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1. 发明申请

US20050154416A1 Expandable fluoropolymer device for delivery of therapeutic agents and method of making 有权
标题翻译：用于递送治疗剂的可扩展含氟聚合物装置和制备方法
公开(公告)号：US20050154416A1
公开(公告)日：2005-07-14
申请号：US11068680
申请日：2005-02-28
申请人： Steve Herweck , Peter Gingras , Paul Martakos , Theodore Karwoski
发明人： Steve Herweck , Peter Gingras , Paul Martakos , Theodore Karwoski
IPC分类号： A61F2/958 , A61L29/04 , B29C47/00 , B29C55/24 , A61M29/00
CPC分类号： A61M25/1029 , A61L29/041 , A61M25/10 , A61M2025/0057 , A61M2025/105 , A61M2025/1075 , B29C47/00 , B29C47/0023 , B29C55/24 , B29C2049/465 , B29K2027/18 , B29L2022/022 , B29L2031/753 , B32B2305/026 , C08L27/18
摘要： A method of making a radially expandable fluid delivery device includes providing a tube of biocompatible fluoropolymer material with a predetermined porosity based on an extrusion and expansion forming process, applying a radial expansion force to the tube expanding the tube to a predetermined diameter dimension, and removing the radial expansion force. The tube is radially inelastic while sufficiently pliable to be collapsible and inflatable from a collapsed configuration to an expanded configuration upon introduction of an inflation force, such that the expanded configuration occurs upon inflation to the predetermined diameter dimension. The fluid delivery device is constructed of a microporous, biocompatible fluoropolymer material having a microstructure that can provide a controlled, uniform, low-velocity fluid distribution through the walls of the fluid delivery device to effectively deliver fluid to the treatment site without damaging tissue proximate the walls of the device.
摘要翻译：一种制造可径向膨胀的流体递送装置的方法包括：基于挤出和膨胀成形方法提供具有预定孔隙率的生物相容性氟聚合物材料管，向扩管管的管施加径向膨胀力至预定直径尺寸，径向膨胀力。该管是径向无弹性的，同时在引入膨胀力时足够柔软地可从折叠构型膨胀到膨胀构型，使得膨胀构型在膨胀到预定直径尺寸时发生。流体输送装置由具有微结构的微孔生物相容性含氟聚合物材料构成，微结构可以通过流体输送装置的壁提供受控的，均匀的低速流体分配，以有效地将流体输送到治疗部位，而不会损伤邻近的设备的墙壁。

2. 发明申请

US20050113687A1 Application of a therapeutic substance to a tissue location using a porous medical device 审中-公开
标题翻译：使用多孔医疗装置将治疗物质施用于组织位置
公开(公告)号：US20050113687A1
公开(公告)日：2005-05-26
申请号：US10943075
申请日：2004-09-15
申请人： Steve Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton
发明人： Steve Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton
IPC分类号： A61B5/05 , A61F2/82 , A61M20060101
CPC分类号： A61M25/10 , A61F2/82 , A61F2/958 , A61F2250/0067 , A61M25/1027 , A61M25/104 , A61M2025/105 , A61M2025/1088
摘要： A non-polymeric or biological coating applied to porous radially expandable interventional medical devices provides uniform drug distribution and permeation of the coating and any therapeutic agents mixed therewith into a targeted treatment area within the body. The coating is sterile, and is capable of being carried by a sterile medical device to a targeted tissue location within the body following radial expansion. The therapeutic coating transfers off the medical device due in part to a biological attraction with the tissue and in part to a physical transference from the medical device to the targeted tissue location in contact with the medical device. Thus, atraumatic local tissue transference delivery is achieved for uniform therapeutic agent distribution and controlled bio-absorption into the tissue after placement within a patient's body with a non-inflammatory coating.
摘要翻译：应用于多孔径向可扩张介入医疗装置的非聚合物或生物涂层提供了涂层和与其混合的任何治疗剂的均匀药物分布和渗透到体内的目标治疗区域。涂层是无菌的，并且能够在径向膨胀后由无菌医疗装置携带到身体内的目标组织位置。治疗涂层部分地由于与组织的生物吸引而部分地转移离开医疗装置，并且部分地从医疗装置到与医疗装置接触的目标组织位置的物理转移。因此，在用非炎性涂层放置在患者体内之后，实现了不均匀的局部组织转移递送，用于均匀的治疗剂分布和对组织的受控生物吸收。

3. 发明申请

US20070084144A1 Packaging and sterilization of medical devices 审中-公开
标题翻译：医疗器械的包装和灭菌
公开(公告)号：US20070084144A1
公开(公告)日：2007-04-19
申请号：US11525328
申请日：2006-09-22
申请人： Roger Labrecque , Suzanne Conroy , Keith Faucher , Thomas Swanick , Paul Martakos , Theodore Karwoski , Steve Herweck , Trevor Carlton
发明人： Roger Labrecque , Suzanne Conroy , Keith Faucher , Thomas Swanick , Paul Martakos , Theodore Karwoski , Steve Herweck , Trevor Carlton
IPC分类号： A61L2/20 , A61L2/07 , A61L2/08 , A61L2/14 , B65B55/02
CPC分类号： A61L2/08 , A61B50/30 , A61B2050/314 , A61F2/0095 , A61F2/82 , A61L2/07 , A61L2/087 , A61L2/14 , A61L2/186 , A61L2/20 , A61L2/206 , A61L2/208 , A61L2/26 , A61L2202/181 , A61L2202/24 , B65B55/16 , B65B55/18
摘要： A method for the sterilization and packaging of a chemically sensitive medical device is provided. The chemically sensitive medical device has a coating derived from fish oil, a vitamin E compound or a combination thereof. The packaging pouch for the chemically sensitive medical device comprises a non-permeable chamber and a gas-permeable header. The sterilizing agent is administered to the packaged chemically sensitive medical device at a temperature of between about 20° C. and 40° C.
摘要翻译：提供了一种杀菌和包装化学敏感性医疗装置的方法。化学敏感性医疗装置具有衍生自鱼油，维生素E化合物或其组合的涂层。用于化学敏感的医疗装置的包装袋包括不可渗透室和透气性头部。灭菌剂在约20℃至40℃的温度下施用于包装的化学敏感性医疗装置。

4. 发明申请

US20070083156A1 Subcutaneous needle connection system 审中-公开
标题翻译：皮下针连接系统
公开(公告)号：US20070083156A1
公开(公告)日：2007-04-12
申请号：US11246462
申请日：2005-10-06
申请人： Rudolph Muto , Steve Herweck
发明人： Rudolph Muto , Steve Herweck
IPC分类号： A61M31/00
CPC分类号： A61M39/0208 , A61M1/285 , A61M1/3661 , A61M2039/0211
摘要： An apparatus for establishing a re-usable, recurring, mechanical connection to an organ within a patient is provided. A subcutaneous needle connection system for providing bidirectional, straight and turbulent-free fluid flow access to a vascular system of a patient includes a housing defining a needle access opening for receiving a needle, a cannula opening in communication with the vascular system and a passageway connecting the needle access opening to the cannula opening. The housing can additionally have a second needle access opening connected to a second cannula opening via a second passageway. The subcutaneous needle connection system allows for blood to be removed from the vascular system via one cannula opening, passed to a hemodialysis system via a needle inserted in an associated needle access opening, treated using the hemodialysis system, and returned to the vascular system via the other needle access opening and associated cannula opening. The implantable needle connection system provides enhanced mechanical stability under the skin, improved fluid flow dynamics, improved needle hole healing potential of the skin, and improved needle edge interfacing to minimize flow turbulence and blood cell trauma during use.
摘要翻译：提供了一种用于建立可再使用的，重复的机械连接到患者体内的器官的装置。用于向患者的血管系统提供双向，直的和无湍流的流体流动的皮下针连接系统包括限定用于接收针的针进入开口的壳体，与血管系统连通的套管开口和连接针入口开口到套管开口。壳体还可以具有经由第二通道连接到第二插管开口的第二针通路口。皮下针连接系统允许通过一个插管开口从血管系统中除去血液，通过插入相关针进入口的针头，通过使用血液透析系统处理的针头传递到血液透析系统，并经由血液透析系统返回到血管系统其他针入口和相关的套管开口。可植入针连接系统在皮肤下提供增强的机械稳定性，改善的流体流动动力学，改善皮肤的针孔愈合能力，以及改进的针边界面，以最小化使用期间的流动湍流和血细胞损伤。

5. 发明申请

US20060079916A1 Body fluid cartridge exchange platform device 审中-公开
公开(公告)号：US20060079916A1
公开(公告)日：2006-04-13
申请号：US11282162
申请日：2005-11-18
申请人： Steve Herweck , Paul Martakos
发明人： Steve Herweck , Paul Martakos
IPC分类号： A61B17/08
CPC分类号： A61M39/0247 , A61M1/285 , A61M1/3653 , A61M1/3659 , A61M1/3661 , A61M2039/0258
摘要： An apparatus for establishing a re-usable, recurring, mechanical connection to an organ within a patient is provided. A body fluid cartridge exchange platform device includes a hollow cartridge platform housing with a first end having an opening. The platform housing can additionally have a second end with a second opening. The first opening and the second opening facilitate insertion of an exchange cartridge insert that sealably engages the housing. The first opening and the second opening additionally facilitate removal of the exchange cartridge insert. The exchange cartridge insert can facilitate a flow path between a first leg and a second leg of the platform housing, and can facilitate a flow path between the platform housing and an external location for medical procedure or drug delivery purposes.

6. 发明申请

US20060067977A1 Pre-dried drug delivery coating for use with a stent 审中-公开
标题翻译：用于支架的预干燥药物递送涂层
公开(公告)号：US20060067977A1
公开(公告)日：2006-03-30
申请号：US11239555
申请日：2005-09-28
申请人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck , Suzanne Conroy , Brian Sunter , Georgette Henrich
发明人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck , Suzanne Conroy , Brian Sunter , Georgette Henrich
IPC分类号： A61F2/00
CPC分类号： A61L31/08 , A61F2/82 , A61F2/86 , A61F2250/0067 , A61K47/10 , A61K47/22 , A61K47/44 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/22 , A61L2300/416 , A61L2300/428 , A61L2300/45 , A61L2300/606 , A61L2300/802 , A61L2420/02 , A61M25/0009 , A61M25/0045
摘要： A method and apparatus for the provision of a coating for application to a medical device results in a medical device having a bio-absorbable coating. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a therapeutic agent component and solvent can also be provided. The solvent is removed from the coating before the coating is applied to the medical device. The coated medical device is implantable in a patient to effect controlled delivery of the coating, including the therapeutic agent, to the patient.
摘要翻译：提供用于医疗装置的涂层的方法和装置导致具有生物可吸收涂层的医疗装置。涂层包括生物吸收载体组分。除了生物吸收性载体成分之外，还可以提供治疗剂成分和溶剂。在将涂层施加到医疗装置之前，从涂层中除去溶剂。涂覆的医疗装置可植入患者体内以实现对包括治疗剂在内的涂层的可控输送。

7. 发明申请

US20070071798A1 Perforated bioabsorbable oil film and methods for making the same 有权
标题翻译：穿孔生物可吸收油膜及其制造方法
公开(公告)号：US20070071798A1
公开(公告)日：2007-03-29
申请号：US11525390
申请日：2006-09-22
申请人： Steve Herweck , Thomas Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Keith Faucher , Philip McNamara , Roger Labrecque , Suzanne Conroy , Trevor Carlton
发明人： Steve Herweck , Thomas Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Keith Faucher , Philip McNamara , Roger Labrecque , Suzanne Conroy , Trevor Carlton
IPC分类号： A61K9/70
CPC分类号： B65B55/18 , A61B2017/00004 , A61B2017/320044 , A61B2090/0816 , A61F2/0059 , A61F2/0095 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/14 , A61L2/186 , A61L2/206 , A61L2/208 , A61L31/00 , A61L31/145 , A61L31/148 , A61L2202/24 , B26F1/18 , B29C39/02 , B65B31/04 , Y10T83/0481
摘要： A bio-absorbable stand-alone film is derived at least in part from fatty acids. The bio-absorbable stand-alone film can have anti-adhesive, anti-inflammatory, non-inflammatory, and wound healing properties, and can additionally include one or more therapeutic agents incorporated therein. The stand-alone film has one or more perforations or depressions formed therein. Corresponding methods of making the bio-absorbable stand-alone film with one or more perforations or depressions include molding, cutting, carving, puncturing or otherwise suitable methods to create the perforations or depressions in the bio-absorbable stand-alone film. The resulting stand-alone film is bioabsorbable.
摘要翻译：生物可吸收的独立膜至少部分地由脂肪酸衍生。生物吸收性独立膜可以具有抗粘连性，抗炎性，非炎性和伤口愈合性，并且还可以包括一种或多种掺入其中的治疗剂。独立膜具有形成在其中的一个或多个穿孔或凹陷。使具有一个或多个穿孔或凹陷的生物吸收性独立薄膜的相应方法包括成型，切割，雕刻，穿刺或以其它方式适当地在生物吸收性独立薄膜中产生穿孔或凹陷的方法。所得到的独立膜是生物可吸收的。

8. 发明申请

US20060088596A1 Solubilizing a drug for use in a coating 审中-公开
标题翻译：溶解用于涂层的药物
公开(公告)号：US20060088596A1
公开(公告)日：2006-04-27
申请号：US11236977
申请日：2005-09-28
申请人： Roger Labrecque , Geoffrey Moodie , Lisa Rogers , Joseph Ferraro , Theodore Karwoski , Steve Herweck , Paul Martakos
发明人： Roger Labrecque , Geoffrey Moodie , Lisa Rogers , Joseph Ferraro , Theodore Karwoski , Steve Herweck , Paul Martakos
IPC分类号： A61K9/28 , A61K9/24 , B05D3/00
CPC分类号： A61L31/08 , A61F2/82 , A61F2/86 , A61F2250/0067 , A61K47/10 , A61K47/22 , A61K47/44 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/22 , A61L2300/416 , A61L2300/428 , A61L2300/45 , A61L2300/606 , A61L2300/802 , A61L2420/02 , A61M25/0009 , A61M25/0045
摘要： A method for the provision of a coating on an implantable medical device results in a medical device having a bio-absorbable coating. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a dissolved therapeutic agent component can also be provided. The coated medical device is implantable in a patient to effect controlled delivery of the coating, including the dissolved therapeutic agent, to the patient.
摘要翻译：在可植入医疗装置上提供涂层的方法导致具有生物可吸收涂层的医疗装置。涂层包括生物吸收载体组分。除了生物吸收性载体成分之外，还可以提供溶解的治疗剂成分。涂覆的医疗装置可植入患者体内以实现对包括溶解的治疗剂在内的包衣的控制递送。

9. 发明申请

US20060083768A1 Method of thickening a coating using a drug 审中-公开
标题翻译：使用药物增稠涂层的方法
公开(公告)号：US20060083768A1
公开(公告)日：2006-04-20
申请号：US11238564
申请日：2005-09-28
申请人： Roger Labrecque , Geoffrey Moodie , Suzanne Conroy , Lisa Rogers , Joseph Ferraro , Theodore Karwoski , Steve Herweck , Paul Martakos
发明人： Roger Labrecque , Geoffrey Moodie , Suzanne Conroy , Lisa Rogers , Joseph Ferraro , Theodore Karwoski , Steve Herweck , Paul Martakos
IPC分类号： A61F2/00 , A61K48/00
CPC分类号： A61L31/08 , A61F2/07 , A61F2/885 , A61F2/90 , A61F2002/065 , A61F2002/075 , A61L31/10 , A61L31/16 , A61L2300/606 , A61L2300/802
摘要： A method for the provision of a coating on an implantable medical device results in a medical device having a bio-absorbable coating. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a dissolved therapeutic agent component can also be provided. The coated medical device is implantable in a patient to effect controlled delivery of the coating, including the dissolved therapeutic agent, to the patient.
摘要翻译：在可植入医疗装置上提供涂层的方法导致具有生物可吸收涂层的医疗装置。涂层包括生物吸收载体组分。除了生物吸收性载体成分之外，还可以提供溶解的治疗剂成分。涂覆的医疗装置可植入患者体内以实现对包括溶解的治疗剂在内的包衣的控制递送。

10. 发明申请

US20060078586A1 Barrier layer 有权
标题翻译：屏障层
公开(公告)号：US20060078586A1
公开(公告)日：2006-04-13
申请号：US11237420
申请日：2005-09-28
申请人： Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck , Keith Faucher , Philip McNamara
发明人： Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck , Keith Faucher , Philip McNamara
IPC分类号： A61F2/00
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A barrier layer and corresponding method of making provide anti-inflammatory, non-inflammatory, and anti-adhesion functionality for a medical device implantable in a patient. The barrier layer can be combined with a medical device structure to provide anti-adhesion characteristics, in addition to improved healing, non-inflammatory, and anti-inflammatory response. The barrier layer is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent.
摘要翻译：阻挡层和相应的制备方法为可植入患者体内的医疗装置提供抗炎，非炎症和抗粘附功能。除了改善的愈合，非炎性和抗炎反应之外，阻挡层可以与医疗装置结构组合以提供抗粘附特性。阻挡层通常由天然存在的油或由天然存在的油的一部分形成的油组合物形成，其至少部分固化形成交联凝胶。此外，油组合物可以包括治疗剂组分，例如药物或其它生物活性剂。

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