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    • 64. 发明授权
    • Acylaminoquinazoline derivatives and a pharmaceutical composition
containing them
    • 酰氨基喹唑啉衍生物和含有它们的药物组合物
    • US4495188A
    • 1985-01-22
    • US324425
    • 1981-11-24
    • Yasunobu SatoHiroshi FukumiHiroyuki KoikeNobuaki Kitahara
    • Yasunobu SatoHiroshi FukumiHiroyuki KoikeNobuaki Kitahara
    • C07D413/14A61K31/505A61K31/55A61P9/12C07D207/16C07D403/12C07D403/14C07D405/14C07D417/12C07D417/14
    • C07D207/16
    • Acylaminoquinazoline derivatives of formula ##STR1## (in which: R.sup.1 represents a lower alkoxy group, a substituted or unsubstituted lower alkyl group, a cycloalkyl group, a lower alkenyl group, a vinyl group having an optionally substituted phenyl or furyl substituent, an optionally substituted phenyl group, a furyl group, an oxazolyl group, a methylthiooxadiazolyl group or a tetrahydrofuryl group;R.sup.2 represents a hydrogen atom or a lower alkyl group;R.sup.3 represents a lower alkyl group or an optionally substituted phenyl group;R.sup.4 represents a hydrogen atom or an acyloxy-substituted phenyl group;X represents a methylene group or a sulphur atom; andn is 2 or 3)and pharmaceutically acceptable acid addition salts thereof are valuable antihypertensive agents and inhibit the activity of the angiotension I-converting enzyme. They may be prepared by reacting a 4-aminoquinazoline derivative with a carboxylic acid or reactive derivative thereof corresponding to the amide group which it is desired to introduce at the 4- position of said compound of formula (I). The compounds of the invention may be formulated with conventional pharmaceutically acceptable carriers or diluents to provide a pharmaceutical composition.
    • 式(I)的酰氨基喹唑啉衍生物(其中:R1表示低级烷氧基,取代或未取代的低级烷基,环烷基,低级烯基,具有任意取代的苯基或呋喃基取代基的乙烯基, 任选取代的苯基,呋喃基,恶唑基,甲硫基二唑基或四氢呋喃基; R 2表示氢原子或低级烷基; R 3表示低级烷基或任意取代的苯基; R 4表示氢 原子或酰氧基取代的苯基; X表示亚甲基或硫原子; n为2或3)及其药学上可接受的酸加成盐是有价值的抗高血压药,并且抑制血管紧张素I转化酶的活性。 它们可以通过4-氨基喹唑啉衍生物与其中所需的引入式(I)化合物的4-位的酰胺基的羧酸或其反应性衍生物反应来制备。 本发明的化合物可以与常规的药学上可接受的载体或稀释剂配制以提供药物组合物。
    • 65. 发明授权
    • Audio device
    • 音频设备
    • US09047876B2
    • 2015-06-02
    • US13637765
    • 2011-03-25
    • Hiroyuki Koike
    • Hiroyuki Koike
    • H03G5/00G10L21/038
    • G10L21/038
    • Disclosed is an audio device that plays back compressed audio signals that can be sufficiently comfortable to be audible even in a play back environment with improved acoustic quality. In order to correct a weak signal component near a frequency with a high output level of a compressed audio, weak-signal component adding unit (121) extracts a specific frequency region based on input audio signals, generates a weak-signal component composed of harmonics signals composed of a harmonic component and the like, and a noise signal and adds the generated weak-signal component to the input audio signal. In order to correct a high-frequency band output level from which compressed audio signals are omitted, high-frequency band audio adding unit (122) generates audio of a high-frequency band composed of a harmonic signal and a noise signal and adds the generated high-frequency band audio to the input audio signal.
    • 公开了一种音频设备,其播放压缩音频信号,即使在具有改善的声学质量的回放环境中也可以足够舒适地听到声音。 为了在压缩音频的高输出电平的频率附近校正弱信号分量,弱信号分量添加单元(121)基于输入音频信号提取特定频率区域,生成由谐波构成的弱信号分量 由谐波分量等构成的信号和噪声信号,并将生成的弱信号分量与输入音频信号相加。 为了校正省略了压缩音频信号的高频带输出电平,高频带音频添加单元(122)产生由谐波信号和噪声信号组成的高频带的音频,并将所产生的 高频带音频输入音频信号。
    • 66. 发明申请
    • AUDIO DEVICE
    • 音频设备
    • US20130016856A1
    • 2013-01-17
    • US13637765
    • 2011-03-25
    • Hiroyuki Koike
    • Hiroyuki Koike
    • H03G5/00
    • G10L21/038
    • Disclosed is an audio device that plays back compressed audio signals that can be sufficiently comfortable to be audible even in a play back environment with improved acoustic quality. In order to correct a weak signal component near a frequency with a high output level of a compressed audio, weak-signal component adding unit (121) extracts a specific frequency region based on input audio signals, generates a weak-signal component composed of harmonics signals composed of a harmonic component and the like, and a noise signal and adds the generated weak-signal component to the input audio signal. In order to correct a high-frequency band output level from which compressed audio signals are omitted, high-frequency band audio adding unit (122) generates audio of a high-frequency band composed of a harmonic signal and a noise signal and adds the generated high-frequency band audio to the input audio signal.
    • 公开了一种音频设备,其播放压缩音频信号,即使在具有改善的声学质量的回放环境中也可以足够舒适地听到声音。 为了在压缩音频的高输出电平的频率附近校正弱信号分量,弱信号分量添加单元(121)基于输入音频信号提取特定频率区域,生成由谐波构成的弱信号分量 由谐波分量等构成的信号和噪声信号,并将生成的弱信号分量与输入音频信号相加。 为了校正省略了压缩音频信号的高频带输出电平,高频带音频添加单元(122)产生由谐波信号和噪声信号组成的高频带的音频,并将所产生的 高频带音频输入音频信号。
    • 67. 发明授权
    • Travel safety apparatus for vehicle
    • 车辆行驶安全装置
    • US07729858B2
    • 2010-06-01
    • US11511530
    • 2006-08-29
    • Hiroyuki KoikeYoichi SugimotoYoshihiro Urai
    • Hiroyuki KoikeYoichi SugimotoYoshihiro Urai
    • G08G1/16B60R21/00
    • B60W30/08B60W10/06B60W10/10B60W10/18B60W30/09B60W30/095B60W40/04B60W2420/403B60W2420/52B60W2550/20
    • A travel safety apparatus for a vehicle, the apparatus includes: a first detector detecting an object in a first detection area; a second detector detecting the object in a second detection area; a braking device decelerating the vehicle; an alarm device which outputs an alarm to an occupant of the vehicle; a third detector measuring the traveling state of the vehicle; a collision determination device which determines a possibility of a collision between the vehicle and the object based on the traveling state; and a controller which operates at least one of the braking device and the alarm device when there is the possibility of collision, wherein the controller changes at least one of operation timing of the alarm device, operation timing of the braking device, and deceleration degree made by the braking device in accordance with whether or not the first detector and the second detector detect the object.
    • 一种用于车辆的旅行安全装置,该装置包括:第一检测器,检测第一检测区域中的物体; 第二检测器,检测第二检测区域中的物体; 制动装置使车辆减速; 向车辆的乘员输出报警的报警装置; 第三检测器,测量车辆的行驶状态; 碰撞确定装置,其基于行驶状态确定车辆与物体之间的碰撞的可能性; 以及当存在碰撞的可能性时操作制动装置和报警装置中的至少一个的控制器,其中控制器改变报警装置的操作定时,制动装置的操作定时和减速度中的至少一个 根据第一检测器和第二检测器是否检测到物体,通过制动装置。
    • 68. 发明授权
    • Information processing apparatus and method, program, and storage medium
    • 信息处理装置和方法,程序和存储介质
    • US07680768B2
    • 2010-03-16
    • US11756477
    • 2007-05-31
    • Hiroyuki KoikeTomohiro Tsunoda
    • Hiroyuki KoikeTomohiro Tsunoda
    • G06F17/30
    • G06F17/30699G06F17/30867Y10S707/99932
    • Disclosed herein is an information processing apparatus including: storage means for storing a recommendation degree that indicates a degree of recommendation of a content for a user; similarity degree calculation means for calculating a degree of similarity between a part of a user profile as updated and a content profile; recommendation degree variation calculation means for calculating, based on the degree of similarity calculated by the similarity degree calculation means, an amount of variation of the recommendation degree of the content for the user; and recommendation degree calculation means for calculating a new recommendation degree by adding the amount of the variation of the recommendation degree calculated by the recommendation degree variation calculation means to the recommendation degree stored in the storage means.
    • 本文公开了一种信息处理设备,包括:存储装置,用于存储指示用户的内容的推荐程度的推荐度; 相似度计算装置,用于计算被更新的用户简档的一部分与内容简档之间的相似程度; 推荐度变动量计算装置,用于根据由相似度计算装置计算出的相似度计算用户内容的推荐程度的变化量; 以及推荐度计算装置,用于通过将由推荐度变化计算装置计算出的推荐程度的变化量加上存储在存储装置中的推荐度来计算新的推荐度。
    • 70. 发明申请
    • Vehicle surroundings monitoring apparatus
    • 车辆周边监控装置
    • US20080130954A1
    • 2008-06-05
    • US11799963
    • 2007-05-03
    • Fuminori TaniguchiHiroyuki KoikeMasakazu Saka
    • Fuminori TaniguchiHiroyuki KoikeMasakazu Saka
    • G09G3/36
    • G06K9/00369G06K9/00805
    • A vehicle surroundings monitoring apparatus is provided herein which is capable of determining an object type, particularly capable of determining an animal other than a human being among objects. The vehicle surroundings monitoring apparatus which monitors the surroundings of a vehicle by using an image captured by a camera (2R, 2L) mounted on the vehicle, including an object extraction process unit which extracts an image area of the object from the captured image (steps 1 to 6) and an object type determination process unit which determines the object type according to whether the image area of the object extracted by the object extraction process unit includes a first object area in which the ratio of widths in different directions is within a predetermined range and a plurality of second object areas located below the first object area and smaller in area than the first object area (steps 31 to 37).
    • 本文提供一种能够确定物体类型的车辆周围环境监测装置,特别是能够确定物体之外的人类以外的动物。 一种车辆周边监视装置,其通过使用安装在车辆上的照相机(2R,2L)拍摄的图像来监视车辆的周围环境,包括物体提取处理单元,其从拍摄图像中提取物体的图像区域 (步骤1至6)以及对象类型确定处理单元,其根据由对象提取处理单元提取的对象的图像区域是否包括其中不同方向上的宽度的比率在其内的第一对象区域来确定对象类型 预定范围和位于第一对象区域下方的多个第二对象区域,并且比第一对象区域小的区域(步骤31至37)。