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61. 发明授权

US09012506B2 Cross-linked fatty acid-based biomaterials 有权
标题翻译：交联脂肪酸基生物材料
公开(公告)号：US09012506B2
公开(公告)日：2015-04-21
申请号：US12325546
申请日：2008-12-01
申请人： Keith M. Faucher , Hui Tang , Joseph Ferraro , Paul Martakos , Steve A. Herweck , Theodore Karwoski , Scott E. Corbeil
发明人： Keith M. Faucher , Hui Tang , Joseph Ferraro , Paul Martakos , Steve A. Herweck , Theodore Karwoski , Scott E. Corbeil
IPC分类号： A61K31/20 , A61K31/225 , A61K31/355 , A61L29/08 , A61L29/16 , A61L31/08 , A61L31/16
CPC分类号： A61L31/08 , A61K31/225 , A61K31/355 , A61L29/08 , A61L29/16 , A61L31/148 , A61L31/16 , A61L2300/22
摘要： Fatty acid-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.
摘要翻译：描述了脂肪酸衍生的生物材料，制备生物材料的方法以及将其用作药物递送载体的方法。脂肪酸衍生的生物材料可以单独使用或与医疗装置组合使用以释放和局部递送一种或多种治疗剂。还提供了形成和调整所述生物材料的性质的方法以及使用所述生物材料治疗哺乳动物的损伤的方法。

62. 发明申请

US20090181937A1 CROSS-LINKED FATTY ACID-BASED BIOMATERIALS 有权
标题翻译：交联的基于脂肪酸的生物材料
公开(公告)号：US20090181937A1
公开(公告)日：2009-07-16
申请号：US12325546
申请日：2008-12-01
申请人： Keith M. Faucher , Hui Tang , Joseph Ferraro , Paul Martakos , Steve A. Herweck , Theodore Karwoski , Scott E. Corbeil
发明人： Keith M. Faucher , Hui Tang , Joseph Ferraro , Paul Martakos , Steve A. Herweck , Theodore Karwoski , Scott E. Corbeil
IPC分类号： A61K31/20 , A61K31/395 , A61P41/00
CPC分类号： A61L31/08 , A61K31/225 , A61K31/355 , A61L29/08 , A61L29/16 , A61L31/148 , A61L31/16 , A61L2300/22
摘要： Fatty acid-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.
摘要翻译：描述了脂肪酸衍生的生物材料，制备生物材料的方法以及将其用作药物递送载体的方法。脂肪酸衍生的生物材料可以单独使用或与医疗装置组合使用以释放和局部递送一种或多种治疗剂。还提供了形成和调整所述生物材料的性质的方法以及使用所述生物材料治疗哺乳动物的损伤的方法。

63. 发明申请

US20080109017A1 Barrier layer with underlying medical device and one or more reinforcing support structures 有权
标题翻译：具有底层医疗装置和一个或多个加强支撑结构的阻隔层
公开(公告)号：US20080109017A1
公开(公告)日：2008-05-08
申请号：US11701799
申请日：2007-02-02
申请人： Steve A. Herweck , Joseph Ferraro , Paul Martakos , Theodore Karwoski , Anthony Richard Horton
发明人： Steve A. Herweck , Joseph Ferraro , Paul Martakos , Theodore Karwoski , Anthony Richard Horton
IPC分类号： A61F2/02
CPC分类号： A61L31/145 , A61F2/0063 , A61F2/82 , A61F2002/0086 , A61F2002/009 , A61L31/16 , A61L2300/41 , A61L2300/606
摘要： A barrier layer device is formed of an underlying biocompatible structure having a barrier layer coating that can exhibit anti-inflammatory properties, non-inflammatory properties, and/or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. As implemented herein, the barrier layer is a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The underlying structure can be in the form of a surgical mesh. The barrier device is further provided with anchoring reinforcements to aid with the fastening of the barrier device for implantation purposes and reinforcing truss sections or portions that prohibit or substantially reduce the occurrence of excessive stretching and tearing. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.
摘要翻译：阻挡层装置由潜在的生物相容性结构形成，该结构具有可显示抗炎性质，非炎症性质和/或粘附限制性质的阻隔层涂层，并且对损伤的组织产生调节的愈合作用。如本文所实施的，阻挡层是至少部分地由脂肪酸化合物衍生的非聚合交联凝胶，并且可以包括治疗剂。底层结构可以是手术网的形式。隔离装置还设置有锚固加强件，以帮助阻挡装置的固定用于植入目的，并且加强桁架部分或部分，其禁止或基本上减少过度拉伸和撕裂的发生。阻挡装置可植入患者体内用于短期或长期应用，并且可包括治疗剂的受控释放。

64. 发明授权

US06395208B1 Method of making an expandable fluoropolymer device 有权
标题翻译：制造可膨胀氟聚合物装置的方法
公开(公告)号：US06395208B1
公开(公告)日：2002-05-28
申请号：US09410329
申请日：1999-10-01
申请人： Steve A. Herweck , Peter H. Gingras , Paul Martakos , Theodore Karwoski
发明人： Steve A. Herweck , Peter H. Gingras , Paul Martakos , Theodore Karwoski
IPC分类号： B29C4904
CPC分类号： B29C55/24 , A61L29/041 , A61M25/10 , B29C47/00 , B29C47/0023 , B29C47/0026 , B29C2049/465 , B29K2027/18 , B29L2022/022 , B29L2031/753 , B32B2305/026 , C08L27/18
摘要： A method of making a radially expandable device having a body constructed of a generally inelastic, expanded fluoropolymer material. The body is deployable upon application of a radial expansion force from a reduced diameter, collapsed configuration to an expanded configuration having a pre-defined and fixed increased diameter. The body has a singular, unitary construction of generally homogenous material that is characterized by a seamless construction of expanded fluoropolymer material, such as expanded polytetrafluoroethylene (ePTFE), and is preferably constructed through an extrusion and expansion process. The body is further characterized by a microstructure of nodes interconnected by fibrils in which substantially all the nodes of the body are oriented generally perpendicularly to the longitudinal axis of the body. The monolithic construction of the body and the orientation of the nodes, perpendicular to the longitudinal axis of the body, yields a radially expandable device that predictably and dependably expands to a predefined, fixed maximum diameter that is generally independent of the expansion force used to radially expand the device.
摘要翻译：一种制造径向可膨胀装置的方法，该装置具有由通常无弹性的膨胀的含氟聚合物材料构成的主体。当径向膨胀力从减小的直径，收缩构型施加到具有预定义和固定的增大直径的膨胀构型时，主体可展开。本体具有通常均匀材料的单一，单一结构，其特征在于扩展的氟聚合物材料如膨胀聚四氟乙烯（ePTFE）的无缝构造，并且优选通过挤出和膨胀方法构造。身体的特征还在于通过原纤维相互连接的节点的微结构，其中主体的基本上所有的节点大致垂直于身体的纵向轴线定向。身体的整体结构和垂直于身体的纵向轴线的节点的取向产生可预测和可靠地扩展到预定的，固定的最大直径的径向可扩张装置，其通常与用于径向的膨胀力无关展开设备。

65. 发明授权

US5925074A Vascular endoprosthesis and method 失效
公开(公告)号：US5925074A
公开(公告)日：1999-07-20
申请号：US759861
申请日：1996-12-03
申请人： Peter Gingras , Paul Martakos , Theodore Karwoski , Steve A. Herweck
发明人： Peter Gingras , Paul Martakos , Theodore Karwoski , Steve A. Herweck
IPC分类号： A61F2/82 , A61L31/04 , A61F2/06
CPC分类号： A61F2/82 , A61F2/07 , A61L31/048 , A61F2/90 , A61F2/958
摘要： A vascular endoprosthesis is formed of a tubular liner preform with a continuous surface and having a diameter smaller than that of an intended vessel. The liner is inserted to a treatment site, and its sheet material undergoes a radially-directed expansion to a final size that fits the vessel. Insertion and in situ expansion are achieved using a catheter assembly in which either an internal stent, such as a stiff-filament helically woven tube, or an inflatable balloon urge the liner preform outwardly against the inner wall of the vessel. The stent, or one or more simple internal snap-rings anchor the expanded liner in place. The expanded liner is porous, or becomes more porous during expansion, and one or more aspects of its porosity are tailored to the intended treatment goal of immobilizing treatment material, isolating cells, or permitting controlled permeation of selected materials.

66. 发明授权

US5411550A Implantable prosthetic device for the delivery of a bioactive material 失效
标题翻译：用于输送生物活性材料的植入式假体装置
公开(公告)号：US5411550A
公开(公告)日：1995-05-02
申请号：US109103
申请日：1993-08-19
申请人： Steve A. Herweck , Theodore Karwoski , Paul Martakos
发明人： Steve A. Herweck , Theodore Karwoski , Paul Martakos
IPC分类号： A61F2/00 , A61F2/06 , A61L27/16 , A61L27/54 , A61L27/56 , A61F2/04
CPC分类号： A61L27/56 , A61F2/06 , A61L27/16 , A61L27/54 , A61F2250/0067 , A61L2300/602
摘要： An implantable prosthetic device for sustained release of a bioactive material into a fluid flow pathway of a patient comprises a body adapted for attachment to the fluid flow pathway. The body defines a primary lumen for accommodating fluid flow therethrough and at least one secondary lumen at least a portion of which is separated from the primary lumen by a wall sufficiently permeable to permit a bioactive material disposed in the lumen to diffuse through the wall and into the primary lumen. The bioactive material can be either a therapeutic or diagnostic agent. In a particular embodiment of the invention, the device comprises a tubular body consisting of stretched and/or expanded polytetrafluoroethylene and is adapted for attachment to a blood vessel of a patient.
摘要翻译：用于将生物活性材料持续释放到患者的流体流动路径中的可植入假体装置包括适于附接到流体流动路径的主体。主体限定用于容纳流体流动的主腔，以及至少一个第二内腔，其至少一部分与主腔分隔开足够透气的壁，以允许设置在内腔中的生物活性材料通过壁扩散并进入主管腔。生物活性物质可以是治疗剂或诊断剂。在本发明的一个具体实施方案中，该装置包括由拉伸和/或膨胀的聚四氟乙烯组成的管状体，并适于附着于患者的血管。

67. 发明授权

US5370681A Polyumenal implantable organ 失效
标题翻译：多节植入器官
公开(公告)号：US5370681A
公开(公告)日：1994-12-06
申请号：US29990
申请日：1993-03-12
申请人： Steve A. Herweck , Theodore Karwoski , Paul Martakos
发明人： Steve A. Herweck , Theodore Karwoski , Paul Martakos
IPC分类号： A61F2/00 , A61F2/06 , A61L27/16 , A61L27/54 , A61L27/56 , A61F2/02 , A61F2/04
CPC分类号： A61L27/56 , A61F2/06 , A61L27/16 , A61L27/54 , A61F2250/0067 , A61L2300/252 , A61L2300/414 , A61L2300/602
摘要： A polylumenal implantable device comprises a body defining a plurality of capillary lumina. The prosthetic device is suitable for implantation in a patient as an arterial or venous bypass graft or shunt, or intra-organ implant as well as other purposes. The improved prosthetic device has increased surface area and preferably a three-dimensional porosity for encouraging the harboring of, for example, endothelial cells, as well as for receiving organized deposition of material such as genetically enhanced cell types. A method for providing a bioactive material to a patient includes the steps of providing a polyluminal implantable organ comprising an implantable body defining a plurality of capillary lumina, treating the interior surfaces of the lumina with a bioactive material or plasma polymerization, and implanting the prosthetic device in the patient so that bodily fluids of the patient come into contact with the treated interior surfaces.
摘要翻译：聚烯烃可植入装置包括限定多个毛细管腔的主体。假体装置适于作为动脉或静脉旁路移植物或分流器，或器官内植入物以及其他目的植入患者体内。改进的假体装置具有增加的表面积，并且优选地具有用于鼓励例如内皮细胞的保留的三维孔隙，以及用于接收诸如遗传增强细胞类型的材料的有组织沉积。用于向患者提供生物活性材料的方法包括以下步骤：提供包含限定多个毛细管腔的可植入体的多腔可植入器官，用生物活性材料或等离子体聚合处理腔的内表面，以及植入假体装置在患者体内使患者的体液与被处理的内表面接触。

68. 发明授权

US5320100A Implantable prosthetic device having integral patency diagnostic indicia 失效
标题翻译：具有整体通畅诊断标记的可植入假体装置
公开(公告)号：US5320100A
公开(公告)日：1994-06-14
申请号：US29982
申请日：1993-03-12
申请人： Steve A. Herweck , Theodore Karwoski , Paul Martakos
发明人： Steve A. Herweck , Theodore Karwoski , Paul Martakos
IPC分类号： A61F2/00 , A61F2/06 , A61L27/16 , A61L27/54 , A61L27/56 , A61B6/00 , A61B19/00 , A61F2/02
CPC分类号： A61L27/56 , A61F2/06 , A61L27/16 , A61L27/54 , A61F2250/0067 , A61L2300/44 , Y10S623/912
摘要： An implantable prosthetic device comprises a remotely detectible component disposed in the body forming the device for allowing the device to be detected by x-ray, ultrasonic, or MRI imaging. By disposing at least two remotely detectible components in the body of the device, the effective flow diameter provided by the device can be monitored. A method for monitoring a patient having a damaged or dysfunctional vascular pathway includes the steps of implanting in the patient the disclosed prosthetic device and monitoring the patency of the device by x-ray, ultrasonic, MRI, or other form of remote imaging.
摘要翻译：可植入假体装置包括设置在身体中的远程可检测部件，其形成用于允许通过X射线，超声或MRI成像来检测装置的装置。通过在装置的主体中设置至少两个可远程检测的部件，可以监视由装置提供的有效流径。用于监测具有损伤或功能障碍的血管通路的患者的方法包括以下步骤：在患者中植入所公开的假体装置，并通过X射线，超声波，MRI或其它形式的远程成像来监测装置的通畅性。

69. 发明授权

US5192310A Self-sealing implantable vascular graft 失效
标题翻译：自密封植入式血管移植
公开(公告)号：US5192310A
公开(公告)日：1993-03-09
申请号：US760718
申请日：1991-09-16
申请人： Steve A. Herweck , Theodore Karwoski , Paul Martakos
发明人： Steve A. Herweck , Theodore Karwoski , Paul Martakos
IPC分类号： A61F2/00 , A61F2/04 , A61F2/06 , A61L27/16 , A61L27/50 , A61L27/54 , A61L27/56
CPC分类号： A61L27/56 , A61F2/06 , A61L27/16 , A61L27/507 , A61F2/04 , A61F2002/065 , A61F2250/0067
摘要： An implantable self-sealing vascular graft device comprises an implantable tubular body defining a primary lumen and at least one secondary lumen, the lumina sharing a common side wall. The primary lumen is adapted for attachment to the vascular system of the patient to accommodate blood flow therethrough. A non-biodegradable elastomeric material disposed in the secondary lumen permits repeated self-sealing penetrations of a cannula through the elastomeric material and into the primary lumen. A method for repeatedly accessing a patient's vascular system by implanting in the patient the disclosed structure and accessing a patient's vascular system by passing a cannula through the secondary lumen, the common side wall, and into the primary lumen is also disclosed.
摘要翻译：植入式自密封血管移植装置包括限定主腔和至少一个次内腔的可植入管状体，所述腔共享共同的侧壁。主腔适于附接到患者的血管系统以适应血液流过其中。设置在次级内腔中的不可生物降解的弹性体材料允许套管经由弹性体材料重复自密封穿透到主腔内。还公开了一种通过将患者的血管系统通过二次内腔，公共侧壁并进入主内腔而将患者血管系统植入患者体内来重复访问患者血管系统的方法。

70. 发明申请

US20060067975A1 UV cured gel and method of making 有权
公开(公告)号：US20060067975A1
公开(公告)日：2006-03-30
申请号：US11236943
申请日：2005-09-28
申请人： Roger Labrecque , Philip McNamara , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck , Keith Faucher , Thomas Swanick
发明人： Roger Labrecque , Philip McNamara , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck , Keith Faucher , Thomas Swanick
IPC分类号： A61L33/00 , A61F2/00 , A61K9/14 , B05D3/00
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A method of UV curing and corresponding resulting non-polymeric cross-linked gel are provided. The cross-linked gel can be combined with a medical device structure. The cross-linked gel can provide anti-adhesion characteristics, in addition to improved healing and anti-inflammatory response. The cross-linked gel is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel derived from at least one fatty acid compound. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent. The curing method can vary the application of UV light in both intensity and duration to achieve a desired amount of cross-linking forming the gel.

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