： C12N948
CPC分类号： C12N9/6421 , A61K38/00
摘要： Mouse mASP1 polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds that either agonize or antagonize mouse mASP1. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to: Alzheimer's disease, cancer, and prohormone processing.
摘要翻译：公开了小鼠mASP1多肽和多核苷酸以及通过重组技术产生此类多肽的方法。还公开了用于筛选激动或拮抗小鼠mASP1的化合物的方法。预期这样的化合物可用于治疗人类疾病，包括但不限于：阿尔茨海默氏病，癌症和激素原处理。

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