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61. 发明申请

US20100093623A1 COMPOSITIONS AND METHODS FOR MODULATING NOD-LIKE RECEPTOR ACTIVITY AND USES THEREOF 审中-公开
标题翻译：用于调节NOD样受体活性的组合物和方法及其用途
公开(公告)号：US20100093623A1
公开(公告)日：2010-04-15
申请号：US12504649
申请日：2009-07-16
申请人： John C. Reed , Benjamin Faustin , Arnold Satterthwait
发明人： John C. Reed , Benjamin Faustin , Arnold Satterthwait
IPC分类号： A61K38/16 , C07K7/06 , C07K7/08 , C07K14/00 , A61P31/04 , C12N9/96 , A61K38/08 , A61K38/10 , A61P29/00 , G01N33/566 , G01N33/53
CPC分类号： C07K14/705
摘要： Disclosed herein are compositions and methods relating to a peptide that inhibits Nod-like Receptors. Further provided are compositions and methods for treating or preventing inflammation, including diseases associated with inflammation such as inflammatory bowel disease, Crohn's disease, ulcerative colitis, arthritis, psoriasis, Alzheimer's disease, cardiovascular disease, diabetes, and sepsis.
摘要翻译：本文公开了与抑制Nod样受体的肽相关的组合物和方法。还提供了用于治疗或预防炎症的组合物和方法，包括与炎症相关的疾病如炎性肠病，克罗恩病，溃疡性结肠炎，关节炎，牛皮癣，阿尔茨海默病，心血管疾病，糖尿病和败血症。

62. 发明授权

US07666607B1 TRAF family proteins 失效
标题翻译： TRAF家族蛋白
公开(公告)号：US07666607B1
公开(公告)日：2010-02-23
申请号：US11788741
申请日：2007-04-20
申请人： Juan M. Zapata , John C. Reed
发明人： Juan M. Zapata , John C. Reed
IPC分类号： G01N33/53 , G01N33/50 , C07K14/00 , C07K16/00
CPC分类号： C07K16/18
摘要： In accordance with the present invention, there are provided novel TRAF-Protein-Binding-Domain polypeptides (TPBDs). The invention also provides nucleic acid molecules encoding TPBDs, vectors containing these nucleic acid molecules and host cells containing the vectors. The invention also provides antibodies that can specifically bind to invention TPBDs. Such TPBDs and/or anti-TPBD antibodies are useful for discovery of drugs that suppress autoimmunity, inflammation, allergy, allograph rejection, sepsis, and other diseases.
摘要翻译：根据本发明，提供了新型TRAF-蛋白结合域多肽（TPBD）。本发明还提供编码TPBD的核酸分子，含有这些核酸分子的载体和含有载体的宿主细胞。本发明还提供可以特异性结合本发明的TPBD的抗体。这样的TPBD和/或抗TPBD抗体可用于发现抑制自身免疫，炎症，过敏，同种异体排斥，败血症和其它疾病的药物。

63. 发明申请

US20090305904A1 APOPTOSIS MODULATOR BCL-B AND METHODS FOR MAKING AND USING SAME 失效
标题翻译：杀虫剂调节剂BCL-B及其制备和使用方法
公开(公告)号：US20090305904A1
公开(公告)日：2009-12-10
申请号：US12426479
申请日：2009-04-20
申请人： John C. Reed , Ning Ke , Adam Godzik
发明人： John C. Reed , Ning Ke , Adam Godzik
IPC分类号： C40B30/04 , C12Q1/68 , C12Q1/02 , C12Q1/37 , G01N33/00 , G01N33/53
CPC分类号： C12N15/8263 , A01K2217/05 , C07K14/4747 , C07K2319/00 , C12N2799/021
摘要： A novel human member of the Bcl-2 family Bcl-B has been identified, which is closest in amino-acid sequence homology to the Boo (Diva) protein. The Bcl-B protein is widely expressed in adult human tissues. The Bcl-B protein modulates apoptosis. Bcl-B also binds Bcl-2. BCl-XL, and Bax but not Bak. Bcl-B displays a unique pattern of selectivity for binding and regulating the function of other members of the Bcl-2 family.
摘要翻译：已经鉴定了Bcl-2家族Bcl-B的新型人类成员，其与Boo（Diva）蛋白质的氨基酸序列同源性最接近。 Bcl-B蛋白在成年人组织中广泛表达。 Bcl-B蛋白调节凋亡。 Bcl-B也结合Bcl-2。 BCl-XL和Bax，但不是Bak。 Bcl-B显示了一种独特的选择性模式，用于结合和调节Bcl-2家族其他成员的功能。

64. 发明申请

US20090215984A1 CONVERSION OF APOPTOTIC PROTEINS 有权
标题翻译：转化蛋白的转化
公开(公告)号：US20090215984A1
公开(公告)日：2009-08-27
申请号：US12364415
申请日：2009-02-02
申请人： John C. Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kumar Kolluri
发明人： John C. Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kumar Kolluri
IPC分类号： C07K14/435 , A61P35/00
CPC分类号： G01N33/5091 , A61K38/1709 , A61K38/177 , C07K16/2857 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5079 , G01N2510/00
摘要： Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members.
摘要翻译：鉴定出调节抗凋亡蛋白（如Bcl-2和Bcl-XL）功能的化合物。这些化合物具有将Bcl-2家族成员蛋白的活性从抗凋亡转化为促凋亡的能力。描述了诱导凋亡的方法，以及用于鉴定通过与Bcl-2家族成员相互作用诱导细胞凋亡的分子的方法。

65. 发明申请

US20090163577A1 METHODS AND COMPOSITIONS FOR ANTAGONIZING ANTI-APOPTOTIC Bcl-2-FAMILY PROTEINS 审中-公开
标题翻译：拮抗抗Bcl-2家族蛋白的方法和组合物
公开(公告)号：US20090163577A1
公开(公告)日：2009-06-25
申请号：US12325315
申请日：2008-12-01
申请人： John C. Reed , Dayong Zhai
发明人： John C. Reed , Dayong Zhai
IPC分类号： A61K31/35 , C12Q1/18 , G01N33/574 , C07D493/02 , A61P35/00
CPC分类号： A61K31/35 , G01N33/57484 , G01N2500/02 , G01N2500/10
摘要： The cytotoxic natural product gambogic acid (GA) competes for BH3 peptide binding sites on several anti-apoptotic members of the Bcl-2 family of proteins and neutralizes the ability of these proteins to suppress release of apoptogenic proteins from isolated mitochondria. Structure-function analysis of GA using analogs suggested a general correlation between BH3 competition and cytoxicity activity. Compositions and methods are provided for using GA and its derivatives for treating cancer and for discovering other compounds that are useful for treating cancer through their interaction with Bcl-2-family proteins.
摘要翻译：细胞毒性天然产物葡萄糖酸（GA）与Bcl-2蛋白家族的几种抗凋亡成员竞争BH3肽结合位点，并中和这些蛋白质抑制细胞凋亡蛋白从分离的线粒体释放的能力。使用类似物的GA的结构功能分析表明BH3竞争与细胞毒性活性之间的一般相关性。提供了使用GA及其衍生物治疗癌症并发现其它可用于通过与Bcl-2家族蛋白质相互作用治疗癌症的化合物的组合物和方法。

66. 发明申请

US20090105319A1 NAPHTHALENE-BASED INHIBITORS OF ANTI-APOPTOTIC PROTEINS 有权
标题翻译：基于萘基的抗微生物蛋白抑制剂
公开(公告)号：US20090105319A1
公开(公告)日：2009-04-23
申请号：US12253918
申请日：2008-10-17
申请人： Maurizio Pellecchia , John C. Reed
发明人： Maurizio Pellecchia , John C. Reed
IPC分类号： A61K31/05 , C07C49/345 , C07C39/14 , C07D417/10 , C07C235/66 , A61K31/428 , A61P29/00 , A61K31/18 , C07C311/29 , A61P35/00 , A61K31/166 , A61K31/12
CPC分类号： C07C39/14 , C07C47/575 , C07C49/83 , C07C49/84 , C07C235/66 , C07C311/29 , C07C2601/08 , C07C2601/14 , C07D277/64
摘要： Methods of using apogossypol and its derivatives for treating inflammation is disclosed. Also, there is described a group of compounds having structure A, or a pharmaceutically acceptable salt, hydrate, N-oxide, or solvate thereof are provided: wherein each R is independently selected from the group consisting of H, C(O)X, C(O)NHX, NH(CO)X, SO2NHX, and NHSO2X, wherein X is selected from the group consisting of an alkyl, a substituted alkyl, an aryl, a substituted aryl, an alkylaryl, and a heterocycle. Compounds of group A may be used for treating various diseases or disorders, such as cancer.
摘要翻译：公开了使用果糖酚及其衍生物治疗炎症的方法。此外，提供了一组具有结构A的化合物或其药学上可接受的盐，水合物，N-氧化物或溶剂合物：其中每个R独立地选自H，C（O）X， C（O）NHX，NH（CO）X，SO2NHX和NHSO2X，其中X选自烷基，取代的烷基，芳基，取代的芳基，烷基芳基和杂环。组A的化合物可用于治疗各种疾病或病症，例如癌症。

67. 发明申请

US20080293699A1 Inhibitors of thapsigargin-induced cell death 审中-公开
标题翻译：毒胡萝卜素诱导的细胞死亡抑制剂
公开(公告)号：US20080293699A1
公开(公告)日：2008-11-27
申请号：US12154544
申请日：2008-05-23
申请人： John C. Reed , In-Ki Kim
发明人： John C. Reed , In-Ki Kim
IPC分类号： A61K31/5513 , C12Q1/02 , C07D243/38 , A61K31/495 , C12N5/02 , A61K31/496 , C07D241/04 , C07D403/10
CPC分类号： C07D243/38 , A61K31/495 , A61K31/496 , A61K31/5513 , C07D295/192 , C07D403/06 , C07D403/10 , C07D513/04 , C12N5/0623 , C12N2503/02
摘要： Methods for screening for inhibitors of endoplasmic reticulum (ER) stress are provided. These methods involve the addition of thapsigargin, which induces ER stress, and a test agent to mammalian cells in multi-well plates. Cell survival can be readily monitored by measuring intracellular ATP content using a bioluminescent reagent. Screening a commercially available library of 50,000 compounds led to the identification of 93 hit compounds that were subjected to secondary assays to confirm their ability to rescue cells from thapsigargin-induced cell death.
摘要翻译：提供了筛选内质网（ER）应激抑制剂的方法。这些方法涉及添加诱导ER应激的毒胡萝卜素，以及多孔板中的哺乳动物细胞的测试试剂。使用生物发光试剂测量细胞内ATP含量可以容易地监测细胞存活。筛选50,000种化合物的商业化库产生93种命中化合物的鉴定，这些化合物进行二次测定，以确认其从毒胡萝卜素诱导的细胞死亡中拯救细胞的能力。

68. 发明授权

US07022831B1 Regulation of BCL-2 gene expression 失效
标题翻译：调节BCL-2基因表达
公开(公告)号：US07022831B1
公开(公告)日：2006-04-04
申请号：US09375514
申请日：1999-08-17
申请人： John C. Reed
发明人： John C. Reed
IPC分类号： C07H21/04 , A61K48/00
CPC分类号： C12N15/1135 , A61K38/00 , A61K45/06 , C12N2310/111 , C12N2310/3125 , C12N2310/315
摘要： The present invention provides novel anticode oligomers and methods of using them for controlling the growth of cancer cells expressing the bcl-2 gene.
摘要翻译：本发明提供了新的抗交联低聚物及其用于控制表达bcl-2基因的癌细胞生长的方法。

69. 发明授权

US06818750B2 Card proteins involved in cell death regulation 失效
标题翻译：卡蛋白参与细胞死亡调节
公开(公告)号：US06818750B2
公开(公告)日：2004-11-16
申请号：US09388221
申请日：1999-09-01
申请人： John C. Reed
发明人： John C. Reed
IPC分类号： C07H2104
CPC分类号： C07K14/4747 , A01K2217/05 , A61K38/00 , A61K2039/505 , C07K2319/00
摘要： The present invention provides NB-ARC and CARD-containing proteins (NACs), nucleic acid molecules encoding NACs and antibodies specific for at least one NAC. The invention further provides chimeric NAC proteins. The invention also provides screening assays for identifying an agent that can effectively alter the association of a NAC with a NAC-associated protein. The invention further provides methods of modulating apoptosis in a cell by introducing into the cell a nucleic acid molecule encoding a NAC or an antisense nucleotide sequence. The invention also provides a method of using a reagent that can specifically bind to a NAC to diagnose a pathology that is characterized by an increased or decreased level of apoptosis in a cell.
摘要翻译：本发明提供NB-ARC和含CARD蛋白（NAC），编码NAC的核酸分子和对至少一种NAC特异的抗体。本发明还提供了嵌合NAC蛋白。本发明还提供用于鉴定可有效改变NAC与NAC相关蛋白的缔合的试剂的筛选试验。本发明还提供了通过将编码NAC或反义核苷酸序列的核酸分子引入细胞来调节细胞凋亡的方法。本发明还提供了使用可以特异性结合NAC的试剂来诊断细胞凋亡水平升高或降低的病理学的方法。

70. 发明授权

US06265556B1 Nucleic acid encoding CD40 associated proteins 失效
标题翻译：编码CD40相关蛋白的核酸
公开(公告)号：US06265556B1
公开(公告)日：2001-07-24
申请号：US08349357
申请日：1994-12-02
申请人： John C. Reed , Takaaki Sato
发明人： John C. Reed , Takaaki Sato
IPC分类号： C07H2102
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , C07K14/70578 , C07K16/28
摘要： The present invention provides a mammalian CD40-associated protein (CAP), a nucleic acid molecule encoding the CAP and antibodies specific for the CAP. The invention further provides a substantially purified human CAP-1 and a nucleic acid molecule encoding human CAP-1. The invention also provides screening assays for identifying an agent that effectively alters the association of a CAP with a second molecule, which can bind to the CAP. In addition, the invention provides methods for identify a CAP agonist or CAP antagonist that can increase or decrease, respectively, the level of expression of the CAP in a cell. Such an effective agent, agonist or antagonist can modulate a function of a cell such as a humoral immune response or cell growth. The invention also provides methods of detecting a CAP in a sample by detecting the CAP or a nucleic acid molecule encoding the CAP. Such methods can be used to diagnose a pathology that is characterized by an increased or decreased level of a CAP in a cell.
摘要翻译：本发明提供哺乳动物CD40相关蛋白（CAP），编码CAP的核酸分子和对CAP特异的抗体。本发明还提供了基本上纯化的人CAP-1和编码人CAP-1的核酸分子。本发明还提供了用于鉴定有效改变CAP与可与CAP结合的第二分子缔合的试剂的筛选试验。此外，本发明提供了鉴定CAP激动剂或CAP拮抗剂的方法，其可分别增加或减少CAP在细胞中的表达水平。这种有效的药剂，激动剂或拮抗剂可以调节细胞的功能，例如体液免疫应答或细胞生长。本发明还提供了通过检测CAP或编码CAP的核酸分子来检测样品中CAP的方法。这样的方法可用于诊断以细胞中CAP增加或降低水平为特征的病理学。

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