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1. 发明授权

US10392625B2 Host cells and methods of use 有权
公开(公告)号：US10392625B2
公开(公告)日：2019-08-27
申请号：US13203056
申请日：2010-02-24
申请人： Yong Hwan Jin , James D. Jowett , Alexander H. Taylor , Yuan Zhu
发明人： Yong Hwan Jin , James D. Jowett , Alexander H. Taylor , Yuan Zhu
IPC分类号： C07K14/00 , C12N15/81 , C07K14/605 , C12N9/10 , C12N9/60
摘要： The present invention provides genetically modified Pichia strains wherein at least one nucleic acid sequence encoding a functional gene product and/or at least one nucleic acid sequence necessary for expression of at least one functional gene product in said Pichia strain is genetically modified, wherein said gene product is responsible for proteolysis and/or glycosylation in said genetically modified Pichia strain. In particular, Pichia strains are provided wherein nucleic acid sequence encoding a functional gene product or expression of said gene product are genetically modified: PEP4, PRB1, YPS1, YPS2, YMP1, YMP2, YMP3 and PMT4. Also provided herein are genetically modified host cells wherein wild type parent of said genetically modified host cell comprises a gene encoding a polypeptide having at least 60% sequence identity to amino acids 1-865 of SEQ ID NO:4, SEQ ID NO:6 and SEQ ID NO:8 wherein said gene is genetically modified in the genome of said host cell such that the gene product is reduced or eliminated in said genetically modified host cell compared with said wild type host cell.

2. 发明申请

US20120142895A1 HOST CELLS AND METHODS OF USE 审中-公开
标题翻译：宿主细胞和使用方法
公开(公告)号：US20120142895A1
公开(公告)日：2012-06-07
申请号：US13203056
申请日：2010-02-24
申请人： Yong Hwan Jin , James D. Jowett , Alexander H. Taylor , Yuan Zhu
发明人： Yong Hwan Jin , James D. Jowett , Alexander H. Taylor , Yuan Zhu
IPC分类号： C07K14/00 , C12P21/00 , C12N1/19
CPC分类号： C12N15/815 , C07K14/605 , C07K2319/31 , C12N9/1051 , C12N9/60
摘要： The present invention provides genetically modified Pichia strains wherein at least one nucleic acid sequence encoding a functional gene product and/or at least one nucleic acid sequence necessary for expression of at least one functional gene product in said Pichia strain is genetically modified, wherein said gene product is responsible for proteolysis and/or glycosylation in said genetically modified Pichia strain. In particular, Pichia strains are provided wherein nucleic acid sequence encoding a functional gene product or expression of said gene product are genetically modified: PEP4, PRB1, YPS1, YPS2, YMP1, YMP2, YMP3 and PMT4. Also provided herein are genetically modified host cells wherein wild type parent of said genetically modified host cell comprises a gene encoding a polypeptide having at least 60% sequence identity to amino acids 1-865 of SEQ ID NO:4, SEQ ID NO:6 and SEQ ID NO:8 wherein said gene is genetically modified in the genome of said host cell such that the gene product is reduced or eliminated in said genetically modified host cell compared with said wild type host cell.
摘要翻译：本发明提供了遗传修饰的毕赤酵母菌株，其中至少一个编码功能性基因产物的核酸序列和/或在所述毕赤酵母属菌株中表达至少一种功能性基因产物所必需的至少一种核酸序列被遗传修饰，其中所述基因产物负责所述遗传修饰的毕赤酵母菌株中的蛋白水解和/或糖基化。具体而言，提供了编码功能性基因产物的核酸序列或所述基因产物的表达被遗传修饰的毕赤酵母菌株：PEP4，PRB1，YPS1，YPS2，YMP1，YMP2，YMP3和PMT4。本文还提供遗传修饰的宿主细胞，其中所述经遗传修饰的宿主细胞的野生型亲本包含编码与SEQ ID NO：4，SEQ ID NO：6的氨基酸1-865至少60％序列同一性的多肽的基因和 SEQ ID NO：8，其中所述基因在所述宿主细胞的基因组中被遗传修饰，使得与所述野生型宿主细胞相比，在所述遗传修饰的宿主细胞中基因产物被还原或消除。

3. 发明申请

US20110189734A1 NOVEL METHODS AND CELL LINES 审中-公开
标题翻译：新的方法和细胞系
公开(公告)号：US20110189734A1
公开(公告)日：2011-08-04
申请号：US12673526
申请日：2008-08-14
申请人： Alexander H. Taylor , Yuan Zhu
发明人： Alexander H. Taylor , Yuan Zhu
IPC分类号： C12P21/00 , C12N15/87 , C12N5/10
CPC分类号： C07K16/18 , C07K16/00 , C07K16/248 , C12N2510/02
摘要： This invention relates to fermentation processes for producing antibodies and other antigen binding compounds. Specifically, the present invention provides methods for increasing the specific productivity of an antibody produced in cell culture, increasing cell growth and increasing viability of cells in cell culture. Also provided are, expression stable, viable cell lines comprising DNA encoding adenovirus GAM1 and capable of producing a monoclonal antibody or fragment and/or variant thereof.
摘要翻译：本发明涉及产生抗体和其他抗原结合化合物的发酵方法。具体而言，本发明提供了增加细胞培养中产生的抗体的比生产率，增加细胞生长和增加细胞培养中的细胞活力的方法。还提供了表达稳定的活细胞系，其包含编码腺病毒GAM1的DNA，并且能够产生单克隆抗体或其片段和/或变体。

4. 发明授权

US10051509B2 Reference signal generation and determining reference signal resource allocation 有权
公开(公告)号：US10051509B2
公开(公告)日：2018-08-14
申请号：US13519312
申请日：2011-12-09
申请人： Yuan Zhu , Alexei Davydov , Xiaogang Chen , Huaning Niu , Jong-Kae Fwu
发明人： Yuan Zhu , Alexei Davydov , Xiaogang Chen , Huaning Niu , Jong-Kae Fwu
IPC分类号： H04W28/02 , H04N21/2365 , H04N21/643 , H04W52/02 , H04B7/0456 , H04W72/04 , H04W48/06 , H04L12/803 , H04L12/801 , H04L29/06 , H04L1/18 , H04L5/00 , H04J11/00 , H04L27/26 , H04L1/00 , H04B7/0413 , H04B7/0417 , H04W68/00 , H04B7/0452 , H04W72/12 , H04W12/06 , H04W12/08 , H04W88/02 , H04W4/70 , H04W88/06 , H04W36/14 , H04B7/06 , H04W84/12 , H04W88/10
摘要： Various embodiments include devices, methods, computer-readable media and system configurations for reference signal generation and resource allocation. In various embodiments, a wireless communication device may include a control module, which may be operated by a processor and configured to transmit to a user equipment (“UE”) device, over a wireless communication interface, a parameter specific to the UE device; wherein the parameter is usable by the eNB to generate a user equipment-specific reference signal (“UE-RS”) to be sent to the UE device. The parameter may be usable by the UE device to identify the UE-RS to facilitate demodulation of multiple-input, multiple-output communications. In various embodiments, a control module may be configured to store, in memory, priority rules, and to determine a UE-RS resource allocated to another UE device based on a UE-RS resource allocated to the UE device and the priority rules.

5. 发明授权

US10044421B2 Wireless communication via combined channel training and physical layer header signaling 有权
公开(公告)号：US10044421B2
公开(公告)日：2018-08-07
申请号：US14583253
申请日：2014-12-26
申请人： Qinghua Li , Xiaogang Chen , Huaning Niu , Yuan Zhu
发明人： Qinghua Li , Xiaogang Chen , Huaning Niu , Yuan Zhu
IPC分类号： H04B7/04 , H04B7/0452 , H04L29/06 , H04B7/06 , H04L5/00
摘要： Embodiments herein relate to wireless communication using combined channel training and physical layer header (SIG) signaling. Devices that comply with the 802.11ax or High Efficiency WLAN (HEW) standard may generate and transmit packets that include such combined information. The combined information may be beamformed to a receiver device via an OFDM signal, which may be decoded by the receiver device to obtain subsequent data included in the signal. For example, initial training symbols associated with channel training subcarriers in the signal may be detected and used to perform a rough estimate of the channel. The rough estimate may thereafter be refined using data symbols detected from adjacent data subcarriers using the channel training symbols. In this way, data subcarriers may also be used to determine a channel response along with channel training subcarriers. Channel training information may be transmitted with data, such as user-specific information, in a single symbol.

6. 发明授权

US10034194B2 System and method of managing wireless communications with multiple transmission points 有权
公开(公告)号：US10034194B2
公开(公告)日：2018-07-24
申请号：US13976464
申请日：2011-09-28
申请人： Yuan Zhu , Alexei Davydov , Kamran Etemad , Qinghua Li , Xiaogang Chen , Jong-Kae Fwu
发明人： Yuan Zhu , Alexei Davydov , Kamran Etemad , Qinghua Li , Xiaogang Chen , Jong-Kae Fwu
IPC分类号： H04W28/02 , H04N21/2365 , H04N21/643 , H04W52/02 , H04B7/0456 , H04W72/04 , H04W48/06 , H04L12/803 , H04L12/801 , H04L29/06 , H04L1/18 , H04L5/00 , H04J11/00 , H04L27/26 , H04L1/00 , H04B7/0413 , H04B7/0417 , H04W68/00 , H04B7/0452 , H04W72/12 , H04W12/06 , H04W12/08 , H04W88/02 , H04W4/70 , H04W88/06 , H04W36/14 , H04B7/06 , H04W84/12 , H04W88/10
摘要： An apparatus includes a processor a channel state information (CSI) module operative on the processor to evaluate channel state information for a multiplicity of transmission points and to allocate a selection of channel state information reference signals (CSI-RS) to an uplink sub-frame allotted for transmitting channel quality/precoding matrix index/rank indicator (CQI/PMI/RI) information to a transmission point. The apparatus may further include a wireless transceiver operative to transmit the selection of CSI-RS in the uplink sub-frame to the transmission point in a wireless network, and receive information from the transmission point in response to the CSI-RS and a digital display operative to present the information received from the transmission point.

7. 发明申请

US20160284340A1 VOICE PERSONALIZATION FOR MACHINE READING 审中-公开
标题翻译：机器阅读的语音个性化
公开(公告)号：US20160284340A1
公开(公告)日：2016-09-29
申请号：US14369443
申请日：2013-12-12
申请人： Honggng Li , Yuan Zhu , Bo Huang , Liu Yang , INTEL CORPORATION
发明人： Honggang Li , Yuan Zhu , Bo Huang , Liu Yang
IPC分类号： G10L13/033 , G10L13/10 , H04L29/06 , G06F3/16
CPC分类号： G10L13/033 , G06F3/165 , G09B21/006 , G10L13/10 , H04L63/10
摘要： Systems and techniques of voice personalization for machine reading are described herein. A message with textual content may be received. A sender of the message may be identified. A voice model that corresponds to the sender may be identified. An audio representation of the textual content may be rendered using the voice model.
摘要翻译：本文描述了用于机器读取的语音个性化的系统和技术。可以接收具有文本内容的消息。可以识别消息的发送者。可以识别与发送者对应的语音模型。可以使用语音模型来呈现文本内容的音频表示。

8. 发明申请

US20160255610A1 Joint Encoding of Wireless Communication Allocation Information 有权
标题翻译：无线通信分配信息的联合编码
公开(公告)号：US20160255610A1
公开(公告)日：2016-09-01
申请号：US14998211
申请日：2015-12-26
申请人： Qinghua Li , Xiaogang Chen , Robert Stacey , Chittabrata Ghosh , Yuan Zhu , Rongzhen Yang
发明人： Qinghua Li , Xiaogang Chen , Robert Stacey , Chittabrata Ghosh , Yuan Zhu , Rongzhen Yang
IPC分类号： H04W72/04 , H04B7/04 , H04L1/00
CPC分类号： H04W72/042 , H04B7/0413 , H04L1/0061 , H04L1/0072 , H04L1/0083 , H04W72/0453 , H04W84/12
摘要： Methods, devices and systems for jointly encoding allocation information of one or more wireless communication stations in a common portion of a physical layer header are disclosed. In some examples, a wireless device may: generate allocation information associated with one or more wireless communication stations; encode the allocation information into the common portion of the physical layer header; and transmit the physical layer header to the one or more wireless communication stations.
摘要翻译：公开了用于在物理层报头的公共部分中共同编码一个或多个无线通信站的分配信息的方法，设备和系统。在一些示例中，无线设备可以：生成与一个或多个无线通信站相关联的分配信息; 将分配信息编码到物理层报头的公共部分中; 并将所述物理层报头发送到所述一个或多个无线通信站。

9. 发明申请

US20160127936A1 USER EQUIPMENT AND METHODS FOR CSI MEASUREMENTS WITH REDUCED BANDWIDTH SUPPORT 审中-公开
标题翻译：用于具有减少带宽支持的CSI测量的用户设备和方法
公开(公告)号：US20160127936A1
公开(公告)日：2016-05-05
申请号：US14711866
申请日：2015-05-14
申请人： Debdeep Chatterjee , Seunghee Han , Alexei Davydov , Gang Xiong , Yuan Zhu
发明人： Debdeep Chatterjee , Seunghee Han , Alexei Davydov , Gang Xiong , Yuan Zhu
IPC分类号： H04W24/10 , H04W4/00 , H04B7/06
CPC分类号： H04B7/0632 , H04B7/0626 , H04W4/70 , H04W24/00
摘要： An enhanced NodeB (eNB), user equipment (UE) and method of Channel State Information (CSI) measurement and reporting using reduced bandwidth are generally described herein. The UE is preconfigured with a resource configuration information or the configuration information is transmitted to the UE from the eNB. The configuration information indicates a narrowband region on which to monitor for and receive physical downlink control and data channels and perform measurements for CSI computation. The region has a reduced bandwidth that is supported by the UE and is free from subbands outside of the region. The UE takes measurements of downlink transmissions using the assigned resources. The measurements are limited to subbands included within the region. The UE calculates the CSI based on an unrestricted time interval within subframes of the region and a restricted frequency interval free from physical resource blocks outside the region. The UE reports a region-specific wideband CSI that includes at least a region-specific wideband Channel Quality Indicator to the eNB.
摘要翻译：通常在此描述增强型节点B（eNB），用户设备（UE）以及使用减少带宽的信道状态信息（CSI）测量和报告的方法。 UE预先配置了资源配置信息，或者从eNB向UE发送配置信息。配置信息指示在其上监视和接收物理下行链路控制和数据信道并执行CSI计算的测量的窄带区域。该区域具有由UE支持的减少的带宽，并且不存在该区域外的子带。 UE使用分配的资源来测量下行链路传输。测量被限制在该区域内包括的子带。 UE基于区域的子帧内的不受限制的时间间隔和区域外的物理资源块的限制频率间隔来计算CSI。 UE向eNB报告区域特定的宽带CSI，其至少包括针对eNB的区域特定的宽带信道质量指示符。

10. 发明授权

US09319965B2 Apparatuses and methods for CSI-RS configuration in distributed RRH systems 有权
标题翻译：分布式RRH系统中CSI-RS配置的设备和方法
公开(公告)号：US09319965B2
公开(公告)日：2016-04-19
申请号：US13990693
申请日：2011-12-16
申请人： Yuan Zhu , Alexei Vladimirovich Davydov , Rongzhen Yang , Kamran Etemad , Xiangying Yang , Jong-Kae Fwu , Yang-Seok Choi , Yujian Zhang , Qinghua Li , Xinrong Wang
发明人： Yuan Zhu , Alexei Vladimirovich Davydov , Rongzhen Yang , Kamran Etemad , Xiangying Yang , Jong-Kae Fwu , Yang-Seok Choi , Yujian Zhang , Qinghua Li , Xinrong Wang
IPC分类号： H04W72/04 , H04W48/10 , H04B7/04 , H04L5/00 , H04L12/26 , H04L12/721 , H04L29/06 , H04W4/00 , H04W24/00 , H04W24/02 , H04W24/10 , H04W28/08 , H04W48/12 , H04W52/02 , H04W52/14 , H04W52/18 , H04L25/02 , H04L25/03 , H04W28/04 , H04W72/00 , H04W88/02 , H04W88/08 , H04W92/20 , H04B7/02
CPC分类号： H04W48/10 , H04B7/022 , H04B7/0417 , H04B7/0456 , H04L5/003 , H04L5/0035 , H04L5/0037 , H04L5/005 , H04L5/0051 , H04L5/0057 , H04L5/0094 , H04L25/0224 , H04L43/50 , H04L45/70 , H04L65/608 , H04L2025/03426 , H04L2025/03802 , H04W4/70 , H04W24/00 , H04W24/02 , H04W24/10 , H04W28/04 , H04W28/08 , H04W48/12 , H04W52/0216 , H04W52/146 , H04W52/18 , H04W72/00 , H04W72/0413 , H04W72/042 , H04W72/0453 , H04W88/02 , H04W88/08 , H04W92/20 , Y02D70/00 , Y02D70/1262 , Y02D70/1264 , Y02D70/142 , Y02D70/146 , Y02D70/164 , Y02D70/22 , Y02D70/442 , Y02D70/444
摘要： Apparatuses and methods for channel state information reference signal (CSI-RS) configuration in distributed remote radio head (RRH) systems are described. A transmission point selection module can receive a user equipment (UE) signal via a transmission point from a plurality of transmission points sharing a single cell identification. A downlink transmission point can be selected based on the UE signal. The UE can then be configured to report CSI-RS measurements for the selected downlink transmission point.
摘要翻译：描述了分布式远程无线电头（RRH）系统中信道状态信息参考信号（CSI-RS）配置的设备和方法。传输点选择模块可以经由来自共享单个小区标识的多个传输点的传输点接收用户设备（UE）信号。可以基于UE信号来选择下行链路传输点。然后可以将UE配置为报告所选择的下行链路传输点的CSI-RS测量。

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