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61. 发明授权

US5545630A Vinylcarboxylic acid derivatives 失效
标题翻译：乙烯基羧酸衍生物
公开(公告)号：US5545630A
公开(公告)日：1996-08-13
申请号：US462450
申请日：1995-06-05
申请人： Peter Maienfisch , Manfred B oger , Thomas Pitterna , Henry Szczepanski
发明人： Peter Maienfisch , Manfred B oger , Thomas Pitterna , Henry Szczepanski
IPC分类号： A01C1/00 , A01N37/18 , A01N37/22 , A01N37/24 , A01N41/06 , A01N41/10 , A01N55/00 , A01N55/10 , C07C51/38 , C07C57/52 , C07C57/76 , C07C69/63 , C07C69/65 , C07C233/09 , C07C233/12 , C07C233/33 , C07C233/55 , C07C237/42 , C07C255/60 , C07C311/46 , C07C317/38 , C07C317/40 , C07C323/37 , C07C323/41 , C07D213/70 , C07D239/38 , C07D291/00 , C07D295/16 , C07D295/192 , C07F7/08 , C07F7/12 , C07F7/18 , C07F7/10
CPC分类号： C07D295/192 , A01N37/22 , A01N37/24 , A01N41/06 , A01N41/10 , A01N55/00 , C07C233/09 , C07C233/33 , C07C233/55 , C07C237/42 , C07C255/60 , C07C311/46 , C07C317/40 , C07C323/41 , C07C51/38 , C07C57/52 , C07C69/63 , C07C69/65 , C07F7/0818 , C07F7/184 , C07C2101/02 , C07C2101/14 , C07C2101/18
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is C.sub.3 -C.sub.8 cycloalkyl, halo-C.sub.3 -C.sub.8 cycloalkyl, C.sub.3 -C.sub.8 cycloalkyl-C.sub.1 -C.sub.6 alkyl, halo-C.sub.3 -C.sub.8 cycloalkyl-C.sub.1 -C.sub.6 alkyl, --Si(R.sub.3).sub.3, --S--R.sub.4, --SO.sub.2 --R.sub.6 or --CO--R.sub.9 ;R.sub.2 is halogen, C.sub.1 -C.sub.4 alkyl or CF.sub.3, the substituents R.sub.2 being identical or different when n is 2;R.sub.3 each independently of the others is C.sub.1 -C.sub.6 alkyl, halo-C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy or phenyl;R.sub.4 is aryl or heteroaryl each of which is unsubstituted or substituted;R.sub.6 is unsubstituted or substituted C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.1 -C.sub.20 alkoxy, C.sub.2 -C.sub.6 alkenyloxy, C.sub.2 -C.sub.6 alkynyloxy, C.sub.1 -C.sub.4 alkylthio, aryl, aryloxy or arylthio, or is optionally substituted amino;R.sub.9 is hydroxy, unsubstituted or substituted C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.3 -C.sub.8 cycloalkyl, aryl or aryloxy, or is optionally substituted amino;R.sub.12 is hydrogen or unsubstituted or substituted C.sub.1 -C.sub.10 alkyl;m is 1, 3, 5, 7, 9 or 11;n is 0, 1 or 2;X is fluorine or chlorine; andY is hydrogen, fluorine or methyl;in free form or in salt form, can be used as pesticides and can be prepared in a manner known per se.
摘要翻译：式（I）的化合物，其中R 1是C 3 -C 8环烷基，卤代-C 3 -C 8环烷基，C 3 -C 8环烷基-C 1 -C 6烷基，卤代-C 3 -C 8环烷基-C 1 -C 6烷基，-Si（R 3）3，-S -R4，-SO2-R6或-CO-R9; R2是卤素，C1-C4烷基或CF3，当n为2时，取代基R2相同或不同; R 3各自独立地为C 1 -C 6烷基，卤代-C 1 -C 6烷基，C 1 -C 6烷氧基或苯基; R4是芳基或杂芳基，其各自为未取代或取代的; R 6是未取代的或取代的C 1 -C 10烷基，C 2 -C 6烯基，C 2 -C 6炔基，C 1 -C 20烷氧基，C 2 -C 6烯氧基，C 2 -C 6炔氧基，C 1 -C 4烷硫基，芳基，芳氧基或芳硫基，或任选取代的氨基; R 9为羟基，未取代或取代的C 1 -C 10烷基，C 2 -C 6烯基，C 2 -C 6炔基，C 3 -C 8环烷基，芳基或芳氧基，或任选取代的氨基; R 12是氢或未取代的或取代的C 1 -C 10烷基; m为1，3，5，7，9或11; n为0,1或2; X是氟或氯; Y为氢，氟或甲基; 游离形式或盐形式可用作农药，并且可以以本身已知的方式制备。

62. 发明授权

US08415369B2 Spiroheterocyclic pyrrolidine dione derivatives useful as pesticides 有权
标题翻译：用作农药的螺杂环吡咯烷二酮衍生物
公开(公告)号：US08415369B2
公开(公告)日：2013-04-09
申请号：US12681861
申请日：2008-10-13
申请人： Werner Zambach , Ottmar Franz Hueter , Jean Wenger , Marcela Goeghova , Thomas Pitterna , Peter Maienfisch , Michel Muehlebach
发明人： Werner Zambach , Ottmar Franz Hueter , Jean Wenger , Marcela Goeghova , Thomas Pitterna , Peter Maienfisch , Michel Muehlebach
IPC分类号： A01N43/40 , A01P5/00 , A01P7/02 , A01P7/04 , A01P9/00 , C07D211/58 , C07D471/10
CPC分类号： C07D211/94 , A01N43/38 , A01N43/90 , C07D471/10
摘要： A compound of the formula (I) wherein the substituents are as defined in the claims, is useful as a pesticide.
摘要翻译：式（I）的化合物，其中取代基如权利要求中所定义，可用作农药。

63. 发明授权

US08263566B2 Avermectin B1 and avermectin B1 monosaccharide derivatives having an alkoxymethyl substituent in the 4″-or 4′-position 有权
标题翻译：在4“ - 或4”位具有烷氧基甲基取代基的阿维菌素B1和除虫菌素B1单糖衍生物
公开(公告)号：US08263566B2
公开(公告)日：2012-09-11
申请号：US13117292
申请日：2011-05-27
申请人： Peter Maienfisch , Fiona Murphy Kessabi , Jerome Cassayre , Laura Quaranta , Thomas Pitterna , Ottmar Franz Hueter , Pierre Jung
发明人： Peter Maienfisch , Fiona Murphy Kessabi , Jerome Cassayre , Laura Quaranta , Thomas Pitterna , Ottmar Franz Hueter , Pierre Jung
IPC分类号： A61K31/70 , C07H17/04
CPC分类号： C07H17/08 , A61K31/7042
摘要： What is described are a compound of the formula wherein n is 0 or 1; A-B is —CH═CH— or —CH2—CH2—; R1 is C1-C12-alkyl, C3-C8-cycloalkyl or C2-C12-alkenyl; R2 is for example C1-C12-alkyl, C2-C12-alkenyl or C2-C12-alkinyl; which are optionally substituted with one to five substituents selected from the group consisting of OH, halogen, CN, —N3, —NO2, C3-C8-Cycloalkyl, norbornylenyl-, C3-C8-Cycloalkenyl; C3-C8-halocycloalkyl, C1-C12-alkoxy, C1-C6-alkoxy-C1-C6-alkoxy, C3-C8-cycloalkoxy, C1-C12-haloalkoxy, C1-C12-alkylthio, C3-C8-cycloalkylthio, C1-C12-haloalkylthio, C1-C12-alkylsulfinyl, C3-C8-cycloalkylsulfinyl, C1-C12-haloalkylsulfinyl, C3-C8-halocycloalkylsulfinyl, C1-C12-alkylsulfonyl, C3-C8-cycloalkylsulfonyl, C1-C12-haloalkylsulfonyl, C3-C8-halocycloalkylsulfonyl, —NR4R6, —X—C(═Y)—R4, —X—C(═Y)—Z—R4, —P(═O)(OC1-C6-alkyl)2, aryl, heterocyclyl, aryloxy, arylthio and heterocyclyloxy; R3 is for example H, C1-C12-alkyl or C1-C12-alkyl which is optionally substituted and, where applicable, to E/Z isomers, mixtures of E/Z isomers and/or tautomers, in each case in free form or in salt form; a process for preparing and using these compounds and their tautomers; pesticides whose active compound is selected from these compounds and their tautomers; and a process for preparing these compounds and compositions, and the use of these compounds and compositions.
摘要翻译：描述的是下式的化合物，其中n是0或1; A-B是-CH = CH-或-CH 2 -CH 2 - ; R1是C1-C12-烷基，C3-C8-环烷基或C2-C12-烯基; R2是例如C1-C12-烷基，C2-C12-烯基或C2-C12-炔基; 其任选被一至五个选自OH，卤素，CN，-N 3，-NO 2，C 3 -C 8 - 环烷基，降冰片基 - ，C 3 -C 8 - 环烯基的取代基取代; C 3 -C 8卤代环烷基，C 1 -C 12烷氧基，C 1 -C 6烷氧基-C 1 -C 6 - 烷氧基，C 3 -C 8环烷氧基，C 1 -C 12卤代烷氧基，C 1 -C 12烷硫基，C 3 -C 8环烷硫基， C 1 -C 12烷基亚磺酰基，C 3 -C 8环烷基亚磺酰基，C 1 -C 12卤代烷基亚磺酰基，C 3 -C 8卤代环烷基亚磺酰基，C 1 -C 12烷基磺酰基，C 3 -C 8环烷基磺酰基，C 1 -C 12卤代烷基磺酰基，卤代环烷基磺酰基，-NR4R6，-X-C（= Y）-R4，-X-C（= Y）-Z-R4，-P（= O）（OC1-C6-烷基）2，芳基，杂环基，芳氧基，芳硫基和杂环氧基; R3是例如任选取代的H，C 1 -C 12 - 烷基或C 1 -C 12 - 烷基，并且在适用的情况下，E / Z异构体，E / Z异构体和/或互变异构体的混合物，在每种情况下为游离形式或盐形式; 一种制备和使用这些化合物及其互变异构体的方法; 活性化合物选自这些化合物及其互变异构体的农药; 以及制备这些化合物和组合物的方法，以及这些化合物和组合物的用途。

64. 发明申请

US20100311777A1 SPIROHETEROCYCLIC PYRROLIDINE DIONE DERIVATIVES USEFUL AS PESTICIDES 有权
标题翻译：用作杀虫剂的螺环衍生的吡咯烷酮二酮衍生物
公开(公告)号：US20100311777A1
公开(公告)日：2010-12-09
申请号：US12681861
申请日：2008-10-13
申请人： Werner Zambach , Ottmar Franz Hueter , Jean Wenger , Marcela Goeghova , Thomas Pitterna , Peter Maienfisch , Michel Muehlebach
发明人： Werner Zambach , Ottmar Franz Hueter , Jean Wenger , Marcela Goeghova , Thomas Pitterna , Peter Maienfisch , Michel Muehlebach
IPC分类号： A01N43/40 , C07D471/10 , C07D211/58 , A01P7/04 , A01P7/02 , A01P5/00 , A01P9/00
CPC分类号： C07D211/94 , A01N43/38 , A01N43/90 , C07D471/10
摘要： A compound of the formula (I) wherein the substituents are as defined in the claims, is useful as a pesticide.
摘要翻译：式（I）的化合物，其中取代基如权利要求中所定义，可用作农药。

65. 发明申请

US20090198054A1 PREPARATION OF THIAZOLES 失效
标题翻译：制备THIAZOLES
公开(公告)号：US20090198054A1
公开(公告)日：2009-08-06
申请号：US12424594
申请日：2009-04-16
申请人： Thomas Pitterna , Henry Szczepanski , Peter Maienfisch , Ottmar Franz Huter , Thomas Rapold , Marcel Senn , Thomas Gobel , Anthony Cornelius O'Sullivan
发明人： Thomas Pitterna , Henry Szczepanski , Peter Maienfisch , Ottmar Franz Huter , Thomas Rapold , Marcel Senn , Thomas Gobel , Anthony Cornelius O'Sullivan
IPC分类号： C07D413/02 , C07D277/20 , C07D277/70
CPC分类号： C07D277/32 , C07D277/16 , C07D277/36 , C07D277/70 , C07D277/74
摘要： The present disclosure is directed to a process for the preparation of a compound having the formula: wherein R is unsubstituted or substituted C1-C12alkyl, unsubstituted or substituted C2-C4alkenyl, unsubstituted or substituted C2-C4alkynyl, unsubstituted or substituted C3-C6cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, or —SR1; R1 is unsubstituted or substituted C1-C12alkyl, unsubstituted or substituted C2-C4alkenyl, unsubstituted or substituted C2-C4alkynyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl or unsubstituted or substituted heteroaryl; and X is a selected leaving group that is not halogen, and may specifically be methylsulfonate, trifluoromethylsulfonate, and p-toluenesulfonate. These compounds are valuable intermediates useful in the synthesis of compounds having pesticidal activity. Generally, the process includes reacting a water-removing reagent, with a compound having the formula Water-removing agents that may be used include thionyl chloride (SOCl2), thionyl bromide (SOBr2), phosphorus oxychloride (POCl3), phosphorus oxybromide (POBr3), phosphorus pentachloride or a sulfonic acid chloride or bromide.
摘要翻译：本公开涉及制备具有下式的化合物的方法：其中R是未取代的或取代的C 1 -C 12烷基，未取代或取代的C 2 -C 4烯基，未取代或取代的C 2 -C 4炔基，未取代或取代的C 3 -C 6环烷基，未取代的或取代的芳基，未取代或取代的杂芳基或-SR1; C 1 -C 12烷基，未取代或取代的C 2 -C 4烯基，未取代或取代的C 2 -C 4炔基，未取代或取代的环烷基，未取代或取代的芳基或未取代或取代的杂芳基; X是不是卤素的选择的离去基团，可以具体为甲基磺酸酯，三氟甲基磺酸酯和对甲苯磺酸酯。这些化合物是有用的合成具有杀虫活性的化合物的中间体。通常，该方法包括使除水试剂与具有式的化合物反应可以使用的除水剂包括亚硫酰氯（SOCl 2），亚硫酰溴（SOBr 2），三氯氧化磷（POCl 3），三溴氧化磷（POBr 3），五氯化磷或磺酰氯或溴化物。

66. 发明授权

US07538229B2 Preparation of thiazoles 失效
标题翻译：噻唑的制备
公开(公告)号：US07538229B2
公开(公告)日：2009-05-26
申请号：US11947891
申请日：2007-11-30
申请人： Thomas Pitterna , Henry Szczepanski , Peter Maienfisch , Ottmar Franz Huter , Thomas Rapold , Marcel Senn , Thomas Gobel , Anthony Cornelius O'Sullivan
发明人： Thomas Pitterna , Henry Szczepanski , Peter Maienfisch , Ottmar Franz Huter , Thomas Rapold , Marcel Senn , Thomas Gobel , Anthony Cornelius O'Sullivan
IPC分类号： C07D277/36
CPC分类号： C07D277/32 , C07D277/16 , C07D277/36 , C07D277/70 , C07D277/74
摘要： A process for the preparation of a compound of formula I wherein R is a range of organic groups and X is a leaving group which process comprises a) reacting a compound of the formula II where R is defined for formula (I) with a water-removing reagent; or b) for the preparation of a compound of formula (I) wherein K is halogen or a sulfonate, reacting a compound of the formula III where R is defined for formula (I) with a halogenating agent or a sulfonylating agent; or c) for the preparation of a compound of formula (I) wherein X is halogen, reacting a compound of the formula IV where R is as defined for formula (I) and R2 and R3 are defined organic groups with a compound of the formula halogen-C(—O)—O—C1-C8alkyl, halogen-C(—O)—O-aryl or halogen-C(—O)—O-benzyl.
摘要翻译：一种制备式I化合物的方法，其中R是有机基团的范围，X是离去基团，该方法包括：a）将式II化合物（其中R定义为式（I））与水 - 去除试剂; 或b）用于制备其中K为卤素或磺酸盐的式（I）化合物，其中R为式（I）所定义的式III化合物与卤化剂或磺酰化剂反应; 或c）用于制备其中X为卤素的式（I）化合物，使式IV化合物（其中R如式（I）所定义）与R 2和R 3定义为有机基团的化合物与式卤素-C（-O）-O-C 1 -C 8烷基，卤素-C（-O）-O-芳基或卤素-C（ - ） - O-苄基。

67. 发明授权

US07378399B2 Avermectins substituted in the 4″ and 4′-positions having pesticidal properties 有权
标题翻译：在4“和4”位取代的阿维菌素具有杀虫特性
公开(公告)号：US07378399B2
公开(公告)日：2008-05-27
申请号：US10544274
申请日：2004-02-03
申请人： Jerome Cassayre , Hans Tobler , Thomas Pitterna , Peter Maienfisch , Fiona Murphy Kessabi , Laura Quaranta , Ottmar Franz Hueter
发明人： Jerome Cassayre , Hans Tobler , Thomas Pitterna , Peter Maienfisch , Fiona Murphy Kessabi , Laura Quaranta , Ottmar Franz Hueter
IPC分类号： A01N43/04 , A01N43/00 , A01N43/40 , A01N43/02 , A01N43/16 , A61K31/40 , A61K31/38 , A61K31/335 , A61K31/35 , A61K31/70 , A61K31/397 , A61K31/445 , A61K31/44 , A01N43/38 , A01N31/40
CPC分类号： C07H17/08
摘要： What is described are a compound of the formula (I) Wherein A-B is —CH═CH— or —CH2—CH2—; n is 0 or 1; R1, is C1-C12alkyl, C3-C8cycloalkyl or C2-C12alkenyl; R2 and R3 for instance are either, (i) independently from each other for instance -Q, —C(═Y)-Q, or —C(═Y)—O-Q; or (ii) together form with the nitrogen atom to which they are bound a three- to seven-membered ring, (iii) together are ═C(R4)R5; R4 and R5 are, independently from each other, for instance -Q, —C(═Y)-Q, or —C(═Y)—O-Q; Y is O or S; Q is for instance H or unsubstituted or mono- to pentasubstituted C1-C12alkyl; or, if appropriate, an E/Z isomer, E/Z isomer mixture and/or tautomer thereof; a process for preparing these compounds, their isomers and tautomers and the use of these compounds, their isomers and tautomers; pesticidal compositions whose active compound is selected from these compounds and their tautomers; intermediates for the preparation of the said compounds of the formula (I), methods for the preparation of the compounds of the formula (I), and a method for controlling pests using these compositions
摘要翻译：描述的是式（I）的化合物，其中A-B是-CH-CH-或-CH 2 -CH 2 - 。 n为0或1; R 1是C 1 -C 12烷基，C 3 -C 8烷基，C 3 -C 12烷基，C 3 -C 12烷基，C 3 -C 12烷基， >环烷基或C 2 -C 12 - 烯基; 例如，R 2和R 3是（i）彼此独立地例如-Q，-C（-Y）-Q或-C（ - Y）-OQ; 或（ii）与其结合的氮原子一起形成三至七元环，（iii）一起为-C（R 4）R 5 >; R 4和R 5各自独立地为例如-Q，-C（-Y）-Q或-C（-Y）-O-Q; Y为O或S; Q是例如H或未被取代或单取代或未取代的C 1 -C 12烷基; 或者，如果合适的话，E / Z异构体，E / Z异构体混合物和/或其互变异构体; 制备这些化合物，其异构体和互变异构体的方法以及这些化合物，其异构体和互变异构体的用途; 活性化合物选自这些化合物及其互变异构体的杀虫组合物; 用于制备所述式（I）化合物的中间体，式（I）化合物的制备方法和使用这些组合物来控制害虫的方法

68. 发明授权

US06369233B1 Process for the preparation of thiazole derivatives 失效
标题翻译：噻唑衍生物的制备方法
公开(公告)号：US06369233B1
公开(公告)日：2002-04-09
申请号：US09628392
申请日：2000-08-01
申请人： Thomas Pitterna , Henry Szczepanski , Peter Maienfisch , Ottmar Franz Hüter , Thomas Rapold , Marcel Senn , Thomas Göbel , Anthony Cornelius O'Sullivan , Gottfried Seifert
发明人： Thomas Pitterna , Henry Szczepanski , Peter Maienfisch , Ottmar Franz Hüter , Thomas Rapold , Marcel Senn , Thomas Göbel , Anthony Cornelius O'Sullivan , Gottfried Seifert
IPC分类号： C07D27716
CPC分类号： C07D277/32 , C07D277/16 , C07D277/36 , C07D417/06
摘要： The Invention relates to a process for the preparation of a compound of the formula wherein Q, Y, Z, R1, R2, R3, R4 and R5 are as defined in the specification, which comprises a) reacting a compound of the formula with a halogenating agent to form a compound of the formula b) converting a compound of formula (II) by means of a halogenating agent into a compound of the formula optionally c) converting the compound of formula (IV) into a compound of formula (III); d) converting a compound of formula (III) by means of a compound of the formula e) converting a compound (IV) by means of a compound (V) into a compound (VI); and f) converting a compound (VI) by means of a chlorinating agent into a compound (I); a compound (IV); to a process for the preparation of a compound (III) and to a process for the preparation of a compound (IV).
摘要翻译：本发明涉及制备糠醛的化合物的方法，其中Q，Y，Z，R 1，R 2，R 3，R 4和R 5如本说明书中所定义，其包括：a）使下式的化合物与卤化剂将式（II）化合物通过卤化剂转化成式的化合物，任选地c）将式（Ⅳ）化合物转化为式（Ⅳ）化合物; d）转化将化合物（Ⅳ）用化合物（Ⅴ）转化成化合物（Ⅵ），将式（Ⅳ）化合物与下式化合物反应; 和（f）通过氯化剂将化合物（VI）转化为化合物（I）;化合物（IV）; 涉及制备化合物（III）的方法和制备化合物（IV）的方法。

69. 发明授权

US06265585B1 Process for the preparation of thiazole derivatives 失效
标题翻译：噻唑衍生物的制备方法
公开(公告)号：US06265585B1
公开(公告)日：2001-07-24
申请号：US09341716
申请日：1999-07-15
申请人： Thomas Pitterna , Peter Maienfisch , David John Wadsworth , Laurenz Gsell , Thomas Rapold , Henry Szczepanski
发明人： Thomas Pitterna , Peter Maienfisch , David John Wadsworth , Laurenz Gsell , Thomas Rapold , Henry Szczepanski
IPC分类号： C07D27732
CPC分类号： C07D277/32
摘要： A process for the preparation of a compound of formula (I), wherein X is a leaving group; which process comprises, a) for the preparation of a compound of formula (I) wherein X is —OS(═O)2A and A is as defined in the specification, reacting a compound of formula (II) with a sulfonylating agent; or, b) for the preparation of a compound of formula (I) wherein X is iodine, reacting a compound of formula (III) with an iodinating agent, preferably sodium iodide; or, c) for the preparation of a compound of formula (I) whrein X is bromine, reacting a compound of formula (IV) with a brominating agent; or, d) for the preparation of a compound (I) wherein X is chlorine or bromine, reacting a compound (V), wherein R and X are as defined in the specification, with a chlorinating agent, a compound of formula (Ib), the use thereof and a process for the preparation of a compound of formula (II) and a compound of formula (A) are described.
摘要翻译：一种制备式（I）化合物的方法，其中X是离去基团; 该方法包括a）制备式（I）化合物，其中X为-OS（= O）2A且A如说明书中所定义，式（II）化合物与磺酰化剂反应; 或b）制备其中X为碘的式（I）化合物，使式（III）化合物与碘化剂，优选碘化钠反应; 或者，c）制备式（I）化合物，其中X是溴，式（Ⅳ）化合物与溴化剂反应; 或者d）制备其中X为氯或溴的化合物（I），其中R和X如说明书中所定义的化合物（Ⅴ）与氯化剂，式（Ib）化合物反应，描述了其用途和制备式（II）化合物和式（A）化合物的方法。

70. 发明授权

US6121455A Process for the preparation of thiazole derivatives 有权
标题翻译：噻唑衍生物的制备方法
公开(公告)号：US6121455A
公开(公告)日：2000-09-19
申请号：US331432
申请日：1999-08-13
申请人： Thomas Pitterna , Henry Szczepanski , Peter Maienfisch , Ottmar Franz Huter , Thomas Rapold , Marcel Senn , Thomas Gobel , Anthony Cornelius O'Sullivan , Gottfried Seifert
发明人： Thomas Pitterna , Henry Szczepanski , Peter Maienfisch , Ottmar Franz Huter , Thomas Rapold , Marcel Senn , Thomas Gobel , Anthony Cornelius O'Sullivan , Gottfried Seifert
IPC分类号： C07D277/16 , C07D277/20 , C07D277/22 , C07D277/28 , C07D277/32 , C07D277/36 , C07D277/74 , C07D417/06 , C07D417/14
CPC分类号： C07D277/32 , C07D277/16 , C07D277/36 , C07D417/06
摘要： The invention relates to a process for the preparation of a compound of the formula ##STR1## and, where applicable, its E/Z-isomers, mixtures of E/Z-isomers and/or tautomers, in each case in free form or in salt form, whereinQ is CH or N,Y is NO.sub.2 or CN,Z is CHR.sub.3, O, NR.sub.3 or S,R.sub.1 and R.sub.2 are either each independently of the other hydrogen or unsubstituted or R.sub.4 -substituted C.sub.1 -C.sub.8 alkyl, or together form an alkylene bridge having two or three carbon atoms, and said alkylene bridge may additionally contain a hetero atom selected from the group consisting of NR.sub.5, O and S,R.sub.3 is H or unsubstituted or R.sub.4 -substituted C.sub.1 -C.sub.12 alkyl,R.sub.4 is unsubstituted or substituted aryl or heteroaryl, andR.sub.5 is H or C.sub.1 -C.sub.12 alkyl; which comprisesa) reacting a compound of the formula ##STR2## and, where applicable, its E/Z-isomers, mixtures of E/Z-isomers and/or tautomers, in each case in free form or in salt form, which is known or can be prepared by processes known.
摘要翻译： PCT No.PCT / EP97 / 07087第 371日期1999年8月13日 102（e）日期1999年8月13日PCT 1997年12月17日PCT公布。第WO98 / 27074号公报日期1998年6月25日本发明涉及一种制备下式化合物和（如适用的话）其E / Z-异构体，E / Z-异构体和/或互变异构体的混合物的方法，在每种情况下为游离形式或盐形式，其中Q是CH或N，Y是NO 2或CN，Z是CHR 3，O，NR 3或S，R 1和R 2各自独立地是另一个氢或未取代的或者R 4取代的C 1 -C 8烷基，或一起形成具有两个或三个碳原子的亚烷基桥，并且所述亚烷基桥可以另外含有选自NR5，O和S的杂原子，R3是H或未取代的或R4取代的C1-C12烷基，R4是未取代的或取代的芳基或杂芳基，R5是H或C1-C12烷基; 其包括：a）使游离形式或盐形式的下式化合物和/或其可能的E / Z-异构体，E / Z-异构体和/或互变异构体的混合物在各种情况下反应，其为已知或可以由已知的方法准备。

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