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61. 发明授权

US06676689B2 Inflatable catheter for selective organ heating and cooling and method of using the same 有权
公开(公告)号：US06676689B2
公开(公告)日：2004-01-13
申请号：US10096240
申请日：2002-03-11
申请人： John D. Dobak, III , Juan C. Lasheras
发明人： John D. Dobak, III , Juan C. Lasheras
IPC分类号： A61F700
CPC分类号： A61F7/12 , A61B18/02 , A61B2017/00292 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61F2007/0056 , A61F2007/126
摘要： A catheter system and method are provided which change the temperature of a fluid, such as blood, by heat transfer. Selective cooling or heating of an organ may be performed by changing the temperature of the blood feeding the organ. The catheter system includes an inlet lumen and an outlet lumen structured and arranged to carry a working fluid having a temperature different from the adjacent blood. The outlet lumen is configured to induce turbulence in the adjacent fluid passing adjacent the outlet lumen.

62. 发明授权

US06491039B1 Medical procedure 有权
标题翻译：医疗程序
公开(公告)号：US06491039B1
公开(公告)日：2002-12-10
申请号：US09539932
申请日：2000-03-31
申请人： John D. Dobak, III
发明人： John D. Dobak, III
IPC分类号： A61B1900
CPC分类号： A61B18/02 , A61B2017/00292 , A61B2018/0212 , A61B2018/0262 , A61F7/12 , A61F7/123 , A61F2007/0056 , A61F2007/0288 , A61F2007/126
摘要： The use of an intravascular cooling element to induce hypothermia in connection with a medical procedure. According to a first aspect of the present, invention, a coronary bypass procedure is conducted in which a patient's blood is oxygenated with the patient's lungs and in which blood is circulated using the patient's heart or using an intracorporeal pump. The procedure preferably comprises: (a) positioning a heat transfer element in a blood vessel of a patient; (b) cooling the body of the patient to less than 35° C., more preferably 32±° C., using the heat transfer element; and (c) forming a fluid communicating graft between an arterial blood supply and the coronary artery. The body of the patient is preferably heated to about 37° C. using the heat transfer element subsequent to the step of forming the fluid communicating graft. According to a further aspect of the invention, a hypothermic medical procedure is provided while a patient is in a conscious or semiconscious state, comprising (a) administering a beta-blocking drug to the patient; (b) delivering a heat transfer element to a blood vessel of the patient; and (c) cooling a region of the patient or the body of the patient to less than 35° C. using the heat transfer element.
摘要翻译：使用血管内冷却元件诱导与医疗过程相关的体温过低。根据本发明的第一方面，进行冠状动脉旁路手术，其中患者的血液与患者的肺充氧，并且使用患者的心脏或使用体内泵循环血液。该方法优选包括：（a）将热传递元件定位在患者的血管中; （b）使用传热元件将患者的身体冷却至小于35℃，更优选32±℃; 和（c）在动脉血液供应和冠状动脉之间形成流体连通的移植物。优选在形成流体连通移植物的步骤之后，使用传热元件将患者的身体加热至约37℃。根据本发明的另一方面，在患者处于有意识或半自觉状态时提供低温医疗程序，其包括（a）向患者施用β-阻断药物; （b）将传热元件输送到患者的血管; 和（c）使用传热元件将患者或患者体内的区域冷却至小于35℃。

63. 发明授权

US06468296B1 Method for low temperature thrombolysis and low temperature thrombolytic agent with selective organ temperature control 有权
标题翻译：低温溶栓治疗方法及选择性器官温度控制低温溶栓剂
公开(公告)号：US06468296B1
公开(公告)日：2002-10-22
申请号：US09714749
申请日：2000-11-16
申请人： John D. Dobak, III , Juan C. Lasheras
发明人： John D. Dobak, III , Juan C. Lasheras
IPC分类号： A61F700
CPC分类号： A61F7/12 , A61B18/02 , A61B2017/00292 , A61B2018/0022 , A61B2018/0212 , A61B2018/0281 , A61F2007/0056 , A61F2007/126 , A61M25/00 , A61M25/0023 , A61M2025/0004 , A61M2025/006 , A61M2205/3606
摘要： The invention provides a method for substantially reducing the size of a thrombus in a blood vessel in which blood is flowing. The method includes delivering a heat transfer element to a blood vessel in fluid communication with a thrombosed blood vessel. The temperature of the heat transfer element is adjusted such that the same is sufficient to remove heat from the flowing blood. Heat is transferred from a volume including the thrombus to the heat transfer element. In a separate embodiment, heat may be delivered to the volume including the thrombus from the heat transfer element. The resultant temperature of the volume may be sufficient to substantially reduce the size of a thrombus. For example, the resultant temperature of the volume may be sufficiently high to substantially enhance plasminogen activation near the thrombus. In a separate embodiment, a therapeutic drug may be delivered to the blood vessel to further reduce the size of a thrombus, the drug having an optimal temperature at the hypothermic or hyperthermic temperature of the blood.
摘要翻译：本发明提供了一种用于在血液流动的血管中显着减少血栓的大小的方法。该方法包括将传热元件输送到与血栓血管流体连通的血管。调节传热元件的温度，使其相当于从流动的血液中除去热量。热量从包括血栓的体积传递到传热元件。在单独的实施例中，可以将热量从传热元件输送到包括血栓的体积。体积的最终温度可足以显着减小血栓的大小。例如，体积的最终温度可能足够高以基本上增加血栓附近的纤溶酶原激活。在单独的实施方案中，可将治疗药物递送至血管，以进一步减小血栓的大小，所述药物在血液的低温或高热温度下具有最佳温度。

64. 发明授权

US06261312B1 Inflatable catheter for selective organ heating and cooling and method of using the same 有权
公开(公告)号：US06261312B1
公开(公告)日：2001-07-17
申请号：US09215038
申请日：1998-12-16
申请人： John D. Dobak, III , Juan C. Lasheras
发明人： John D. Dobak, III , Juan C. Lasheras
IPC分类号： A61F700
CPC分类号： A61F7/12 , A61B18/02 , A61B2017/00292 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61F2007/0056 , A61F2007/126
摘要： A catheter system and method are provided which change the temperature of a fluid, such as blood, by heat transfer. Selective cooling or heating of an organ may be performed by changing the temperature of the blood feeding the organ. The catheter system includes an inlet lumen and an outlet lumen structured and arranged to carry a working fluid having a temperature different from the adjacent blood. The outlet lumen is configured to induce turbulence in the adjacent fluid passing adjacent the outlet lumen.

65. 发明授权

US06238428B1 Selective organ cooling apparatus and method employing turbulence-inducing element with curved terminations 有权
标题翻译：选择性器官冷却装置和采用具有弯曲终端的湍流诱发元件的方法
公开(公告)号：US06238428B1
公开(公告)日：2001-05-29
申请号：US09246514
申请日：1999-02-09
申请人： Randell L. Werneth , John D. Dobak, III , Juan C. Lasheras
发明人： Randell L. Werneth , John D. Dobak, III , Juan C. Lasheras
IPC分类号： A61F700
CPC分类号： A61B18/02 , A61B2017/00292 , A61B2018/0212 , A61B2018/0281 , A61F7/12 , A61F2007/0056 , A61F2007/126
摘要： A selective organ heat transfer device with deep irregularities in a turbulence-inducing exterior surface. The device can have a plurality of elongated, articulated segments, each having a turbulence-inducing exterior surface. A flexible joint connects adjacent elongated, articulated segments. An inner lumen is disposed within the heat transfer segments. The inner lumen is capable of transporting a pressurized working fluid to a distal end of the heat transfer element. The irregularities may be grooves, and the grooves have a curved termination point which directs blood along a direction having a component perpendicular to the axis of the segments, thereby enhancing turbulence and heat transfer.
摘要翻译：湍流诱导外表面具有深度不规则的选择性器官传热装置。该装置可以具有多个细长的关节节段，每个节段具有引起湍流的外表面。柔性接头连接相邻的细长铰接段。内腔设置在传热段内。内腔能够将加压工作流体输送到传热元件的远端。凹凸可以是凹槽，并且凹槽具有弯曲的终止点，其将血液沿着具有垂直于段的轴线的分量的方向引导，从而增强湍流和热传递。

66. 发明授权

US06231595B1 Circulating fluid hypothermia method and apparatus 失效
公开(公告)号：US06231595B1
公开(公告)日：2001-05-15
申请号：US09052545
申请日：1998-03-31
申请人： John D. Dobak, III
发明人： John D. Dobak, III
IPC分类号： A61F700
CPC分类号： A61F7/12 , A61B2018/0212 , A61B2018/0262 , A61F2007/0056 , A61F2007/126
摘要： A method and apparatus for performing hypothermia of a selected organ without significant effect on surrounding organs or other tissues. A flexible coaxial catheter is inserted through the vascular system of a patient to place the distal tip of the catheter in an artery feeding the selected organ. A chilled perfluorocarbon fluid is pumped through an insulated inner supply conduit of the catheter to cool a flexible bellows shaped heat transfer element in the distal tip of the catheter. The heat transfer bellows cools the blood flowing through the artery, to cool the selected organ, distal to the tip of the catheter.

67. 发明授权

US06224624B1 Selective organ cooling apparatus and method 有权
标题翻译：选择性器官冷却装置及方法
公开(公告)号：US06224624B1
公开(公告)日：2001-05-01
申请号：US09291824
申请日：1999-04-14
申请人： Juan C. Lasheras , Randell L. Werneth , John D. Dobak, III
发明人： Juan C. Lasheras , Randell L. Werneth , John D. Dobak, III
IPC分类号： A61F700
CPC分类号： A61F7/12 , A61F2007/0056 , A61F2007/126
摘要： The present invention involves a selective organ heat transfer device having a flexible coaxial catheter capable of insertion into a selected feeding artery in the vascular system of a patient. A heat transfer element is attached to a distal portion of the catheter as well as a turbulence-enhancing element which is adapted to enhance turbulent blood flow along the heat transfer element. The heat transfer element may include the turbulence-enhancing element and/or a turbulence-enhancing element may be located proximal of the heat transfer element.
摘要翻译：本发明涉及一种选择性器官传热装置，其具有能够插入患者血管系统中的选定进食动脉的柔性同轴导管。传热元件附接到导管的远端部分以及湍流增强元件，其适于增强沿着传热元件的湍流血流。传热元件可以包括湍流增强元件和/或湍流增强元件可以位于传热元件的近侧。

68. 发明授权

US06096068A Selective organ cooling catheter and method of using the same 失效
标题翻译：选择性器官冷却导管及其使用方法
公开(公告)号：US06096068A
公开(公告)日：2000-08-01
申请号：US103342
申请日：1998-06-23
申请人： John D. Dobak, III , Juan C. Lasheras
发明人： John D. Dobak, III , Juan C. Lasheras
IPC分类号： A61B17/00 , A61B18/02 , A61F7/00 , A61F7/12
CPC分类号： A61B18/02 , A61F7/12 , A61B2017/00292 , A61B2018/0212 , A61B2018/0262 , A61F2007/0056 , A61F2007/126 , A61F7/0085
摘要： A heat transfer device has first and second elongated, articulated segments, each having a turbulence-inducing exterior surface. A flexible joint connects the first and second elongated, articulated segments. An inner coaxial lumen is disposed within the first and second elongated, articulated segments. The inner coaxial lumen is capable of transporting a pressurized working fluid to a distal end of the first elongated, articulated segment.
摘要翻译：传热装置具有第一和第二细长的铰接段，每个段具有湍流诱导外表面。柔性接头连接第一和第二细长铰接段。内部同轴的内腔设置在第一和第二细长的关节部分内。内同轴内腔能够将加压工作流体输送到第一细长铰接段的远端。

69. 发明授权

US06035657A Flexible catheter cryosurgical system 有权
标题翻译：柔性导管冷冻手术系统
公开(公告)号：US06035657A
公开(公告)日：2000-03-14
申请号：US287669
申请日：1999-04-07
申请人： John D. Dobak, III , Ray Radebaugh , Eric Marquardt
发明人： John D. Dobak, III , Ray Radebaugh , Eric Marquardt
IPC分类号： F28F7/00 , A61B18/02 , C09K5/04 , F25B9/00 , F25B9/02 , F28D7/02 , F28D7/12 , F28F13/06 , F28F21/08 , F25D3/00
CPC分类号： C09K5/045 , A61B18/02 , F25B9/006 , F25B9/02 , F28D7/12 , F28F13/06 , F28F21/082 , F28F21/085 , A61B2018/0212 , A61B2018/0275 , A61B2018/0281 , C09K2205/12 , C09K2205/122 , C09K2205/13 , C09K2205/132 , F25B2309/003 , F25B2309/021 , F25B2309/022 , F25B2309/023 , F25B2400/12 , F28F2260/02
摘要： A microminiature laminated heat exchanger for use in a cryogenic probe, and a method of manufacture. The heat exchanger has high and low pressure flow patterns etched into oxygen free copper sheets, with the flow patterns being tortuous paths promoting turbulent flow. The sheets containing the flow patterns are bonded into a laminated assembly in the shape of a cylinder, with a high pressure inlet and a low pressure outlet in a first end, and a high pressure outlet and a low pressure inlet in a second end. The high pressure flow path lies alongside the low pressure flow path, with flow in the two paths being in opposite directions, to accomplish counterflow heat exchange.
摘要翻译：用于低温探针的微型层压热交换器及其制造方法。热交换器具有蚀刻成无氧铜片的高压和低压流动图案，其中流动模式是促进湍流的曲折路径。含有流动图案的片材以气缸的形式结合到层压组件中，在第一端具有高压入口和低压出口，在第二端中具有高压出口和低压入口。高压流动路径位于低压流动路径旁边，两条路径中的流动处于相反的方向，以实现逆流热交换。

70. 发明授权

US08157794B2 Method and device for performing cooling-or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation 有权
标题翻译：用于进行冷冻或低温治疗的方法和装置，例如血管成形术，减少再狭窄或肺静脉细胞坏死以抑制心房颤动
公开(公告)号：US08157794B2
公开(公告)日：2012-04-17
申请号：US11978888
申请日：2007-10-30
申请人： John D. Dobak, III , Hans W. Kramer , Steven A. Yon
发明人： John D. Dobak, III , Hans W. Kramer , Steven A. Yon
IPC分类号： A61B18/02
CPC分类号： A61F7/12 , A61B18/02 , A61B2017/22002 , A61B2017/22054 , A61B2018/00023 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61F2007/126
摘要： The present invention provides an enhanced method and device to inhibit or reduce the rate of restenosis following angioplasty or stent placement. The invention involves placing a balloon tipped catheter in the area treated or opened through balloon angioplasty immediately following angioplasty. The balloon, which can have a dual balloon structure, may be delivered through a guiding catheter and over a guidewire already in place from a balloon angioplasty. A fluid such as a perfluorocarbon may be flowed into the balloon to freeze the tissue adjacent the balloon, this cooling being associated with reduction of restenosis. The catheter may also be used to reduce atrial fibrillation by inserting and inflating the balloon such that an exterior surface of the balloon is in contact with at least a partial circumference of the portion of the pulmonary vein adjacent the left atrium.
摘要翻译：本发明提供了抑制或降低血管成形术或支架放置后再狭窄发生率的增强方法和装置。本发明涉及将气囊顶端的导管放置在血管成形术后立即通过球囊血管成形术处理或打开的区域中。可以具有双气囊结构的气囊可以通过引导导管并且已经从球囊血管成形术已经就位的导线传送。诸如全氟化碳的流体可以流入气囊中以冷冻邻近球囊的组织，这种冷却与再狭窄的减少有关。导管还可用于通过插入和充气气囊来减少心房颤动，使得球囊的外表面与邻近左心房的肺静脉部分的至少部分圆周接触。

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